Abstracts Archive - Page 804 of 2607 - ACR Meeting Abstracts

Abstract Number: 1483 • ACR Convergence 2021
Down-regulation of Hematopoietic Progenitor Kinase 1 by Aberrant Epigenetic Alterations in T Follicular Helper Cells Accounts for Excessive Immunity in Systemic Lupus Erythematosus
Qing Zhang¹, Huilin Zhang² and Yuming Xie¹, ¹Department of Dermatology, Second Xiangya Hospital, Central South University, Changsha, China (People's Republic), ²Clinical Nursing Teaching and Research Section, Second Xiangya Hospital, Central South University, Changsha, China (People's Republic)
Background/Purpose: Recently, T follicular helper cells (Tfh cells) have been discovered to be the main CD4+ T cells assisting B cells to produce antibody. Tfh…
Abstract Number: 1484 • ACR Convergence 2021
B Cell Intracellular IFNβ as a Unique Cellular Marker for the Development of Lupus Nephritis
Fatima Alduraibi¹, Huma Fatima¹, Winn Chatham², Hui-Chen Hsu¹ and John Mountz¹, ¹University of Alabama Birmingham, Birmingham, AL, ²University of Alabama at Birmingham, Birmingham, AL
Background/Purpose: Our laboratory previously demonstrated a strong association of B cell intracellular interferon beta (IFNβ) with the development of anti-Smith/ribonuclear protein (Sm/RNP), anti-DNA, and lupus…
Abstract Number: 1485 • ACR Convergence 2021
Glycosphingolipids: Potential Urine Biomarkers of Therapeutic Response in Lupus Nephritis
Tammy Nowling, Jessalyn Rodgers, Bethany Wolf, Brian Troyer and Jim Oates, Medical University of South Carolina, Charleston, SC
Background/Purpose: Lupus nephritis (LN) is a chronic, immune complex-mediated glomerulonephritis affecting up to 60% of patients with lupus. Progression of the most aggressive forms of…
Abstract Number: 1486 • ACR Convergence 2021
A Novel Requirement for IFNβ1 Signaling for IFNκ Induction in Keratinocytes
Bin Xu¹, Yee Sun Tan¹, Jon Musai¹, William R Swindell², Mrinal Sakar¹, Johann Gudjonsson¹, J. Michelle Kahlenberg¹ and Grace Hile¹, ¹University of Michigan, Ann Arbor, MI, ²Ohio University, Cincinnati, OH
Background/Purpose: Cutaneous lupus erythematosus (CLE) affects up to 70% of patients with systemic lupus erythematosus (SLE), and type I interferons (IFNs) are important promoters of…
Abstract Number: 1487 • ACR Convergence 2021
Type I Interferon Modulates Langerhans Cell ADAM17 in Lupus to Contribute to Photosensitivity
Thomas Li¹, Keila Veiga², Noa Schwartz³, Jose Lora⁴, Yong Liu⁴, Ali Jabbari⁵, William Shipman¹, Mehdi Rashighi⁶, James Krueger⁷, Niroshana Anandasabapathy⁴, David Oliver⁸, Yurii Chinenov⁸, Carl Blobel¹ and Theresa Lu¹, ¹Hospital for Special Surgery, New York, NY, ²New York Medical College, Hawthorne, NY, ³Albert Einstein College of Medicine/Montefiore Medical Center, New York, NY, ⁴Weill Cornell Medicine, New York, NY, ⁵University of Iowa, Iowa City, IA, ⁶University of Massachusetts Medical School, Worcester, MA, ⁷Rockefeller University, New York, NY, ⁸David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery, New York, NY
Background/Purpose: Photosensitivity is a common feature in the autoimmune disease lupus erythematosus (LE) where patients develop inflammatory skin lesions in response to ultraviolet radiation (UVR).…
Abstract Number: 1488 • ACR Convergence 2021
Metabolic Alterations of Systemic Lupus Erythematosus NK Cells Determine Response to Anti-CD38 and Anti-SLAMF7 Monoclonal Antibodies
Morgane Humbel, Natalia Fluder, Florence Bellanger, Alice Horisberger, Craig Fenwick, Camillo Ribi and Denis Comte, CHUV, Lausanne, Switzerland
