Abstracts Archive - Page 813 of 2425 - ACR Meeting Abstracts

Abstract Number: 819 • 2019 ACR/ARP Annual Meeting
The Long Noncoding RNA HOTTIP Regulates Cell Cycle and Inflammatory Response in Hand Synovial Fibroblasts
Mojca Frank-Bertoncelj ¹, Tadeja Kuret², Ana Županič ³, Snezna Sodin-Semrl ⁴, Oliver Distler ⁵ and Caroline Ospelt ¹, ¹University Hospital Zürich, Zürich, Switzerland, ²University Hospital Zürich, Zurich, Tajikistan, ³University Hospital Zürich, Zurich, Switzerland, ⁴University Medical Center Ljubljana, Ljubljana, Slovenia, ⁵Dept. of Rheumatology, University Hospital Zürich, Zürich, Switzerland, Zürich, Switzerland
Background/Purpose: Previously we showed that the long noncoding RNA (lncRNA) HOTTIP is exclusively expressed in synovial fibroblasts (SF) from distal joints, such as small joints…
Abstract Number: 820 • 2019 ACR/ARP Annual Meeting
Diurnal Stability of Transcriptional Profiles in Rheumatoid Arthritis
Louise Bennett¹, Fraser Morton ¹, George Fragoulis ¹, Caron Paterson ¹, Dominic Rimmer ², Gary Semple ³, Alison Young ³, Jagtar S Nijjar ⁴, Michael Barrett ⁵, Stefan Siebert ¹, Duncan Porter ⁵, Carl Goodyear ⁶ and Iain McInnes ¹, ¹Institute of Infection, Immunity & Inflammation, University of Glasgow, Glasgow, United Kingdom, ²Clinical Research Facility, NHS Greater Glasgow and Clyde, Glasgow, United Kingdom, ³Clinical Research Facility, NHS Greater Glasgow and Clyde, Glasgow, ⁴Department of Medicine, University of Cambridge, Cambridge, United Kingdom, ⁵Institute of Infection, Immunity & Inflammation, University of Glasgow, Glasgow, ⁶University of Glasgow, Glasgow, United Kingdom
Background/Purpose: Our understanding of disease pathogenesis in Rheumatoid Arthritis (RA) is rapidly expanding with the advent of ‘Omics’ techniques. Importantly, current analysis takes into account…
Abstract Number: 821 • 2019 ACR/ARP Annual Meeting
Trends in Incidence and Prevalence of Osteoarthritis in the United Kingdom: Findings from the Clinical Practice Research Datalink (CPRD)
Subhashisa Swain¹, Aliya Sarmanova ², Christian Mallen ³, Chang Fu Kuo ⁴, Carol Coupland ⁵ and Weiya Zhang ⁶, ¹University of Nottingham, Nottingham, England, United Kingdom, ²2. Bristol Medical School, Population Health Sciences, University of Bristol, UK, Bristol, England, United Kingdom, ³Research Institute for Primary Care and Health Sciences, Keele University, UK, Keele, United Kingdom, ⁴4. Division of Rheumatology, Allergy and Immunology, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan (Republic of China), ⁵5. Division of Primary Care, School of Medicine, University of Nottingham, Nottingham, England, United Kingdom, ⁶1. Academic Rheumatology, Division of Rheumatology, Orthopaedics and Dermatology, University of Nottingham, Nottingham, England, United Kingdom
Background/Purpose: Osteoarthritis (OA) is by far the most common arthritis.(1) However, its chronological trend in the United Kingdom (UK) is not known. We aimed to…
Abstract Number: 822 • 2019 ACR/ARP Annual Meeting
Cigarette Smoking Is a Risk Factor for ANCA-Associated Vasculitis
Greg McDermott¹, Xiaoqing Fu ¹, John Stone ², Yuqing Zhang ³, Hyon K. Choi ³ and Zachary Wallace ¹, ¹Massachusetts General Hospital, Boston, ²Massachusetts General Hospital Rheumatology Unit, Harvard Medical School, Boston, MA, ³Massachusetts General Hospital, Boston, MA
