Abstracts Archive - Page 998 of 2607 - ACR Meeting Abstracts

Abstract Number: 868 • 2019 ACR/ARP Annual Meeting
The Effect of Atorvastatin on Microvascular Endothelial Function and Raynaud Phenomenon in Early Diffuse Scleroderma: Results of the “Tamer”‘ Study
Robyn Domsic¹, Maureen Laffoon ¹, Balasubramani Goundappa ², Thomas Medsger ¹, Robert Lafyatis ¹ and Steven Wisniewski ¹, ¹University of Pittsburgh, Pittsburgh, PA, ²University of Pittsburgh Epidemiology Data Center, Pittsburgh, PA
Background/Purpose: Statins have pleiotropic effects felt to influence in their beneficial cardiovascular effects. These include increased nitric oxide production and improved endothelial function, modulation of…
Abstract Number: 869 • 2019 ACR/ARP Annual Meeting
Clinical Manifestations of Patients with Eosinophilic Granulomatosis with Polyangiitis in a Large North American Cohort
Irena Doubelt¹, David Cuthbertson ², Simon Carette ¹, Nader A. Khalidi ³, Curry L. Koening ⁴, Carol Langford ⁵, Carol A. McAlear ⁶, Larry W. Moreland ⁷, Paul Monach ⁸, Philip Seo ⁹, Ulrich Specks ¹⁰, Antoine Sreih ¹¹, Steven Ytterberg ¹⁰, Peter A. Merkel ¹², Christian Pagnoux ¹ and VCRC Vasculitis Clinical Research Consortium ¹³, ¹Mount Sinai Hospital and University Health Network, Toronto, ON, Canada, ²University of South Florida, Tampa, FL, ³McMaster University, Hamilton, ON, Canada, ⁴University of Utah Hospital, Salt Lake City, UT, ⁵Cleveland Clinic, Cleveland, OH, ⁶University of Pennsylvania - VCRC Project Manager, Philadelphia, PA, ⁷University of Pittsburgh, Pittsburgh, PA, ⁸Brigham and Women's Hospital, Boston, MA, ⁹Johns Hopkins Medicine, Baltimore, MD, ¹⁰Mayo Clinic College of Medicine, Rochester, MN, ¹¹University of Pennsylvania, Philadelphia, PA, ¹²Univeristy of Pennsylvania, Philadelphia, PA, ¹³University of Pennsylvania, Division of Rheumatology, philadelphia
Background/Purpose: Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare, systemic necrotizing small-vessel vasculitis, with only a few published North American series. This project aimed to…
Abstract Number: 870 • 2019 ACR/ARP Annual Meeting
Off-Label Use of Biotherapies to Treat Relapsing And/or Refractory Eosinophilic Granulomatosis with Polyangiitis (Churg–Strauss)
Alice Canzian ¹, Nils Venhoff ², Silvia Sartorelli ³, Anne-Marie Ruppert ⁴, Matthieu Groh ⁵, Camille Taille ⁶, Virginie Rieu ⁷, Perrine Smets ⁷, François Maurier ⁸, Nicolas Girszyn ⁹, Maxime Samson ¹⁰, Claire de Moreuil ¹¹, Grégory Pugnet ¹², Xavier Delbrel ¹³, Jean-Emmanuel Kahn ¹⁴, Xavier Puéchal for the French Vasculitis Study Group ¹⁵, Giacomo Emmi ¹⁶, Loic Guillevin ¹⁵, Lorenzo Dagna ¹⁷, Jens Thiel ², Augusto Vaglio ¹⁸ and Benjamin Terrier¹⁵, ¹Cochin Hospital, Paris, France, ²Clinic for Rheumatology and Clinical Immunology, Faculty of Medicine, Medical Center, University of Freiburg, Freiburg, Germany, ³Vita-Salute San Raffaele University, IRCCS San Raffaele Hospital, Milan, Italy, ⁴Tenon Hospital, Paris, France, ⁵Service de Médecine Interne, Centre de Référence des Syndromes Hyperéosinophiliques-CEREO, Hôpital Foch, Université Versailles–Saint-Quentin-en-Yvelines, Suresnes, France, Suresnes, France, ⁶Bichat Hospital, Paris, France, ⁷CHU, Clermont-Ferrand, France, ⁸Service de Médecine Interne, Hôpital Belle Isle, Metz, Metz, France, ⁹CHU, Rouen, France, ¹⁰Service de Médecine Interne et Immunologie Clinique, CHU Dijon Bourgogne, Hôpital François Mitterrand, Dijon ; Université Bourgogne-Franche