Abstracts Archive - Page 903 of 2607 - ACR Meeting Abstracts

Abstract Number: 0999 • ACR Convergence 2020
CXCL13 Is a Key Driver for Migration and Differentiation of Regulatory B Cells
Claire Rempenault¹, Julie Mielle², Kristina Schreiber¹, Pierre Corbeau³, Jacques Morel⁴, Claire Daien⁴ and Rachel Audo², ¹Rheumatology, Montpellier, France, ²Institut de génétique moléculaire de Montpellier (IGMM), Montpellier, France, ³immunology, Nimes, France, ⁴Rheumatology department, CHU Montpellier and University of Montpellier, Montpellier, France
Background/Purpose: Human regulatory B cells still need to be characterized. Given the absence of phenotypical definition, a functional definition based on their ability to secrete…
Abstract Number: 1000 • ACR Convergence 2020
Passive Smoking Throughout the Life Course and the Risk of Incident Rheumatoid Arthritis in Adulthood Among Women
Kazuki Yoshida¹, Jiaqi Wang², Susan Malspeis³, Bing Lu⁴, Lauren C. Prisco³, Lily Martin³, Julia Ford², Karen Costenbader⁵, Elizabeth Karlson² and Jeffrey Sparks⁶, ¹Brigham & Women's Hospital and Harvard Medical School, Boston, MA, ²Brigham and Women's Hospital, Boston, MA, ³Brigham and Women's Hospital, Boston, ⁴Brigham and Women's Hospital and Harvard Medical School, Newton, MA, ⁵Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ⁶Division of Rheumatology, Inflammation, and Immunity; Brigham and Women’s Hospital and Harvard Medical School, Boston, MA
Background/Purpose: Personal cigarette smoking has been strongly associated with the risk for developing seropositive RA. Previous studies concerning passive smoking conflict; some suggested that childhood…
Abstract Number: 1001 • ACR Convergence 2020
Risk of Malignant Melanoma and Nonmelanoma Skin Cancer in Rheumatoid Arthritis Patients Initiating Methotrexate versus Hydroxychloroquine
Hemin Lee¹, Sarah Chen², Nileesa Gautam², Seanna Vine¹, Mengdong He², Rishi Desai², Michael Weinblatt¹, Robert Glynn² and Seoyoung Kim², ¹Brigham and Women's Hospital, Boston, MA, ²Brigham and Women's Hospital, Boston
Background/Purpose: Previous randomized clinical trials and observational studies have signaled an increased risk of skin cancer in rheumatoid arthritis (RA) patients treated with immunosuppressants such…
Abstract Number: 1002 • ACR Convergence 2020
Prostate Cancer Risk Is Not Increased in Rheumatoid Arthritis After Accounting for Retention in a Health Care System
Kaitlyn Brittan¹, Punyasha Roul¹, Joshua Baker², Yangyuna Yang¹, Brian Sauer³, Namrata Singh⁴, Harlan Sayles¹, Grant Cannon⁵, Ted Mikuls¹ and Bryant England¹, ¹University of Nebraska Medical Center, Omaha, NE, ²University of Pennsylvania, Philadelphia, PA, ³University of Utah, Omaha, NE, ⁴University of Washington, Bellevue, WA, ⁵Salt Lake City VA Medical Center and University of Utah, Salt Lake City
Background/Purpose: Patients with rheumatoid arthritis (RA) may have up to a 15% increased risk of prostate cancer per a recent meta-analysis (Simon et al. Arthritis…
Abstract Number: 1003 • ACR Convergence 2020
Long-term Weight Changes and Risk of Rheumatoid Arthritis Among Women in a Prospective Cohort: A Marginal Structural Model Approach
Nathalie Marchand¹, Jeffrey Sparks², Kazuki Yoshida³, Susan Malspeis⁴, Xuehong Zhang⁵, Karen Costenbader⁶, Elizabeth Karlson¹ and Bing Lu⁷, ¹Brigham and Women's Hospital, Boston, MA, ²Division of Rheumatology, Inflammation, and Immunity; Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, ³Brigham & Women's Hospital and Harvard Medical School, Boston, MA, ⁴Brigham and Women's Hospital, Boston, ⁵Brigham and Women's Hospital and Channing Division of Network Medicine, Boston, MA, ⁶Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ⁷Brigham and Women's Hospital and Harvard Medical School, Newton, MA
Background/Purpose: The risk of rheumatoid arthritis (RA) has been shown to be elevated among overweight and obese women in several studies, but whether weight gain…
Abstract Number: 1004 • ACR Convergence 2020
The Incidence, Mortality, and Economic Burden of Potentially Preventable Infections in Rheumatoid Arthritis Patients
