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  • Abstract Number: 834 • 2019 ACR/ARP Annual Meeting

    Implementing Patient-Reported Outcome Measures in Clinical Care: Rheumatologist Perspectives on Opportunities and Challenges

    Shanthini Kasturi1, John Wong 1, Lisa Mandl 2, Timothy McAlindon 3 and Amy LeClair 1, 1Tufts Medical Center, Boston, 2Hospital for Special Surgery/Weill Cornell Medicine, New York, NY, New York, NY, 3Tufts Medical Center, Boston, MA

    Background/Purpose: There is growing interest in the implementation of patient-reported outcome measures (PROMs) in clinical rheumatology to promote patient-centered care and to meet the mandates…
  • Abstract Number: 835 • 2019 ACR/ARP Annual Meeting

    High Baseline Patient’s Compared with Evaluator’s Global Assessment Is Associated with Lower Retention and Remission Rates of First TNF Inhibitor in Psoriatic Arthritis Patients – Data from the EuroSpA Research Collaboration Network

    Brigitte Michelsen1, Lykke Midtbøll Ørnbjerg 2, Herman Mann 3, Tore Kvien 4, Michael J. Nissen 5, Maria José Santos 6, Dan Nordström 7, Lennart Jacobsson 8, Ziga Rotar 9, Bjorn Gudbjornsson 10, Süleyman Serdar Koca 11, Catalin Codreanu 12, Manuel Pombo-Suarez 13, Irene van der Horst-Bruinsma 14, Anne Gitte Loft 15, Karel Pavelka 3, Eirik Kristianslund 16, Burkhard Moeller 17, Elsa Vieira-Sousa 18, Anna Mari Hokkanen 19, Ulf Lindström 20, Matija Tomsic 21, Thorvardur J Love 22, Abdurrahman Tufan 23, Ruxandra IONESCU 24, Carlos Sánchez-Piedra 25, Marleen van de Sande 26, Gary Macfarlane 27, Florenzo Iannone 28, Lise Hyldstrup 2, Mikkel Østergaard 29 and Merete Lund Hetland 30, 1Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet Glostrup, Denmark/ Hospital of Southern Norway Trust, Kristiansand, Norway/ Diakonhjemmet Hospital, Oslo, Norway, Oslo, Norway, 2Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet Glostrup, Denmark, Copenhagen, Denmark, 3Institute of Rheumatology, Department of Rheumatology, 1st Faculty of Medicine, Prague, Czech Republic, Prague 2, Czech Republic, 4Diakonhjemmet Hospital, Dept. of Rheumatology / University of Oslo, Faculty of Medicine, Oslo, Norway, 5University Hospital Geneva, Geneva, Switzerland, 6Rheumatology department, Hospital Garcia de Orta, Almada, Portugal, 7Department of Medicine, ROB-FIN, Helsinki University Hospital and Helsinki University, Helsinki, Finland., Helsinki, Finland, 8Dept of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Sweden,, Gothenburg, Sweden, 9UMC LJUBLJANA, DPT. OF RHEUMATOLOGY, LJUBLJANA, Slovenia, 10Centre for Rheumatology Research, Landspitali and Faculty of Medicine, University of Iceland, Reykjavik, Iceland, 11Fırat University School of Medicine Division of Rheumatology, Elazığ, Turkey, 12Center of Rheumatic Diseases, University of Medicine and Pharmacy, Bucharest, Romania., Bucharest, Romania, 13Unit Research, Spanish Society of Rheumatology, Madrid, Spain, 14Amsterdam University Medical Center, Amsterdam, Netherlands, 15Department of Rheumatology, Aarhus University Hospital, Aarhus, Denmark, Århus, Denmark, 16Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway., Oslo, Norway, 17University Hospital Bern, Bern, Switzerland, 18Rheumatology and Metabolic Bone Diseases, Hospital de Santa Maria - Centro Hospitalar Lisboa Norte, EPE | Rheumatology Research Unit, Instituto de Medicina Molecular - Faculty of Medicine, University of Lisbon, Lisbon Academic Medical Centre, Lisbon, Portugal,, Lisbon, Portugal, 19Helsinki University Hospital, Helsinki, Finland, 20University of Gothenburg, Gothenburg, Sweden, 21Department of Rheumatology, University Medical Center Ljubljana, Slovenia, Ljubljana, Slovenia, 22Faculty of Medicine, University of Iceland, Reykjavik, Iceland, 23Division of Rheumatology, Gazi University School of Medicine, Ankara, Turkey, Ankara, Turkey, 24SPITALUL CLINIC SFANTA MARIA, Bucharest, 25Research Unit, Spanish Society of Rheumatology, Madrid, Spain, 26Amsterdam UMC, Amsterdam, Netherlands, 27University of Aberdeen, Aberdeen, United Kingdom, 28Department of Emergency and Transplantation , Rheumatology Unit, University Hospital of Bari, Bari, Italy., Bari, Italy, 29Copenhagen Center for Arthritis Research, University of Copenhagen, Copenhagen, Denmark, 30DANBIO and Copenhagen Center for Arthritis Research (COPECARE), Center for Rheumatology and Spine Diseases, Centre of Head and Orthopaedics, Rigshospitalet, Copenhagen, Denmark

