Abstracts Archive - Page 891 of 2425 - ACR Meeting Abstracts

Abstract Number: 1989 • 2019 ACR/ARP Annual Meeting
Netrin-1 and Its Receptor Unc5B Mediates Tenofovir Induced Bone Loss and Dipyridamole, an Agent That Blocks Adenosine Transporter, Is Able to Modulate the Signal
Aranzazu Mediero¹, Patricia Llamas-Granda ², Bruce Cronstein ³, Raquel Largo ⁴ and Gabriel Herrero-Beaumont ⁴, ¹IIS-FUNDACION JIMENEZ DIAZ, Madrid, Spain, ²IIS-FUNDACION JIMENEX DIAZ, Madrid, Spain, ³Department of Medicine, Division of Rheumatology NYUSoM, NYC, ⁴IIS-Fundación Jiménez Díaz, Madrid, Madrid, Spain
Background/Purpose: Osteopenia and fragility fractures have been associated with HIV infection. Tenofovir, a common antiviral in HIV treatment, also leads to increases in bone catabolism…
Abstract Number: 1990 • 2019 ACR/ARP Annual Meeting
Tenofovir Modulates Semaphorin 4D Signaling and Regulates Bone Homeostasis, Which Can Be Counteracted by Dipyridamole and Adenosine A2A Receptor
Aranzazu Mediero¹, Patricia Llamas-Granda ², Bruce Cronstein ³, Raquel Largo ⁴ and Gabriel Herrero-Beaumont ⁴, ¹IIS-FUNDACION JIMENEZ DIAZ, Madrid, Spain, ²IIS-FUNDACION JIMENEX DIAZ, Madrid, Spain, ³Department of Medicine, Division of Rheumatology NYUSoM, NYC, ⁴IIS-Fundación Jiménez Díaz, Madrid, Madrid, Spain
Background/Purpose: Semaphorins (Sema) are a family of proteins associated with neuronal development and guidance. Sema4D/CD100 was first identified as a regulator of immune response in…
Abstract Number: 1991 • 2019 ACR/ARP Annual Meeting
Inhibition of CD44 Intracellular Domain Production Suppresses Bovine Articular Chondrocyte De-differentiation Induced by Excessive Mechanical Stress Loading
Yasumori Sobue¹, Nobunori Takahashi ², Naoki Ishiguro ² and Toshihisa Kojima ², ¹Nagoya University Graduate School of Medicine, Nagoya, Japan, ²Department of Orthopedic Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan
Background/Purpose: CD44 fragmentation is enhanced in chondrocytes of osteoarthritis (OA) patients. Excessive mechanical stress loading is a risk factor for OA, but the molecular mechanism…
Abstract Number: 1992 • 2019 ACR/ARP Annual Meeting
Adenosine A2A Receptor (A2AR) Stimulation Mitigates Mitochondrial Inflammaging, Enhances Mitochondrial Metabolism and Reduces Reactive Oxygen Species-Mediated Mitochondrial Injury In Vitro and In Vivo in Osteoarthritis
Cristina Castro¹, Carmen Corciulo ², Maria Solecio ³, Benjamin Friedman ⁴, Fengxia Liang ⁵, Zhi Li ⁶, Samson Jacob ⁷, David Fenyo ⁸, Evgeny Pavlov ⁹ and Bruce Cronstein ⁴, ¹Immunology and Inflammation Training Program at Skirball Institute of Graduate Biomolecular Sciences, New York University School of Medicine (NYUSoM), NYC, ²Division of Translational Medicine NYUSoM, NYC, ³NYU College of Dentistry, NYC, ⁴Department of Medicine, Division of Rheumatology NYUSoM, NYC, ⁵Department of Cell Biology, NYU Langone Health, NYC, ⁶Institute for Systems Genetics, Department of Biochemistry and Molecular Pharmacology, NYU Langone Helalth, NYC, ⁷Institute for Systems Genetics, NYU Langone Health, NYC, ⁸Institute for Systems Genetics, Department of Biochemistry and Molecular Pharmacology, NYC, ⁹Basic Science and Craniofacial Biology, NYU College of Dentistry, NYC
Background/Purpose: Osteoarthritis (OA) is the most common form of arthritis, affecting nearly 10% of the US population and one of the contributing factors in OA…
Abstract Number: 1993 • 2019 ACR/ARP Annual Meeting
Inhibition of Choline Kinase Alpha Improves Synovitis and Cartilage Damage in Animal Models of Osteoarthritis
