Patients with Inflammatory Arthritis Who Are More Adherent to Treatment Do Not Perform More Physical Activity Collected by Smartphone Apps: A Cross-sectional Study of 101 Patients, the ImBAIA Study

Thomas Davergne¹, Rawdha Tekaya², Camille Deprouw³, Anne Tournadre⁴, Stéphane Mitrovic⁵, Adeline Ruyssen-Witrand⁶, Christophe Hudry⁷, Sabrina Dadoun⁸, Jérôme Avouac⁹, Kate Betteridge¹⁰, Bruno Fautrel¹¹ and Laure Gossec¹², ¹Sorbonne University, INSERM, IPLES, Paris, France, ²Hôpital Charles Nicolle, Rheumatology department, Tunis, Tunisia, Tunis, Tunisia, ³1. AP-HP, Hôpital Saint-Antoine, Service de Rhumatologie, Paris, 75012, France, Paris, France, ⁴CHU Gabriel Montpied, Clermont-Ferrand, ⁵Institut Mutualiste Montsouris, Rheumatology department, Paris, France, Paris, Ile-de-France, France, ⁶Hôpital Purpan, CHU Toulouse, Toulouse, France, ⁷CeSOA, MGEN, Paris, France, Paris, Ile-de-France, France, ⁸Medical centre, Paris, France, paris, Ile-de-France, France, ⁹Cochin hospital, Rheumatology department, Paris, France, Paris, Ile-de-France, France, ¹⁰Patient research partner, UK, london, England, United Kingdom, ¹¹Sorbonne University, INSERM, IPLES; Pitié-Salpêtrière Hospital, Paris, Ile-de-France, France, ¹²Sorbonne University, INSERM; Pitié-Salpêtrière Hospital, Paris, Ile-de-France, France

Meeting: ACR Convergence 2020

Keywords: Adhesion, Adhesion molecules, physical activity, Psoriatic arthritis, rheumatoid arthritis, spondyloarthritis

Session Information

Date: Monday, November 9, 2020

Session Title: Patient Outcomes, Preferences, & Attitudes II: Engagement, Perceptions, & Quality of Life (1978–1982)

Session Type: Abstract Session

Session Time: 11:00AM-11:50AM

Background/Purpose: Adherence to both medications and physical activity is insufficient in patients with inflammatory arthritis (IA), such as spondyloarthritis (axSpA), rheumatoid arthritis (RA) or psoriatic arthritis (PsA). Are there patterns towards adherence to both of these aspects of management?

Objectives: to assess and compare adherence to medication and levels of physical activity collected through Apps, in patients with IA.

Methods: This was an international, multicentric, cross-sectional study performed between October 2019 and June 2020 (ClinicalTrial NCT04426747). Consecutive patients were included if they had definite axSpA, RA or PsA, were aged above 18 and able to walk, with smartphones compatible with Apps measuring steps. Adherence to medication was assessed using the Medication Adherence Report Scale MARS-9 (ranging from 9 to 45 with higher scores indicating higher adherence). Physical activity was measured by steps per day over the past week, through the patient’s smartphone apps. The link between the MARS-9 score and physical activity was assessed by linear and logistic regression. For the logistic regression, patients were considered less adherent for the lowest tertile of the MARS score. They were compared to more adherent patients by univariable and multivariable logistic regression. There was no imputation of missing data.

Results: Of 130 patients included, 101 had analyzable data (46 (46%) axSpA, 26 (26%) RA, 27 (27%) PsA). Mean age was 45.2 years (standard deviation 13.1), mean disease duration 10.0 (8.5) years and 47% were women. 67% were receiving a biologic, and disease activity was moderate. Adherence to medication was high: the mean MARS score was 38.9 (7.0) with a median of 41. Physical activity was moderate: the mean steps per day collected with apps was 5631 (4286), median 4244 with 29% walking over 7000 steps per day. The linear regression between adherence to medications and steps per day did not indicate a link (R=-0.04, p=0.72). Furthermore, patients with a lower adherence to medication (lowest tertile scores, ie, < =38) did not differ in terms of physical activity 5703 (4014) versus 5602 (4419) steps per day, p=0.80 in multivariable analysis.

Conclusion: In this population of long-standing IA, adherence to medication was high whereas physical activity was insufficient. Patients with IA who were more adherent to treatment were not more physically active than those less adherent. Adherence to medication and adherence to lifestyle changes may be linked to different coping mechanisms.

Disclosure: T. Davergne, None; R. Tekaya, None; C. Deprouw, None; A. Tournadre, None; S. Mitrovic, None; A. Ruyssen-Witrand, None; C. Hudry, None; S. Dadoun, None; J. Avouac, None; K. Betteridge, None; B. Fautrel, MSD France, 1, 2, Abbvie, 1, 2, Pfizer, 1, 2, Biogen, 1, BMS, 1, Boehringer Ingelheim, 1, Celgene, 1, Janssen, 1, Lilly, 1, Medac, 1, Nordic Pharma, 1, Novartis, 1, Roche, 1, Sanofi-Aventis, 1, SOBI, 1, UCB Pharma, 1; L. Gossec, None.

To cite this abstract in AMA style:

Davergne T, Tekaya R, Deprouw C, Tournadre A, Mitrovic S, Ruyssen-Witrand A, Hudry C, Dadoun S, Avouac J, Betteridge K, Fautrel B, Gossec L. Patients with Inflammatory Arthritis Who Are More Adherent to Treatment Do Not Perform More Physical Activity Collected by Smartphone Apps: A Cross-sectional Study of 101 Patients, the ImBAIA Study [abstract]. Arthritis Rheumatol. 2020; 72 (suppl 10). https://acrabstracts.org/abstract/patients-with-inflammatory-arthritis-who-are-more-adherent-to-treatment-do-not-perform-more-physical-activity-collected-by-smartphone-apps-a-cross-sectional-study-of-101-patients-the-imbaia-study/. Accessed March 8, 2021.

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