Abstracts Archive - Page 873 of 2425 - ACR Meeting Abstracts

Abstract Number: 1719 • 2019 ACR/ARP Annual Meeting
Clinical Phenotypes in Relapsing Polychondritis in a Prospective Cohort
Marcela Ferrada¹, Kaitlin Quinn ², Wendy Goodspeed ³, Jeffrey KIm ⁴, Clint Allen ⁴, Arlene Sirajuddin ⁵, Marcus Chen ⁵, K Bates Gribbons ⁶, Joel S. Rosenblum ⁷, Casey A. Rimland ⁸, James Katz ¹ and Peter C. Grayson ⁹, ¹NIAMS, Bethesda, MD, ²Georgetown University Hospital/National Institutes of Health, Washington, DC, ³NIAMS, Bethesda, ⁴NIDCD, Bethesda, ⁵NHLBI, Bethesda, ⁶National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, ⁷National Institute of Arthritis, Musculoskeletal and Skin Disease (NIAMS), Bethesda, MD, Bethesda, MD, ⁸National Institute of Arthritis, Musculoskeletal and Skin Disease (NIAMS), Bethesda, MD, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, Chapel Hill, NC, ⁹National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) of the National Institutes of Health, Bethesda, MD, Bethesda, MD
Background/Purpose: Relapsing polychondritis (RP) is a systemic inflammatory disease that can be fatal. The main clinical feature that typically leads to diagnosis is ear inflammation,…
Abstract Number: 1720 • 2019 ACR/ARP Annual Meeting
Pentoxifylline Gel for Oral Ulcers in Patients with Behçet’s Syndrome
Gulen Hatemi¹, Berna Yurttas ², Zekayi Kutlubay ³, Tim Cote ⁴, Semsi Burak Derkunt ⁴, Yusuf Yazici ⁵ and Hasan Yazici ⁶, ¹Istanbul University-Cerrahpasa, Cerrahpasa Medical Faculty, Department of Internal Medicine, Division of Rheumatology, Istanbul University-Cerrahpasa, Behcet's Disease Research Center, Istanbul, Turkey, Istanbul, Turkey, ²Istanbul University-Cerrahpasa, Cerrahpasa Medical Faculty, Department of Internal Medicine, Division of Rheumatology, Istanbul University- Cerrahpasa, Behçet's Disease Research Center, Istanbul, Turkey, Istanbul, ³Istanbul University-Cerrahpasa, Cerrahpasa Medical Faculty, Department of Dermatology, Istanbul University – Cerrahpasa, Behçet’s Disease Research Center, Istanbul, Turkey, Istanbul, Turkey, ⁴Silk Road Therapeutics, Washington, DC, USA, Washington, WA, ⁵New York University School of Medicine, New York, NY, USA, New York, NY, ⁶Academic Hospital, Istanbul, Turkey, Istanbul, Turkey
Background/Purpose: Oral ulcers, the hallmark lesion of Behçet’s syndrome (BS) can be disabling and impair eating, drinking and speaking. Despite recent advances in systemic medications…
Abstract Number: 1721 • 2019 ACR/ARP Annual Meeting
Adult Primary Central Nervous System Vasculitis Treatment and Course: A Long-term Follow-up Study
Carlo Salvarani¹, Robert D Brown ², Teresa JH Christianson ², John Huston III ², Caterina Giannini ² and Gene G Hunder ², ¹Division of Rheumatology, Arcispedale Santa Maria Nuova-IRCCS, Reggio Emilia, Italy, ²Mayo Clinic, Rochester
Background/Purpose: To evaluate long-term treatment and outcomes of a large cohort of patients with primary central nervous system vasculitis (PCNSV)Methods: The study cohort consisted of…
Abstract Number: 1722 • 2019 ACR/ARP Annual Meeting
Mixed Cryoglobulin Immune Complex Proteomics: Analysis by Mass Spectroscopy
Peter Gorevic¹, Frank Eng ², Andrea Branch ³, Ahmed Elshamy ⁴, Erin Doyle ² and Thomas Schiano ², ¹Mount Sinai Hospital, New York, ²Mount Sinai Medical Center, New York, ³Mount Sinai Medical School, New York, ⁴California Northstate University, Sacramento
Background/Purpose: BACKGROUND. Mixed Cryoglobulins (MCs) are cold precipitable Rheumatoid Factors (RFs) that provide a biomarker for immune complex formation, particularly associated with chronic Hepatitis C…
Abstract Number: 1723 • 2019 ACR/ARP Annual Meeting
