Abstracts Archive - Page 829 of 2607 - ACR Meeting Abstracts

Abstract Number: 1858 • ACR Convergence 2021
Serum Interferon Score Is a Biomarker of Active Disease in Patients with Early Diffuse Cutaneous Systemic Sclerosis Enrolled in the Prospective Registry of Early Systemic Sclerosis (PRESS) Cohort
Monique Hinchcliff¹, Suiyuan Huang², Shervin Assassi³, Elana Bernstein⁴, Flavia Castelino⁵, Robyn Domsic⁶, Tracy Frech⁷, Jessica Gordon⁸, Faye Hant⁹, Ami Shah¹⁰, Victoria Shanmugam¹¹, Virginia Steen¹², Dinesh Khanna² and Francesco Del Galdo¹³, ¹Yale School of Medicine, Westport, CT, ²University of Michigan, Ann Arbor, MI, ³University of Texas McGovern Medical School at Houston, Houston, TX, ⁴Columbia University, New York, NY, ⁵Massachusetts General Hospital, Boston, MA, ⁶University of Pittsburgh, Pittsburgh, PA, ⁷University of Utah, Salt Lake City, UT, ⁸Hospital for Special Surgery, New York, NY, ⁹Medical University of South Carolina, Charleston, SC, ¹⁰Johns Hopkins Rheumatology, Baltimore, MD, ¹¹The George Washington University, Great Falls, VA, ¹²Division of Rheumatology, Georgetown University, Washington, DC, ¹³University of Leeds, Leeds, United Kingdom
Background/Purpose: Several published studies have demonstrated activation of the interferon type 1 (IFN) pathway in sera from patients with systemic sclerosis (SSc). Specifically, levels of…
Abstract Number: 1859 • ACR Convergence 2021
Bone Mineral Density in Patients Diagnosed with Giant Cell Arteritis Taking Glucocorticoids: A Case-control Study
Adam Geressu¹ and Marwan Bukhari², ¹Royal Lancaster Infirmary, Lancaster, United Kingdom, ²British Society for Rheumatology, London, United Kingdom
Background/Purpose: The standard treatment for Giant Cell Arteritis (GCA) is high dose glucocorticoid (GC). It is unknown whether steroids are more detrimental to the spine…
Abstract Number: 1860 • ACR Convergence 2021
Three Distinct Transcriptional Profiles of Monocytes Correlate with Disease Activity in SSc Patients
Hadijat Makinde¹, Gaurav Gadhvi¹, Salina Dominguez¹, Miranda Gurra¹, Kathleen Aren², Mary Carns², Tracy Frech³, Dinesh Khanna⁴, Shervin Assassi⁵, Lutfiyya Muhammad⁶, Carla Cuda¹, Monique Hinchcliff⁷, Deborah Winter² and Harris Perlman¹, ¹Northwestern University, Chicago, IL, ²Northwestern University Division of Rheumatology, Chicago, IL, ³University of Utah, Salt Lake City, UT, ⁴University of Michigan, Ann Arbor, MI, ⁵University of Texas McGovern Medical School at Houston, Houston, TX, ⁶Northwestern University Feinberg School of Medicine, Chicago, IL, ⁷Yale School of Medicine, Westport, CT
Background/Purpose: Patients with SSc display a complex clinical phenotype.Our group has made important contributions to an emerging understanding of monocytes and macrophages as central to…
Abstract Number: 1861 • ACR Convergence 2021
Epidermal Growth Factor Receptor Pathway and Fibrosis in Systemic Sclerosis Skin
Miruna Carnaru¹, Monique Hinchcliff², Ian Odell¹ and F. Perry Wilson³, ¹Yale School Of Medicine, New Haven, CT, ²Yale School of Medicine, Westport, CT, ³Section of Nephrology, Department of Medicine, Yale School of Medicine, New Haven, CT; Department of Medicine Clinical and Translational Research Accelerator Yale School of Medicine, New Haven, CT
Background/Purpose: Systemic sclerosis (SSc) is a rare autoimmune disorder with chronic morbidity and high mortality. Disease pathogenesis involves microvascular damage, immune dysregulation, and fibrosis affecting…
Abstract Number: 1862 • ACR Convergence 2021
Clonal Hematopoiesis Across the Age Spectrum in Patients with Systemic Vasculitis
