ACR Meeting Abstracts

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  • Abstract Number: 2335 • 2019 ACR/ARP Annual Meeting

    Prediction of Myocardial Fibrosis in Rheumatoid Arthritis Assessed by Cardiac Magnetic Resonance Imaging Using Artificial Neural Networks Models

    Hitomi Kobayashi1, Isamu Yokoe 2, Yasuyuki Kobayashi 3, Eichi Takaya 4, Atsuma Nishiwaki 1, Kaita Sugiyama 1, Noboru Kitamura 1, Masaki Haraoka 3 and Masami Takei 1, 1Nihon University School of Medicine, Tokyo, Japan, 2Kyoundo Hospital, Tokyo, Japan, 3St.Marianna University School of Medicine, Kawasaki, Japan, 4Graduate School, Keio University, Tokyo, Japan

    Background/Purpose: Cardiac involvements cause of morbidity and mortality globally in rheumatoid arthritis (RA). Myocardial dysfunction may arise from a number of distinct processes, including myocardial…
  • Abstract Number: 2336 • 2019 ACR/ARP Annual Meeting

    Levels of Proinflammatory Cytokines in Rheumatoid Arthritis Patients with Carotid Plaque: A Case-Control Study

    Dionicio Galarza-Delgado 1, Jose Azpiri-Lopez 1, Iris Colunga-Pedraza 1, Rosa Arvizu-Rivera 2, Karla Paola Cuellar-Calderon1, Gisela Garcia-Arellano 3, Ileana Cecilia Reynosa-Silva 1, Marielva Castro-Gonzalez 1, Carolina Marlene Martinez-Flores 1, Raymundo Vera-Pineda 3, Jesus Cardenas-De la Garza 3, Guillermo Elizondo-Riojas 3 and Cinthia Guillen-Gutierrez 4, 1Universidad Autonoma de Nuevo Leon, Hospital Universitario "Dr Jose Eleuterio Gonzalez", Monterrey, Nuevo Leon, Mexico, 2Universidad Autonoma de Nuevo Leon, Hospital Universitario " Dr. Jose Eleuterio Gonzalez", Monterrey, Nuevo Leon, Mexico, 3Universidad Autonoma de Nuevo Leon, Hospital Universitario "Dr. Jose Eleuterio Gonzalez", Monterrey, Nuevo Leon, Mexico, 4Universidad Autonoma de Nuevo Leon, Hospital Universitario "Dr. Jose E. Gonzalez", Monterrey, Nuevo Leon, Mexico

    Background/Purpose: Patients with RA have an augmented cardiovascular mortality up to 50% compared to controls. Chronic inflammation of the disease causes endothelial dysfunction and accelerated…
  • Abstract Number: 2337 • 2019 ACR/ARP Annual Meeting

    Treat to Target Is Not Linked to Best Myocardial Strain Indices: Is There Really a Myocardial Dysfunction Directly Associated with Disease Activity?

    Alisson Pugliesi1, Hugo Nourani 1, José Roberto Matos Souza 1 and Manoel Bertolo 2, 1University of Campinas, Campinas, Sao Paulo, Brazil, 2University of Campinas, Campinas, Brazil

    Background/Purpose: The risk of developing heart failure (HF) is twice as high in the RA population. It is hypothesized that, in addition to the atherosclerotic…
  • Abstract Number: 2338 • 2019 ACR/ARP Annual Meeting

    Validation of a Claims Algorithm to Identify Interstitial Lung Disease in Patients with Rheumatoid Arthritis

    Margaret Guthrie1, Ankoor Shah 2, Leonard Lobo 3, Jim Oates 4, Cassie Clinton 1, Narender Annapureddy 5, Fenglong Xie 6, Bryant England 7 and Jeffrey Curtis 1, 1University of Alabama at Birmingham, Birmingham, AL, 2Duke University, Durham, NC, 3University of North Carolina at Chapel Hill, Chapel Hill, NC, 4Division of Rheumatology & Immunology/Medical University of South Carolina, Charleston, SC, 5Vanderbilt University, Nashville, TN, 6University of Alabama at Birmingham, Birmingham, 7VA Nebraska-Western IA Health Care System & University of Nebraska Medical Center, Omaha

    Background/Purpose: Interstitial lung disease (ILD) is an increasingly important problem for patients with Rheumatoid Arthritis (RA). However, current approaches to ILD case finding are suboptimal…
  • Abstract Number: 2339 • 2019 ACR/ARP Annual Meeting