Background/Purpose: Systemic lupus erythematosus (SLE) is a multisystem inflammatory condition of unknown pathogenesis. We have previously shown that SLE Natural killer (NK) cells are decreased…
Abstract Number: 1489 • ACR Convergence 2021
Identification of Mitochondrial Antigens Targeted by Autoantibodies in Systemic Lupus Erythematosus (SLE)
Yann BECKER¹, Jean-Philippe Gagné², Anne-Sophie Julien³, Tania Lévesque¹, Nadine Gougeard⁴, Vicente Rubio⁴, François-Michel Boisvert⁵, Dominique Jean⁶, Guy Poirier², Paul R Fortin⁷ and Éric Boilard¹, ¹Centre de Recherche ARThrite, Université Laval, Québec City, QC, Canada, ²Centre de Recherche du Centre Hospitalier Universitaire de Québec - Université Laval, Québec City, QC, Canada, ³Département de mathématiques et statistique, Université Laval, Québec, QC, Canada, ⁴Structural Enzymopathology Unit, Instituto de Biomedicina de Valencia, Consejo Superior de Investigaciones Científicas, Valencia, Spain, ⁵Department of Anatomy and Cell Biology, Université de Sherbrooke, Sherbrooke, QC, Canada, ⁶Department of Anatomy and Cell Biology, Université de Sherbrooke, Sherbrooke, Canada, ⁷CHU de Quebec - Universite Laval, Québec City, QC, Canada
Background/Purpose: Mitochondria are organelles that possess several bacterial features such as a double-stranded genome with hypomethylated CpG islets, formylated proteins, and a double membrane composed…
Abstract Number: 1490 • ACR Convergence 2021
Myeloid and B Cell Transcriptional Phenotypes Reveal Race Dependent Differences in Early Autoimmunity
Aleksandra Bylinska, Samantha Slight-Webb, Kevin Thomas, Miles Smith, Susan Macwana, Nicolas Dominguez, Eliza Chakravarty, Joan Merrill, Judith James and Joel Guthridge, Oklahoma Medical Research Foundation, Oklahoma City, OK
Background/Purpose: Early immune events leading to clinical autoimmune disease are complex and the pathways involved remain incompletely defined. Anti-nuclear antibody (ANA) positivity is a feature…
Abstract Number: 1491 • ACR Convergence 2021
Single-cell Analysis of Paired Skin and Blood Samples from Patients with SLE and Cutaneous Lupus Suggests CD16+ DCs Arise from Non-classical Monocytes That Enter Nonlesional Skin, Undergo Type I IFN Education, and Engage in Extensive Crosstalk with Diverse Immune and Stromal Cell Types
Allison Billi¹, Feiyang Ma², Olesya Plazyo³, Grace Hile³, Xianying Xing³, Mehrnaz Gharaee-Kermani⁴, Rachael Wasikowski³, Lam Tsoi³, Matteo Pellegrini², Robert L. Modlin², Johann Gudjonsson¹ and J. Michelle Kahlenberg³, ¹Department of Dermatology, University of Michigan, Ann Arbor, MI, ²University of California Los Angeles, Los Angeles, CA, ³University of Michigan, Ann Arbor, MI, ⁴Internal Medicine - Division of Rheumatology and Department of Dermatology, University of Michigan, Ann Arbor, MI
Background/Purpose: Cutaneous lupus erythematosus (CLE) is an incompletely understood autoimmune disease that can occur in isolation or in the context of SLE. CLE is often…
Abstract Number: 1492 • ACR Convergence 2021
A Permissive Factor of Anti-Ro+ Mothers of Neonatal Lupus Children Is Linked to Overt SLE Associated with Immunity to a Gut Commensal
Robert Clancy¹, Miranda Marion², Hannah Ainsworth², Miao Chang¹, Timothy Howard³, Peter Izmirly⁴, Mala Masson⁵, Jill Buyon⁶ and Carl Langefeld⁷, ¹NYU Grossman School of Medicine, New York, NY, ²Wake Forest University, Winston-Salem, NC, ³Wake Forest University, Quakertown, NC, ⁴New York University School of Medicine, New York, NY, ⁵NYU Grossman School Medicine, New York, NY, ⁶NYU School of Medicine, New York, NY, ⁷Wake Forest University, Winston Salem, NC
