Abstracts Archive - Page 882 of 2607 - ACR Meeting Abstracts

Abstract Number: 0684 • ACR Convergence 2020
The Shrinking Toe: A Sign of Crystal Dissolution During Urate Lowering Treatment of Severe Gouty Arthropathy
Thomas Bardin¹, Nguyen Dinh Quang², Hieu Le Nghia², Tran Minh Khoi², Hang Korng EA³, Valérie Bousson⁴ and Pascal Richette⁵, ¹Université de Paris, INSERM U1132 and Hôpital Lariboisièe, Paris, France, Paris, France, ²Vien Gut Medical Center, Ho Chi Minh City, Vietnam, ³Universite de Paris, AP-HP, INSERM, paris, France, ⁴Lariboisière Hospital, Paris, France, ⁵Department of Rheumatology, Lariboisière Hospital, Paris, France
Background/Purpose: Serum urate (SU) lowering has been reported to improve gout erosions. We observed that it may also lead to compaction of toe MTP or…
Abstract Number: 0685 • ACR Convergence 2020
The Impact of Azathioprine on the Frequency of Persistent Responsiveness to Pegloticase in Patients with Chronic Refractory Gout
Herbert S. Baraf¹, Hope Rainey², Peter Lipsky² and Peter Lipsky³, ¹The Ctr for Rheumatology and Bone Research, Wheaton, MD, ²AMPEL BioSolutions LLC., Charlottesville, VA, ³RILITE Foundation, Charlottesville, VA
Background/Purpose: Pegloticase is a mammalian recombinant uricase coupled to monomethoxy polyethylene glycol that is approved in the US for treatment of patients with chronic refractory…
Abstract Number: 0686 • ACR Convergence 2020
Renal Evolution During the First Year of Urate-lowering Therapy According to Sonographic Joint Deposition: Data from the Lille-Alicante Inception Cohort
Irene Calabuig¹, Anne Marty-Ané², Laurène Norberciak³, Jean--Francois Budzik⁴, Agustín Martínez-Sanchis⁵, Mariano Andrés¹ and Tristan Pascart³, ¹Hospital General Universitario de Alicante-ISABIAL and Universidad Miguel Hernández de Elche, Alicante, Spain, ²GHICL, Lille, France, ³GHICL, Lomme, France, ⁴University of Lille, Lille, France, ⁵Hospital General Universitario de Alicante-ISABIAL, Alicante, Spain
Background/Purpose: Gout is associated with chronic kidney disease, but how the kidney function evolves when gout is treated with urate lowering therapy (ULT) is still…
Abstract Number: 0687 • ACR Convergence 2020
Musculoskeletal Manifestations in Patients with CD73 Deficiency
Cornelia Cudrici¹, Kam Newman², Deepak Lakshmipathy¹, Elisa Ferrante¹, Rebecca Huffstutler¹, Katherine Carney¹, Blas Betancourt², Markku Miettinen³, James Katz⁴, Leon Nesti⁵, Han Wen¹, Manfred Boehm⁶ and Alessandra Brofferio¹, ¹National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, ²National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, ³National Cancer Institute, National Institutes of Health, Bethesda, MD, ⁴NIH NIAMS, Bethesda, MD, ⁵Clinical and Experimental Orthopaedics, Walter Reed National Military Medical Center, Bethesda, MD, ⁶Center for Molecular Medicine, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD
Background/Purpose: Arterial calcification due to deficiency of CD73 (ACDC) is a hereditary autosomal recessive ectopic mineralization syndrome caused by loss-of-function mutations in the 5'-nucleotidase Ecto…
Abstract Number: 0688 • ACR Convergence 2020
The Discontinuation of Allopurinol in the Inpatient Setting and the Risk of Gout Flare: A Community-Hospital Experience
Artem Minalyan¹, Waqas Ullah², Shristi Khanal³, Bikash Basyal⁴ and Qian Zhang³, ¹Department of Medicine/Abington Hospital - Jefferson Health, Jenkintown, PA, ²Department of Medicine/Abington Hospital - Jefferson Health, Horsham, ³Department of Medicine/Abington Hospital - Jefferson Health, Jenkintown, ⁴Department of Medicine/Abington Hospital - Jefferson Health, Abington