    Background/Purpose: Discordance between baseline patient’s and evaluator’s global assessment of disease activity is common1 and may reduce the likelihood of remission following tumor necrosis factor…
  • Abstract Number: 836 • 2019 ACR/ARP Annual Meeting

    Patient-Reported Outcomes from a Randomised, Open-Label, Parallel-Group Study Evaluating Ixekizumab versus Adalimumab in Patients with PsA Who Are Biologic DMARD Naïve: 24-Week Results

    Filip Van den Bosch1, Lars-Erik Kristensen 2, Dennis McGonagle 3, Maurizio Rossini 4, Soyi Liu-Leage 5, Christophe Sapin 5, Gabriella Meszaros 5 and Joseph Merola 6, 1Ghent University Hospital, Ghent, Belgium, 2Copenhagen University Hospital, Bispebjerg-Frederiksberg, Denmark, 3University of Leeds, Leeds, United Kingdom, 4University of Verona, Verona, Italy, 5Eli Lilly and Company, Indianapolis, 6Harvard Medical School, Brigham and Women’s Hospital, Boston, MA

    Background/Purpose: Therapeutic options for patients with PsA are increasing but data directly comparing biologics are limited. The multicentre, open-label SPIRIT-H2H trial (NCT03151551) evaluated the efficacy…
  • Abstract Number: 837 • 2019 ACR/ARP Annual Meeting

    Does Discordance Between Baseline Patient’s and Evaluator’s Global Assessment of Disease Activity Impact Retention and Remission Rates of a First TNF Inhibitor in Patients with Axial Spondyloarthritis? Data from the EuroSpA Research Collaboration Network

    Brigitte Michelsen1, Lykke Midtbøll Ørnbjerg 2, Anne Gitte Loft 3, Tore Kvien 4, Adrian Ciurea 5, Herman Mann 6, Kari K. Eklund 7, Ayten Yazici 8, Maria José Santos 9, Johan Askling 10, Ziga Rotar 11, Bjorn Gudbjornsson 12, Manuel Pombo-Suarez 13, Catalin Codreanu 14, Irene van der Horst-Bruinsma 15, Eirik Kristianslund 16, Michael J. Nissen 17, Karel Pavelka 6, Nina Trokovic 18, Nevsun Inanc 19, Elsa Vieira-Sousa 20, Daniela DiGuiseppe 21, Matija Tomsic 22, Arni Jon Geirsson 23, Ruxandra IONESCU 24, Marleen van de Sande 25, Florenzo Iannone 26, Carlos Sánchez-Piedra 27, Gareth Jones 28, Lise Hyldstrup 2, Merete Lund Hetland 29 and Mikkel Østergaard 30, 1Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet Glostrup, Denmark/ Hospital of Southern Norway Trust, Kristiansand, Norway/ Diakonhjemmet Hospital, Oslo, Norway, Oslo, Norway, 2Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet Glostrup, Denmark, Copenhagen, Denmark, 3Department of Rheumatology, Aarhus University Hospital, Aarhus, Denmark, Århus, Denmark, 4Diakonhjemmet Hospital, Dept. of Rheumatology / University of Oslo, Faculty of Medicine, Oslo, Norway, 5University Hospital Zürich, Zürich, Switzerland, 6Institute of Rheumatology, Department of Rheumatology, 1st Faculty of Medicine, Prague, Czech Republic, Prague 2, Czech Republic, 7ROB-FIN registry, Department of Medicine, Helsinki University and University Hospital, Helsinki, Finland, 8Kocaeli University, Faculty of Medicine, Division of Rheumatology, Kocaeli, Kocaeli, Turkey, 9Rheumatology department, Hospital Garcia de Orta, Almada, Portugal, 10Karolinska Institutet, Stockholm, Sweden, 11UMC LJUBLJANA, DPT. OF RHEUMATOLOGY, LJUBLJANA, Slovenia, 12Centre for Rheumatology Research, Landspitali and Faculty of Medicine, University of Iceland, Reykjavik, Iceland, 13Unit Research, Spanish Society of Rheumatology, Madrid, Spain, 14Center of Rheumatic Diseases, University of Medicine and Pharmacy, Bucharest, Romania., Bucharest, Romania, 15Amsterdam University Medical Center, Amsterdam, Netherlands, 16Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway., Oslo, Norway, 17University Hospital Geneva, Geneva, Switzerland, 18Helsinki University Central Hospital, Helsinki, Finland, 19Marmara University, Faculty of Medicine, Division of Rheumatology, Istanbul, Turkey, ISTANBUL, Turkey, 20Rheumatology and Metabolic Bone Diseases, Hospital de Santa Maria - Centro Hospitalar Lisboa Norte, EPE | Rheumatology Research Unit, Instituto de Medicina Molecular - Faculty of Medicine, University of Lisbon, Lisbon Academic Medical Centre, Lisbon, Portugal,, Lisbon, Portugal, 21Clinical Epidemiology Division, Dept of Medicine Solna, Karolinska Institutet,, Stockholm, Sweden, 22Department of Rheumatology, University Medical Center Ljubljana, Slovenia, Ljubljana, Slovenia, 23Centre for Rheumatology Research, University Hospital and Faculty of Medicine, Reykjavik, Iceland, 24SPITALUL CLINIC SFANTA MARIA, Bucharest, 25Amsterdam UMC, Amsterdam, Netherlands, 26Department of Emergency and Transplantation , Rheumatology Unit, University Hospital of Bari, Bari, Italy., Bari, Italy, 27Research Unit, Spanish Society of Rheumatology, Madrid, Spain, 28University of Aberdeen, Aberdeen, United Kingdom, 29DANBIO and Copenhagen Center for Arthritis Research (COPECARE), Center for Rheumatology and Spine Diseases, Centre of Head and Orthopaedics, Rigshospitalet, Copenhagen, Denmark, 30Copenhagen Center for Arthritis Research, University of Copenhagen, Copenhagen, Denmark

