Abstracts Archive - Page 993 of 2425 - ACR Meeting Abstracts

Abstract Number: 580 • 2019 ACR/ARP Annual Meeting
Association of Comorbidities with Disease Activity and Functional Impairment in Axial Spondyloarthritis: Results from a Nationwide Population-Based Study
Imke Redeker¹, Johanna Callhoff ², Falk Hoffmann ³, Hildrun Haibel ⁴, Joachim Sieper ⁴, Angela Zink ⁵ and Denis Poddubnyy ⁶, ¹Charité – Universitätsmedizin Berlin and German Rheumatism Research Centre, Berlin, Germany, ²German Rheumatism Research Centre, Berlin, Germany, ³Carl von Ossietzky University, Oldenburg, Germany, ⁴Charité Universitätsmedizin Berlin, Germany, Berlin, Germany, ⁵German Rheumatism Research Centre and Charité University medicine, Berlin, Germany, ⁶Charité - Universitätsmedizin Berlin and German Rheumatism Research Centre, Berlin, Germany, Berlin, Germany
Background/Purpose: Data on the prevalence of comorbidities and their association with disease activity and functional impairment in axial spondyloarthritis (axSpA) are scarce. The aim of…
Abstract Number: 581 • 2019 ACR/ARP Annual Meeting
Allograft Inflammatory factor-1 Drives Th17 Like Pathologic Signature and Predict Poor Response to TNF Inhibitor in Ankylosing Spondylitis
Jeong Seok Lee¹, Eunyoung Lee ², Ji Yong Choi ³, Yeong-Wook Song ⁴, Eui-Cheol Shin ¹ and Eun Young Lee ², ¹Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea, ²Division of Rheumatology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea, Seoul, Republic of Korea, ³Seoul National University College of Medicine, Seoul, Republic of Korea, ⁴Seoul National University Hospital, Seoul, Republic of Korea
Background/Purpose: Ankylosing spondylitis (AS) is an inflammatory disease that commonly treated with TNF inhibitors for controlling active inflammation. To predict treatment response to TNF inhibitors…
Abstract Number: 582 • 2019 ACR/ARP Annual Meeting
Rheumacheck – Spondyloarthritis: Comprehensive Fast-track Diagnosis Program. What Benefits Does It Offer in a Developing Country?
Einer Sanchez Prado¹, Alvaro Ruta ², Jessica Torres Chichande ², Santiago Ruta ³, Sebastian Magri ², Facundo Salvatori ² and Rodrigo Garcia Salinas ², ¹Hospital Italiano de La Plata, La Plata, ²Hospital Italiano de La Plata, La plata, Buenos Aires, Argentina, ³Rheumatology Department, Hospital San Martín de La Plata and Rheumatology Unit, Hospital Italiano de La Plata, Argentina., La Plata, Argentina
Background/Purpose: In our region, the lack of knowledge, timely referral and access to laboratory tests and images are the main causes in the diagnostic delay…
Abstract Number: 583 • 2019 ACR/ARP Annual Meeting
A Biomarker of Type VI Collagen Degradation (C6M) Is Associated with Changes in ASDAS MRI Measures of Inflammation in Patients with Axial Spondyloarthritis During TNF Inhibitor Therapy
Signe Holm Nielsen¹, Anne Bay-Jensen ², Mikkel Østergaard ³, Anne Siebuhr ⁴, Morten Karsdal ⁵, inge Juul Sørensen ⁶, Ulrich Weber ⁷, Anne Gitte Loft ⁸, Gina Kollerup ⁹, Gorm Thamsborg ⁹, Ole Rintek Madsen ¹⁰, Jakob Møller ¹¹ and Susanne Juhl Pedersen ¹², ¹Nordic Bioscience/Technical University of Denmark, Herlev, Denmark, ²Nordic Bioscience, Herlev, Denmark, ³Copenhagen Center for Arthritis Research, University of Copenhagen, Copenhagen, Denmark, ⁴Nordic Bioscience, Herlev, ⁵Nordic Bioscience, Copenhagen, Denmark, ⁶Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, Glostrup, Denmark, Glostrup, Denmark, ⁷Danish Hospital for Rheumatic Diseases, University Hospital of Southern Denmark, Sonderborg, Denmark, ⁸Department of Rheumatology, Aarhus University Hospital, Aarhus, Denmark, Århus, Denmark, ⁹Center for Rheumatology and Spine Diseases, Rigshospitalet, Copenhagen, Denmark, Copenhagen, Hovedstaden, Denmark, ¹⁰Center for Rheumatology and Spine Diseases, Rigshospitalet, Copenhagen, Denmark, Copenhagen, Denmark, ¹¹Department of Radiology, Herlev and Gentofte University Hospital, Herlev, Denmark, Copenhagen, Denmark, ¹²Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, Copenhagen, Denmark, Copenhagen, Hovedstaden, Denmark
