Abstracts Archive - Page 962 of 2425 - ACR Meeting Abstracts

Abstract Number: 115 • 2019 ACR/ARP Annual Meeting
CD8+ Cytotoxic T Lymphocytes Are Clonally-expanded in IgG4-related Disease and Home to Affected Tissues
Cory Perugino¹, Naoki Kaneko ², Takashi Maehara ², Jesper Kers ³, Hang Liu ⁴, Vinay Mahajan ⁴, Yesim Tuncay ⁴, Zachary Wallace ¹, Lloyd Liang ¹, Sydney Montesi ⁵, John Stone ⁶ and Shiv Pillai ⁷, ¹Massachusetts General Hospital, Boston, ²Kyushu University, Fukuoka, Japan, ³University of Amsterdam, Amsterdam, Netherlands, ⁴Ragon Institute of MGH, MTI and Harvard, Cambridge, ⁵Massachusetts General Hospital, Boston, MA, ⁶Massachusetts General Hospital Rheumatology Unit, Harvard Medical School, Boston, MA, ⁷Ragon Institude of MGH, MIT and Harvard, Charlestown, MA
Background/Purpose: IgG4-related disease (IgG4-RD) is a chronic immune-mediated fibrotic disease often causing multi-organ involvement. We have previously reported the association of SLAMF7+ CD4+ cytotoxic T…
Abstract Number: 116 • 2019 ACR/ARP Annual Meeting
Defective EZH2 Expression Attenuates Treg Differentiation in Rheumatoid Arthritis
Xinyue Xiao¹, Yueting Li ², Hua Chen ¹ and Xuan Zhang ², ¹Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Clinical Immunology Center, Chinese Academy of Medical Sciences and Peking Union Medical College; The Ministry of Education Key Laboratory, Beijing, China, Beijing, Beijing, China (People's Republic), ²Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Clinical Immunology Center, Chinese Academy of Medical Sciences and Peking Union Medical College; The Ministry of Education Key Laboratory, Beijing, China, Beijing, China (People's Republic)
Background/Purpose: To explore the role of EZH2, a histone methylation regulator, in the pathogenesis of rheumatoid arthritis (RA).Methods: Forty treatment-naïve patients with active disease and…
Abstract Number: 117 • 2019 ACR/ARP Annual Meeting
The Indole Derivative NecroX Blocks Th17 Cell Differentiation and Fibroblast-like Synoviocytes-mediated Th1/Th17 Responses in Rheumatoid Arthritis
Hyun Jung Yoo¹, Shin Eui Kang ², Ji Hye Lee ³, Ra Ham Kim ⁴ and Yeong-Wook Song ⁵, ¹Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology and College of Medicine, Seoul National University, Seoul, Repulbic of Korea, Seoul, Republic of Korea, ²Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology and College of Medicine, Seoul National University, Seoul, Republic of Korea, Seoul, Republic of Korea, ³Division of Rheumatology, Department of Internal Medicine, Seoul National University Hospital, Seoul, Republic of Korea., Seoul, Republic of Korea, ⁴Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology and College of Medicine, Seoul National University, Seoul, Republic of Korea, Seoul, Republic of Korea, ⁵Seoul National University Hospital, Seoul, Republic of Korea
Background/Purpose: Rheumatoid arthritis (RA) is an autoimmune disease characterized by chronic inflammation of synovium, which causes progressive joint destruction and reduction in quality of life.…
Abstract Number: 118 • 2019 ACR/ARP Annual Meeting
Polymorphonuclear Neutrophils and Regulatory T Lymphocytes (Treg) Cooperate to Sustain Treg Activity but This Interaction Is Altered in Rheumatoid Arthritis Patients
Maxime Batignes ¹, François Santinon ¹, Marie-Christophe Boissier ², Patrice Decker ¹ and Natacha Bessis¹, ¹Inserm UMR 1125, University of Paris 13, Sorbonne Paris Cité, Bobigny, France, ²Assistance Publique-Hôpitaux de Paris (AP-HP), Rheumatology Department, Avicenne Hospital, Bobigny, France