    Background/Purpose: Discordance between baseline patient’s and evaluator’s global assessment of disease activity is common.1 However, the impact of such discordance on retention and remission rates…
  • Abstract Number: 838 • 2019 ACR/ARP Annual Meeting

    Are PROMIS Measures Associated with Minimal Disease Activity in Psoriatic Arthritis?

    Juliette Yedimenko1, Yuxuan Jin 2, Alexis Ogdie 3, Jessica Walsh 4, Jose Scher 5, Soumya Reddy 6 and M. Elaine Husni 1, 1Department of Rheumatologic and Immunologic Diseases, Cleveland Clinic, Cleveland, OH, 2Quantitative Health Science, Cleveland Clinic, Cleveland, OH, 3Department of Medicine and Rheumatology and Department of Epidemiology and Biostatistics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 4Division of Rheumatology, University of Utah, Salt Lake City, UT, 5Division of Rheumatology, New York University School of Medicine and NYU Langone Orthopedic Hospital, New York, NY, 6Division of Rheumatology, New York University School of Medicine, New York, NY

    Background/Purpose: Patient-reported outcomes (PROs) are an important part of clinical decision making and are frequently used in combination with objective measures of disease activity and…
  • Abstract Number: 839 • 2019 ACR/ARP Annual Meeting

    Disease Activity, Cytokine Profiles, and the Risk of Incident Diabetes in Rheumatoid Arthritis

    Joshua Baker1, Bryant England 2, Michael George 3, Grant Cannon 4 and Ted Mikuls 5, 1University of Pennsylvania, Philadelphia, PA, 2VA Nebraska-Western IA Health Care System & University of Nebraska Medical Center, Omaha, 3University of Pennsylvania, Philadelphia, 4Salt Lake City VA Medical Center and Univeristy of Utah, Salt Lake City, UT, 5VA Nebraska-Western IA Health Care System & University of Nebraska Medical Center, Omaha, NE

    Background/Purpose: Rheumatoid arthritis is associated with a higher risk of diabetes mellitus (DM) and cardiovascular disease. While disproportional obesity and visceral fat accumulation may contribute…
  • Abstract Number: 840 • 2019 ACR/ARP Annual Meeting

    Trajectory of Multimorbidity in Rheumatoid Arthritis in a U.S. Commercial Insurance Claims Database from 2006-2015

