Session Type: Abstract Submissions (ACR)
Background/Purpose: To determine whether knee cartilage composition differs between African-American and matched Caucasian-American women at risk for Osteoarthitis (OA) using in-vivo 3T MRI T2 relaxation time measurements.
Methods: Right knee 3 Tesla MRI studies of 200 subjects (100 African-American women, 100 Caucasian-American were selected from the Osteoarthritis Initiative Cohort and closely matched for age, BMI, Kellgren-Lawrence Scores (KL≤1), subcohort and clinical site. Knee cartilage was segmented and T2 maps were generated in five compartments (patella (PAT), medial and lateral femur (MF/LF), medial and lateral tibia (MT/LT)). Mean T2 relaxation time values per compartment and per whole joint cartilage were generated and analyzed spatially via laminar and grey-level-co-occurrence-matrix texture methods. Presence and severity of cartilage lesions per compartment were graded using a modified whole-organ magnetic resonance imaging score (WORMS). Statistical analysis employed paired t- and McNemar testing.
Results: Although African-American and matched Caucasian-Americans did not differ in their WORMS cartilage lesion score (p=0.970), African American women showed significantly lower mean T2 values than Caucasian-Americans in the whole knee cartilage (p<0.001), and in the subcompartments (LF: p=0.001, MF: p<0.001, LT: p=0.019, MT: p=0.001) and particularly in the superficial cartilage layer (whole cartilage: p<0.001, LF: p<0.001, MF: p<0.001, LT: p=0.003, MT: p<0.001). T2 texture parameters were also significantly lower in the whole joint cartilage of African-American women than in Caucasian-Americans (variance: p=0.001; contrast: p=0.018). In analyses limited to matched pairs with no cartilage lesions in a given compartment, T2 values remained significantly lower in African-Americans.
Conclusion: Using T2 relaxation time as a biomarker for the cartilage collagen network, our findings suggest racial differences in the biochemical knee cartilage composition between African-American and Caucasian-American women.
G. B. Joseph,
C. E. McChulloch,
M. C. Nevitt,
N. E. Lane,
T. M. Link,
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ACR Meeting Abstracts - https://acrabstracts.org/abstract/racial-differences-in-biochemical-knee-cartilage-composition-between-african-american-and-caucasian-american-women-with-mr-based-t2-relaxation-time-measurements-data-from-the-osteoarthritis/