Background/Purpose: Regulatory T cells (Treg) are necessary for immune homeostasis but are functionally deficient in inflammatory/autoimmune diseases such as rheumatoid arthritis (RA). On the other…
Abstract Number: 119 • 2019 ACR/ARP Annual Meeting
Mitochondrial Transplantation Suppressed Muscle Inflammation and Improved the Mitochondrial Dysfunction in C Protein-induced Myositis Model
Jeong Yeon Kim¹, Seon Uk Kim ², Ji soo Park ¹, Ji Hye Lee ³, Jae Hwan Shin ⁴, Do Wan Hwang ⁵, Yun Sang Lee ⁴, Jin Chul Paeng ⁴, Yong Soo Choi ⁶, Jung Wook hwang ⁷, Kyuboem Han ⁸, Chun Hyung Kim ⁸, Mi Jin Kim ⁸, Yeong-Wook Song ⁹ and Eun Young Lee ¹⁰, ¹Division of Rheumatology, Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea., Seoul, Republic of Korea, ²Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, and College of Medicine, Seoul National University, Seoul, Republic of Korea, ³Division of Rheumatology, Department of Internal Medicine, Seoul National University Hospital, Seoul, Republic of Korea., Seoul, Republic of Korea, ⁴Department of Nuclear Medicine, Seoul National University Hospital, Seoul, Republic of Korea, ⁵Department of Nuclear Medicine, Seoul National University Hospital, Seoul, Korea., Seoul, Republic of Korea, ⁶Department of Biotechnology, CHA University, Seongnam, Korea, Seongnam, Republic of Korea, ⁷Department of Biotechnology, CHA University, Seongnam, Korea., Seongnam, Republic of Korea, ⁸PAEAN Biotechnology Inc., Daejeon, Korea, Daejeon, Republic of Korea, ⁹Seoul National University Hospital, Seoul, Republic of Korea, ¹⁰Division of Rheumatology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea, Seoul, Republic of Korea
Background/Purpose: Polymyositis is a chronic inflammatory myopathy associated with lymphocyte infiltration, especially CD8 + T cells to the muscle layer. C protein-induced myositis (CIM) is a murine…
Abstract Number: 120 • 2019 ACR/ARP Annual Meeting
Administration of a CD45 Antibody Drug Conjugate as a Novel, Targeted Approach to Achieve Immune System Reset: A Single Dose of CD45-targeted ADC Safely Conditions for Autologous Transplant and Ameliorates Disease in Multiple Models of Autoimmune Disease
Geoffrey Gillard¹, Jennifer Proctor ¹, Melissa Brooks ¹, Tahirih Lamothe ¹, Sharon Hyzy ¹, Sean McDonough ¹, Rahul Palchaudhuri ², Anjali Bhat ¹, Ganapathy Sarma ¹, Prashant Bhattarai ¹, Pranoti Sawant ¹, Brad Pearse ¹, Charlotte McDonagh ¹, Anthony Boitano ¹ and Michael Cooke ¹, ¹Magenta Therapeutics, Cambridge, MA, ²Magenta Therapeutics, Cambridge
Background/Purpose: Autologous hematopoietic stem cell transplant (autoHSCT) is a highly effective treatment in selected patients with autoimmune diseases. AutoHSCT can induce long-term remission (up to…
Abstract Number: 121 • 2019 ACR/ARP Annual Meeting
In Vitro Human Enthesitis Model with Induced IL-17A and TNFα from CD4+ and CD8+ T Cells and Effect of Pharmacological Antagonism with Janus Kinase and Retinoic Acid Receptor-related Orphan Receptor γ Inhibition
Hannah Rowe¹, Abdulla Watad ², Charles Bridgewood ¹, Tobias Russell ³, Darren Newton ⁴, Miriam Wittmann ⁵, Qiao Zhou ⁶, Almas Khan ⁷, Robert Dunsmuir ⁷, Peter Loughenbury ⁷, Richard Cuthbert ³ and Dennis McGonagle ⁶, ¹Leeds Institute of Rheumatic and Muscoskeletal Medicine(LIRMM), University of Leeds, Leeds, United Kingdom, ²Department of Medicine “B”, Zabludowicz Center for Autoimmune Diseases Sheba Medical Center, Ramat-Gan, Israel, ³Leeds Institute of Rheumatic and Musculoskeletal Medicine (LIRMM)University of Leeds, Leeds, England, United Kingdom, ⁴Leeds Institute of Rheumatic and Muscoskeletal Medicine, Leeds, United Kingdom, ⁵Leeds Institute of Rheumatic and Musculoskeletal Medicine (LIRMM)University of Leeds, Leeds, United Kingdom, ⁶University of Leeds, Leeds, United Kingdom, ⁷Leeds Teaching Hospitals NHS Trust, Leeds