Roxana Coras¹, Leening P Liu ², Serena Z Shi ², Anyan Cheng ³, Alexandra Stubelius ⁴, Elsa Sanchez-Lopez ⁵, Robert Sah ⁶, Ru Liu-Bryan ⁷ and Monica Guma ⁸, ¹Department of Medicine, University of California San Diego, La Jolla, San Diego, CA, ²Department of Bioengineering, University of California San Diego, La Jolla, San Diego, ³Department of Medicine, University of California San Diego, La Jolla, San Diego, ⁴Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, San Diego, ⁵Department of Pharmacology, University of California San Diego, La Jolla, San Diego, ⁶Department of Bioengineering and Medicine, University of California San Diego, La Jolla, San Diego, ⁷San Diego VA/UCSD, La Jolla, CA, ⁸Department of Medicine, School of Medicine. University of California San Diego, La Jolla, United States
Background/Purpose: Osteoarthritis (OA) is a disease of the whole joint, affecting cartilage, ligaments, menisci, bone and synovial tissue. We previously found that choline kinase alpha…
Abstract Number: 1994 • 2019 ACR/ARP Annual Meeting
Helicobacter Pylori Infection Among Korean Patients with Rheumatoid Arthritis and Its Interaction with Shared Epitope
Eun Ha Kang¹, So-Young Bang ², Ye Ji Lee ³, You-Jung Ha ¹, Yun Jong Lee ⁴, Yeong-Wook Song ³, Sang-Cheol Bae ² and Eun Bong Lee ⁵, ¹Division of Rheumatology, Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Republic of Korea, Seongnam, Republic of Korea, ²Hanyang University Hospital for Rheumatic Diseases, Seoul, Republic of Korea, ³Seoul National University Hospital, Seoul, Republic of Korea, ⁴Division of Rheumatology, Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Republic of Korea, ⁵Division of Rheumatology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea, seoul
Background/Purpose: While smoking is an important environmental risk factor for rheumatoid arthritis (RA) development, only a small proportion of Korean patients with RA were found…
Abstract Number: 1995 • 2019 ACR/ARP Annual Meeting
Gingival-Derived Mesenchymal Stem Cells Alleviate Cartilage Damage in Collagen-Induced Arthritis via Suppressing Activities of Inflamed Synovial Fibroblast
Ximei Zhang¹, Julie Wang ², Nancy Olsen ³, Wael Jarjour ⁴ and Song Guo Zheng ⁴, ¹Ohio State College of Medicine, Columbus, ²Ohio State University, columbus, ³Penn State University, Hershey, PA, ⁴Ohio State College of Medicine, Columbus, OH
Background/Purpose: Dysfunction of immunology and inflammatory responses is crucial in initiating and promoting bone/cartilage destruction in rheumatic arthritis (RA). Inflamed synovial fibroblast cells (ISFs) are…
Abstract Number: 1996 • 2019 ACR/ARP Annual Meeting
Bromodomain Inhibitor, I-BET762 Inhibits Production of Pro-inflammatory in Rheumatoid Arthritis Fibroblast-like Synoviocytes and Differentiation of Osteoclast
Ra Ham Kim¹, Hyun Jung Yoo ², Shin Eui Kang ³, Ji soo Park ⁴, Seon Uk Kim ⁵, Eun Young Lee ⁶, Jin Kyun Park ⁶ and Yeong-Wook Song ⁷, ¹Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology and College of Medicine, Seoul National University, Seoul, Republic of Korea, Seoul, Republic of Korea, ²Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology and College of Medicine, Seoul National University, Seoul, Repulbic of Korea, Seoul, Republic of Korea, ³Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology and College of Medicine, Seoul National University, Seoul, Republic of Korea, Seoul, Republic of Korea, ⁴Division of Rheumatology, Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea., Seoul, Republic of Korea, ⁵Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, and College of Medicine, Seoul National University, Seoul, Republic of Korea, ⁶Division of Rheumatology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea, Seoul, Republic of Korea, ⁷Seoul National University Hospital, Seoul, Republic of Korea