Background/Purpose: Axial spondyloarthritis (AxSpa) is characterized by inflammation in the sacroiliac joints and spine and associated with extracellular matrix (ECM) remodelling of affected tissues. Type…
Abstract Number: 584 • 2019 ACR/ARP Annual Meeting
Radiographic Association of Hip and SI Joints in Ankylosing Spondylitis Patients
Juyeon Kang¹, Seoung Wan Nam ², Hyo-Kyung Sung ³, Kyung Bin Joo ⁴, Bon San Koo ⁵, Seunghun Lee ⁴ and Tae-Hwan Kim ¹, ¹Hanyang University Hospital for Rheumatic Diseases, Seoul, Republic of Korea, ²Wonju Severance Christian Hospital, Yonsei University Wonju College of Medicine, Wonju, Republic of Korea, ³Hanyang University Hospital for Rheumatic Diseases, Seoul, ⁴Dertment of Radiology, Hanyang University Hospital for Rheumatic Diseases, Seoul, Republic of Korea, ⁵Department of Internal Medicine, Inje University Seoul Paik Hospital, Inje University College of Medicine, Seoul, Republic of Korea
Background/Purpose: The modified Stoke Ankylosing Spondylitis Spinal Score (mSASSS) is a representative tool for assessing radiographic progression in spine of ankylosing spondylitis (AS) patients. However,…
Abstract Number: 585 • 2019 ACR/ARP Annual Meeting
Effect of Testosterone on Spinal Ankylosis in Ankylosing Spondylitis : in Vivo and in Vitro
Sungsin Jo¹, Eun-Ju Lee ², Juyeon Kang ¹, Seunghun Lee ³, Jeehee Youn ⁴, Yong-Gil Kim ⁵ and Tae-Hwan Kim ¹, ¹Hanyang University Hospital for Rheumatic Diseases, Seoul, Republic of Korea, ²Ulsan university, seoul, Republic of Korea, ³Dertment of Radiology, Hanyang University Hospital for Rheumatic Diseases, Seoul, Republic of Korea, ⁴Hanyang University, seoul, Republic of Korea, ⁵Division of Rheumatology, Department of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Republic of Korea
Background/Purpose: Ankylosing spondylitis (AS) is a predominantly male disease and spinal ankylosis more severely affect male AS1 suggesting role of testosterone on spinal ankylosis. In…
Abstract Number: 586 • 2019 ACR/ARP Annual Meeting
Drug Concentrations and Anti-drug Antibodies Influence in Response to Adalimumab: Results from the BioEfficacySpA Clinical Trial
José Marona¹, Santiago Rodrigues-Manica ², João Lagoas Gomes ¹, Carina Lopes ³, Inês Iria ⁴, Miguel Bernardes ⁵, Helena Santos ⁶, Jose Tavares-Costa ⁷, João Madruga-Dias ⁸, Patrícia Pinto ⁹, Alexandra Bernardo ¹⁰, Sara Maia ¹¹, Jaime Branco ², João Gonçalves ⁴ and Fernando Pimentel-Santos ², ¹Rheumatology Department, Hospital de Egas Moniz, Centro Hospitalar de Lisboa Ocidental; CEDOC, NOVA Medical School, Faculdade de Ciências Médicas, Lisbon., Lisbon, Portugal, ²CEDOC, NOVA-Medical School | Hospital Egas Moniz, CHLO, Lisbon, Lisbon, Portugal, ³Rheumatology Department, Hospital de Egas Moniz, Centro Hospitalar de Lisboa Ocidental; CEDOC, NOVA Medical School, Faculdade de Ciências Médicas, Lisbon, Lisbon, Portugal, ⁴Faculdade de Farmácia da Universidade de Lisboa; Portugal, Lisbon, Portugal, ⁵Rheumatology, Centro Hospitalar de São João, Porto, Portugal, Porto, Portugal, ⁶Instituto Português de Reumatologia (IPR), Lisbon, Portugal, ⁷ULSAM, Ponte de Lima, Portugal, Ponte de Lima, Portugal, ⁸CHMT, Torres Novas, Portugal, Torres Novas, ⁹Rheumatology Department, CHVNG, Vila Nova de Gaia, Portugal, ¹⁰Rheumatology Department, CHSJ, Porto, Portugal, ¹¹CEDOC, NOVA Medical School, Faculdade de Ciências Médicas, Lisbon, Lisbon, Portugal
