ACR Meeting Abstracts

ACR Meeting Abstracts

  • Home
  • Meetings Archive
    • ACR Convergence 2020
    • 2020 ACR/ARP PRSYM
    • 2019 ACR/ARP Annual Meeting
    • 2018 ACR/ARHP Annual Meeting
    • 2017 ACR/ARHP Annual Meeting
    • 2017 ACR/ARHP PRSYM
    • 2016-2009 Meetings
    • Download Abstracts
  • Keyword Index
  • Advanced Search
  • Your Favorites
    • Favorites
    • Login
    • Register
    • View and print all favorites
    • Clear all your favorites
  • Meeting Resource Center

Abstract Number: 2732

Recommendations for the Management of Neuro-Behcet’s Disease By the Japanese National Research Committee for Behcet’s Disease

Hirotoshi Kikuchi1, Tetsuji Sawada2, Masato Okada3, Mitsuhiro Takeno4, Masataka Kuwana4, Yoshiaki Ishigatsubo5, Izumi Kawachi6, Hideki Mochizuki7, Susumu Kusunoki8 and Shunsei Hirohata9, 1Department of Internal Medicine, Teikyo University School of Medicine, Tokyo, Japan, 2Rheumatology, Tokyo Medical University, Shinjuku Tokyo, Japan, 3Immuno-Rheumatology Center, St. Luke’s International Hospital, Tokyo, Japan, 4Department of Allergy and Rheumatology, Nippon Medical School Graduate School of Medicine, Tokyo, Japan, 5Department of Internal Medicine and Clinical Immunology, Yokohama City University Graduate School of Medicine, Yokohama, Japan, 6Department of Neurology, Niigata University Medical and Dental Hospital, Niigata, Japan, 7Department of Neurology, Osaka University Graduate School of Medicine, Osaka, Japan, 8Department of Neurology, Kinki University School of Medicine, Osaka, Japan, 9Rheumatology and Infectious Diseases, Kitasato University School of Medicine, Kanagawa, Japan

Meeting: 2017 ACR/ARHP Annual Meeting

Date of first publication: September 18, 2017

Keywords: Behcet's syndrome, central nervous system involvement, guidelines and management

  • Tweet
  • Email
  • Print
Save to PDF
Session Information

Date: Tuesday, November 7, 2017

Session Title: Vasculitis Poster III: Other Vasculitis Syndromes

Session Type: ACR Poster Session C

Session Time: 9:00AM-11:00AM

Background/Purpose: Central nervous system involvement is one of the most serious complications in Behçet’s disease (BD). This condition is referred to as neuro-Behçet’s disease (NB) and can be classified into acute type (ANB) and chronic progressive type (CPNB) based upon differences in the clinical course and responses to corticosteroid treatment. Diagnostic criteria were generated in 2013 based on a multicenter clinical survey performed by the Behçet’s Disease Research Committee of the Ministry of Health, Labor and Welfare of the Japanese Government. Although ‘Guidelines for Treatment of NB’ was also proposed based on the survey, it is still preliminary. The aim of the current study is to develop evidence-based recommendations for the management of NB supplemented by expert opinions where necessary.

Methods: First, clinical questions (CQs) on NB were extracted from a literature search for problem areas and related keywords, and draft CQs and a flow chart were prepared. The expert committee, a task force of the research subcommittee for NB, consisted of 7 board-certified rheumatologists (one was also a board-certified neurologist) and 3 board-certified neurologists. A systematic literature search was performed using Medline and the Japan Medical Abstract Society databases from 1997 to 2016. A total of 15 initial CQs were generated. These yielded the final recommendations developed from 3 blind Delphi rounds, in which the rate of agreement scores on CQs (range 1[strongly disagree]-5[strongly agree]) was determined though voting by the whole committee.

Results: Thirteen recommendations were developed for the management of NB (general 1, ANB 7, CPNB 5). The strength of each recommendation was established based on the evidence level as well as rate of agreement. There was excellent concordance between the level of agreement of rheumatologists and that of neurologists. Based on these recommendations, a flow chart was established for the management for ANB and CPNB (Figure).

Conclusion: The recommendations generated in this study are mainly based not only on expert opinions but on the results of uncontrolled evidence from open trials and retrospective cohort studies. Nevertheless, such guidelines that can be used for international studies would be needed, for which verification by further properly designed controlled clinical trials is required.


Disclosure: H. Kikuchi, Mitsubishi Tanabe Pharma, 2; T. Sawada, Mitsubishi Tanabe Pharma, 2; M. Okada, Mitsubishi Tanabe Pharma, 2; M. Takeno, Mitsubishi Tanabe Pharma, 2; M. Kuwana, Mitsubishi Tanabe Pharma, 2; Y. Ishigatsubo, Mitsubishi Tanabe Pharma, 2; I. Kawachi, None; H. Mochizuki, None; S. Kusunoki, None; S. Hirohata, Mitsubishi Tanabe Pharma, 2.

To cite this abstract in AMA style:

Kikuchi H, Sawada T, Okada M, Takeno M, Kuwana M, Ishigatsubo Y, Kawachi I, Mochizuki H, Kusunoki S, Hirohata S. Recommendations for the Management of Neuro-Behcet’s Disease By the Japanese National Research Committee for Behcet’s Disease [abstract]. Arthritis Rheumatol. 2017; 69 (suppl 10). https://acrabstracts.org/abstract/recommendations-for-the-management-of-neuro-behcets-disease-by-the-japanese-national-research-committee-for-behcets-disease/. Accessed January 20, 2021.
  • Tweet
  • Email
  • Print
Save to PDF

« Back to 2017 ACR/ARHP Annual Meeting

ACR Meeting Abstracts - https://acrabstracts.org/abstract/recommendations-for-the-management-of-neuro-behcets-disease-by-the-japanese-national-research-committee-for-behcets-disease/

Advanced Search

Your Favorites

You can save and print a list of your favorite abstracts by clicking the “Favorite” button at the bottom of any abstract. View your favorites »

ACR Convergence: Where Rheumatology Meets. All Virtual. November 5-9.

ACR Pediatric Rheumatology Symposium 2020

© COPYRIGHT 2021 AMERICAN COLLEGE OF RHEUMATOLOGY

Wiley

  • Home
  • Meetings Archive
  • Advanced Search
  • Meeting Resource Center
  • Online Journal
  • Privacy Policy
  • Permissions Policies
loading Cancel
Post was not sent - check your email addresses!
Email check failed, please try again
Sorry, your blog cannot share posts by email.
This site uses cookies: Find out more.