Background/Purpose: ANCA-associated vasculitis (AAV) is a systemic small vessel vasculitis of unclear etiology associated with excess morbidity and mortality compared to the general population. Environmental…
Abstract Number: 823 • 2019 ACR/ARP Annual Meeting
The Risk of Venous Thromboembolism in Patients with Psoriatic Disease and Rheumatoid Arthritis, a Population-based Study
Lingyi Li¹, Na Lu ¹, Eric Sayre ¹, Hui Xie ², Diane Lacaille ³, John Esdaile ⁴ and J. Antonio Avina-Zubieta ⁵, ¹Arthritis Research Canada, Vancouver, BC, Canada, ²Arthritis Research Canada and Simon Fraser University, Vancouver, BC, Canada, ³Arthritis Research Canada and University of British Columbia, Vancouver, BC, Canada, ⁴Arthritis Research Canada and the University of British Columbia, Richmond, BC, Canada, ⁵Arthritis Research Canada and the University of British Columbia, Vancouver, BC, Canada
Background/Purpose: Venous thromboembolism (VTE, which includes pulmonary embolism [PE] and deep vein thrombosis [DVT]) is associated with increased morbidity and mortality. Previous studies have shown…
Abstract Number: 824 • 2019 ACR/ARP Annual Meeting
Results from a Randomized Controlled Trial of the Safety of the Live Varicella Vaccine in TNF-Treated Patients
Jeffrey Curtis¹, S Louis Bridges ², Stacey S Cofield ², John Bassler ¹, Theresa Ford ³, Stephen Lindsey ⁴, Alan Kivitz ⁵, Ilhem Messaoudi ⁶, Kaleb Michaud ⁷, Joseph Huffstutter ⁸, Ted Mikuls ⁹, David Ridley ¹⁰, William Shergy ¹¹, Sarah Siegel ¹² and Kevin Winthrop ¹³, ¹University of Alabama at Birmingham, Birmingham, AL, ²University of Alabama at Birmingham, Birmingham, ³North Georgia Rheumatology Group, PC, Lawrenceville, GA, ⁴Ochsner Clinic Foundation, Baton Rouge, LA, ⁵Altoona Center for Clinical Research, Duncansville, PA, ⁶University of California Irvine, Irvine, CA, ⁷University of Nebraska Medical Center, Omaha, NE, ⁸Arthritis Associates, Hixon, TN, ⁹VA Nebraska-Western IA Health Care System & University of Nebraska Medical Center, Omaha, NE, ¹⁰St. Paul Rheumatology, Eagan, MN, ¹¹Rheumatology Associates of North Alabama, Huntsville, AL, ¹²Oregon Health Science University, Portland, OR, ¹³Oregon Health and Science University, Portland, OR
Background/Purpose: There has been minimal evaluation of the safety of live virus vaccines in patients receiving biologic therapies who may be immunocompromised. The Varicella Zoster…
Abstract Number: 825 • 2019 ACR/ARP Annual Meeting
Systemic Sclerosis Deaths at Younger Ages Have Decreased over the past Five Decades
Eric Yen¹, Devanshu Singh ² and Ram Raj Singh ¹, ¹UCLA, Los Angeles, ²Johns Hopkins University, Baltimore, MD
Background/Purpose: Patients with systemic sclerosis (SSc) can die prematurely of disease-associated complications. Over the past 2 decades, several advances in the treatment of SSc-associated complications…
Abstract Number: 826 • 2019 ACR/ARP Annual Meeting
Immune-Mediated Inflammatory Diseases (IMID) Collectively Rank Among the Leading Causes of Death
Meifang Wu¹, Eric Yen ² and Ram Raj Singh ², ¹UCLA David Geffen School of Medicine, Los Angeles, CA, ²UCLA, Los Angeles
