Abstracts Archive - Page 885 of 2425 - ACR Meeting Abstracts

Abstract Number: 1899 • 2019 ACR/ARP Annual Meeting
sFlt-1, PlGF and VEGF in the Differential Diagnosis Between Active SLE Nephritis During Pregnancy and Preeclampsia
Guilherme De Jesus¹, Marcela Lacerda ¹, Bruna Rodrigues ¹, Flavia dos Santos ¹, Adriana Nascimento ¹, Luis Cristóvão Porto ¹, Nilson Ramires de Jesús ¹, Roger Levy ² and Evandro Klumb ¹, ¹Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil, ²GlaxoSmithKline, Upper Providence, PA
Background/Purpose: Pregnancy in patients with SLE is associated with significant morbidity and mortality. SLE activity during pregnancy, specifically nephritis, makes the differential diagnosis with preeclampsia…
Abstract Number: 1900 • 2019 ACR/ARP Annual Meeting
Assessing Commercial Titers of anti-Ro60 and Ro52 Antibodies to Risk Stratify Surveillance of Anti-Ro/SSA Antibody Positive Pregnancies
Kimberly Robins ¹, Rohit Bhan¹, Catherine Trad ¹, Rebecca Cohen ¹, Miao Chang ¹, Benjamin Wainwright ¹, Mala Masson ¹, Shilpi Mehta-Lee ¹, Peter Izmirly ¹, Robert Clancy ¹, Bettina Cuneo ² and Jill Buyon ¹, ¹NYU School of Medicine, New York, ²Children's Hospital Colorado, Aurora
Background/Purpose: Pregnancy counseling of all anti-Ro positive women includes advice regarding the development of congenital heart block (CHB), albeit the risk is only 2% for…
Abstract Number: 1901 • 2019 ACR/ARP Annual Meeting
Serious Infections in Offspring Exposed in Utero to Non-TNFi Biologics and Tofacitinib
Evelyne Vinet¹, Yvan St-Pierre ¹, Cristiano S. Moura ¹, Jeffrey Curtis ² and Sasha Bernatsky ³, ¹McGill University Health Centre, Montreal, QC, Canada, ²University of Alabama at Birmingham, Birmingham, AL, ³Research Institute of the McGill University Health Centre, Montreal, QC, Canada
Background/Purpose: During pregnancy, maternal circulating immunoglobulins G (IgG) are actively transported across the placenta through their Fc portion. Thus, TNFi and other biologics harbouring an Fc…
Abstract Number: 1902 • 2019 ACR/ARP Annual Meeting
Systems Biology in 874 Patients with Primary Sjögren’s Syndrome Indicates the Predominant Role of Interferon Alpha Compared to Interferon Gamma, Its Association with Systemic Complications, and a New Aspect of the Genetic Contribution of HLA
Pierre Bost ¹, Xavier Mariette ², Vincent Bondet ³, Alba Llibre ¹, Céline Posseme ³, Bruno Charbit ³, Christian Thorball ⁴, Roland Jonsson ⁵, Chris Lessard ⁶, Renaud Felten ⁷, Fai Ng ⁸, K Silvis ⁹, Lucienne Chatenoud ¹⁰, Hélène Dumortier ¹¹, Jacques Fellay ⁴, Karl A Brostadt ¹², Silke Appel ⁵, Jessica R Tarn ⁸, Lluis Quintana-Murci ³, Michael Minguenau ¹³, Nicolas Meyer ¹⁴, Darragh Duffy ¹, Benno Schwikowski ¹ and Jacques-Eric Gottenberg¹⁵, ¹PASTEUR, PARIS, France, ²Université Paris-Sud, Paris, France, Paris, Centre, France, ³PASTEUR, PARIS, Centre, France, ⁴School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland, ⁵University of Bergen, Bergen, Norway, ⁶ORMF, Oklahoma City, ⁷Strasbourg Unviersity Hospital, Strasbourg, Alsace, France, ⁸Newcastle Hospital, Newcastle, United Kingdom, ⁹ORMF, Oklahoma, ¹⁰Necker Hospital, Paris, France, ¹¹IBMC, Strasbourg, Alsace, France, ¹²Universiy of Bergen, Bergen, Norway, ¹³Biogen, Boston, ¹⁴Strasbourg University Hospital, STRASBOURG, France, ¹⁵Department of Rheumatology, Strasbourg University Hospital, Strasbourg, France
Background/Purpose: Primary Sjögren’s syndrome (pSS) is the second most frequent systemic autoimmune disease affecting 0.1% of the general population. No specific immunomodulatory drug has demonstrated…