Kristina Wells¹, Fernanda Gutierrez-Rodrigues², Bhavisha Patel², Kaitlin Quinn³, Keith Sikora¹, Neal Young⁴ and Peter Grayson⁵, ¹National Institute of Arthritis, Musculoskeletal and Skin Diseases (NIAMS), National Institutes of Health (NIH), Bethesda, MD, ²National Heart, Lung, and Blood Institute (NHLBI), National Institutes of Health (NIH), Bethesda, MD, ³National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institutes of Health (NIH), Washington, DC, ⁴National Heart, Lung, and Blood Institute (NHLBI), National Institues of Health, Bethesda, MD, ⁵National Institutes of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institutes of Health (NIH), Bethesda, MD
Background/Purpose: Clonal hematopoiesis (CH) is a pre-malignant state characterized by somatic mutations in hematologic precursor cells in genes associated with myeloid malignancies. Incidence of CH…
Abstract Number: 1863 • ACR Convergence 2021
Consistent Efficacy with Apremilast in Men and Women to Treat Oral Ulcers Associated with Behçet’s Syndrome: Results from Phase 3 Researching Oral Apremilast Safety and Efficacy in Behçet’s Disease (RELIEF) Study
Gülen Hatemi¹, Alfred Mahr², Mitsuhiro Takeno³, Doyoung Kim⁴, Melike Melikoğlu⁵, Sue Cheng⁶, Sven Richter⁶, Shauna Jardon⁷, Maria Paris⁶, Mindy Chen⁶ and Yusuf Yazici⁸, ¹Istanbul University‒Cerrahpaşa, Cerrahpaşa Medical School and Behçet’s Disease Research Center, İstanbul, Turkey, ²Kantonsspital St. Gallen, St.Gallen, Switzerland, ³Musashi Kosugi Hospital, Kawasaki, Japan, ⁴Yonsei University College of Medicine and Severance Hospital, Seoul, Republic of Korea, ⁵Istanbul University‒Cerrahpaşa, İstanbul, Turkey, ⁶Amgen Inc., Thousand Oaks, CA, ⁷Amgen Inc., Gilbert, AZ, ⁸New York University School of Medicine, New York, NY
Background/Purpose: Painful, recurring oral ulcers (OU) associated with Behçet’s syndrome negatively affect quality of life (QoL). Differences across sexes were reported in the frequency of…
Abstract Number: 1864 • ACR Convergence 2021
18F-Fluorodeoxyglucose PET/MRI as an Alternative Hybrid Imaging Modality: Comparative Study in a Prospective, Longitudinal Cohort of Patients with Large-Vessel Vasculitis
Ertugrul Cagri bolek¹, Kaitlin Quinn², Hugh Alessi³, Elaine Novakovich⁴, Mark A. Ahlman⁴ and Peter Grayson⁵, ¹Vasculitis Translational Research Program, NIAMS, NIH, US, Lanham, MD, ²National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institutes of Health (NIH), Washington, DC, ³National Institutes of Health, Bethesda, Maryland, ⁴National Institutes of Health, Bethesda, MD, ⁵National Institutes of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institutes of Health (NIH), Bethesda, MD
Background/Purpose: Imaging modalities play an important role in the diagnosis and management of patients with large-vessel vasculitis (LVV). Use of 18F-fluorodeoxyglucose (FDG) positron emission tomography…
Abstract Number: 1865 • ACR Convergence 2021
Incidence, Prevalence, and Mortality of Chronic Periaortitis: A Population-based Study
Umar Ghaffar¹, Kenneth Warrington², Stephanie Duong¹, Cynthia Crowson³, Michelle Burke¹, Boyd Viers¹, Aaron Potretzke¹, Haraldur Bjarnason¹ and Matthew Koster¹, ¹Mayo Clinic, Rochester, MN, ²Mayo Clinic, Rochester, Minnesota, ³Mayo Clinic, Eyota, MN
Background/Purpose: Chronic periaortitis is an inflammatory condition that typically involves the infrarenal portion of the abdominal aorta. To date, no epidemiologic studies have been performed…
Abstract Number: 1866 • ACR Convergence 2021
Vasculitis in Patients with Sarcoidosis: A Single-Institution Case Series of 17 Patients