Comté, INSERM, EFS BFC, UMR1098, F-21000 Dijon, Dijon, France, ¹¹CHU Brest, Brest, France, ¹²CHU de Toulouse, Hôpital Purpan, Service de Médecine Interne, Toulouse, France, ¹³CH, Pau, France, ¹⁴APHP, Boulogne Billancourt, France, ¹⁵National Referral Center for Rare Systemic Autoimmune Diseases Paris Cochin, Paris, France, ¹⁶Department of Experimental and Clinical Medicine, University of Firenze, Florence, Italy, Florence, Italy, ¹⁷Unit of Immunology, Rheumatology, Allergy and Rare Diseases (UnIRAR), IRCCS San Raffaele Hospital, Vita-Salute San Raffaele University, Milan, Italy, ¹⁸Nephrology Unit, Parma University Hospital, Parma, Italy, Nephrology Unit, Parma University Hospital, Parma, Italy, Italy
Background/Purpose: Eosinophilic granulomatosis with polyangiitis (EGPA; formerly Churg–Strauss syndrome), is characterized by small-vessel necrotizing vasculitis, and blood and tissue eosinophilia in asthmatic individuals. Glucocorticoids (GCs)…
Abstract Number: 871 • 2019 ACR/ARP Annual Meeting
ANCA-Associated Vasculitis Management in the United States: Data from the RISE Registry
Zachary Wallace¹, Huifeng Yun ², Jeffrey Curtis ², Shuo Yang ², Lang Chen ², John Stone ³ and Hyon K. Choi ⁴, ¹Massachusetts General Hospital, Boston, ²University of Alabama at Birmingham, Birmingham, AL, ³Massachusetts General Hospital Rheumatology Unit, Harvard Medical School, Boston, MA, ⁴Massachusetts General Hospital, Boston, MA
Background/Purpose: The management of ANCA-associated vasculitis (AAV) evolved substantially in recent years because of evidence supporting the efficacy of various treatment regimens. As such, treatment…
Abstract Number: 872 • 2019 ACR/ARP Annual Meeting
Granulomatosis with Polyangiitis Sustained Remission Off-Therapy: Data from the French Vasculitis Study Group Registry
Xavier Puéchal for the French Vasculitis Study Group¹, Michele Iudici ², Christian Pagnoux ³, Alexandre Karras ⁴, Pascal Cohen ¹, François Maurier ⁵, Thomas Quémeneur ⁶, François Lifermann ⁷, Mohamed Hamidou ⁸, Luc Mouthon ¹, Benjamin Terrier ¹ and Loic Guillevin ¹, ¹National Referral Center for Rare Systemic Autoimmune Diseases Paris Cochin, Paris, France, ²National Referral Center for Rare Systemic Autoimmune Diseases Paris Cochin and Geneva Switzerland, Paris, France, ³National Referral Center for Rare Systemic Autoimmune Diseases Paris Cochin and Toronto Canada, Paris, France, ⁴Paris HEGP, Paris, France, ⁵Service de Médecine Interne, Hôpital Belle Isle, Metz, Metz, France, ⁶CH Valenciennes, Valenciennes, France, ⁷CH Dax, Dax, France, ⁸CHU Nantes, Nantes, France
Background/Purpose: Data on granulomatosis with polyangiitis (GPA) sustained remission off-therapy (SROT) are limited and it is unknown whether disease characteristics or treatment regimen may affect…
Abstract Number: 873 • 2019 ACR/ARP Annual Meeting
Survival After Lung Transplantation in Adults with Primary Systemic Vasculitides: Analysis of the United Network of Organ Sharing (UNOS) Database
Sebastian E. Sattui¹, Zafir Abutalib ², Jackie Finik ² and Robert Spiera ³, ¹Hospital for Special Surgery, New York, ²Hospital for Special Surgery, New York, NY, New York, NY, ³Hospital for Special Surgery, New York, NY
Background/Purpose: Pulmonary involvement, including pulmonary vascular disease and interstitial lung disease can be an important cause of morbidity and even mortality in patients with primary…
Abstract Number: 874 • 2019 ACR/ARP Annual Meeting
