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Abstract Number: 1200

Prevalence and Joint Involvement Patterns of Erosive and Non-erosive Hand Osteoarthritis in the General Population in China

Jing Ye1, Yuqing Wang1, Tuo Yang2, David Hunter3, Yuqing Zhang4, Weiya Zhang5, Michael Doherty5, Jiatian Li1, wei Li1, Zeqin Wen1, Chao Zeng6, Guanghua Lei7 and Jie Wei8, 1Department of Orthopaedics, Xiangya Hospital, Central South University, Changsha, China (People's Republic), 2Health Management Center, Xiangya Hospital, Central South University, Changsha, China (People's Republic), 3Sydney Musculoskeletal Health, University of Sydney, St Leonards, New South Wales, Australia, 4Division of Rheumatology, Allergy, and Immunology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School; The Mongan Institute, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 5Academic Rheumatology, School of Medicine, University of Nottingham; Pain Centre Versus Arthritis, University of Nottingham, Nottingham, United Kingdom, 6Department of Orthopaedics, Xiangya Hospital, Central South University; Key Laboratory of Aging-related Bone and Joint Diseases Prevention and Treatment, Ministry of Education, Xiangya Hospital, Central South University; Hunan Key Laboratory of Joint Degeneration and Injury, Xiangya Hospital, Central South University; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University; Department of Epidemiology and Health Statistics, Xiangya School of Public Health, Central South University, Changsha, China (People's Republic), 7Department of Orthopaedics, Xiangya Hospital, Central South University; Key Laboratory of Aging-related Bone and Joint Diseases Prevention and Treatment, Ministry of Education, Xiangya Hospital, Central South University; Hunan Key Laboratory of Joint Degeneration and Injury, Xiangya Hospital, Central South University; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China (People's Republic), 8Department of Orthopaedics, Xiangya Hospital, Central South University; Key Laboratory of Aging-related Bone and Joint Diseases Prevention and Treatment, Ministry of Education, Xiangya Hospital, Central South University; Hunan Key Laboratory of Joint Degeneration and Injury, Xiangya Hospital, Central South University; Department of Epidemiology and Health Statistics, Xiangya School of Public Health, Central South University, Changsha, China (People's Republic)

Meeting: ACR Convergence 2024

Keywords: Epidemiology, hand, Osteoarthritis

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Session Information

Date: Sunday, November 17, 2024

Title: Osteoarthritis – Clinical Poster I

Session Type: Poster Session B

Session Time: 10:30AM-12:30PM

Background/Purpose: Erosive hand osteoarthritis (HOA) poses challenges due to its aggressive nature and limited epidemiological insights. We aimed to describe the prevalence and joint involvement patterns of erosive and non-erosive HOA.

Methods: Participants aged 50 years or older underwent posteroanterior radiographs of both hands in the Xiangya Osteoarthritis Study, a community-based observational study in China. Erosive HOA was determined using the Verbruggen-Veys erosive or remodeled phase progression score and OARSI atlas. Non-erosive HOA was defined by the Kellgren-Lawrence scale ≥ 2 without erosive features. We estimated the age and sex-specific prevalence of erosive and non-erosive HOA at the person level and subsequently estimated the prevalence at the joint level. We performed Generalized Estimating Equations (Poisson distribution and log link) to calculate the prevalence ratio (PR) to describe the inter-joint relationship of each type of HOA, focusing on symmetry (i.e., same joint in the opposite hand), row (i.e., joints in the same row of the same hand), and ray (i.e., joints in the same ray of the same hand). In the regression models, we adjusted for age, sex, BMI, smoking status, alcohol consumption, education level, and hand injury history.

Results: Among the 3,906 participants, the prevalence of erosive and non-erosive HOA was 4.02% and 26.50%, respectively. The prevalence of both erosive and non-erosive HOA increased with age, and was higher in men than in women between the ages 50-55, but was higher in women than in men among those aged 55 years or older (Figure 1). Both erosive and non-erosive HOA often involved multiple joints. However, erosive HOA predominantly affected distal interphalangeal (DIP) joints, with a prevalence ranging from 0.77% to 2.10%, and no case affected the metacarpophalangeal (MCP) joints of the fingers or thumb (Figure 2A). In contrast, non-erosive HOA mainly targeted thumb interphalangeal joints (10%) and could affect the finger and thumb MCP joints (Figure 2B). Erosive HOA displayed significant symmetry (PR = 287.8, 95% confidence interval [CI]: 196.7, 421.2) and clustering by row (PR = 229.1, 95%CI: 154.8, 338.9), but not by ray (PR = 1.5, 95%CI: 0.7, 3.5). Non-erosive HOA also showed symmetry (PR = 12.7, 95%CI: 11.3, 14.3) and clustering both by row (PR = 14.6, 95%CI: 12.6, 16.9) and by ray (PR = 2.2, 95%CI: 1.9, 2.6) (Table 1).

Conclusion: The prevalence of both erosive and non-erosive HOA increased with age and was higher among women than men among those aged 55 years or older. Erosive HOA displayed symmetry and clustering by row but not by ray and did not affect MCP joints. In contrast, non-erosive HOA exhibited symmetry, clustering both by row and by ray, and did involve MCP joints. These findings support the view that erosive and non-erosive HOA are distinct conditions with a different pathophysiology.

Supporting image 1

Figure 1. Prevalence of Erosive HOA and Non-erosive HOA according to age and sex. HOA, hand osteoarthritis.

Supporting image 2

Figure 2. Prevalence of Erosive HOA and Non-erosive HOA by joints. The prevalence of HOA at various joint sites is indicated by the color depth, ranked from the highest to lowest in the following order: red, orange, blue, and green. HOA, hand osteoarthritis; CMC, carpometacarpal; MCP, metacarpophalangeal; PIP, proximal interphalangeal; IP, interphalangeal; DIP, distal interphalangeal.

Supporting image 3

Table 1. Clustering patterns of Erosive HOA and Non-erosive HOA


Disclosures: J. Ye: None; Y. Wang: None; T. Yang: None; D. Hunter: Novartis, 2, TLC, 2; Y. Zhang: None; W. Zhang: None; M. Doherty: None; J. Li: None; w. Li: None; Z. Wen: None; C. Zeng: None; G. Lei: None; J. Wei: None.

To cite this abstract in AMA style:

Ye J, Wang Y, Yang T, Hunter D, Zhang Y, Zhang W, Doherty M, Li J, Li w, Wen Z, Zeng C, Lei G, Wei J. Prevalence and Joint Involvement Patterns of Erosive and Non-erosive Hand Osteoarthritis in the General Population in China [abstract]. Arthritis Rheumatol. 2024; 76 (suppl 9). https://acrabstracts.org/abstract/prevalence-and-joint-involvement-patterns-of-erosive-and-non-erosive-hand-osteoarthritis-in-the-general-population-in-china/. Accessed .
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