    Exposure to Avian and Fungal Antigens in Patients with Rheumatoid Arthritis-AssociatedInterstitial Lung Disease: Something to Keep in Mind

    Sebastian Rodriguez-Garcia1, Raul Castellanos-Moreira 2, Fernanda Hernández-González 3, Albert Perez 4, Joel Francesqui 5, Sandra Cuerpo-Cardeñosa 5, Virginia Ruiz-Esquide 6, Mariana Benegas 7, José Ramírez 8, Carmen Lucena-Pozo 3, Carlos Agustí 3, Marc Boada 9, Estíbaliz Ruiz 4, Odette Viñas 4, Sergio Prieto-González 10, Raimon Sanmarti 11, Gerard Espinosa 12, Mariona Pascal 13, Jose Gomez-Puerta 11, Marcelo Sánchez 7 and Jacobo Sellares 3, 1Rheumatology Department. Hospital Clínic Barcelona, Barcelona, Spain, 2Rheumatology Department. Hospital Clínic Barcelona, Barcelona, Catalonia, Spain, 3Department of Pneumology, Hospital Clínic, Barcelona, Barcelona, Spain, 4Department of Immunology, Hospital Clínic, Barcelona, Barcelona, Spain, 5Pneumology Department. Hospital Clínic Barcelona, Barcelona, Catalonia, Spain, 6Department of Rheumatology, Hospital Clínic, Barcelona, Barcelona, Catalonia, Spain, 7Department of Radiodiagnosis, Hospital Clínic, Barcelona, Barcelona, Spain, 8Department of Pathological Anatomy, Hospital Clínic, Barcelona, Barcelona, Spain, 9Department of Thoracic Surgery, Hospital Clínic, Barcelona, Barcelona, Spain, 10Department of Systemic Autoimmune Diseases Hospital Clínic, Barcelona, Barcelona, Spain, 11Department of Rheumatology, Hospital Clínic, Barcelona, Barcelona, Spain, 12Department of Autoimmune Diseases, Hospital Clínic, Barcelona, Barcelona, Catalonia, Spain, 13Immunology Department. Hospital Clínic Barcelona, Barcelona, Catalonia, Spain

    Background/Purpose: Rheumatoid arthritis associated interstitial lung disease (RA-ILD) is an extra-articular manifestation with a poor prognosis. In clinical practice, to establish such a diagnosis requires…
  • Abstract Number: 2340 • 2019 ACR/ARP Annual Meeting

    Treatment of Interstitial Lung Disease and Airway Disease Complicated with Rheumatoid Arthritis

    Takeshi Shoda1, Tohru Takeuchi 2, Takuya Kotani 2, Koji Nagai 2, Kennichiro Hata 2, Shigeki Makino 2 and Shigeki Arawaka 2, 1Yodogawa christian hospital / Osaka medical college, Osaka, Japan, 2Osaka medical college, Osaka, Japan

    Background/Purpose: Interstitial lung disease (ILD) complicated with rheumatoid arthritis (RA) is detected in 27 to 67% of patients on high-resolution computed tomography (HRCT), and airway…
  • Abstract Number: 2341 • 2019 ACR/ARP Annual Meeting

    Findings of Pulmonary Abnormalities on High Resolution Computed Tomography in a Cohort of Rheumatoid Arthritis Patients Without Known Lung Disease

    Scott Matson1, Kevin Deane 2, Christopher Collora 1, Xi Zheng 1, Marie Fester 1, Joyce Lee 1 and M. Kristen Demoruelle 3, 1University of Colorado, Denver, 2University of Colorado Denver, Division of Rheumatology, Aurora, CO, USA, Aurora, CO, 3University of Colorado Denver, Division of Rheumatology, Aurora, CO, USA, Aurora

    Background/Purpose: Pulmonary manifestations of rheumatoid arthritis (RA) lead to significant morbidity and mortality. Lung manifestations in RA are myriad, however little is known about how…
  • Abstract Number: 2342 • 2019 ACR/ARP Annual Meeting

    Association of Serum KL-6 Level and Change of Pulmonary Function in Interstitial Lung Disease of Rheumatoid Arthritis – Data from Prospective KOrean Rheumatoid Arthritis Interstitial Lung Disease (KORAIL) Study