Background/Purpose: Almost all protein-based biotherapeutics can induce immunogenicity, which may result in loss of efficacy and/or increased risk of adverse reactions. Despite all the efforts…
Abstract Number: 587 • 2019 ACR/ARP Annual Meeting
Increased Prevalence of Cardiac Disorders in Dutch Ankylosing Spondylitis Patients: The CARDAS Study
Milad Baniaamam¹, Sjoerd Heslinga ², Thelma Konings ³, Otto Kamp ³, Vokko van Halm ³, Irene van der Horst-Bruinsma ² and Mike Nurmohamed ⁴, ¹Amsterdam Rheumatology and immunology Center, Rheumatology, Reade, Amsterdam|Amsterdam Rheumatology and immunology Center, Rheumatology, Amsterdam University Medical Center location VUmc, Amsterdam, Amsterdam, Netherlands, ²Amsterdam Rheumatology and immunology Center, Rheumatology, Amsterdam University Medical Center location VUmc, Amsterdam, Amsterdam, Netherlands, ³Amsterdam University Medical Center, location VUmc, Department of Cardiology, Amsterdam, Amsterdam, Netherlands, ⁴Amsterdam Rheumatology and immunology Center location Reade and Amsterdam UMC location VU medical center, Amsterdam, Netherlands
Background/Purpose: The overall mortality rate in ankylosing spondylitis (AS) patients is increased by 60–90% compared with the general population. This higher mortality rate is predominately…
Abstract Number: 588 • 2019 ACR/ARP Annual Meeting
The Gut Enthesis Axis Coming into Focus with the Description of Enriched Entheseal Resident Mucosal Associated Invariant T-cells (MAITs) Capable of IL17A and TNF Production
Richard Cuthbert ¹, Qiao Zhou ², Abdulla Watad ³, Robert Dunsmuir ⁴, Peter Loughenbury ⁴, Almas Khan ⁴, Peter Milner ⁴, Charles Bridgewood ⁵ and Dennis McGonagle², ¹University of Leeds, Leeds, ²University of Leeds, Leeds, United Kingdom, ³Department of Medicine “B”, Zabludowicz Center for Autoimmune Diseases Sheba Medical Center, Ramat-Gan, Israel, ⁴Leeds Teaching Hospitals NHS Trust, Leeds, ⁵Leeds Institute of Rheumatic and Muscoskeletal Medicine(LIRMM), University of Leeds, Leeds, United Kingdom
Background/Purpose: Mucosal associated invariant T-cells (MAITs) are innate-like T lymphocytes that express a semi-invariant TCR repertoire that are activated by microbial ligands or cytokines including…
Abstract Number: 589 • 2019 ACR/ARP Annual Meeting
Smoking, Alcohol Intake and Body Mass Index in Prediction of Disease Activity over Time in Early Axial Spondyloarthritis – Results from the SPondyloArthritis Caught Early (SPACE) Cohort
Sofia Exarchou ¹, Carl Turesson¹, Ulf Lindström ², Roberta Ramonda ³, Robert B.M. Landewé ⁴, Hanne Dagfinrud ⁵, Floris van Gaalen ⁶, Désirée van der Heijde ⁶ and Lennart Jacobsson ⁷, ¹Lund University, Malmö, Sweden, ²University of Gothenburg, Gothenburg, Sweden, ³University of Padova, Padova, Italy, ⁴Amsterdam University Medical Center, Amsterdam, Netherlands, ⁵University of Oslo, Oslo, Norway, ⁶Leiden University Medical Center, Leiden, Netherlands, ⁷Dept of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Sweden,, Gothenburg, Sweden
Background/Purpose: In ankylosing spondylitis (AS), smokers have been found to have both higher disease activity and greater syndesmophyte progression, and a higher body mass index…
Abstract Number: 590 • 2019 ACR/ARP Annual Meeting
What Is the Impact of MRI on the Performance of the ASAS Classification Criteria in Patients Presenting with Undiagnosed Back Pain?