    Bryant England1, Punyasha Roul 2, Fang Yu 2, Harlan Sayles 2, Kaleb Michaud 2, Fenglong Xie 3, Jeffrey Curtis 4 and Ted Mikuls 5, 1VA Nebraska-Western IA Health Care System & University of Nebraska Medical Center, Omaha, 2University of Nebraska Medical Center, Omaha, NE, 3University of Alabama at Birmingham, Birmingham, 4University of Alabama at Birmingham, Birmingham, AL, 5VA Nebraska-Western IA Health Care System & University of Nebraska Medical Center, Omaha, NE

    Background/Purpose: Multimorbidity, the presence of multiple chronic conditions, predisposes individuals to disability and premature mortality. RA is well known to be associated with select chronic…
  • Abstract Number: 841 • 2019 ACR/ARP Annual Meeting

    Elevation of Anti-Citrullinated Protein Antibodies Prior to Rheumatoid Arthritis Onset and Risks for Developing Chronic Obstructive Pulmonary Disease or Asthma

    Alessandra Zaccardelli1, Xinyi Liu 1, Julia Ford 1, Jing Cui 1, Bing Lu 1, Su H. Chu 2, Peter Schur 1, Cameron Speyer 1, Karen Costenbader 1, William Robinson 3, Jeremy Sokolove 4, Elizabeth Karlson 1, Carlos Camargo 5 and Jeffrey Sparks 1, 1Brigham and Women's Hospital, Boston, MA, 2Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 3Stanford University, Stanford, CA, 4AbbVie Immunology Clinical Development, Redwood City, 5Massachusetts General Hospital, Boston, MA

    Background/Purpose: Elevation of anti-citrullinated protein antibodies (ACPA) precedes clinical rheumatoid arthritis (RA) diagnosis by years and may originate at inflamed mucosa, including airways. Damage from…
  • Abstract Number: 842 • 2019 ACR/ARP Annual Meeting

    Mortality Ratio and Risk Factors in CT Confirmed Rheumatoid Arthritis Related Lung Disease: UIP, Pleural Effusion and the Time of Diagnosis of Rheumatoid Arthritis – Lung Disease

    Mustafa Ekici 1, Alper Sarı 2, Yusuf Baytar 3, Ertugrul Cagri Bolek 2, Berkan Armagan 4, Emre Bilgin 2, Bayram Farisoğulları 2, Omer Karadag 5, Ali İhsan Ertenli 2, Sedat Kiraz 5, Şule Apras Bilgen 5, Levent Kilic 5, Ali Akdoğan 2, Gamze durhan 3, Macit arıyürek 3 and Umut Kalyoncu6, 1Hacettepe University, Faculty of Medicine, Department of Internal Medicine, Ankara, Turkey, 2Hacettepe University Vasculitis Centre, Ankara, Turkey, Ankara, Turkey, 3Hacettepe University, Faculty of Medicine, Department of Radiology, Ankara, Turkey, 4Department of Internal Medicine, Hacettepe University, Faculty of Medicine, Ankara, Turkey., Ankara, Turkey, 5Hacettepe University, Faculty of Medicine, Department of Internal Medicine, Division of Rheumatology, ankara, Turkey, 6Hacettepe University Department of Rheumatology, Ankara, Turkey

    Background/Purpose: The frequency of pulmonary involvement in rheumatoid arthritis varies between 7-35%. The most important cause of death in RA patients is lung disease in…
  • Abstract Number: 843 • 2019 ACR/ARP Annual Meeting

    High Lung Attenuation Measured with Quantitative Densitometry as a Surrogate Marker for Interstitial Lung Disease in RA: Association with Anti-CCP, Smoking, and Absence of Shared Epitope

    Michail Alevizos1, Sonye Danoff 2, Dimitrios Pappas 1, David Lederer 3, Cheilonda Johnson 4, Elana Bernstein 5, Joan Bathon 5 and Jon Giles 5, 1Division of Rheumatology, Columbia University, New York, 2Division of Pulmonary & Critical Care Medicine, Johns Hopkins University, Baltimore, 3Division of Pulmonary & Critical Care Medicine, Columbia University, New York, 4Division of Pulmonary & Critical Care Medicine, University of Pennsylvania, Philadelphia, 5Division of Rheumatology, Columbia University, New York, NY

    Background/Purpose: Risk factors for rheumatoid arthritis-associated interstitial lung disease (RA-ILD), a significant cause of morbidity and mortality, are poorly understood. RA-ILD detection is limited by…
  • Abstract Number: 844 • 2019 ACR/ARP Annual Meeting

    Impact of Glucocorticoid Tapering on Markers of Bone Metabolism in Patients with Rheumatoid Arthritis Who Achieved Low Disease Activity or Remission on Tocilizumab: Exploratory Analysis from a Randomized Controlled Trial