    Jeong Seok Lee1, Young Im Yoon 2, Eun Young Lee 3, Jung Yoon Choe 4, Hwa Jung Lee 5, Yong-Beom Park 6, Eun Ha Kang 7, You-Jung Ha 7, Yeon-Ah Lee 8 and Seong Hye Jang 9, 1Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea, 2Seoul National University Hospital, Seoul, Republic of Korea, 3Division of Rheumatology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea, Seoul, Republic of Korea, 4Division of Rheumatology, Daegu Catholic University Medical Center, Daegu, Republic of Korea, 5DAEGU CATHOLIC UNIVERSITY, Daegu, Republic of Korea, 6Yonsei university college of medicine, severance hospital, Seodaemun-gu, Seoul-t'ukpyolsi, Republic of Korea, 7Division of Rheumatology, Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Republic of Korea, Seongnam, Republic of Korea, 8School of Medicine, Kyung Hee University, Seoul, Republic of Korea, 9Soonchunhyang University, Cheonan, Republic of Korea

    Background/Purpose: Interstitial lung disease (ILD) is the most common lung disease among rheumatoid arthritis (RA) patients. Although the overall mortality rates for RA have decreased…
  • Abstract Number: 2343 • 2019 ACR/ARP Annual Meeting

    Treatment with Biologic DMARDs Does Not Increase Risk of Severe Pulmonary Events in Patients with Rheumatoid Arthritis and Pre-existing Lung Disease

    Shinji Watanabe1, Takahisa Gono 1, Ryosuke Fukue 1, Seiji Kobayashi 1, Yuichiro Shirai 2, Mitsuhiro Takeno 3 and Masataka Kuwana 2, 1Department of Allergy and Rheumatology, Nippon Medical School Graduate School of Medicine, Tokyo, Japan, Tokyo, Japan, 2Department of Allergy and Rheumatology, Nippon Medical School Graduate School of Medicine, Tokyo, Japan, Bunkyo-ku, Tokyo, Japan, 3Nippon Medical School, Tokyo, Japan

    Background/Purpose: Pulmonary complication is one of the leading causes of mortality in patients with rheumatoid arthritis (RA). Pre-existing lung disease is known as a risk…
  • Abstract Number: 2344 • 2019 ACR/ARP Annual Meeting

    Efficacy of Mycophenolate Mofetil in the Treatment of Rheumatoid Arthritis Associated Interstitial Lung Disease

    Jonathan Amos1, Jennifer Kendall 1, Robyn Moran 2, Megan Krause 3, Paul Schmidt 4, Chase Hall 5, Mark Hamblin 6 and Mehrdad Maz 7, 1University of Kansas Medical Center, Division of Rheumatology, KANSAS CITY, KS, 2University of Kansas Medical Center, Kansas City, KS, 3University of Kansas, KANSAS CITY, KS, 4University of Kansas Medical Center, Division of Rheumatology, Kansas City, 5University of Kansas Medical Center, Division of Pulmonary and Critical Care, KANSAS CITY, 6University of Kansas Medical Center, Division of Pulmonary and Critical Care, Kansas City, KS, 7The University of Kansas Medical Center, KANSAS CITY, KS

    Background/Purpose: Interstitial lung disease (ILD) as an extra-articular manifestation of rheumatoid arthritis (RA) leads to significant morbidity and mortality.  As data is limited, this study…
  • Abstract Number: 2345 • 2019 ACR/ARP Annual Meeting

    Abatacept in Rheumatoid Arthritis with Interstitial Lung Disease: A Retrospective Multicenter Study of 263 Patients