Background/Purpose: Animal models of experimental spondyloarthritis (SpA), human genetics and therapies support a central role for adaptive immunity in disease pathogenesis. However, there is very…
Abstract Number: 122 • 2019 ACR/ARP Annual Meeting
Inhibition of Necroptosis Suppresses Muscle Cell Death and Inflammatory Infiltrate, and Improves Muscle Strength in Experimental Polymyositis
Mari Kamiya¹, Kimito Kawahata ², Hitoshi Kohsaka ¹ and Fumitaka Mizoguchi ¹, ¹Department of Rheumatology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo, Japan, Tokyo, Japan, ²Rheumatology and Allergology, St. Marianna University School of Medicine, Tokyo, Japan
Background/Purpose: In polymyositis (PM), CD8+ cytotoxic T lymphocytes (CTLs) are assumed to induce muscle cell death. We presumed that the injured muscle cells release pro-inflammatory…
Abstract Number: 123 • 2019 ACR/ARP Annual Meeting
Blockade of Antigen-specific T Cell Activation by a Non-Depleting Anti-HLA-DR Monoclonal Antibody with a Unique Binding Epitope
Fang Shen¹, Karen Duffy ¹, Stephane Becart ², Robert Kuhn ¹, Melissa Swiecki ¹, Brian Jones ¹, Yawei Li ¹, Jeffrey Hall ¹, Ravi Malaviya ¹, Nathan Felix ¹, Mimi Zhou ², Sunil Nagpal ¹ and Navin Rao ¹, ¹Janssen R&D, Spring House, PA, ²Janssen R&D, La Jolla, CA
Background/Purpose: The activation of T helper cells requires cognate recognition of antigen-derived peptides presented by Major Compatibility Complex Class II (MHC II) molecules, which are…
Abstract Number: 124 • 2019 ACR/ARP Annual Meeting
Treatment with Abatacept but Not with TNF Blockers, Is Associated with a Reduction of Constitutively Elevated Circulating Follicular Helper T Cells in Rheumatoid Arthritis
Maria-Eugenia Miranda-Carus¹, Paula Fortea-Gordo ², Laura Nuño ³, Alejandro Villalba ⁴, Maria-Jose Santos-Bornez ², Diana Peiteado ², Irene Monjo ¹ and Alejandro Balsa ⁵, ¹FIBHULP-IdiPAZ-Hospital La Paz-Rheumatology, Madrid, Spain, ²FIBHULP-IdiPAZ-Hospital La Paz, Madrid, Spain, ³Rheumatology Department, Hospital Universitario La Paz, Madrid, Spain, Madrid, Spain, ⁴FIBHULP-IdiPAZ-Hospital La Paz-Rheumatology, Madrid, ⁵Immuno-Rheumatology Research Group, IdiPaz & Rheumatology Department. La Paz University Hospital, Madrid, Spain
Background/Purpose: Circulating CD4 T cells that express CXCR5 together with PD-1 and/or ICOS are considered as counterparts of bona fide Tfh cells and function as…
Abstract Number: 125 • 2019 ACR/ARP Annual Meeting
Elevated Proliferative Capacity of CD8+ T Cells in Giant Cell Arteritis
Rosanne Reitsema¹, Rebeca Hid Cadena ², Wayel Abdulahad ³, Annemieke Boots ³, Peter Heeringa ⁴ and Elisabeth Brouwer ¹, ¹Department of Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands, ²Department of Pathology and Medical Biology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands, ³Department of Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, Groningen, ⁴Department of Pathology and Medical Biology, University of Groningen, University Medical Center Groningen, Groningen
Background/Purpose: Giant cell arteritis (GCA) is the most frequent form of systemic vasculitis affecting the large- and medium-sized vessels. The involvement of innate immune cells…