Abstract Number: 1903 • 2019 ACR/ARP Annual Meeting
BTK Overexpression Is Associated with the Risk of Lymphoma in Primary Sjögren’s Syndrome: Data from Whole Blood Transcriptome of 346 Patients Followed-up Prospectively for 10 Years
Pierre-Marie Duret¹, Tao Ye ², Wan-Fai Ng ³, Alain Saraux ⁴, Valérie Devauchelle Pensec ⁵, Raphaele Seror ⁶, Veronique Le-Guern ⁷, Claire Larroche ⁸, Aleth Perdriger ⁹, Jean Sibilia ¹⁰, Jessica Tarn ¹¹, Gaetane Nocturne ¹², Xavier Mariette ¹³ and Jacques-Eric Gottenberg ¹⁴, ¹Hôpitaux civils de Colmar, COLMAR CEDEX, France, ²GenomEAST platform / Institut National de la Santé et de la Recherche Médicale (INSERM), U1258, Institut de Génétique et de Biologie Moléculaire, IGBMC, Strasbourg, France, ³Musculoskeletal Research Group Institute of Cellular Medicine Faculty of Medical Sciences Newcastle University, Newcastle, United Kingdom, ⁴CHU de la Cavale-Blanche Brest, Brest, France, ⁵University Hospital of Brest, Brest, France, ⁶Hopitaux universitaires Paris Sud, Kremlin-Bicetre, France, ⁷Department of Internal Medicine, Referral Center for Rare Autoimmune and Systemic Diseases, Hôpital Cochin, AP-HP, Université Paris Descartes, Paris, France,, Paris, France, ⁸Internal Medicine, Paris, France, Paris, France, ⁹Rheumatology department, Rennes University Hospital, France, Rennes, France, ¹⁰CHU Strasbourg, Strasbourg, France, ¹¹Institute of Cellular Medicine Newcastle University, Newcastle, United Kingdom, ¹²Center for Immunology of Viral Infections and Autoimmune Diseases, Assistance Publique – Hôpitaux de Paris, Hôpitaux Universitaires Paris-Sud, Le Kremlin-Bicêtre, Université Paris Sud, INSERM, Paris, France., Paris, France, ¹³Center for Immunology of Viral Infections and Autoimmune Diseases, Assistance Publique – Hôpitaux de Paris, Hôpitaux Universitaires Paris-Sud, Le Kremlin-Bicêtre, Université Paris Sud, INSERM, Paris, France, ¹⁴Department of Rheumatology, Strasbourg University Hospital, Strasbourg, France
Background/Purpose: To identify a molecular signature associated with lymphomagenesis in primary Sjögren’s Syndrome (pSS).Methods: Whole peripheral blood samples were collected from 346 well-phenotyped pSS patients…
Abstract Number: 1904 • 2019 ACR/ARP Annual Meeting
IL-6 Receptor Inhibition in Primary Sjögren Syndrome : Results from a Randomized Multicenter Academic Double Blind Placebo-controlled Trial of Tocilizumab in 110 Patients
Renaud Felten ¹, Nicolas Meyer ¹, P Duffaut ², D Saadoun ³, Eric Hachulla ⁴, Pierre Yves Hatron ⁴, Carine Salliot ⁵, Aleth Perdriger ⁶, Jacques Morel ⁷, Arsène Mekinian ⁸, Olivier Vittecoq ⁹, Jean Marie Berthelot ¹⁰, Emmanuelle Dernis ¹¹, Véronique Le Guern ¹², Philippe Dieudé ¹³, Claire Larroche ¹⁴, Christophe Richez ¹⁵, Thierry Martin ¹, Charles Zarnitsky ¹⁶, Gilles Blaison ¹⁷, P Kieffer ¹⁸, François Maurier ¹⁹, Stéphanie Rist ⁵, Patrice Cacoub ²⁰, Emmanuel Andres ²¹, Emmanuel Chatelus ¹, Christelle Sordet ¹, Jean Sibilia ¹, Cécile Arnold ¹, Mira Tawk ¹, Ouafaa Aberkane ¹, Raphaele Seror ²², Lise Holterbach ¹, Xavier Mariette ²² and Jacques-Eric Gottenberg²³, ¹Strasbourg University Hospital, Strasbourg, France, ²Bordeaux University Hospital, Bordeaux, Aquitaine, France, ³Pitie Salpetrière Hospital, APHP, Paris, France, ⁴Lille University Hospital, Lille, France, ⁵Orleans Hospital, Orleans, France, ⁶Rennes University Hospital, Rennes, France, ⁷Montpellier University