Session Type: ACR Poster Session C
Session Time: 9:00AM-11:00AM
Background/Purpose: Increased risk of several comorbidities has been reported in spondyloarthritis (SpA). Data and knowledge regarding the prevalence of these comorbidities and risk factors in Latin America are limited. The objective of this study is to determine the prevalence and risk of develop comorbidities as assessed in the ASAS-COMOSPA study in patients with SpA in three Latin American countries, and to compare this prevalence with the information in the general population to determine whether the prevalence and the risk of comorbidities is increased.
Data from 390 consecutive patients with SpA enrolled in the international cross-sectional ASAS-COMOSPA study from Argentina, Colombia and Mexico were analyzed. The prevalence (95% CI) standardized by age and gender was estimated for arterial hypertension (AHT), tuberculosis (TB), and malignancies (colon, skin, lung, lymphoma, prostate, cervix and breast). Data from the general population (stratified by gender and age group) were obtained from the CARMELA study for AHT, the Global TB report and the GLOBOCAN project for malignancies. The prevalence in SpA patients was compared with the prevalence. in the general population by calculating the age- and gender-specific categories. A standardized risk ratio (SRR) was calculated for corrected age and gender groups between the SpA patients and the data from the general population. SPSS 22 was used to perform the statistical analyses.
In total, 64% were male, the mean age was 45 (14.7) years and the disease duration was 7.0 (8.1) years. The most common comorbidities were AHT (25.3%), hypercholesterolemia (21.8%), osteoporosis (9.4%) and gastrointestinal ulcer (7.8%). The prevalence of AHT was 25.3% (95% CI 21.2 to 29.4) and was higher compared with the general population (16.3%, 95% CI 15.4 to 17.2). The AHT risk of patients with SpA was increased 8.8 times compared with the general population The overall prevalence of TB was 3.33% (95% CI 1.8 to 5.7), and was higher compared with the general population (0.03%). The total risk of TB was found to increase 14.6 times than expected to general population. There was no a significantly increased prevalence of malignancies compared with the general population.
In patients with SpA we observed a higher prevalence and risk for AHT and TB in three Latin American countries than expected from the age-and gender-adjusted general population. A systematic evaluation and screening of these comorbidities and risk factors may help to properly monitor and detect these conditions in SpA patients.
To cite this abstract in AMA style:BAUTISTA-MOLANO W, Landewé R, Molto A, Burgos-Vargas R, Maldonado-Cocco JA, Valle-Oñate R, van der Heijde D. Prevalence of Comorbidities and Risk Factors of Spondyloarthritis in Latin America: A Comparative Study with the General Population: Data from the Multinational ASAS-Comospa Study [abstract]. Arthritis Rheumatol. 2016; 68 (suppl 10). https://acrabstracts.org/abstract/prevalence-of-comorbidities-and-risk-factors-of-spondyloarthritis-in-latin-america-a-comparative-study-with-the-general-population-data-from-the-multinational-asas-comospa-study/. Accessed September 19, 2020.
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ACR Meeting Abstracts - https://acrabstracts.org/abstract/prevalence-of-comorbidities-and-risk-factors-of-spondyloarthritis-in-latin-america-a-comparative-study-with-the-general-population-data-from-the-multinational-asas-comospa-study/