Background/Purpose: The discontinuation of urate-lowering therapy (ULT) in the outpatient setting increases the risk of gout flare. It was reported that in hospitalized patients with…
Abstract Number: 0689 • ACR Convergence 2020
The Changing Epidemiology of Inpatient Gout and Associated Mortality: A 17-year National Study
Jasvinder Singh¹ and John Cleveland¹, ¹University of Alabama at Birmingham, Birmingham, AL
Background/Purpose: Knowledge gaps exist regarding time-trends for the main causes (Cardiac/renal disease vs. infections) hospitalizations in gout. Therefore, we examined whether specific causes (cardiovascular, renal,…
Abstract Number: 0690 • ACR Convergence 2020
AR882, a Potent and Selective Uricosuric Agent, Significantly Reduced Serum Urate in Patients with Gout in a Phase 2a Study
Li-Tain Yeh¹, Elizabeth Polvent¹, Zancong Shen², Vijay Hingorani¹, Andrea Clouser-Roche¹, Chris Mikelatis¹, Shunqi Yan¹ and Rongzi Yan¹, ¹Arthrosi Therapeutics Inc, Laguna Hills, CA, ²Arthrosi therapeutics, Laguna Hills, CA
Background/Purpose: AR882 is a potent and selective uric acid transporter 1 (URAT1) inhibitor under development for the treatment of hyperuricemia or gout. Phase 1 single…
Abstract Number: 0691 • ACR Convergence 2020
Denosumab Did Not Improve Computerized Tomography Erosion Scores When Added to Intensive Urate-Lowering Therapy in Gout: Results from a Pilot Study
Angelo Gaffo¹, Kenneth Saag², Anthony Doyle³, Joshua Melnick⁴, Anne Horne⁵, Jeffrey Foster¹, Amy Mudano¹, Stephanie Biggers¹, David Redden¹ and Nicola Dalbeth⁶, ¹University of Alabama at Birmingham, Birmingham, AL, ²University of Alabama at Birmingham, Division of Clinical Immunology and Rheumatology, Birmingham, AL, ³University of Auckland, Grafton, Auckland, New Zealand, ⁴University of Alabama at Birmingham (UAB), Vestavia Hills, AL, ⁵The University of Auckland, Auckland, New Zealand, ⁶University of Auckland, Auckland, New Zealand
Background/Purpose: Bone erosion is a common complication of tophaceous gout. Disordered osteoclast activity has been implicated in the pathogenesis of gouty bone erosion. We sought…
Abstract Number: 0692 • ACR Convergence 2020
Pre-Operative Opioid Usage Increases Length of Stay for Rheumatoid Arthritis Patients Undergoing Total Hip Arthroplasty and Total Knee Arthroplasty
Kyle Morse¹, Nicole Heinz¹, Jeremy Abolade¹, Joshua Wright-Chisem¹, Linda Russell², Meng Zhang³, Serene Mirza¹, Dana Orange⁴, Mark Figgie⁵, Peter Sculco² and Susan Goodman⁵, ¹Hospital for Special Surgery, New York, ²Hospital for Special Surgery/Weill Cornell Medicine, New York, NY, ³Feinstein Institute, Northwell Health, New York, ⁴Rockefeller University, New York, ⁵Hospital for Special Surgery, Weill Cornell Medicine, New York, NY
Background/Purpose: Total Hip (THA) and total knee arthroplasty (TKA) are cost-effective procedures that improve the health-related quality of life for patients with advanced symptomatic joint…
Abstract Number: 0693 • ACR Convergence 2020
Effect of Physical Activity on Cartilage Degradation and Inflammation in Individuals with Lumbar Spinal Stenosis
Gustavo Almeida¹, Samannaaz Khoja², Lauren Terhorst³, Gwendolyn Sowa⁴, Sara Piva² and Michael Schneider², ¹Department of Physical Therapy, UT HEALTH SAN ANTONIO, San Antonio, TX, ²Department of Physical Therapy, University of Pittsburgh, Pittsburgh, PA, ³Department of Occupational Therapy, University of Pittsburgh, Pittsburgh, PA, ⁴Department of Physical Medicine and Rehabilitation, University of Pittsburgh, Pittsburgh, PA