    C. Fernández-Díaz1, Rafael Melero 2, Javier Loricera 3, Santos Castañeda 4, Francisco Ortiz-Sanjuán 5, I. Casafont-Solé 6, Carmen carrasco-Cubero 7, A. Juan-Mas 8, Raquel Almodovar-Gonzalez 9, S. Rodriguez-Garcia 10, R. Castellanos 11, O. Maiz-Alonso 12, C. Aguilera-Cros 13, I. Cabezas-rodriguéz 14, EC Cervantes 15, M. Moreno 16, L. Arboleya 17, C. Montagut 18, Patricia Carreira 19, C. Ojeda-Garcia 20, Gema Bonilla 21, T. Perez-Sandoval 22, P. Vela 23, JL Andreu 24, Susana Romero-Yuste 25, A. Urruticoechea-Arana 26, E. Salgado-Pérez 27, Cristina Hidalgo 28, Javier Narváez 29, E. Raya 30, MJ. Moreno-Ramos 31, P. Morales-Garrido 32, L. Pérez-alba 33, Carlos Fernández-López 34, Ignacio Villa 35, Noelia Álvarez-Rivas 36, Juan María Blanco-Madrigal 37, JR Jimenez-Aberasturi 38, A. Perez-Linaza 39, N. Del-val-del-amo 40, Sabela Fernández 41, A. García-valle 42, C.A. Peralta-Ginés 43, A. Garcia-Aparicio 44, L. Exposito-pérez 45, N. Mena-Vazquez 46, R. López-Sánchez 47, B. Garcia-magallon 48, Miguel Angel González-Gay 49 and Ricardo Blanco 50, 1HU Vinalopo, Madrid, Madrid, Spain, 2Complexo Hospitalario Universitario de Vigo, Vigo, Galicia, Spain, 3Rheumatology Department. Hospital Marqués de Valdecilla, Santander, Cantabria, Spain, 4Rheumatology Department, Hospital Universitario de la Princesa, IIS-Princesa, Madrid, Spain, Madrid, Spain, 5Hospital Universitario y Politécnico La Fe, Valencia, Comunidad Valenciana, Spain, 6HU German Trias i pujol, BAacelona, 7CHU de Badajoz, Badajoz, Spain, 8H Son Llázer, Palma de Mallorca, Islas Baleares, Spain, 9Hospital Universitario Fundación Alcorcón, Madrid, Spain, 10HU. Clinic, Barcelona, 11Fundacio Clinic. Hospital Clinic de Barcelona, Barcelona, Spain, 12HU Donostia, Donostia, Spain, 13hospital virgen del rocio, Sevilla, Spain, 14HU. Río Hortega, Valladolid, Spain, 15HU Santiago de compostela, Santiago, 16Parc Tauli Hospital Universitari, Sabadell, Spain, 17Hospital Central Asturias, OViedo, 18HCU Valladolid, Valladolid, Spain, 19Hospital Universitario 12 de Octubre, Madrid, Spain, 20HU Virgen de la Macarena, Sevilla, 21Rheumatology Department, Hospital Universitario La Paz, Madrid, Spain, Madrid, Spain, 22HU León, León, Spain, 23Hospital General Universitario de Alicante, Alicante, Comunidad Valenciana, Spain, 24HU Puerta del Hierro, Madrid, 25Complejo Hospitalario Universitario Pontevedra, Pontevedra, Galicia, Spain, 26HU Can Misses, Ibiza, Spain, 27C.H Ourense, Ourense, 28Hospital Clínico Universitario de Salamanca, Salamanca, Castilla y Leon, Spain, 29Rheumatology Department, Hospital Universitario de Bellvitge, Barcelona, Spain, Barcelona, Catalonia, Spain, 30Hospital San Cecilio, Granada, Andalucia, Spain, 31HU Arrixaca, Murcia, Spain, 32Hospital San Cecilio, Granada, Spain, 33HU San Cecilio, Granada, Spain, 34Servicio de Reumatología. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC). As Xubias, 15006. A Coruña, España, A Coruña, Spain, 35Hospital de Sierrallana, Torrelavega, Cantabria, Spain, 36Hospital Universitario Lucus Augusti, Lugo, Galicia, Spain, 37Rheumatology Unit, Basurto University Hospital, Bilbao, Spain, Bilbao, Spain, 38HU Araba, Vitoria, Spain, 39HU Puerta del Mar, Cadiz, 40HU Navarra, Pamplona, Spain, 41Hospital Universitario San Agustín, Avilés, Asturias, Spain, 42Rheumatology Department. Hospital Rio Carrión, Palencia, Spain, 43HU Lozano Blesa, Zaragoza, 44H Virgen de la salud, Toledo, Spain, 45HU Canarias, Tenerife, Spain, 46HU Malaga., Malaga, 47Hospital Negrin, Tenerife, 48H Huesca, HUesca, 49Universidad de Cantabria and IDIVAL, Hospital Universitario Marqués de Valdecilla, Santander, Spain, 50Rheumatology, Hospital Universitario Marques de Valdecilla, Santander, Spain

    Background/Purpose: Interstitial Lung Disease (ILD) is a severe extraarticular manifestation of rheumatoid arthritis (RA).Interstitial lung disease (ILD) associated with Rheumatoid Arthritis (RA) has a poor…
  • Abstract Number: 2346 • 2019 ACR/ARP Annual Meeting

    Interstitial Lung Abnormalities in Rheumatoid Arthritis Patients: Identifying Associated Risk Factors