Bradly Kimbrough¹, Kenneth Warrington², Hannah Langenfeld³, Cynthia Crowson⁴, Eva Carmona³, Andrew Virata³ and Matthew Koster³, ¹Mayo Clinic Rochester, Rochester, MN, ²Mayo Clinic, Rochester, Minnesota, ³Mayo Clinic, Rochester, MN, ⁴Mayo Clinic, Eyota, MN
Background/Purpose: Vasculitis in patients with sarcoidosis is rare and can affect blood vessels of any size. Limited information describing this association is available. The purpose…
Abstract Number: 1867 • ACR Convergence 2021
Investigating Adenosine Deaminase 2 Activity in Large Vessel Vasculitis
Andrew Porter¹, Robert Maughan¹, Charis Pericleous¹, Allan Kiprianos¹, Hyuk Jee², Pui Lee², Taryn Youngstein¹ and Justin Mason¹, ¹Imperial College London, London, United Kingdom, ²Boston Children's Hospital, Newton, MA
Background/Purpose: Deficiency of adenosine deaminase 2 (DADA2) leads to a broad phenotype that in some resembles polyarteritis nodosa with fever and rash, but in others…
Abstract Number: 1868 • ACR Convergence 2021
Neutrophil Extracellular Trap Formation in Patients with Vasculitis
Despina Michailidou¹, Runa Kuley¹, Tomas Mustelin², David Cuthbertson³, Peter Grayson⁴, Nader Khalidi⁵, CURRY LEE MD KOENING⁶, Carol Langford⁷, Carol McAlear⁸, Larry Moreland⁹, Christian Pagnoux¹⁰, Philip Seo¹¹, Ulrich Specks¹², Antoine Sreih⁸, Kenneth Warrington¹³, Paul Monach¹⁴, Peter Merkel¹⁵ and Christian Lood², ¹Division of Rheumatology, University of Washington, Seattle, WA, ²University of Washington, Seattle, WA, ³Health Informatics Institute, University of South Florida, South Florida, FL, ⁴National Institutes of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institutes of Health (NIH), Bethesda, MD, ⁵McMaster University, Hamilton, ON, Canada, ⁶LIMITED TO OFFICIAL UNIVERSITY DUTIES ONLY, Salt Lake City, UT, ⁷Cleveland Clinic, Moreland Hills, OH, ⁸Division of Rheumatology, University of Pennsylvania, Philadelphia, PA, ⁹Division of Rheumatology, University of Pittsburgh, Pittsburgh, PA, ¹⁰Mount Sinai Hospital, Toronto, ON, Canada, ¹¹Johns Hopkins University, Baltimore, MD, ¹²Mayo Clinic, Rochester, MN, ¹³Mayo Clinic, Rochester, Minnesota, ¹⁴Brigham and Women's Hospital, Boston, MA, ¹⁵University of Pennsylvania, Philadelphia, PA
Background/Purpose: Neutrophil extracellular trap (NET) formation, the extrusion of chromatin and granular components from activated neutrophils, is essential in host defense. However, NET formation has…
Abstract Number: 1869 • ACR Convergence 2021
The Role of Faecal Calprotectin in IgA Vasculitis
Alojzija Hocevar¹, Matija Bajzelj¹, Matija Tomšič² and Katja Lakota³, ¹UKC Ljubjana, Ljubjana, Slovenia, ²Department of Rheumatology, University Medical Centre Ljubljana, Ljubljana, Slovenia, ³Department of Rheumatology, University Medical Centre Ljubljana, Llubljana, Slovenia
Background/Purpose: Gastrointestinal involvement (GI) is associated with significant morbidity in acute IgA vasculitis (IgAV). Besides the abdominal pain, bowel ischemia could lead to bleeding, perforation,…
Abstract Number: 1870 • ACR Convergence 2021
Comparative Study on Anti-TNF vs Tocilizumab for Treatment of Refractory Uveitic Cystoid Macular Edema Due to Behcet’s Disease: Multicenter Study of 49 Patients