Mixed Cryoglobulinaemia Since the Advent of New Direct-acting Antivirals for Hepatitis C Infection: Clinical Characteristics, Etiologies and Biological Features in 679 Patients
Gonçalo Boleto¹, Pascale Ghillani-Dalbin ², Lucile Musset ², Patrice Cacoub ¹ and David Saadoun ¹, ¹AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Department of Internal Medicine and Clinical Immunology, F-75013, Paris, France, Paris, France, ²Department of Immunology, UF d’Immunochimie et d’autoimmunité, APHP, Groupe Hospitalier Pitié-Salpétrière, Paris, France, Paris, France
Background/Purpose: Previously chronic hepatitis C virus (HCV) infection was accountable for 80-90% of cases of mixed cryoglobulinemia (MC). The advent of direct-acting antivirals (DAA) has…
Abstract Number: 1724 • 2019 ACR/ARP Annual Meeting
Disease Manifestations and Impact on Quality of Life in Subjects with Pre-Pubertal Onset Systemic Lupus Erythematosus
Brandi Stevens¹, Martha Rodriquez ¹, Amy Rakestraw ² and Kathleen O'Neil ¹, ¹Indiana University, Indianapolis, IN, ²Indiana University Health, Indianapolis, IN
Background/Purpose: Systemic Lupus Erythematosus (SLE) can be a severe disease, especially when diagnosed in childhood. Onset prior to puberty (Tanner stage II) is rare, and…
Abstract Number: 1725 • 2019 ACR/ARP Annual Meeting
Disease Activity in Childhood-Onset Systemic Lupus Erythematosus: Initial Analysis of the Childhood Arthritis and Rheumatology Research Alliance Registry
Emily Smitherman¹, Mary Beth Son ², Andrea Knight ³, Timothy Beukelman ⁴, Jeffrey Curtis ¹ and Aimee Hersh ⁵, ¹University of Alabama at Birmingham, Birmingham, AL, ²Boston Children's Hospital, Boston, MA, ³Division of Rheumatology, The Hospital for Sick Children, Department of Paediatrics, University of Toronto, Toronto, ON, Canada, ⁴University of Alabama Birmingham, Birmingham, AL, ⁵University of Utah, Salt Lake City, UT
Background/Purpose: Substantial risk of early morbidity and mortality exists for patients with childhood-onset systemic lupus erythematosus (cSLE) despite widespread use of immunosuppressive therapy. There are…
Abstract Number: 1726 • 2019 ACR/ARP Annual Meeting
Disease Activity and Health Care Utilization Among Young Adults with Childhood-onset Lupus Transitioning to Adult Care: Follow-Up Data from the Pediatric Lupus Outcomes Study
Sara Haro¹, Erica Lawson ² and Aimee Hersh ³, ¹University of California San Francisco, San Francisco, CA, ²University of California San Francisco Benioff Children’s Hospital, San Francisco, CA, ³University of Utah, Salt Lake City, UT
Background/Purpose: Individuals with childhood-onset systemic lupus erythematosus (cSLE) must transfer from pediatric to adult health care as they enter adulthood. Previous analyses of the Pediatric…
Abstract Number: 1727 • 2019 ACR/ARP Annual Meeting
Worsening Disease Activity and Inability to Taper Corticosteroids in an Ethnically Diverse Cohort of Pediatric-Onset Lupus Patients After Transition to Adult Care
Marla Guzman¹, B.Anne Eberhard ¹ and Joyce Hui-Yuen ¹, ¹Cohen Children's Medical Center, New Hyde Park, NY
Background/Purpose: Transition of pediatric lupus (pSLE) patients from pediatric to adult rheumatology care is historically difficult and challenging. Although our division routinely assesses for transition…
Abstract Number: 1728 • 2019 ACR/ARP Annual Meeting
Persistent Disease Activity Is Associated with Avascular Necrosis Development in Juvenile Systemic Lupus Erythematosus
Anthony Hoang ¹, Howard Yang ², Tracy Andrews ³, Jennifer Weiss ⁴, Kathleen Haines ⁴, Yukiko Kimura ⁵ and Suzanne Li⁴, ¹Rutgers University, New Brunswick, NJ, ²David Geffen School of Medicine at UCLA, Santa Monica, CA, ³Rutgers University, Newark, NJ, ⁴Joseph M. Sanzari Children's Hospital, Hackensack University Medical Center, Hackensack, NJ, ⁵Joseph M Sanzari Children's Hospital, Hackensack University Medical Center, Cincinnati, OH