Background/Purpose: Almost every organ system can be affected by primary immune-mediated diseases characterized by inflammation and therapeutic response to immune-suppressive or anti-inflammatory drugs. These diseases…
Abstract Number: 827 • 2019 ACR/ARP Annual Meeting
A Phase 3 Randomized, Double-Blind, Placebo-Controlled Trial of Bedtime Sublingual Cyclobenzaprine (TNX-102 SL) for the Treatment of Fibromyalgia (FM): Evidence for a Broad Spectrum of Activity on the FM Syndrome
Gregory Sullivan¹, R. Michael Gendreau ², Judith Gendreau ³, Ashild Peters ⁴, Perry Peters ⁵ and Seth Lederman ⁶, ¹Tonix Pharmaceuticals Inc., New York, ²Gendreau Consulting, Poway, CA, ³Tonix Pharmaceuticals Inc, Poway, CA, ⁴Tonix Pharmaceuticals Inc., San Diego, CA, ⁵Tonix Pharmaceuticals Inc, San Diego, CA, ⁶Tonix Pharmaceuticals Inc, New York, NY
Background/Purpose: Fibromyalgia (FM) is characterized by chronic widespread pain, unrefreshing sleep, fatigue, and cognitive complaints. TNX-102 SL* is a sublingual (SL) formulation of cyclobenzaprine (CBP)…
Abstract Number: 828 • 2019 ACR/ARP Annual Meeting
A Path Model Analysis of the Cognitive Determinants of Physical Activity Among Patients with Fibromyalgia (FM)
Dennis Ang ¹, Anthony Kaleth ² and William Bush³, ¹Wake Forest School of Medicine, Winston Salem, ²Indiana University-Purdue University Indianapolis, IN, Indianapolis, IN, ³Wake Forest Baptist Medical Center, Winston-Salem, NC
Background/Purpose: In individuals with FM, regular participation in physical activity (PA) is associated with improvement of symptoms, daily physical functioning, and overall well-being. Given the…
Abstract Number: 829 • 2019 ACR/ARP Annual Meeting
Dietary Intake Does Not Explain Microbiome Alterations or Symptom Severity in Fibromyalgia
Amir minerbi¹, Stéphanie Chevalier ², Abraham Anjarkouchian ², Audrey Moyen ², Yoram Shir ¹ and Mary-Ann Fitzcharles ¹, ¹Alan Edwards Pain Management Unit, McGill University Health Centre, Montreal, Canada, ²School of Human Nutrition, McGill University, Montreal, Canada
Background/Purpose: We have recently reported significant alterations in gut microbiome compositionin women with fibromyalgia (FM). As gut microbiome is affected by diet, differences in nutritional…
Abstract Number: 830 • 2019 ACR/ARP Annual Meeting
The Efficacy of Non-Pharmacological Interventions for Fibromyalgia: A Systematic Review with Meta-Analysis
Burak Kundakci¹, Jaspreet Kaur ², Siew-Li Goh ³, Michelle Hall ⁴, Michael Doherty ⁵, Weiya Zhang ⁵ and Abhishek Abhishek ⁶, ¹Academic Rheumatology, Division of Rheumatology, Orthopaedics and Dermatology, School of Medicine, University of Nottingham, Nottingham, UK/Arthritis Research UK Pain Centre, Nottingham, UK, Nottingham, United Kingdom, ²Academic Rheumatology, Division of Rheumatology, Orthopaedics and Dermatology, School of Medicine, University of Nottingham, Nottingham, UK, Nottingham, United Kingdom, ³Sports Medicine Unit, University of Malaya, Kuala Lumpur, Malaysia, Kuala Lumpur, Malaysia, ⁴Academic Rheumatology, Division of Rheumatology, Orthopaedics and Dermatology, School of Medicine, University of Nottingham, Nottingham, UK/Arthritis Research UK Pain Centre, Nottingham, UK/National Institute for Health Research, Nottingham Biomedical Research Centre, Nottingham, UK/Division of Physiotherapy and