Hospital, Montpellier, France, ⁸Saint-Antoine Hospital, APHP, Paris, France, ⁹Rouen University Hospital, ROUEN, France, ¹⁰Nantes University Hospital, Nantes, France, ¹¹Le Mans Hospital, Le Mans, France, ¹²Cochin Hospital, APHP, PARIS, France, ¹³Bichat Hospital, APHP, PARIS, ¹⁴Avicenne Hospital, PARIS, France, ¹⁵Bordeaux University Hospital, Bordeaux, France, ¹⁶Le Havre Hospital, Le Havre, ¹⁷Colmar Hospital, Colmar, France, ¹⁸Mulhouse Hospital, Mulhouse, France, ¹⁹Metz Hospital, Metz, France, ²⁰Pitie Salpéterière, APHP, Paris, France, ²¹CHU Strasbourg, strasbourg, ²²Bicetre Hospital, APHP, Paris, France, ²³Department of Rheumatology, Strasbourg University Hospital, Strasbourg, France
Background/Purpose: IL-6 is suspected to play an important pathogenic role in primary Sjögren’s syndrome (pSS) through its crucial roles in B-cell activation, and T-cell polarization,…
Abstract Number: 1905 • 2019 ACR/ARP Annual Meeting
Sicca/Sjögren Syndrome Triggered by PD-1/PD-L1 Checkpoint Inhibitors: Data from the International ImmunoCancer Registry (ICIR)
Manuel Ramos-Casals ¹, Alexandre Maria ², Maria E. Suárez-Almazor ³, Olivier Lambotte ⁴, Benjamin A. Fisher ⁵, Gabriela Hernandez-Molina ⁶, Philippe Guilpain ², Xerxes Pundole ³, Soledad Retamozo⁷, Alejandra Flores-Chávez ⁸, Chiara Baldini ⁹, Clifton Bingham ¹⁰, Pilar Brito-Zerón ¹¹, Jacques-Eric Gottenberg ¹², Marie Kostine ¹³, Timothy R.D. Radstake ¹⁴, Thierry Schaeverbeke ¹⁵, Hendrik Schulze-Koops ¹⁶, Leonard Calabrese ¹⁷, Munther A Khamashta ¹⁸ and Xavier Mariette ¹⁹, ¹Department of Autoimmune Diseases, ICMiD. Sjögren Syndrome Research Group (AGAUR), Laboratory of Autoimmune Diseases Josep Font, IDIBAPS-CELLEX. Department of Medicine, University of Barcelona, Hospital Clínic, Barcelona, Spain., Barcelona, Spain, ²Department of Internal Medicine, Multi-Organic Diseases, Local Referral Center for Autoimmune Diseases, Saint Eloi Hospital- Montpellier-1 University, Montpellier Cedex 5, France, Montpellier, France, ³Department of Rheumatology/Clinical Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX , USA., Houston, TX, ⁴APHP Médecine Interne/Immunologie Clinique, Hôpital Bicêtre, Paris, France. Université Paris Sud 11 – INSERM U1184 - CEA, Immunology of Viral Infections and Autoimmune Diseases, IDMIT Department, IBFJ, Fontenay-aux-Roses & Le Kremlin-Bicêtre, France., Paris, France, ⁵Institute of Inflammation and Ageing, University of Birmingham; and National Institute of Health Research Birmingham Biomedical Research Centre and Department of Rheumatology, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK, Birmingham, United Kingdom, ⁶Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico, ⁷Instituto De Investigaciones En Ciencias De La Salud, Univ. Nacional de Córdoba, Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto Universitario de Ciencias Biomédicas de Córdoba, Córdoba, Argentina., Cordoba, Argentina, ⁸Department of Autoimmune Diseases, ICMiD, Barcelona, Spain., Barcelona, Spain, ⁹Rheumatology Unit, University of Pisa, Italy., Pisa, Italy, ¹⁰Johns Hopkins University, Baltimore, MD, ¹¹Sjögren Syndrome Research Group (AGAUR), Laboratory of Autoimmune Diseases Josep Font, IDIBAPS-CELLEX, Department of Autoimmune Diseases, ICMiD, University of Barcelona, Hospital Clínic. Autoimmune Diseases Unit, Department of Medicine, Hospital CIMA- Sanitas, Barcelona, Spain., Barcelona, Spain, ¹²Department of Rheumatology, Strasbourg University Hospital, Strasbourg, France, ¹³Department of