    Karina Bonfiglioli1, Márcio Sawamura 2, Renato Nakagawa 3, Fábio Arimura 3, Diana Rangel 3, Cleonice Bueno 4, Ana Cristina de Medeiros Ribeiro 1, Carlos Carvalho 3, Eloisa Bonfa 5, Ronaldo Kairalla 3 and Leticia Kawano-Dourado 6, 1Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo, Sao Paulo, Sao Paulo, Brazil, 2Division of Radiology, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, Br, Sao Paulo, Sao Paulo, Brazil, 3Pulmonary Division, Heart Institute (InCor)- Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, BR, Sao Paulo, Sao Paulo, Brazil, 4Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, BR, Sao Paulo, Sao Paulo, Brazil, 5Rheumatology Division, Hospital das Clinicas, Faculdade de Medicina da Universidade de Sao Paulo (HCFMUSP), Sao Paulo, Brazil., Sao Paulo, Sao Paulo, Brazil, 6University of Sao Paulo, Sao Paulo, Brazil

    Background/Purpose: A wide spectrum of interstitial lung abnormalities (ILA) occurs in patients with rheumatoid arthritis (RA). This study characterized ILA in large single-center cohort, including…
  • Abstract Number: 2347 • 2019 ACR/ARP Annual Meeting

    Long-term Survival in Lung Transplantation and Allograft Rejection in Patients with Interstitial Lung Disease Related with Rheumatoid Arthritis: Study from a Single Referral Center

    DIANA PRIETO- PENA1, Amaya Martinez Meñaca 2, Mónica Calderón-Goercke 3, Victor Manuel Mora Cuesta 4, Sonia M. Fernández Rozas 4, David Iturbe Fernandez 2, Iñigo Gonzalez-Mazon 1, Lara Sanchez-Bilbao 5, Jose Manuel Cifrian Martínez 4, Miguel Angel González-Gay 6 and Ricardo Blanco 5, 1Rheumatology, Hospital Universitario Marques de Valdecilla, Santander, Cantabria, Spain, 2Hospital Universitario Marqués de Valdecilla, Santander, Spain, 3Hospital Marqués de Valdecilla, Santander, Cantabria, Spain, 4Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, IDIVAL; and Pneumology Department, Hospital Universitario Marqués de Valdecilla, Santander, Spain, Santander, Spain, 5Rheumatology, Hospital Universitario Marques de Valdecilla, Santander, Spain, 6Universidad de Cantabria and IDIVAL, Hospital Universitario Marqués de Valdecilla, Santander, Spain

    Background/Purpose: Interstitial lung disease (ILD) is a leading cause of death in patients with rheumatoid arthritis (RA). In end-stage RA-ILD, lung transplant becomes the only…
  • Abstract Number: 2348 • 2019 ACR/ARP Annual Meeting

    KL-6 Is a Useful Marker to Monitor the Progression of RA-ILD, but Not to Diagnose or Predict the Development of ILD

    Yuta Takamura1, Ayae Tanaka 1, Kazuhiro Kurasawa 1, Anna Hasegawa 2, Chika Hiyama 2, Toshiyuki Miyao 1, Ryutaro Yamazaki 1, Satoko Arai 1, Takayoshi Owada 1, Reika Maezawa 1 and Masafumi Arima 2, 1Dokkyo Medical University, Mibu-machi, Shimotsuga-gun, Tochigi, Japan, 2Dokkyo Medical University, Mibu, Tochigi, Japan

    Background/Purpose: Interstitial lung disease (ILD) is a critical comorbidity in RA. To manage RA-ILD, early diagnosis and monitoring disease progression are important. KL-6 is a marker…
  • Abstract Number: 2349 • 2019 ACR/ARP Annual Meeting

    Epidemiology, Risk/Prognostic Factors, and Treatment Landscape in Rheumatoid Arthritis-Associated Interstitial Lung Disease: A Systematic Literature Review

    Xue Han1, Leticia Ferri 1, Grace Crocket 2, Sophie Yoon 3, Tracy Slanger 3 and Mir Sohail Fazeli 3, 1Bristol-Myers Squibb Company, Princeton, NJ, 2Bristol-Myers Squibb; Rutgers University, New York City, NY, 3Doctor Evidence, Santa Monica, CA

    Background/Purpose: Interstitial lung disease (ILD) is the most common lung manifestation of RA and the 2nd leading cause of death in RA patients.1,2 The purpose…
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