Background/Purpose: Rheumatoid arthritis (RA) is a chronic autoimmune disorder, characterized by joint inflammation and bone destruction. The fibroblast-like synoviocyte(FLS) contributes to the pathogenesis of RA…
Abstract Number: 1997 • 2019 ACR/ARP Annual Meeting
Histologic and Clinical Correlates of Ultrasound Measures of Joint Inflammation: Analysis of RA Tissue Obtained by Ultrasound Guided Biopsy in Phase 2 of the Accelerating Medicines Partnership RA Network
Diane Horowitz¹, Andrew Filer ², Jennifer Albrecht ³, Arthur Mandelin ⁴, Darren Tabechian ⁵, Edward DiCarlo ⁶, Brendan Boyce ³, Ellen Gravallese ⁷, Peter Gregersen ⁸, Dagmar Scheel-Toellner ⁹, Kevin Wei ¹⁰, Katherine Liao ¹¹, Larry Moreland ¹², V. Michael Holers ¹³, Michael Brenner ¹⁴, Jennifer Anolik ³ and Vivian Bykerk ¹⁵, ¹Northwell Health, Great Neck, NY, ²Institute of Inflammation and Ageing College of Medical and Dental Sciences University of Birmingham, Birmingham, United Kingdom, ³University of Rochester Medical Center, Rochester, NY, ⁴Northwestern University Feinberg School of Medicine, Division of Rheumatology, Chicago, IL, ⁵University of Rochester, Rochester, NY, ⁶Hospital for Special Surgery, New York, ⁷University of Massachusetts Medical School, Worcester, MA, ⁸Feinstein Institutes for Medical Research, Manhasset, NY, ⁹University of Birmingham, Birmingham, United Kingdom, ¹⁰Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ¹¹Brigham and Women's Hospital, Boston, ¹²University of Pittsburgh, PITTSBURGH, PA, ¹³University of Colorado Denver, Division of Rheumatology, Aurora, CO, USA, Denver, ¹⁴Brigham and Women’s Hospital:, Boston, ¹⁵Hospital for Special Surgery, New York City, NY
Background/Purpose: The AMP-RA network applies cutting edge molecular single cell technologies to study synovial tissue obtained from rheumatoid arthritis (RA) patients using US guided synovial…
Abstract Number: 1998 • 2019 ACR/ARP Annual Meeting
Major Histocompatibility Antigen HLA-DQB1*0601 Is Associated with Rheumatoid Arthritis Among Indians in a Replication Study: Evidence of Gene-Environment Interaction with LPG Stove Use
Able Lawrence¹, Anshul Dhar ², Swayam Prakash ³, Suvrat Arya ⁴, Amita Aggarwal ⁵ and Suraksha Agrawal ⁶, ¹Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Lucknow, Uttar Pradesh, India, ²SGPGIMS, Lucknow, India, ³Cellular and Molecular Immunology Laboratory University of California Irvine, School of Medicine USA, Irvine, CA, ⁴Sanjay Gandhi Postgraduate Institute, Lucknow, India, Lucknow, India, ⁵Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India, Lucknow, Uttar Pradesh, India, ⁶SGPGIMS, Lucknow, Uttar Pradesh, India
Background/Purpose: Shared epitope smoking interaction does not fully explain MHC association in Rheumatoid Arthritis (RA). We have previously shown HLA-DQB1*0601 (DQ6.1) to be a susceptibility…
Abstract Number: 1999 • 2019 ACR/ARP Annual Meeting
NADPH Oxidase 4 Regulates the Migration and Invasion of Synoviocytes in Rheumatoid Arthritis Through Pro-angiogenic Factor Secretion
Ha-Reum Lee¹, Su-Jin Yoo ², Chan-Geol Park ², Jinhyun Kim ², In Seol Yoo ² and Seong Wook Kang ², ¹Chungnam National University Hospital,, Daejeon, Republic of Korea, ²Chungnam National University Hospital, Daejeon, Republic of Korea
Background/Purpose: Fibroblast-like synoviocytes (FLS) are key effector cells in the pathogenesis of rheumatoid arthritis (RA) through the increased cell migration, degradation of extracellular matrix, and…
Abstract Number: 2000 • 2019 ACR/ARP Annual Meeting
Anti-inflammatory Effect of Novel Spleen Tyrosine Kinase Inhibitor, SKI-O-592, on Fibroblast-like Synoviocyte in Rheumatoid Arthritis and THP-1 Cell