Rheumatology, Centre Hospitalier Universitaire, Bordeaux, France, Bordeaux, France, ¹⁴Department of Rheumatology/Clinical Immunology, University Medical Center Utrecht, Utrecht, The Netherlands., Utrecht, Netherlands, ¹⁵FHU ACRONIM, Department of Rheumatology, Centre Hospitalier Universitaire, Bordeaux, France, Bordeaux, France, ¹⁶Department of Rheumatology/Clinical Immunology, Ludwig-Maximilians-University Munich, Munich, Germany., Munich, Germany, ¹⁷Rheumatologic and Immunologic Disease/Cleveland Clinic, Cleveland, OH, ¹⁸King's College London School of Medicine, London, United Kingdom, ¹⁹Center for Immunology of Viral Infections and Autoimmune Diseases, Assistance Publique – Hôpitaux de Paris, Hôpitaux Universitaires Paris-Sud, Le Kremlin-Bicêtre, Université Paris Sud, INSERM, Paris, France
Background/Purpose: To analyse the worldwide occurrence of sicca/Sjögren (SjS) syndrome associated with the use of immune checkpoint inhibitors (ICI) in patients with cancer.Methods: The ImmunoCancer…
Abstract Number: 1906 • 2019 ACR/ARP Annual Meeting
Using Multi-modal Ultrasound to Assess Disease Activity Within the Salivary Glands of Patients with Primary Sjögren’s Syndrome Treated with Ianalumab (VAY736)
Torsten Diekhoff ¹, Maximilian Posch ², Frank Wagner ², Thomas Fischer ¹, Quirino Schefer ², Thomas Dörner ³, Didier Laurent ⁴, Yue Li ⁴ and Stephen Oliver⁴, ¹Charité University Hospital, Berlin, Germany, ²Charité Research Organisation, Berlin, Germany, ³Charite Universitätsmedizin Berlin and DRFZ, Berlin, Germany, ⁴Novartis Pharma AG, Basel, Switzerland
Background/Purpose: To use ultrasound (US) to demonstrate that ianalumab, a monoclonal antibody with dual mechanisms-of-action of BAFF:BAFF-R blockade and enhanced, ADCC-mediated B cell depletion, can…
Abstract Number: 1907 • 2019 ACR/ARP Annual Meeting
Abatacept Reduces Serum CXCL13 and Disease-Relevant Immune Cell Phenotypes in a Double-Blind, Placebo-Controlled Primary Sjögren’s Syndrome Clinical Trial
Jacques-Eric Gottenberg¹, Sumanta Mukherjee ², Marleen Nys ³, Robert Wong ⁴, Hendrika Bootsma ⁵ and Neelanjana Ray ⁴, ¹Department of Rheumatology, Strasbourg University Hospital, Strasbourg, France, ²Bristol-Myers Squibb, Princeton, NJ, ³Bristol-Myers Squibb, Braine L’Alleud, Belgium, ⁴Bristol-Myers Squibb, Princeton, ⁵University of Groningen, Groningen, Netherlands
Background/Purpose: Chemokine (C-X-C motif) ligand 13 (CXCL13), produced by follicular helper T (Tfh) cells, plays a pivotal role in B-cell homing and activation in germinal…
Abstract Number: 1908 • 2019 ACR/ARP Annual Meeting
Preliminary Identification of Arthritis-Associated Microbiota in Experimental Spondyloarthritis
Tejpal Gill¹, Tri Tran ², Stephen Brooks ³ and Robert Colbert ⁴, ¹NIAMS/NIH, Bethesda, MD, ²NIAMS, NIH, Bethesda, MD, ³Biomining and Discovery Section/NIAMS/NIH, Bethesda, MD, ⁴Pediatric Clinical Trials Unit, Pediatric Translational Research Branch, NIAMS, NIH, Bethesda, MD
Background/Purpose: Gut microbiota are strongly implicated in the pathogenesis of spondyloarthritis (SpA). Previous studies from our lab have documented extensive gut microbial dysbiosis in rats…
Abstract Number: 1909 • 2019 ACR/ARP Annual Meeting
miR-21-5p Expression as a Marker of Treatment Response in Psoriatic Arthritis Patients
Rohan Machhar¹, Justine (Yang) Ye ², Remy Pollock ¹ and Dafna Gladman ³, ¹Krembil Research Institute, University Health Network, Toronto, Canada, ²University Health Network, University of Toronto, Toronto, ON, Canada, ³Toronto Western Hospital, Toronto, Canada, Toronto, ON, Canada
