ACR Meeting Abstracts

ACR Meeting Abstracts

  • Home
  • Meetings Archive
    • ACR Convergence 2020
    • 2020 ACR/ARP PRSYM
    • 2019 ACR/ARP Annual Meeting
    • 2018 ACR/ARHP Annual Meeting
    • 2017 ACR/ARHP Annual Meeting
    • 2017 ACR/ARHP PRSYM
    • 2016-2009 Meetings
    • Download Abstracts
  • Keyword Index
  • Advanced Search
  • Your Favorites
    • Favorites
    • Login
    • Register
    • View and print all favorites
    • Clear all your favorites
  • Meeting Resource Center

Abstract Number: 1896

No Relationship Between Lumbar Bone Mineral Density and Syndesmophyte Formation at the Same Level – A Multilevel Analysis in Patients with Radiographic Axial Spondyloarthritis

Mary Lucy Marques1, Sofia Ramiro2, Pedro M Machado3, Désirée van der Heijde4 and Floris van Gaalen5, 1Leiden University Medical Center, Coimbra, Portugal, 2Leiden University Medical Center, Bunde, Netherlands, 3University College London, London, United Kingdom, 4Leiden University Medical Center, Leiden, Netherlands, 5Leiden University Medical Center (LUMC), Leiden, Netherlands

Meeting: ACR Convergence 2020

Keywords: Bone density, spondyloarthritis

  • Tweet
  • Email
  • Print
Save to PDF
Session Information

Date: Monday, November 9, 2020

Session Title: Spondyloarthritis Including Psoriatic Arthritis – Diagnosis, Manifestations, & Outcomes Poster III: Axial SpA

Session Type: Poster Session D

Session Time: 9:00AM-11:00AM

Background/Purpose: In radiographic axial spondyloarthritis (r-axSpA) it has been hypothesized that inflammation-driven bone loss triggers bone repair but at anatomically distinct sites of the same vertebra (i.e. bone loss occurring in the trabecular bone and bone repair in the periosteum)1. However, the possible association between bone loss and new bone formation at the same individual vertebra has never been studied. The purpose of this study was to investigate if in r-axSpA low vertebral bone mineral density (BMD) is associated with development of new syndesmophytes at the same vertebral level.

Methods: In a post-hoc analysis from the ASSERT trial (infliximab vs placebo) dual-energy X-ray absorptiometry was used to measure baseline BMD (g/cm2) of the lumbar spine L1 to L4. Syndesmophyte formation was assessed in the same vertebrae on conventional radiographs defined as an increase in modified Stoke Ankylosing Spondylitis Spine Score from 0 or 1 to 2 or 3 after 2 years. Radiographs were scored by two readers. Generalized estimating equations (GEE) adjusted for within-patient correlation across multiple vertebrae, taking potential confounders into account (Table 1).

Results: We analyzed 599 vertebrae in 165 r-axSpA patients (78% male, mean (SD) age 38 (10) years, 67% with at least one syndesmophyte anywhere in the spine). In total, 24 to 74 new syndesmophytes developed in 9 (5%) to 30 (18%) patients and 13 (2%) to 39 (7%) vertebrae, if either a syndesmophyte was seen by both or only one of the readers (i.e. specific and sensitive definitions) respectively. Analyses with both definitions, and both uni- and multivariable, showed no significant association between baseline local vertebral BMD and new syndesmophyte formation after two years in the same vertebra (multivariable analysis adjOR (95%CI): 0.56 (0.01, 44.45) (specific definition) and 0.26 (0.03, 2.63) (sensitive definition)) (Table 1).

Conclusion: In patients with active and established r-axSpA, with an observed low incidence of lumbar spine syndesmophyte formation over two years, no relationship was found between baseline BMD and new radiographic syndesmophyte formation in the same vertebra.

1 Lories RJ. Best Pract Res Clin Rheumatol. 2018 Jun;32(3):331–41.

This study, carried out under YODA Project #2018-2761, used data obtained from the Yale University Open Data Access Project, which has an agreement with JANSSEN RESEARCH & DEVELOPMENT, L.L.C.. The interpretation and reporting of research using this data are solely the responsibility of the authors and does not necessarily represent the official views of the Yale University Open Data Access Project or JANSSEN RESEARCH & DEVELOPMENT, L.L.C..


Disclosure: M. Marques, None; S. Ramiro, Abbvie, 8, Eli Lilly, 8, Novartis, 8, MSD, 8, UCB, 8, Sanofi, 8; P. Machado, Abbvie, 5, 8, Eli Lilly, 5, Novartis, 5, 8, UCB, 5, 8, Pfizer, 8; D. van der Heijde, AbbVie, 5, Bristol-Myers Squibb, 5, Cyxone, 5, Galapagos NV, 5, Gilead Sciences, Inc., 5, GlaxoSmithKline, 5, Eli Lilly, 5, Novartis, 5, Pfizer, 5, UCB Pharma, 5, Amgen Inc., 5, Astellas, 5, AstraZeneca, 5, Boehringer Ingelheim, 5, Celgene, 5, Daiichi-Sankyo, 5, Janssen, 5, Merck, 5, Regeneron, 5, Roche, 5, Sanofi, 5, Takeda, 5, Imaging Rheumatology bv, 3, Eisai, 5; F. van Gaalen, Reuma Nederland, 1, Stichting vrienden van Sole Mio, 1, MSD, 1, Abbvie, 1, Novartis, 1.

To cite this abstract in AMA style:

Marques M, Ramiro S, Machado P, van der Heijde D, van Gaalen F. No Relationship Between Lumbar Bone Mineral Density and Syndesmophyte Formation at the Same Level – A Multilevel Analysis in Patients with Radiographic Axial Spondyloarthritis [abstract]. Arthritis Rheumatol. 2020; 72 (suppl 10). https://acrabstracts.org/abstract/no-relationship-between-lumbar-bone-mineral-density-and-syndesmophyte-formation-at-the-same-level-a-multilevel-analysis-in-patients-with-radiographic-axial-spondyloarthritis/. Accessed March 2, 2021.
  • Tweet
  • Email
  • Print
Save to PDF

« Back to ACR Convergence 2020

ACR Meeting Abstracts - https://acrabstracts.org/abstract/no-relationship-between-lumbar-bone-mineral-density-and-syndesmophyte-formation-at-the-same-level-a-multilevel-analysis-in-patients-with-radiographic-axial-spondyloarthritis/

Advanced Search

Your Favorites

You can save and print a list of your favorite abstracts by clicking the “Favorite” button at the bottom of any abstract. View your favorites »

ACR Convergence: Where Rheumatology Meets. All Virtual. November 5-9.

ACR Pediatric Rheumatology Symposium 2020

© COPYRIGHT 2021 AMERICAN COLLEGE OF RHEUMATOLOGY

Wiley

  • Home
  • Meetings Archive
  • Advanced Search
  • Meeting Resource Center
  • Online Journal
  • Privacy Policy
  • Permissions Policies
loading Cancel
Post was not sent - check your email addresses!
Email check failed, please try again
Sorry, your blog cannot share posts by email.
This site uses cookies: Find out more.