Seon Uk Kim¹, Hyun Jung Yoo ², Shin Eui Kang ³, Ji soo Park ⁴, Ra Ham Kim ⁵, Jung-Ho Kim ⁶, Hae-Jun Hwang ⁶, Jin Kyun Park ⁷, Eun Young Lee ⁷ and Yeong-Wook Song ⁸, ¹Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, and College of Medicine, Seoul National University, Seoul, Republic of Korea, ²Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology and College of Medicine, Seoul National University, Seoul, Repulbic of Korea, Seoul, Republic of Korea, ³Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology and College of Medicine, Seoul National University, Seoul, Republic of Korea, Seoul, Republic of Korea, ⁴Division of Rheumatology, Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea., Seoul, Republic of Korea, ⁵Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology and College of Medicine, Seoul National University, Seoul, Republic of Korea, Seoul, Republic of Korea, ⁶Oscotec Inc., Seongnam, Republic of Korea, ⁷Division of Rheumatology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea, seoul, Republic of Korea, ⁸Seoul National University Hospital, Seoul, Republic of Korea
Background/Purpose: Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease characterized by bone and cartilage destruction with leukocyte infiltration and activation at synovial tissue. The…
Abstract Number: 2001 • 2019 ACR/ARP Annual Meeting
Survivin Controls the Transcriptional Activity by Changing the Pattern of Histone H3 Marks on Chromatin
Karin Andersson ¹, Malin Erlandsson ¹, Anastasius Damdimopoulos ², Robin Bremer ¹, Maja Jensen ³, Maria-José Garcia-Bonete ³, Gergely Katona ³ and Maria Bokarewa¹, ¹Department of Rheumatology and Inflammation Research, the Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden, Gothenburg, Sweden, ²Department of Biosciences and Nutrition, Karolinska Institute, Solna, Sweden, Stockholm, Sweden, ³Department of Chemistry and Molecular Biology, the Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden, Gothenburg, Sweden
Background/Purpose: The oncoprotein survivin coded by the BIRC5 gene was described as an important marker in rheumatoid arthritis (RA). Survivin participates in cell division being…
Abstract Number: 2002 • 2019 ACR/ARP Annual Meeting
Presence of the MerTK Receptor on Human Synovial Tissue Macrophages Lowers Inflammatory Cytokine Production and Activation of the MerTK+CD206+ Subpopulation Limits the Inflammatory Response of Synovial Fibroblasts
Samuel Finlay¹, Stefano Alivernini ², Aziza Elmesmari ³, Barbara Tolusso ², Luca Petricca ², Clara Di Mario ⁴, Annunziata Capacci ², Andrew Filer ⁵, Gianfranco Ferraccioli ², Iain McInnes ¹, Elisa Gremese ² and Mariola Kurowska-Stolarska ¹, ¹Institute of Infection, Immunity & Inflammation, University of Glasgow, Glasgow, United Kingdom, ²Division of Rheumatology - Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy, ³Institute of Infection, Immunity & Inflammation, University of Glasgow, Glasgow, Scotland, United Kingdom, ⁴Institute of Rheumatology - Università Cattolica del Sacro Cuore, Rome, Italy, ⁵Institute of Inflammation and Ageing College of Medical and Dental Sciences University of Birmingham, Birmingham, United Kingdom
Background/Purpose: Background: A substantial proportion of Rheumatoid Arthritis patients do not respond to treatment and only a small proportion achieve sustained disease remission. We showed…
Abstract Number: 2003 • 2019 ACR/ARP Annual Meeting
Anti-Polygalacturonic Acid Antibody (PGA-Ab) Induced Bone Destruction in Rheumatoid Arthritis by Promoting Osteoclastogenesis via Integrin Beta 5
JIAWEI XIE¹ and HUI DAI ¹, ¹Peking University, Beijing, China (People's Republic)
Background/Purpose: Anti-polygalacturonic acid antibody (PGA-Ab) is a new rheumatoid arthritis (RA)-related autoantibody first identified by our group. The sensitivity and specificity of PGA-Ab is even…

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