ACR Meeting Abstracts

ACR Meeting Abstracts

  • Home
  • Meetings Archive
    • 2019 ACR/ARP Annual Meeting
    • 2018 ACR/ARHP Annual Meeting
    • 2017 ACR/ARHP Annual Meeting
    • 2017 ACR/ARHP PRSYM
    • 2016 ACR/ARHP Annual Meeting
    • 2015 ACR/ARHP Annual Meeting
    • 2014 ACR/ARHP Annual Meeting
    • 2013 ACR/ARHP Annual Meeting
    • 2012 ACR/ARHP Annual Meeting
    • 2011 ACR/ARHP Annual Meeting
    • 2010 ACR/ARHP Annual Meeting
    • 2009 ACR/ARHP Annual Meeting
    • Download Abstracts
  • Keyword Index
  • Advanced Search
  • Your Favorites
    • Favorites
    • Login
    • Register
    • View and print all favorites
    • Clear all your favorites
  • Meeting Resource Center

Abstract Number: 801

PET-CT Findings and Clinical Outcomes in Takayasu Arteritis – Does 18F-Fluorodeoxyglucose Uptake in Arteries Predict Relapses?

Anna Larissa Faria Janes1, Míriam Fang Castro1, Bruna Savioli1, Anne Elisabeth Diniz Arraes1, Emilia Sato2 and Alexandre W.S. Souza3, 1Internal Medicine - Rheumatology Division, Universidade Federal de São Paulo - Escola Paulista de Medicina, São Paulo, Brazil, 2Rheumatology Division, Universidade Federal de Sao Paulo, Sao Paulo, Brazil, 3Rheumatology Div/Dept of Med, Escola Paulista de Medicina - Universidade Federal de São Paulo, Sao Paulo, Brazil

Meeting: 2017 ACR/ARHP Annual Meeting

Date of first publication: September 18, 2017

Keywords: large vessel vasculitis, positron emission tomography (PET) and takayasu arteritis

  • Tweet
  • Email
  • Print
Save to PDF
Session Information

Date: Sunday, November 5, 2017

Session Title: Vasculitis Poster I: Large Vessel Vasculitis

Session Type: ACR Poster Session A

Session Time: 9:00AM-11:00AM

Background/Purpose: PET-CT scan with 18F-Fluorodeoxyglucose (18F-FDG) has been frequently used as a tool to assess disease activity in Takayasu arteritis (TA) and increased 18F-FDG uptake in arteries is considered a surrogate marker of ongoing arterial inflammation. A previous cross-sectional study showed an association between the maximal standardized uptake value (SUVmax) in TA and disease activity in TA. To date, it is not known whether 18F-FDG uptake in arteries is associated with disease progression in TA with the development of new angiographic lesions. This study aims to evaluate associations between 18F-FDG uptake in arteries from TA and the risk to develop relapses, ischemic events, sustained remission (i.e. absence of disease activity and complete withdrawal of glucocorticoids for at least 6 months), new angiographic lesions and the need to change therapy in TA patients.

Methods: TA patients underwent PET-CT scan with 18F-FDG with arterial uptake measured by the SUV and SUVmax in arterial walls to asses disease activity and were longitudinally assessed for disease activity using Kerr’s criteria and for the development of new angiographic lesions by magnetic resonance angiography and/or by computerized tomography angiography.

Results: Amongst 36 TA patients initially evaluated by 18F-FDG PET-CT scan, 32 were longitudinally followed for a median of 83.5 months. The median SUVmax value in arteries was 1.57 (1.16-2.23). At baseline, 20 TA patients (62.5%) had SUVmax ≥ 1.3, whereas 11 TA patients (34.4%) had active disease by Kerr’s criteria. At follow-up, 23 (71.9%) patients had at least one disease relapse at a median of 17.0 months and new arterial lesions were observed in 14 (43.8%) cases. There were no differences regarding the baseline SUV value in arteries that developed and arteries that did not develop new angiographic lesions in TA patients. A higher frequency of disease relapses (85.0% vs. 50.0%, p = 0.049) and the need for changing immunosuppressive therapy (85.0% vs. 41.7%, p = 0.018) was observed in TA patients with SUVmax ≥1.3 at baseline compared with those with SUVmax <1.3. No differences regarding SUVmax ≥1.3 in arteries and the development of ischemic events, sustained remission and new angiographic lesions were found in TA patients. Using the Kaplan-Meier curve, a trend for a higher frequency of relapses was observed in TA patients with SUVmax ≥1.3 (p = 0.056) by the log rank test. No independent associations were found between baseline SUVmax ≥1.3 and the risk of relapses (HR = 1.07; 95CI: 0.39-2.92; p = 0.892) or between baseline SUVmax ≥1.3 and the risk of developing new angiographic lesions in (HR = 0.24; 95CI: 0.02-2.57; p = 0.239) by the multivariate Cox’s proportional hazard analysis.

Conclusion: There is no association between arterial SUV and development of new arterial lesion in TA, but arterial SUVmax in TA patients is marginally associated with a higher frequency of disease relapses and with the need for changing immunosuppressive therapy.

Arraes AE, de Souza AW, Mariz HA, et al. (18)F-Fluorodeoxyglucose positron emission tomography and serum cytokines and matrix metalloproteinases in the assessment of disease activity in Takayasu’s arteritis. Rev Bras Reumatol 2016;56:299-308.


Disclosure: A. L. Faria Janes, None; M. Fang Castro, None; B. Savioli, None; A. E. Diniz Arraes, None; E. Sato, None; A. W. S. Souza, None.

To cite this abstract in AMA style:

Faria Janes AL, Fang Castro M, Savioli B, Diniz Arraes AE, Sato E, Souza AWS. PET-CT Findings and Clinical Outcomes in Takayasu Arteritis – Does 18F-Fluorodeoxyglucose Uptake in Arteries Predict Relapses? [abstract]. Arthritis Rheumatol. 2017; 69 (suppl 10). https://acrabstracts.org/abstract/pet-ct-findings-and-clinical-outcomes-in-takayasu-arteritis-does-18f-fluorodeoxyglucose-uptake-in-arteries-predict-relapses/. Accessed December 10, 2019.
  • Tweet
  • Email
  • Print
Save to PDF

« Back to 2017 ACR/ARHP Annual Meeting

ACR Meeting Abstracts - https://acrabstracts.org/abstract/pet-ct-findings-and-clinical-outcomes-in-takayasu-arteritis-does-18f-fluorodeoxyglucose-uptake-in-arteries-predict-relapses/

Advanced Search

Your Favorites

You can save and print a list of your favorite abstracts by clicking the “Favorite” button at the bottom of any abstract. View your favorites »

Annual Meeting in Atlanta, Georgia

© COPYRIGHT 2019 AMERICAN COLLEGE OF RHEUMATOLOGY

Wiley

  • Home
  • Meetings Archive
  • Advanced Search
  • Meeting Resource Center
  • Online Journal
  • Privacy Policy
  • Permissions Policies
loading Cancel
Post was not sent - check your email addresses!
Email check failed, please try again
Sorry, your blog cannot share posts by email.
This site uses cookies: Find out more.