Predictive Factors of Increased Vascular Stiffness in Patient with Gout and Hyperuricemia

WooSeong Jeong¹, Jinseok Kim², Joon Hyouk Choi³ and Byeongzu Ghang¹, ¹Division of Rheumatology, Department of Internal Medicine, Jeju National University Hospital, University of Jeju School of Medicine, Jeju, Korea, Republic of (South), ²Department of Medicine, Jeju National University Hospital, University of Jeju School of Medicine, Jeju, Korea, Republic of (South), ³Division of Cardiology, Department of Internal Medicine, Jeju National University Hospital, University of Jeju School of Medicine, Jeju, Korea, Republic of (South)

Meeting: ACR/ARHP Annual Meeting 2018

Keywords: gout

Session Information

Date: Monday, October 22, 2018

Title: Metabolic and Crystal Arthropathies – Basic and Clinical Science Poster I

Session Type: ACR Poster Session B

Session Time: 9:00AM-11:00AM

Background/Purpose:

Background: Gout is the most common form of inflammatory arthritis and its prevalence is increasing in more affluent countries in recent decades. Many studies have reported that gout and hyperuricemia are associated with an increase in all-cause mortality and cardiovascular mortality. Increased arterial stiffness is an independent marker of cardiovascular diseases and risk predictors. Many studies have shown a significant correlation between uric acid levels and arterial stiffness. Augmentation Index (AI) is an indirect measure of arterial stiffness.

Purpose: The aim of this study is to evaluate the predictors of increased arterial stiffness in gout and hyperuricemia patients.

Methods: Between June 2017 and June 2018, AI was measured using SphygmoCor for patients who visited Jeju National University Hospital in South Korea with gout or hyperuricemia. Medical records, laboratory and AI data were retrospectively analyzed and multivariate analysis was performed.

Results: One hundred twenty two patients participated in the study and AI was measured. Most (96.7%) of the patients were male. At the time of the examination, 99 patients (81.1%) were treated with uric acid lowering and the mean duration of the disease was 6.9 years. When the patients were divided into two groups according to the presence or absence of Tophi, the average age (60.2±11.6 vs 53.4±13.2, p=0.023) of the patients with Tophi was significantly higher, duration of disease (13.0±6.5 vs 5.4±5.4, p=0.000) was longer and the AI (28.7±7.8 vs 20.7±10.4, p=0.001) was higher. When univariate regression analysis was performed, tophi was able to predict high AI (b = 7.99, 95% CI 3.50-12.49, p=0.001). When multivariate regression analysis was performed to exclude the effects of other variables(DM, HTN, hyperlipidemia, age, BMI, total cholesterol, creatinine), tophi was a predictor of high AI (b = 6.10, 95% CI 0.43-11.79, p=0.035)

Conclusion: This study suggests that the presence of tophi is an independent predictor of increased arterial stiffness in patients with gout and hyperuricemia.

Disclosure: W. Jeong, None; J. Kim, None; J. H. Choi, None; B. Ghang, None.

To cite this abstract in AMA style:

Jeong W, Kim J, Choi JH, Ghang B. Predictive Factors of Increased Vascular Stiffness in Patient with Gout and Hyperuricemia [abstract]. Arthritis Rheumatol. 2018; 70 (suppl 9). https://acrabstracts.org/abstract/predictive-factors-of-increased-vascular-stiffness-in-patient-with-gout-and-hyperuricemia/. Accessed .

ACR Meeting Abstracts - https://acrabstracts.org/abstract/predictive-factors-of-increased-vascular-stiffness-in-patient-with-gout-and-hyperuricemia/