Prevalence of Abortions and Fetal Atrioventricular Block in Patients with Positive ANTI-RO and ANTI-La Antibodies

Isabel Martinez Cordellat¹, Francisco Miguel Ortiz-Sanjuán¹, Jose Ivorra Cortes¹, Luis Gonzalez Puig¹, Inmaculada Chalmeta Verdejo¹, Irene Calabuig Sais², Elena Grau Garcia^1,3, Carlos Feced Olmos¹, Eztizen Labrador Sanchez¹, Karla Arevalo Ruales¹, Rosa Negueroles Albuixech¹, Jorge Fragio Gil¹, Jose Luis Valero Sanz¹, Cristina Alcañiz Escandell^1,3, Carmen Najera Herranz¹, Gema Poveda Marin^1,3 and Jose Andres Roman Ivorra^1,2,3, ¹Department of Rheumatology, Hospital Universitario y Politecnico La Fe, Valencia, Spain, ²Universidad Católica de Valencia, Valencia, Spain, ³IIS La Fe, Valencia, Spain

Meeting: ACR/ARHP Annual Meeting 2016

Date of first publication: September 28, 2016

Keywords: Antibodies

Session Information

Date: Tuesday, November 15, 2016

Title: Sjögren's Syndrome - Poster II: Clinical Science

Session Type: ACR Poster Session C

Session Time: 9:00AM-11:00AM

Background/Purpose: Anti-SSA/Ro and anti-SSB/La antibodies are present in inflammatory autoimmune disease patient sera, and there are related to different clinical manifestations. It is well known the association between the presence of these antibodies in maternal blood and fetal atrioventricular block. However, there are no much studies about infertility or repeated abortions and anti-SSA/Ro and anti-SSB/La antibodies in broad series. The aim of this study is to characterise a cohort of patients with positive anti-SSA/Ro and/or anti-SSB/La antibodies and to evaluate the prevalence of abortions and neonatal mortality.

Methods: Observational descriptive study with 162 patients older than 15 years old with pregnancies history and positive anti-SSA/Ro and/or anti-SSB/La antibodies from February 2011 to July 2015. We consider healthy women with pregnancies history and with comparable characteristics as negative control group.

Results: We included 162 patients with positive anti-SSA/Ro and/or anti-SSB/La antibodies with a mean age of 50.5±14.2 years old. Main diagnosis were systemic lupus erythematosus (n=85), Sjögren syndrome (n=40), rheumatoid arthritis (n=16), systemic sclerosis (n=6), mixed connective tissue disease (n=3) and other diagnosis (n=12). Lupus anticoagulant was positive in 8 cases and 57 patients showed low complement values. 37% of patients had at least one pregnancy, and the 36.7% aborted during pregnancy. There were no significant differences in the abortion incidence between our cohort of patients and the healthy control group considered. We observed 4 cases of fetal atrioventricular block, all of them with positive anti-SSA/Ro and/or anti-SSB/La antibodies and only in one case also with positive lupus anticoagulant.

Conclusion: In our series, pregnant women with positive anti-SSA/Ro and/or anti-SSB/La antibodies did not show high prevalence of abortion. However, the positivity of these antibodies was statistically correlated with the presence of fetal atrioventricular block.

Disclosure: I. Martinez Cordellat, None; F. M. Ortiz-Sanjuán, None; J. Ivorra Cortes, None; L. Gonzalez Puig, None; I. Chalmeta Verdejo, None; I. Calabuig Sais, None; E. Grau Garcia, None; C. Feced Olmos, None; E. Labrador Sanchez, None; K. Arevalo Ruales, None; R. Negueroles Albuixech, None; J. Fragio Gil, None; J. L. Valero Sanz, None; C. Alcañiz Escandell, None; C. Najera Herranz, None; G. Poveda Marin, None; J. A. Roman Ivorra, None.

To cite this abstract in AMA style:

Martinez Cordellat I, Ortiz-Sanjuán FM, Ivorra Cortes J, Gonzalez Puig L, Chalmeta Verdejo I, Calabuig Sais I, Grau Garcia E, Feced Olmos C, Labrador Sanchez E, Arevalo Ruales K, Negueroles Albuixech R, Fragio Gil J, Valero Sanz JL, Alcañiz Escandell C, Najera Herranz C, Poveda Marin G, Roman Ivorra JA. Prevalence of Abortions and Fetal Atrioventricular Block in Patients with Positive ANTI-RO and ANTI-La Antibodies [abstract]. Arthritis Rheumatol. 2016; 68 (suppl 10). https://acrabstracts.org/abstract/prevalence-of-abortions-and-fetal-atrioventricular-block-in-patients-with-positive-anti-ro-and-anti-la-antibodies/. Accessed .

ACR Meeting Abstracts - https://acrabstracts.org/abstract/prevalence-of-abortions-and-fetal-atrioventricular-block-in-patients-with-positive-anti-ro-and-anti-la-antibodies/