Background/Purpose: Psoriatic arthritis (PsA) is an inflammatory arthritis occurring in patients with psoriasis. Links between altered miRNA expression with the pathogenesis of several autoimmune disorders…
Abstract Number: 1910 • 2019 ACR/ARP Annual Meeting
Inflammatory Processes in Experimental Spondyloarthritis Are Accompanied by Formation of Ectopic Lymphoid Structures and B Cell Lineage Alterations in the Bone Marrow
Merlijn Kaaij¹, Jan Piet van Hamburg ¹, Jasper Rip ², George Kollias ³, Leonie van Duivenvoorde ¹, Martijn Nolte ⁴, Dominique Baeten ¹ and Sander Tas ¹, ¹Amsterdam Rheumatology & immunology Center, Amsterdam UMC/University of Amsterdam, Amsterdam, Netherlands, ²Department of Pulmonary Medicine, Erasmus MC, Rotterdam, Rotterdam, Netherlands, ³Division of Immunology, Biomedical Sciences Center ”Alexander Fleming”, Vari, Greece, Vari, Greece, ⁴Sanquin Research and Landsteiner Laboratory, Molecular & Cellular Hemostasis, Amsterdam UMC/University of Amsterdam, Amsterdam, Netherlands
Background/Purpose: Tumour necrosis factor a (TNF) is important in immune-mediated inflammatory diseases such as spondyloarthritis (SpA). Transmembrane (tm)TNF-transgenic (tg) mice that overexpress tmTNF develop typical…
Abstract Number: 1911 • 2019 ACR/ARP Annual Meeting
Targeting the Oxidative Stress Pathway in Experimental Spondyloarthritis Reduces Pro-inflammatory Response in Rat Macrophages and Modulates Their Metabolic Requirements
Fatemeh Navid¹, Francesca LiCausi ¹, Breanna Nguyen ¹, Antony Cougnoux ², Pierre-Christian Violet ³, Mark Levine ³ and Robert Colbert ¹, ¹NIAMS/NIH, bethesda, ²NICHDR/NIH, Bethesda, ³NIDDK/NIH, Bethesda
Background/Purpose: HLA-B27 is associated with the development of spondyloarthritis (SpA) and has a tendency to generate ER stress due to misfolding which can activate the…
Abstract Number: 1912 • 2019 ACR/ARP Annual Meeting
High Dimensional Flowcytometric Profiling Distinguishes Psoriasis and Psoriatic Arthritis
Michelle Mulder¹, Juul van den Reek ², Elke de Jong ², Bram van Cranenbroek ², Ruben Smeets ², Irma Joosten ², Xuehui He ³, Frank van den Hoogen ¹, Hans Koenen ³ and Mark Wenink ¹, ¹Sint Maartenskliniek, Nijmegen, Netherlands, ²Radboudumc, Nijmegen, Netherlands, ³Radboudumc, Njimegen, Netherlands
Background/Purpose: Psoriasis (Pso) is a common chronic inflammatory skin disease. About 30% of Pso patients develop psoriatic arthritis (PsA), a chronic inflammation of joints and…
Abstract Number: 1913 • 2019 ACR/ARP Annual Meeting
Associations of HLA-B Alleles, Enthesitis and Peripheral Arthritis in Ankylosing Spondylitis
Benjamin Naovarat¹, Michael Weisman ², Lianne Gensler ³, Michael Ward ⁴, Mark Hwang ¹, Amirali Tahanan ¹, MinJae Lee ¹, Mohammad Rahbar ¹, Mariko Ishimori ⁵, Matthew Brown ⁶ and John Reveille ⁷, ¹University of Texas-McGovern Medical School, Houston, TX, ²David Geffen School of Medicine at UCLA, Los Angeles, CA, ³University San Francisco California, San Francisco, CA, ⁴NIAMS, Bethesda, MD, ⁵Cedars-Sinai Medical Center, Los Angeles, CA, ⁶Queensland University of Technology, Queensland, Australia, ⁷University of Texas McGovern Medical School, Houston
Background/Purpose: Recent studies have suggested that peripheral arthritis in patients with spondyloarthritis is associated with HLA-B*15. Studies of white patients with psoriatic arthritis (PsA) have…

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