    Frank Buttgereit1, Gerd Burmester 2, J. Michael Nebesky 3, Jenny Devenport 3, Marc Y. Donath 4 and Markus R. John 3, 1Charité-Universitätsmedizin Berlin, Berlin, Germany, 2Charité—University Medicine Berlin, Berlin, Germany, 3F. Hoffmann-La Roche, Basel, Switzerland, 4University Hospital Basel, Basel, Switzerland

    Background/Purpose: Glucocorticoids (GCs) directly impact bone metabolism via increased bone resorption and inhibited bone formation1; hence, systemic fracture risk increases with daily and cumulative GC…
  • Abstract Number: 845 • 2019 ACR/ARP Annual Meeting

    Comparison of Rituximab-Associated Hypogammaglobulinemia Rates in Patients with Systemic Rheumatologic Conditions

    Stefanie Wade1 and Vasileios Kyttaris 1, 1Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA

    Background/Purpose: Rituximab (RTX) is used in a wide variety of rheumatic disease. Emerging guidelines suggest measuring immunoglobulins (Ig) at pre-treatment screening and prior to repeat…
  • Abstract Number: 846 • 2019 ACR/ARP Annual Meeting

    MACE and VTE Across Multiple Upadacitinib Studies in Rheumatoid Arthritis: Integrated Analysis from the SELECT Phase 3 Clinical Program

    Ernest Choy1, Iain McInnes 2, John Cush 3, Jacob Aelion 4, Ying Zhang 5, Nasser Khan 6, Jianzhong Liu 6, Heidi Camp 7, Sebastian Meerwein 8, William Rigby 9 and Alexander Cohen 10, 1Cardiff University School of Medicine, Cardiff, United Kingdom, 2Institute of Infection, Immunity & Inflammation, University of Glasgow, Glasgow, United Kingdom, 35Baylor University Medical Center, Dallas, 4Arthritis Clinic PLLC, Jackson, 5AbbVie Inc., North Chicago, IL, USA, North Chicago, IL, 6Abbvie Inc, North Chicago, IL, 7AbbVie Inc., North Chicago, IL, 8AbbVie GmbH Co. KG, Ludwigshafen, Germany, Wiesbaden, Germany, 9Dartmouth-Hitchcock Medical Center, Lebanon, 10Guy’s and St Thomas’ NHS FT Hospitals, King’s College London, London, United Kingdom

    Background/Purpose: Patients (pts) with RA have an approximate 2-fold increased risk of cardiovascular (CV) morbidity and mortality and of venous thromboembolic events (VTE)1,2. Among RA…
  • Abstract Number: 847 • 2019 ACR/ARP Annual Meeting

    Safety Profile of Baricitinib for the Treatment of Rheumatoid Arthritis up to 7 Years: An Updated Integrated Safety Analysis

    Mark Genovese1, Josef Smolen 2, Tsutomu Takeuchi 3, Gerd Burmester 4, Dennis Brinker 5, Terence Rooney 5, Jinglin Zhong 6, Daojun Mo 5, Chadi Saifan 5, Anabela Cardoso 5, Maher Issa 5, Wen-Shuo Wu 5 and Kevin Winthrop 7, 1Stanford University, Stanford, CA, 2Medical University of Vienna, Vienna, Austria, 3Keio University School of Medicine, Tokyo, Japan, 4Charité—University Medicine Berlin, Berlin, Germany, 5Eli Lilly and Company, Indianapolis, IN, 6IQVIA, Morrisville, NC, 7Oregon Health and Science University, Portland, OR

    Background/Purpose: Baricitinib (bari), an oral, selective inhibitor of Janus kinase (JAK) 1 and 2, is used to treat moderately to severely active RA in adults.…
  • Abstract Number: 848 • 2019 ACR/ARP Annual Meeting

    Risk of Serious Infection with Long-Term Use of Low-Dose Glucocorticoids in Patients with Rheumatoid Arthritis

    Michael George1, Joshua Baker 2, Kevin Winthrop 3, Qufei Wu 2, Lang Chen 4, Fenglong Xie 5, Huifeng Yun 4 and Jeffrey Curtis 4, 1University of Pennsylvania, Philadelphia, 2University of Pennsylvania, Philadelphia, PA, 3Oregon Health and Science University, Portland, OR, 4University of Alabama at Birmingham, Birmingham, AL, 5University of Alabama at Birmingham, Birmingham

    Background/Purpose: As many as 30-40% of patients with RA remain on long term glucocorticoids. Infection risk with higher dose glucocorticoids is well known, but evidence…
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