Rehabilitation Sciences, University of Nottingham, Nottingham, UK, Nottingham, United Kingdom, ⁵Academic Rheumatology, Division of Rheumatology, Orthopaedics and Dermatology, School of Medicine, University of Nottingham, Nottingham, UK/Arthritis Research UK Pain Centre, Nottingham, UK/National Institute for Health Research, Nottingham Biomedical Research Centre, Nottingham, UK, Nottingham, United Kingdom, ⁶Academic Rheumatology, Division of Rheumatology, Orthopaedics and Dermatology, School of Medicine, University of Nottingham, Nottingham, UK/National Institute for Health Research, Nottingham Biomedical Research Centre, Nottingham, UK, Nottingham, United Kingdom
Background/Purpose: Non-pharmacological interventions are recommended as first-line treatment for fibromyalgia (FM)1. However, the evidence base supporting this has not been updated comprehensively, and the recent…
Abstract Number: 831 • 2019 ACR/ARP Annual Meeting
Maintaining Musculoskeletal Health: A Randomized Controlled Prevention Trial Amongst People at High Risk of Developing Chronic Widespread Pain
Gary Macfarlane¹, Marcus Beasley ¹, Neil Scott ¹, Gordon Prescott ², Paul McNamee ¹, John McBeth ³, Gareth Jones ¹, Neil Basu ⁴, Phil Hannaford ¹, Phil Keeley ⁵ and Karina Lovell ⁶, ¹University of Aberdeen, Aberdeen, United Kingdom, ²University of Central Lancashire, Preston, United Kingdom, ³Versus Arthritis Centre for Epidemiology, Centre for Musculoskeletal Research, Division of Musculoskeletal and Dermatological Sciences, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, United Kingdom, Manchester, United Kingdom, ⁴University of Glasgow, Glasgow, United Kingdom, ⁵University of Huddersfield, Huddersfield, United Kingdom, ⁶University of Manchester, Manchester, United Kingdom
Background/Purpose: Cognitive behaviour therapy (CBT) is effective in the management of fibromyalgia (and its characteristic feature Chronic Widespread Pain (CWP). CBT is recommended in all…
Abstract Number: 832 • 2019 ACR/ARP Annual Meeting
Diagnosis of Fibromyalgia: Comparison of AAPT and ACR Criteria
Marco Antivalle¹, Federica Rigamonti ¹, Michele Agosti ¹ and Piercarlo Sarzi-Puttini ¹, ¹L. Sacco University Hospital, Milano, Italy
Background/Purpose: In recent years, the diagnostic criteria for fibromyalgia (FM) have been reviewed multiple times, up to the publication of the provisional criteria of the…
Abstract Number: 833 • 2019 ACR/ARP Annual Meeting
Effect of a Mobile App to Monitor Patient Reported Outcomes in Rheumatoid Arthritis: A Randomized Controlled Trial
Yvonne Lee¹, Fengxin Lu ², Joshua Colls ², Meredith Murray ², Dong Suh ², Jing Song ³, Julia (Jungwha) Lee ⁴, Dorothy Dunlop ⁴ and Daniel Solomon ⁵, ¹Northwestern University Feinberg School of Medicine, Chicago, ²Brigham and Women's Hospital, Boston, MA, ³Northwestern University Feinberg School of Medicine, Worthington, OH, ⁴Northwestern University Feinberg School of Medicine, Chicago, IL, ⁵Brigham and Women´s Hospital, Div. of Rheumatology, Immunology and Allergy, Boston, MA
Background/Purpose: Treat to target (TTT) is an effective strategy to improve outcomes in rheumatoid arthritis (RA). However, barriers to TTT include frequent clinic visits, poor…

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