Abstract Number: 126 • 2019 ACR/ARP Annual Meeting
Antibodies Targeting Mitochondrial Antigens Are Associated with Reduced Thrombotic Events in APS
Yann Becker¹, Anne-Sophie Julien ², Alexandra Godbout ³, Éric Boilard ³ and Paul Fortin ⁴, ¹Département de microbiologie et immunologie, Centre de recherche du CHU de Québec - Université Laval, Canada, Quebec, QC, Canada, ²Service de consultation statistique (SCS). Département de mathématiques et de statistique, Québec, QC, Canada, ³Axe maladies infectieuses et inflammatoires, Centre de recherche du CHU de Québec – Université Laval, Québec, Qc, Canada, Québec, QC, Canada, ⁴Division de Rhumatologie, Département de Médecine, CHU de Québec – Université Laval, Axe maladies infectieuses et inflammatoires, Centre de recherche du CHU de Québec – Université Laval, Canada, Quebec, QC, Canada
Background/Purpose: Mitochondria are intracellular organelles involved in many biological pathways such as energy supply by oxidative phosphorylation and apoptosis. Mitochondria are considered as derived from…
Abstract Number: 127 • 2019 ACR/ARP Annual Meeting
Elevated Levels of the Neutrophil Extracellular Trap-binding Protein LILRA3 in Primary Antiphospholipid Syndrome
Hui Shi¹, Srilakshmi Yalavarthi ², Jianping Guo ³ and Jason Knight ⁴, ¹University of Michigan, Ann Arbor, ²University of Michigan, Ann Arbor, MI, ³Department of Rheumatology and Immunology, Peking University People's Hospital, Beijing, China (People's Republic), ⁴Division of Rheumatology, Department of Internal Medicine, Michigan Medicine, Ann Arbor, MI
Background/Purpose: The leukocyte immunoglobulin-like receptor A3 (LILRA3) gene encodes the only soluble receptor within the LILR family. LILRA3 polymorphisms have been associated with both rheumatoid…
Abstract Number: 128 • 2019 ACR/ARP Annual Meeting
Metabolomics Analysis Identifies Biomarkers for APS and Suggests a Potential New Pathway Related to APS Pathogenesis
Chun Li ¹, Yu Zuo², Jason Knight ³, Juan Feng ⁴, Xian Wang ⁴, David Karp ⁵ and Zhanguo Li ⁶, ¹Peking Univerisity People's Hospital, Beijing, China (People's Republic), ²University of Texas Southwestern, Dallas, TX, ³Division of Rheumatology, Department of Internal Medicine, Michigan Medicine, Ann Arbor, MI, ⁴Peking University School of Basic Medical Science, Beijing, China (People's Republic), ⁵UTSouthwestern Medical Center, Dallas, TX, ⁶People's Hospital, Beijing University Medical School, Beijing, China (People's Republic)
Background/Purpose: The metabolic disturbances that underlie antiphospholipid syndrome (APS) are currently unknown. The goal of this study was to utilize high-throughput metabolomics screening to identify…
Abstract Number: 129 • 2019 ACR/ARP Annual Meeting
Surface Proteins on Exosomes Derived from Plasma of APS Patients Indicate an Altered Immune, Cell Adhesion and Coagulation Profile
Ula Štok ¹, Elizabeta blokar ¹, Aleš Ambrožič ¹, Matija Tomsic ¹, Snezna Sodin-Semrl ², Saša Čučnik ¹ and Polona Žigon³, ¹Department of Rheumatology, University Medical Center Ljubljana, Slovenia, Ljubljana, Slovenia, ²Department of Rheumatology, University Medical Centre Ljubljana, Ljubljana, Slovenia, Ljubljana, Slovenia, ³Department of Rheumatology, University Medical Center Ljubljana, Slovenia, Ljubljana
Background/Purpose: Antiphospholipid syndrome (APS) is characterized by thromboses and/or obstetric complications in presence of antiphospholipid antibodies (aPL). Extracellular vesicles have been suggested to play a…

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