Comparative Analysis Between ANCA-associated Interstitial Lung Disease and Interstitial Pneumonitis with Autoimmune Features
Iazsmin Ventura¹, Anisha Dua ², Ayodeji Adegunsoye ³, Mary Strek ³, James Curran ¹, Alexandra Weiss ¹ and Jonathan Chung ¹, ¹University of Chicago, Chicago, ²Northwestern University Feinberg School of Medicine, Chicago, IL, ³University of Chicago, Department of Pulmonary and Critical Care, Chicago
Background/Purpose: Anti-neutrophil cytoplasmic antibodies (ANCA) have been identified in patients who have pneumonia without a diagnosis of ANCA-associated vasculitis (AAV). These patients are presently categorized…
Abstract Number: 875 • 2019 ACR/ARP Annual Meeting
Effect of the Dr. Bart Application on Healthcare Use and Clinical Outcomes in People with Osteoarthritis of the Knee And/or Hip in the Netherlands; A Randomized Controlled Trial
Tim Pelle¹, Karen Bevers ¹, Job van der Palen ², Frank van den Hoogen ³ and Cornelia van den Ende ¹, ¹Sint Maartenskliniek Nijmegen, Nijmegen, Netherlands, ²Department of research methodology, Univeristy of Twente, Enschede, Netherlands, ³Sint Maartenskliniek, Nijmegen, Netherlands
Background/Purpose: Self-management is of paramount importance in non-surgical treatment of knee/hip osteoarthritis (OA). Modern technologies offer the possibility to support self-management 24/7. We developed an…
Abstract Number: 876 • 2019 ACR/ARP Annual Meeting
“When You Read This, You Really Feel Old!” Perspectives of Young People with Inflammatory Arthritis on Patient Reported Outcome Measures from a European Qualitative Study
Erika Mosor¹, Paul Studenic ¹, Alessia Alunno ², Ivan Padjen ³, Wendy Olsder ⁴, Sofia Ramiro ⁵, Ilaria Bini ⁶, Nele Caeyers ⁷, Laure Gossec ⁸, Marios Kouloumas ⁹, Elena Nikiphorou ¹⁰, Simon Stones ¹¹, Tanita Wilhelmer ¹² and Tanja Stamm ¹, ¹Medical University of Vienna, Vienna, Austria, ²Rheumatology Unit, Department of Medicine, University of Perugia, Perugia, Italy, Perugia, Italy, ³UHC Zagreb and University of Zagreb School of Medicine, Zagreb, Croatia, ⁴Patient Research Partner, Amsterdam, Netherlands, ⁵Leiden University Medical Center and Zuyderland Medical Centre, Leiden, Netherlands, ⁶ANMAR Young Patient Advocate, Avellino, Italy, ⁷Patient Research Partner, Brussels, Belgium, ⁸Sorbonne Université and Hôpital Pitié-Salpêtrière, Paris, France, ⁹Cyprus League Against Rheumatism, Nicosia, Cyprus, ¹⁰King's College London, London, United Kingdom, ¹¹University of Leeds, Leeds, United Kingdom, ¹²Österreichische Rheumaliga, Bregenz, Austria
Background/Purpose: Although patient-reported outcome measures (PROMs) are extensively used in clinical practice and research, it is unclear whether the most commonly used instruments adequately cover…
Abstract Number: 877 • 2019 ACR/ARP Annual Meeting
Rheumatoid Arthritis Patients’ Perspectives on Tapering of Biologics: A Qualitative Study
Jack Chan ¹, Lisa Stamp², Nicola Liebergreen ¹, Henry Ndukwe ¹, Carlo Marra ¹ and Gareth Treharne ¹, ¹University of Otago, Dunedin, New Zealand, ²University of Otago, Christchurch, Christchurch, Canterbury, New Zealand
Background/Purpose: Tapering of biologics is now recommended in the management of people with RA in sustained remission.1 Clinical studies have shown some RA patients can…
Abstract Number: 878 • 2019 ACR/ARP Annual Meeting
The Association of Serum Magnesium with Chondrocalcinosis and Osteoarthritis
