ACR Meeting Abstracts

ACR Meeting Abstracts

  • Meetings
    • ACR Convergence 2024
    • ACR Convergence 2023
    • 2023 ACR/ARP PRSYM
    • ACR Convergence 2022
    • ACR Convergence 2021
    • ACR Convergence 2020
    • 2020 ACR/ARP PRSYM
    • 2019 ACR/ARP Annual Meeting
    • 2018-2009 Meetings
    • Download Abstracts
  • Keyword Index
  • Advanced Search
  • Your Favorites
    • Favorites
    • Login
    • View and print all favorites
    • Clear all your favorites
  • ACR Meetings

Abstract Number: 1526

Patient Reported Outcomes in ANCA-Associated Vasculitis. A Prospective Comparison Between Birmingham Vasculitis Activity Score and Routine Assessment of Patient Index Data 3

Osama ElSallabi1, Joel A. Block1 and Antoine Sreih2, 1Section of Rheumatology, Rush University Medical Center, Chicago, IL, 2Medicine/Rheumatology, Rush University Medical Center, Chicago, IL

Meeting: 2012 ACR/ARHP Annual Meeting

Keywords: Activity score, Clinical, Outcome measures, patient questionnaires and vasculitis

  • Tweet
  • Click to email a link to a friend (Opens in new window) Email
  • Click to print (Opens in new window) Print
Session Information

Title: Vasculitis

Session Type: Abstract Submissions (ACR)

Background/Purpose:

ANCA-associated vasculitis (AAV) is a rare group of diseases comprising Granulomatosis with polyangiitis (Wegener’s; GPA), Microscopic Polyangiitis (MPA), and Churg-Strauss Syndrome (CSS). These diseases often result in severe morbidity and frequent relapses. The Birmingham Vasculitis Activity Score v3 (BVAS) is a well-established and validated tool to measure AAV activity. However, current tools do not include patient-reported outcomes to assess for disease activity. The Multi-Dimensional Health Assessment Questionnaire (MDHAQ) has been documented to be effective in many rheumatic diseases. Therefore, we compared BVAS scores to a patient-only index termed the “Routine Assessment of Patient Index Data 3” (RAPID3) on an MDHAQ.

Methods:

Patients with AAV treated by one rheumatologist at Rush University Medical Center in Chicago, IL from Jan 2010 to May 2012 were asked to participate and given MDHAQ to complete for 4 consecutive visits approximately every 6 months.  An independent investigator scored RAPID3, which comprises 3 Core Data Set measures on the MDHAQ for function, pain, and patient global assessment (PATGL) and takes 5 seconds to score; scores range from 0 to 30, with higher scores being worse. BVAS was calculated at each patient visit; scores range from 0 to 63, with worse disease being higher. Both scores were compared using Spearman non-parametric correlations. BVAS was also compared to PATGL, which is a visual analogue scale from 0 to 10 and is one of the Core Data Set measures in RAPID3. Linear regression was used to adjust for age, sex, ethnicity, RAPID3 version language, type of the disease, duration of the disease, years of schooling and type of insurance. P ≤ 0.5 was considered significant. The institutional Review Board approved the study.

Results:

Twenty-nine patients with AAV consented and were included in the study, 22 had GPA, 5 MPA and 2 CSS. The mean age was 54.1 years, 77% were females, 69% Caucasians, 23% Hispanics, and 8% African-Americans. The mean duration of disease was 4.3 years. The mean BVAS at first visit was 6.1 ± 0.9 (range: 0-17), RAPID3 was 8 ± 1.3 (range: 0-22.7), and PTGA was 3.6 ± 0.5. RAPID3 correlated with BVAS at each visit (rho =0.45, 0.75, 0.73, 0.54 with p values of 0.02, <0.0001, 0.002, and 0.05 for visits 1 to 4, respectively) and PATGL correlated with BVAS at 3 out of 4 visits, independently of RAPID3 (rho= 0.24, 0.75, 0.64, 0.59 with p values of 0.23, <0.0001, 0.01, 0.01 for visits 1 to 4, respectively).

Conclusion:

RAPID3, a patient-only index, is correlated significantly with the BVAS. RAPID3 can be calculated in 5 seconds and does not require physician input, laboratory or imaging information. PATGL, a one simple measure of patient global assessment, may also reflect disease activity. As patient-relevant outcomes become increasingly important to insurers and to society, it is critical to identify valid patient-reported markers of vasculitis activity; RAPID3 permit longitudinal assessments of disease activity at any medical facility by any physician or even away from physician’s offices. In the face of increased expenses and busy practices, such instruments may help document patient status and add to clinical decisions.


Disclosure:

O. ElSallabi,
None;

J. A. Block,
None;

A. Sreih,
None.

  • Tweet
  • Click to email a link to a friend (Opens in new window) Email
  • Click to print (Opens in new window) Print

« Back to 2012 ACR/ARHP Annual Meeting

ACR Meeting Abstracts - https://acrabstracts.org/abstract/patient-reported-outcomes-in-anca-associated-vasculitis-a-prospective-comparison-between-birmingham-vasculitis-activity-score-and-routine-assessment-of-patient-index-data-3/

Advanced Search

Your Favorites

You can save and print a list of your favorite abstracts during your browser session by clicking the “Favorite” button at the bottom of any abstract. View your favorites »

All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying colleagues, institutions, communications firms, and all other stakeholders related to the development or promotion of the abstract about this policy. If you have questions about the ACR abstract embargo policy, please contact ACR abstracts staff at [email protected].

Wiley

  • Online Journal
  • Privacy Policy
  • Permissions Policies
  • Cookie Preferences

© Copyright 2025 American College of Rheumatology