Soumyasri Kambhatla¹, Estefania Gauto-Mariotti² and Augustine Manadan³, ¹John H Stroger Hospital of Cook County, Riverside, IL, ²John H. Stroger Jr. Hospital of Cook County, Chicago, IL, ³Rush University Medical Center, Chicago, IL
Background/Purpose: Streptococcus pneumoniae, Herpes zoster, and influenza infections are common and potentially preventable causes of morbidity and mortality. Vaccinations have been shown to reduce infection…
Abstract Number: 1005 • ACR Convergence 2020
Risk of Non-vertebral Fractures Among Rheumatoid Arthritis Patients Treated with Biologic or Targeted-Synthetic DMARDs: A Multi-Database Comparative Safety Study
Ajinkya Pawar¹, Rishi Desai¹, Mengdong He¹, Lily Bessette¹ and Seoyoung Kim², ¹Brigham and Women's hospital, Boston, ²Brigham and Women's Hospital, Boston, MA
Background/Purpose: Rheumatoid arthritis (RA) increases risk of osteoporosis and fractures. However, limited head-to-head comparative data exists on the risk of non-vertebral osteoporotic fractures (NVFs) among…
Abstract Number: 1006 • ACR Convergence 2020
Post-menopausal Rheumatoid Arthritis Is Inversely Associated with Lifetime High Level of Estrogen Exposure in the French E3N Cohort
Carine Salliot¹, Yann Nguyen², Amandine Gelot³, Xavier Mariette⁴, Marie-Christine Boutron-Ruault³ and Raphaèle Seror⁵, ¹CHR orleans, Orleans, France, ²1Department of Internal Medicine, Hôpital Beaujon, APHP Nord, Université de Paris, Clichy, Clichy, France, ³Institut Gustave Roussy, Villejuif, France, ⁴Paris-Sud University, Rueil-Malmaison, France, ⁵Rheumatology Department, Bicetre Hospital, APHP, France, Paris, France
Background/Purpose: The involvement of female hormones in the pathogenesis of Rheumatoid Arthritis (RA) is supported by numerous observations: a female predominance, an increased incidence in…
Abstract Number: 1007 • ACR Convergence 2020
Atopic Dermatitis and Risk of Incident Rheumatoid Arthritis: A Systematic Review and Meta-analysis
Thanitsara Rittiphairoj¹, Nipith Charoenngam¹, Ben Ponvilawan¹, Surapa Tornsatitkul¹, Phuuwadith Wattanachayakul¹, Pongprueth Rujirachun¹ and Patompong Ungprasert², ¹Mahidol University, Bangkok, Thailand, ²Cleveland Clinic, Cleveland, OH, Cleveland Heights, OH
Background/Purpose: Recent observational studies have suggested that patients with atopic dermatitis (AD) may have a higher risk of several non IgE-mediated inflammatory disorders, such as…
Abstract Number: 1008 • ACR Convergence 2020
Assessing Improved Risk Prediction of Seropositive Rheumatoid Arthritis by Environmental, Genetic, and Preclinical Plasma Metabolite Factors
Karen Costenbader¹, Jeffrey Sparks², Elizabeth Karlson³, Kazuki Yoshida⁴, Jing Cui⁵, Susan Malspeis⁶ and Lilia Bouzit⁷, ¹Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ²Division of Rheumatology, Inflammation, and Immunity; Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, ³Brigham and Women's Hospital, Boston, MA, ⁴Brigham & Women's Hospital and Harvard Medical School, Boston, MA, ⁵Brigham Women's Hospital, Boston, MA, ⁶Brigham and Women's Hospital, Boston, ⁷Harvard Chan School of Public Health, Boston, MA
Background/Purpose: Recent research has advanced the understanding of associations between environmental, genetic, and metabolic factors and rheumatoid arthritis (RA), introducing potential to improve risk prediction.…
Abstract Number: 1009 • ACR Convergence 2020
Missing Data and Multiple Imputation in Rheumatoid Arthritis Registries Using Sequential Random Forest Method
Ahmed Al-Saber¹, Adeeba Al-Herz², Jiazhu Pan¹, Khulood Saleh³, Adel Al-Awadhi⁴, Waleed Al-Kandari³, Eman Hasan⁵, Aqeel Ghanem⁶, Mohammed Hussain⁵, Yaser Ali⁷, Ebrahim Nahar⁷, Ahmad Alenizi⁸, Sawsan Hayat⁷, Fatemah Abutiban⁹, Ali Aldei⁵, Amjad Alkadi¹⁰, Heba Alhajeri⁷, Husain Behbehani³, Naser Alhadhood³, Khaled Mokaddem⁵, Ahmed Khadrawy³, Ammad Fazal³, Agaz Zaman⁷, Ghada Mazloum⁷, Youssef Bartella⁵, Sally Hamed⁵ and Ramia Alsouk⁸, ¹Department of Mathematics and Statistics, University of Strathclyde, Glasgow, United Kingdom, ²Al-Amiri Hospital, Kuwait City, Kuwait, ³Farwania Hosiptal, Farwania, Kuwait, ⁴Faculty of Medicine, Kuwait University, Jabria, Kuwait, ⁵Al-Amiri Hospital, Kuwait, Kuwait, ⁶Mubarak Al-Kabeer Hospital, Kuwait City, Kuwait, ⁷Mubarak Al-Kabeer Hospital, Hawally, Kuwait, ⁸Jahra Hospital, Jahra, Kuwait, ⁹Rheumatology Unit, Department of Medicine, Jaber Alahmed Alsabah hospital, State of Kuwait, Jahra, Kuwait, ¹⁰Sabah Hospital, Kuwait, Kuwait