Devyani Misra¹, Xianbang Sun ², Michael Nevitt ³, Beth Lewis ⁴, James Torner ⁵, Tuhina Neogi ², Alice Lichtenstein ⁶, Nirupa Matthan ⁶ and David Felson ⁷, ¹Beth Israel Deaconess Medical Center, Waban, MA, ²Boston University School of Medicine, Boston, MA, ³University of California at San Francisco, San Francisco, CA, ⁴University of Alabama at Birmingham, Birmingham, AL, ⁵University of Iowa at Iowa City, Iowa City, ⁶Tufts University, Boston, MA, ⁷Boston University School of Medicine, Department of Rheumatology, Boston
Background/Purpose: High serum magnesium (Mg) may have anti-inflammatory effects and prevents the release of extracellular pyrophosphate, inhibiting CPP deposition. Cross-sectional data has linked low serum…
Abstract Number: 879 • 2019 ACR/ARP Annual Meeting
Evaluation of Marijuana and Cannabidiol Use in the Rheumatologic Population from a Patient and Clinician Perspective: A Survey-Based Study
Heather Goodwin ¹, Ali Porter¹, Melinda Edwards ¹ and Bonita Libman ¹, ¹The University of Vermont Medical Center, Burlington, VT
Background/Purpose: To evaluate use of marijuana (MJ) and cannabidiol (CBD) as described by rheumatology patients at an academic medical center in Vermont, and to describe beliefs and…
Abstract Number: 880 • 2019 ACR/ARP Annual Meeting
Diseased Lupus Nephritis Kidneys Serve as a Primary Site of Systemic Autoimmune Development
Matthew Woodruff¹, Christopher Tipton ¹, Jennifer Hom ¹ and Iñaki Sanz ¹, ¹Emory University, Atlanta, GA
Background/Purpose: Lupus nephritis (LN) is an autoimmune destruction of the kidney glomeruli and loss of kidney function affecting almost half of lupus patients. Although the…
Abstract Number: 881 • 2019 ACR/ARP Annual Meeting
Auto-antibodies Targeting Components of Sarcolemma Repair: A Pathogenic Mechanism in Human Inflammatory Myopathies
Kevin McElhanon¹, Ana Capati ², Nicholas Young ³, Brian Paleo ², Eric Beck ², Zarife Sahenk ⁴, Rohit Aggarwal ⁵, Chester Oddis ⁵, Noah Weisleder ¹ and Wael Jarjour ⁶, ¹Dorothy M. Davis Heart and Lung Research Institute & Dept. of Physiology & Cell Biology, The Ohio State University Wexner Medical Center, Columbus, OH, ²The Ohio State University Wexner Medical Center, Columbus, OH, ³The Ohio State University Wexner Medical Center, Division of Immunology and Rheumatology, Columbus, OH, ⁴Nationwide Children's Hospital, Columbus, OH, ⁵University of Pittsburgh Medical Center, Pittsburgh, PA, ⁶Ohio State College of Medicine, Columbus, OH
Background/Purpose: Idiopathic inflammatory myopathies (IIM) represent a group of disorders causing chronic inflammation and significant damage to skeletal muscle due to an unchecked autoimmune response. …
Abstract Number: 882 • 2019 ACR/ARP Annual Meeting
Serum Anti-Vimentin Autoantibodies May Uniquely Predict Response to Therapy in Lupus Nephritis
Andrew Kinloch¹, Matthew Cascino ², Jian Dai ³, Rene Bermea ¹, Kichul Ko ¹, Margaret Vesselits ⁴, Maureen Legendre ⁵, Michael Okoreeh ¹, David Markovitz ⁵, Leonard Dragone ⁶, Michael Townsend ³ and Marcus Clark ¹, ¹University of Chicago, Chicago, IL, ²Genentech, Inc., San Fransisco, CA, ³Genentech, San Fransisco, CA, ⁴University of Chicago, Chicago, ⁵University of Michigan, Ann Arbor, MI, ⁶UCSF, San Fransisco, CA
Background/Purpose: Tubulointerstitial inflammation (TII) in lupus nephritis (LN) is associated with a worse prognosis. Vimentin, a cytoplasmic antigen, is commonly targeted by in situ activated…

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