Walter P. Maksymowych¹, Raj Carmona ², Jonathan Chan ³, James Yeung ⁴, Sibel Zehra Aydin ⁵, Liam Martin ⁶, Ariel Masetto ⁷, Dianne Mosher ⁸, Olga Ziouzina ⁶, Stephanie Keeling ⁹, Sherry Rohekar ¹⁰, Rana Dadashova ¹¹, Joel Paschke ¹¹, Amanda Carapellucci ¹¹ and Robert Lambert ¹², ¹University of Alberta/CARE ARTHRITIS, Edmonton, AB, Canada, ²McMaster University, Hamilton, Canada, ³Artus Health Clinic, Vancouver, BC, Canada, ⁴Yeung Rheumatology, Vancouver, Canada, ⁵University of Ottawa Faculty of Medicine, Rheumatology,Ottawa Hospital Research Institute, 1967 Riverside Drive, Ottawa, ON, K1H 7W9, CANADA, Ottawa, Canada, ⁶University of Calgary, Calgary, Canada, ⁷Université de Sherbrooke, Sherbrooke, QC, Canada, ⁸University of Calgary, Calgary, AB, Canada, ⁹University of Alberta, Edmonton, AB, Canada, ¹⁰Western University, London, ON, Canada, ¹¹CARE Arthritis, Edmonton, Canada, ¹²University of Alberta, Edmonton, Canada
Background/Purpose: Classification criteria for axSpA comprise an imaging and a clinical arm, the former requiring radiographic or MRI evidence of sacroiliitis. Several cohorts have reported…
Abstract Number: 591 • 2019 ACR/ARP Annual Meeting
Longitudinal Assessment of MRI of the Sacroiliac Joints in the ASAS Classification Cohort: Evolution of Diagnostic Features and Predictive Utility for Axial Spondyloarthritis
Walter P. Maksymowych¹, Xenofon Baraliakos ², Manouk de Hooge ³, Iris Eshed ⁴, Susanne Juhl Pedersen ⁵, Ulrich Weber ⁶, Joachim Sieper ⁷, Stephanie Wichuk ⁸, Denis Poddubnyy ⁹, Martin Rudwaleit ¹⁰, Désirée van der Heijde ¹¹, Robert B.M. Landewé ¹², Joel Paschke ¹³, Robert Lambert ⁸ and Mikkel Østergaard ¹⁴, ¹University of Alberta/CARE ARTHRITIS, Edmonton, AB, Canada, ²Rheumatology Department, Rheumazentrum Ruhrgebiet Herne, Ruhr-University Bochum, Bochum, Germany, ³Ghent University Hospital, Ghent, Belgium, ⁴Sheba Medical Center, Tel Aviv, Israel, ⁵Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, Copenhagen, Denmark, Copenhagen, Hovedstaden, Denmark, ⁶Danish Hospital for Rheumatic Diseases, University Hospital of Southern Denmark, Sonderborg, Denmark, ⁷Charité Universitätsmedizin Berlin, Germany, Berlin, Germany, ⁸University of Alberta, Edmonton, Canada, ⁹Charité - Universitätsmedizin Berlin and German Rheumatism Research Centre, Berlin, Germany, Berlin, Germany, ¹⁰Klinikum Bielefeld, Charité Berlin, Gent University, Bielefeld, Germany, ¹¹Leiden University Medical Center, Leiden, Netherlands, ¹²Amsterdam University Medical Center, Amsterdam, Netherlands, ¹³CARE Arthritis, Edmonton, Canada, ¹⁴Copenhagen Center for Arthritis Research, University of Copenhagen, Copenhagen, Denmark
Background/Purpose: Follow up of the ASAS Classification Cohort (CC) indicated a high positive predictive value for the ASAS classification criteria derived from baseline patient and…
Abstract Number: 592 • 2019 ACR/ARP Annual Meeting
Replacement of Radiographic Sacroilitis by MRI Structural Lesions: What Is the Impact on Classification of Axial Spondyloarthritis in the ASAS Classification Cohort?