Belén Atienza-Mateo¹, Iván Ferraz-Amaro², Emma Beltrán Catalán³, Alfredo Adán⁴, Marisa Hernandez Garfella⁵, Lucía Martínez-Costa⁶, Miguel Cordero Coma⁷, Manuel Diaz-Llopis⁸, José M. Herreras⁹, Ana Blanco¹⁰, Ignacio Torre¹¹, David Díaz-Valle¹², Antonio Atanes-Sandoval¹³, Felix Hernandez¹⁴, Santos Insua¹⁵, Julio Sánchez¹⁶, raquel almodovar¹⁷, Oscar Ruiz-Moreno¹⁸, Myriam Gandia Martinez¹⁹, Joan M. Nolla²⁰, José Luis Martin-Varillas²¹, Vanesa Calvo-Río²², Diana Prieto-Peña²³, Miguel Ángel gonzalez-Gay²⁴ and Ricardo Blanco²², ¹Group "Research in genetic epidemiology and atherosclerosis of systemic diseases and in bone metabolic diseases of the locomotor system", IDIVAL; and Department of Rheumatology, Hospital Universitario Marqués de Valdecilla, Santander, Spain, ²Hospital Universitario de Canarias, Santa Cruz de Tenerife, Spain, ³Hospital del Mar, Barcelona, Spain, ⁴Hospital Clinic, Barcelona, Spain, ⁵Hospital General Universitario de Valencia, Valencia, Spain, ⁶Hospital Peset, Valencia, Valencia, Spain, ⁷Hospital de León, Leon, Spain, ⁸Hospital Universitario La Fe, Valencia, Spain, ⁹Hospital Universitario IOBA, Valladolid, Spain, ¹⁰Hospital Universitario de Donostia, San Sebastián, ¹¹Hospital Universitario de Basurto, Bilbao, Spain, ¹²Hospital Clínico San Carlos, Madrid, Madrid, Spain, ¹³Complejo Hospitalario Universitario de A Coruña, A Coruña, Spain, ¹⁴Hospital Doctor Negrín, Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Spain, ¹⁵Hospital Universitario Santiago de Compostela, A Coruña, Spain, ¹⁶Hospital Universitario 12 de Octubre, Madrid, Spain, ¹⁷Hospital Universitario Fundación de Alcorcón, Madrid, Spain, ¹⁸Hospital Universitario Miguel Servet, Zaragoza, Zaragoza, Spain, ¹⁹Hospital Puerta del Mar, Cádiz, Spain, ²⁰Hospital Universitario de Bellvitge, Barcelona, Barcelona, Spain, ²¹Hospital Sierrallana, Torrelavega, Spain, ²²Hospital Universitario Marqués de Valdecilla, IDIVAL, Santander, Spain, ²³Hospital Universitario Marqués de Valdecilla, santander, Spain, ²⁴Research group on Genetic Epidemiology and Atherosclerosis in Systemic Diseases and in Metabolic Bone Diseases of the Musculoskeletal System, IDIVAL, Division of Rheumatology, Hospital Universitario Marqués de Valdecilla; School of Medicine, Universidad de Cantabria, Santander, Spain. Cardiovascular Pathophysiology and Genomics Research Unit, School of Physiology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa
Background/Purpose: Posterior segment involvement is the most serious affection of uveitis in Behçet’s disease (BD), with cystoid macular edema (CME) being the leading cause of…
Abstract Number: 1871 • ACR Convergence 2021
Characterization of Symptoms of Nasal Disease in Relapsing Polychondritis Using Patient-Reported Data
Shubhasree Banerjee¹, Nancy Linn², nathalie costedoat-Chalumeau³, Guillaume Moulis⁴, Peter Merkel¹, Peter Grayson⁵ and Marcela Ferrada⁶, ¹University of Pennsylvania, Philadelphia, PA, ²Relapsing Polychondritis Foundation Inc., New York, NY, ³Inserm DR Paris 5, Paris, France, ⁴Toulouse University Hopital, Toulouse, France, ⁵National Institutes of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institutes of Health (NIH), Bethesda, MD, ⁶National Institutes of Health, Bethesda, MD
Background/Purpose: Nasal chondritis is a well-recognized manifestation of relapsing polychondritis (RP), occasionally leading to saddle nose deformity. Early symptoms of nasal chondritis such as nose…
Abstract Number: 1872 • ACR Convergence 2021
Differentiating Primary Central Nervous System Vasculitis from Non-inflammatory Intracranial Vasculopathy
Moein Amin¹, Takashi Shimoyama², Ken Uchino¹, Leonard Calabrese¹ and Rula Hajj-Ali³, ¹Cleveland Clinic, Cleveland, OH, ²Nippon Medical School, Tokyo, Japan, ³Cleveland Clinic, Hunting Valley, OH
Background/Purpose: Establishing the diagnosis of Primary central nervous system vasculitis CNSV is challenging. In this study we aimed to investigate distinguishing primary CNSV compared to…

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