Background/Purpose: Missing data in clinical epidemiological researches violate the intention to treat principle, reduce statistical power and can induce bias if they are related to…
Abstract Number: 1010 • ACR Convergence 2020
Infection and Malignancy Outcomes in Patients with RA Treated with Abatacept: Results from a Multinational Surveillance Study
Alyssa Dominique¹, Merete Hetland², Axel Finckh³, Jacques-Eric Gottenberg⁴, Florenzo Iannone⁵, Roberto Caporali⁶, Dan Nordstrom⁷, M Victoria Hernandez⁸, Carlos Sanchez-Piedra⁹, Fernando Sanchez-Alonso⁹, Karel Pavelka¹⁰, Zlatuše Křístková¹¹ and Teresa Simon¹², ¹Bristol-Myers Squibb Company, Princeton, NJ, ²The DANBIO Registry, Rigshospitalet, Glostrup, Denmark, ³Division of Rheumatology, University Hospitals of Geneva, Geneva, Switzerland, ⁴Strasbourg University Hospital, Strasbourg, France, ⁵DETO-Rheumatology Unit, University of Bari, Bari, Italy, ⁶Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy, ⁷Helsinki University Hospital and Helsinki University, Helsinki, Finland, ⁸Rheumatology Department, Hospital Clinic of Barcelona, Barcelona, Spain, ⁹Biobadaser, Research Unit, Sociedad Española de Reumatología, Madrid, Spain, ¹⁰Institute of Rheumatology and Department of Rheumatology, First Faculty of Medicine, Charles University, Prague, Czech Republic, ¹¹Institute of Biostatistics and Analyses, Ltd., Brno, Czech Republic, ¹²Bristol-Myers Squibb Company (at time of analysis), Princeton, NJ
Background/Purpose: Compared with the general population, patients with RA are at an increased risk of infection and certain malignancies, which may be increased further with…
Abstract Number: 1011 • ACR Convergence 2020
Effectiveness, Safety and Quality of Life with Tofacitinib Treatment in Adult Patients with Rheumatoid Arthritis Under Routine Clinical Care: First Interim Results from a German Non-Interventional, Prospective, Multi-Center Study
Frank Behrens¹, Ulrich Prothmann², Thilo Klopsch³, Ann-Dörthe Holst⁴, Lisa Blindzellner⁵, Olaf Behmer⁵, Pascal Klaus⁵, Thomas Meng⁵ and Peter-Andreas Löschmann⁵, ¹CIRI/Rheumatology & Fraunhofer IME, Research Division Translational Medicine and Pharmacology, Goethe University Hospital, Frankfurt, Hessen, Germany, ²Knappschaftsklinikum Saar, Püttlingen, Saarland, Germany, ³Rheumatological Practice, Neubrandenburg, Mecklenburg-Vorpommern, Germany, ⁴Specialist Practice for General Medicine incl. Rheumatology and Acupuncture, Ludwigslust, Mecklenburg-Vorpommern, Germany, ⁵Pfizer Pharma GmbH, Berlin, Berlin, Germany
Background/Purpose: Tofacitinib is an orally applied Janus kinase inhibitor, which is approved for rheumatoid arthritis (RA) treatment in the USA since 2012, so that ‘real…
Abstract Number: 1012 • ACR Convergence 2020
The Global Prevalence of Rheumatoid Arthritis: A Meta-Analysis
Khalid Almutairi¹, Johannes Nossent¹, David Preen¹, Helen Keen¹ and Charles Inderjeeth¹, ¹The University of Western Australia, Perth, Western Australia, Australia
Background/Purpose: To determine the global population prevalence of rheumatoid arthritis (RA) based on published studies and assess factors that influence RA prevalence estimates.Methods: Four electronic…
Abstract Number: 1013 • ACR Convergence 2020
National Burden of RA in Canada 1990-2017: Findings from the Global Burden of Disease Study 2017
Nejat Hassen¹, Diane Lacaille², Nizal Sarrafzadegan³, Alice Xu⁴, Sophia Sidi⁴, Amani Alandejani⁴, Marjan Mansourian⁵ and Jacek Kopec¹, ¹University of British Columbia, Arthritis Research Canada, Richmond, BC, Canada, ²University of British Columbia / Arthritis Research Canada, Richmond, BC, Canada, ³Isfahan University of Medical Sciences, University of British Columbia, Isfahan, Esfahan, Iran, ⁴University of British Columbia, Vancouver, BC, Canada, ⁵Isfahan University of Medical Sciences, Isfahan, Iran
Background/Purpose: It is estimated that over 120,000 individuals currently have rheumatoid arthritis (RA) in Canada, yet a comprehensive study summarizing the epidemiology of RA burden…

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