Background/Purpose: Avascular necrosis (AVN) is a serious comorbidity of juvenile systemic lupus erythematosus (jSLE) associated with disability, impaired quality of life, and increased cost of…
Abstract Number: 1729 • 2019 ACR/ARP Annual Meeting
Infections and Mortality in 230 Childhood Lupus Patients: A Single Center Experience from North India
Sumidha Mittal ¹, Manjari Agarwal ¹ and Sujata Sawhney¹, ¹Department of pediatric rheumatology, Sir Ganga Ram Hospital, New Delhi, India, New Delhi, India
Background/Purpose: Children with systemic lupus erythematosus(cSLE) have more severe disease as compared to adults. Additionally, Asians in their geographic area have high burden of infections…
Abstract Number: 1730 • 2019 ACR/ARP Annual Meeting
Impact of Preceding and Co-existing Autoimmune Cytopenias on Severity of Childhood-onset Systemic Lupus Erythematosus: A Single-Center Retrospective Cohort Study
Ekemini Ogbu¹, Shanmuganathan Chandrakasan ¹, Kelly Rouster-Stevens ¹, Larry Greenbaum ¹, Chelsea Marion ², Karli Singer ³, Iñaki Sanz ³ and Sampath Prahalad ¹, ¹Emory University and Children's Healthcare of Atlanta, ATLANTA, GA, ²Children's Healthcare of Atlanta, Atlanta, GA, ³Emory University, Atlanta, GA
Background/Purpose: Autoimmune cytopenias may precede or occur with childhood-onset systemic lupus erythematosus (cSLE). Adult studies suggest that lupus patients with concurrent autoimmune cytopenias have relatively…
Abstract Number: 1731 • 2019 ACR/ARP Annual Meeting
Validation of the 2017 Weighted Criteria in Pediatric Systemic Lupus Erythematosus (SLE)
Meiqian Ma ¹, Joyce Hui-Yuen², Jane Cerise ³, Sabah Iqbal ⁴ and B. Anne Eberhard ⁵, ¹Cohen Children's Medical Center Northwell Health, Lake Success, NY, ²Cohen Children's Medical Center, Northwell Health, New Hyde Park, NY, ³Feinstein Institute for Medical Research, Manhasset, ⁴Hofstra Northwell School of Medicine, Hempstead, ⁵Cohen Children's Medical Center Northwell Health, Lake Success
Background/Purpose: Different classification criteria for systemic lupus erythematosus (SLE) have been proposed over many years. The most widely used and accepted criteria have been the…
Abstract Number: 1732 • 2019 ACR/ARP Annual Meeting
Evaluating the New 2018 ACR/EULAR SLE Classification in Pediatric Patients
Catherine Strahle¹, Angela Merritt ², Xiaoling Niu ³, Arjun Mathur ⁴, Allen Watts ² and Hermine Brunner ⁵, ¹Univeristy of Cincinnati Medical Center, Cincinnati, ²Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ³Fudan University, Shanghai, Shanghai, China (People's Republic), ⁴Division of Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ⁵Pediatric Rheumatology Collaborative Study Group (PRCSG), Cincinnati Children’s Hospital Medical Center, Cincinnati, OH
Background/Purpose: The traditional 1997 ACR SLE classification criteria classify a patient as having SLE if 4 of the 11 criteria have been met over time.…
Abstract Number: 1733 • 2019 ACR/ARP Annual Meeting
Long-term Renal Survival of Pediatric Onset Lupus Patients in a Population-Based Cohort
Catherine Park ¹, Janet Figueroa ¹, Cristina Drenkard ¹, Laura Plantinga ¹, Larry Greenbaum ² and S Sam Lim¹, ¹Emory University, Atlanta, GA, ²Emory University and Children's Healthcare of Atlanta, Atlanta, GA
Background/Purpose: Compared to adult-onset disease, pediatric-onset SLE (p-SLE) has more severe renal involvement. There are no population-based, long-term follow-up studies of pediatric lupus nephritis (LN)…

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