Background/Purpose: Guidelines recommend 150 minutes a week in moderate-intensity physical activity (MPA) to improve health in individuals with chronic disease such as those with lumbar…
Abstract Number: 0694 • ACR Convergence 2020
Relationships Among Adherence and Patient Outcomes in a Cognitive Behavioral Plus Physical Activity Intervention for Older Adults with Osteoarthritis and Hypertension
Xiaojun Shi¹, Elizabeth Schlenk² and Susan Sereika¹, ¹University of Pittsburgh School of Nursing, Pittsburgh, ²University of Pittsburgh School of Nursing, Pittsburgh, PA
Background/Purpose: Osteoarthritis of the knee (OAK) affects nearly 14 million older adults and more than half are diagnosed with hypertension (HTN). Cognitive behavior therapy (CBT)…
Abstract Number: 0695 • ACR Convergence 2020
Chronic Inflammatory Back Pain Occurring Later in Life: A Neglected Concept
Lauren Ridley¹, Nahid Rianon², Mark Hwang³, MinJae Lee⁴, Lianne Gensler⁵, Michael Ward⁶, Matthew Brown⁷, Amirali Tahanan², Mohammad Rahbar², Mariko Ishimori⁸, Michael Weisman⁹ and John Reveille¹⁰, ¹McGovern Medical School at UTHealth, Houston, TX, ²McGovern Medical School at UTHealth, Houston, ³McGovern Medical School at the University of Texas Health Science Center at Houston, Houston, TX, ⁴UT Southwestern, Dallas, ⁵University of California San Francisco, San Francisco, CA, ⁶National Institutes of Health, Bethesda, MD, ⁷Guy's and St Thomas, NHS Foundation Trust and King's College London NIHR Biomedical Research Centre, King's College London, London, United Kingdom, London, United Kingdom, ⁸Cedars-Sinai Medical Center, Los Angeles, CA, ⁹Distinguished Professor of Medicine Emeritus, David Geffen School of Medicine at UCLA, LOS ANGELES, CA, ¹⁰Department of Internal Medicine, University of Texas, Houston, TX
Background/Purpose: Chronic back pain (CBP) is a common musculoskeletal complaint and a significant cause of disability (Weisman et al., 2013). A subset of CBP, chronic…
Abstract Number: 0696 • ACR Convergence 2020
Femoral Cartilage Ultrasound Echo-Intensity Associates with Arthroscopic Cartilage Damage in People Following Anterior Cruciate Ligament Reconstruction
Matthew Harkey¹, Erin Little², Mikaela Thompson³, Ming Zhang⁴, Jeffrey Driban⁴ and Matthew Salzler³, ¹University of Massachusetts, Worcester, MA, ²Tufts Medical Center, Cambridge, MA, ³Tufts Medical Center, Boston, ⁴Tufts Medical Center, Boston, MA
Background/Purpose: Over one-third of people will develop knee osteoarthritis within 10 years of an anterior cruciate ligament (ACL) injury. Ultrasound may be used to monitor…
Abstract Number: 0697 • ACR Convergence 2020
Inferior Tendon Structure and Function Seen in Patients with Achilles Tendinopathy and Neovascularization of the Achilles Tendon
Brian Honick¹, Haraldur Sigurdsson¹ and Karin Silbernagel¹, ¹University of Delaware, Newark, DE
Background/Purpose: In prior research, the incidence rate of neovascularization with Achilles tendinopathy ranged between 47-88% of cases. The purpose of this study was to identify…
Abstract Number: 0698 • ACR Convergence 2020
Baseline Factors Are Not Associated with Rehabilitation Dose over Six Months Among Adults with RA
Louise Thoma¹, Elizabeth Wellsandt², Kristin Wipfler³ and Kaleb Michaud², ¹University of North Carolina at Chapel Hill, Chapel Hill, NC, ²University of Nebraska Medical Center, Omaha, NE, ³FORWARD, The National Databank for Rheumatic Diseases, Omaha, NE
Background/Purpose: Functional limitation is common in adults with rheumatoid arthritis (RA). Rehabilitation services, like physical therapy (PT) and occupational therapy (OT), are effective in improving…

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