Walter P. Maksymowych¹, Pedro Machado ², Robert Lambert ³, Xenofon Baraliakos ⁴, Mikkel Østergaard ⁵, Joachim Sieper ⁶, Stephanie Wichuk ³, Denis Poddubnyy ⁷, Martin Rudwaleit ⁸, Désirée van der Heijde ⁹, Robert B.M. Landewé ¹⁰, Joel Paschke ¹¹, Susanne Juhl Pedersen ¹² and Ulrich Weber ¹³, ¹University of Alberta/CARE ARTHRITIS, Edmonton, AB, Canada, ²University College London, London, United Kingdom, ³University of Alberta, Edmonton, Canada, ⁴Rheumatology Department, Rheumazentrum Ruhrgebiet Herne, Ruhr-University Bochum, Bochum, Germany, ⁵Copenhagen Center for Arthritis Research, University of Copenhagen, Copenhagen, Denmark, ⁶Charité Universitätsmedizin Berlin, Germany, Berlin, Germany, ⁷Charité - Universitätsmedizin Berlin and German Rheumatism Research Centre, Berlin, Germany, Berlin, Germany, ⁸Klinikum Bielefeld, Charité Berlin, Gent University, Bielefeld, Germany, ⁹Leiden University Medical Center, Leiden, Netherlands, ¹⁰Amsterdam University Medical Center, Amsterdam, Netherlands, ¹¹CARE Arthritis, Edmonton, Canada, ¹²Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, Copenhagen, Denmark, Copenhagen, Hovedstaden, Denmark, ¹³Danish Hospital for Rheumatic Diseases, University Hospital of Southern Denmark, Sonderborg, Denmark
Background/Purpose: xClassification of axial spondyloarthritis is based on the application of either an imaging or clinical arm. Radiographic or MRI evidence of sacroiliitis can be…
Abstract Number: 593 • 2019 ACR/ARP Annual Meeting
Performance of the ASAS Classification Criteria Presenting with Undiagnosed Back Pain: Data from the Screening in Axial Spondyloarthritis in Psoriasis, Iritis, and Colitis Cohort
Walter P. Maksymowych¹, Raj Carmona ², Jonathan Chan ³, James Yeung ⁴, Sibel Zehra Aydin ⁵, Liam Martin ⁶, Ariel Masetto ⁷, Dianne Mosher ⁸, Olga Ziouzina ⁶, Stephanie Keeling ⁹, Sherry Rohekar ¹⁰, Rana Dadashova ¹¹, Joel Paschke ¹¹, Amanda Carapellucci ¹¹ and Robert Lambert ¹², ¹University of Alberta/CARE ARTHRITIS, Edmonton, AB, Canada, ²McMaster University, Hamilton, Canada, ³Artus Health Clinic, Vancouver, BC, Canada, ⁴Yeung Rheumatology, Vancouver, Canada, ⁵University of Ottawa Faculty of Medicine, Rheumatology,Ottawa Hospital Research Institute, 1967 Riverside Drive, Ottawa, ON, K1H 7W9, CANADA, Ottawa, Canada, ⁶University of Calgary, Calgary, Canada, ⁷Université de Sherbrooke, Sherbrooke, QC, Canada, ⁸University of Calgary, Calgary, AB, Canada, ⁹University of Alberta, Edmonton, AB, Canada, ¹⁰Western University, London, ON, Canada, ¹¹CARE Arthritis, Edmonton, Canada, ¹²University of Alberta, Edmonton, Canada
Background/Purpose: Classification criteria for axial spondyloarthritis (axSpA) that capture the spectrum of disease present challenges due to the frequency of back pain, the relative infrequency…
Abstract Number: 594 • 2019 ACR/ARP Annual Meeting
Enhanced Performance of the ASAS Classification Criteria by Deletion of Non-Discriminatory Clinical Items: Data from the Screening in Axial Spondyloarthritis in Psoriasis, Iritis, and Colitis Cohort
Walter P. Maksymowych¹, Raj Carmona ², Jonathan Chan ³, James Yeung ⁴, Sibel Zehra Aydin ⁵, Liam Martin ⁶, Ariel Masetto ⁷, Dianne Mosher ⁸, Olga Ziouzina ⁶, Stephanie Keeling ⁹, Sherry Rohekar ¹⁰, Rana Dadashova ¹¹, Joel Paschke ¹¹, Amanda Carapellucci ¹¹ and Robert Lambert ¹², ¹University of Alberta/CARE ARTHRITIS, Edmonton, AB, Canada, ²McMaster University, Hamilton, Canada, ³Artus Health Clinic, Vancouver, BC, Canada, ⁴Yeung Rheumatology, Vancouver, Canada, ⁵University of Ottawa Faculty of Medicine, Rheumatology,Ottawa Hospital Research Institute, 1967 Riverside Drive, Ottawa, ON, K1H 7W9, CANADA, Ottawa, Canada, ⁶University of Calgary, Calgary, Canada, ⁷Université de Sherbrooke, Sherbrooke, QC, Canada, ⁸University of Calgary, Calgary, AB, Canada, ⁹University of Alberta, Edmonton, AB, Canada, ¹⁰Western University, London, ON, Canada, ¹¹CARE Arthritis, Edmonton, Canada, ¹²University of Alberta, Edmonton, Canada
Background/Purpose: xThe ASAS classification criteria for axial spondyloarthritis (axSpA) have overall sensitivity/specificity of 82.9%/84.4% but component imaging and clinical arms differ in performance (66.2%/97.3% and…

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