Background/Purpose: Unknown factors trigger the transition of anti-Ro+ mothers of neonatal lupus (NL) children from preclinical autoimmunity to clinical disease. One candidate may be the…
Abstract Number: 1493 • ACR Convergence 2021
Association of the Soluble Terminal Complement Complex C5b-9 (sC5b-9) with Urinary Signs of Kidney Disease in a Swiss SLE Cohort
Kristin Schmiedeberg¹, Ruediger B. Mueller², Thomas Neumann³, Ian Pirker¹, Philipp Rein⁴, Camillo Ribi⁵, Andrea Rubbert-Roth⁶, Michael Kirschfink⁷, Jutta Schroeder-Braunstein⁷, Reinhard Voll⁸ and Johannes von Kempis¹, ¹Kantonsspital St. Gallen, St.Gallen, Switzerland, ²Clinic of Rheumatology, Medical University Hospital Aarau, Aarau, Switzerland, ³Kantonsspital St.Gallen, St.Gallen, Switzerland, ⁴Landeskrankenhaus Hohenems, Wolfurt, Austria, ⁵CHUV, Lausanne, Switzerland, ⁶Kantonspital St Gallen, St.Gallen, Switzerland, ⁷Universitätsklinikum Heidelberg, Heidelberg, Germany, ⁸Department of Rheumatology and Clinical Immunology, University Medical Center, Faculty of Medicine, Albert-Ludwigs-University of Freiburg, Freiburg, Germany
Background/Purpose: Few reliable laboratory biomarkers exist to determine disease activity in SLE. The role of the soluble terminal complement complex, sC5b-9, in active SLE has…
Abstract Number: 1494 • ACR Convergence 2021
Functional Effects of a Lupus-associated PRKG1 Variant on the RhoA-ROCK Pathway and Response to Type I Interferon
Ruth Fernandez Ruiz¹, Justine Shum², Kayla Van Buren³ and Timothy Niewold⁴, ¹NYU Grossman School of Medicine, New York, NY, ²Marinhealth Medical Center, San Francisco, CA, ³Mnemo Therapeutics, New York, NY, ⁴Colton Center for Autoimmunity NYU School of Medicine, New York, NY
Background/Purpose: Interferon (IFN)-α contributes to susceptibility and severe manifestations in systemic lupus erythematosus (SLE). The PRKG1 rs7897633 variant has been previously identified as the top…
Abstract Number: 1495 • ACR Convergence 2021
Multiplexed Profiling of Treatment Naïve Cutaneous Lupus Skin Stratified by Patient Response to Antimalarials
Thomas Vazquez¹, Jay Patel², Daisy Yan³, Emily Keyes⁴, DeAnna Diaz⁵, Yubin Li⁶, Madison Grinnell⁶, Rui Feng⁷ and Victoria Werth³, ¹FIU Wertheim College of Medicine, Virginia Beach, VA, ²Corporal Michael J. Crescenz VAMC, Department of Dermatology, U Penn, Philadelphia, NJ, ³Philadelphia VAMC, Philadelphia, PA, USA and Department of Dermatology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, ⁴Department of Dermatology, Perelman School of Medicine at the University of Pennsylvania and Philadelphia VAMC, Philadelphia, PA, ⁵Philadelphia College of Medicine, Philadelphia, PA, ⁶Corporal Michael J. Crescenz VAMC, Department of Dermatology, U Penn, Philadelphia, PA, ⁷University of Pennsylvania Department of Biostatistics, Philadelphia, PA
Background/Purpose: Lupus erythematous (LE) is a systemic autoimmune disease with a variety of cutaneous manifestations. Antimalarials are first-line systemic therapy, yet not all patients respond…
Abstract Number: 1496 • ACR Convergence 2021
A Metagenome-wide Association Study Revealed Disease-specific Landscape of the Gut Microbiome of Systemic Lupus Erythematosus in Japanese
Yoshihiko Tomofuji¹, Yuichi Maeda², Eri Oguro-Igashira², Toshihiro Kishikawa¹, Kenichi Yamamoto¹, Kyuto Sonehara¹, Daisuke Motooka³, Yuki Matsumoto³, Hidetoshi Matsuoka⁴, Maiko Yoshimura⁴, Mayu Yagita², Takuro Nii², Shiro Ohshima⁵, Shota Nakamura³, Hidenori Inohara⁶, Kiyoshi Takeda⁷, Atsushi Kumanogoh² and Yukinori Okada¹, ¹Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Japan, ²Department of Respiratory Medicine and Clinical Immunology, Osaka University Graduate School of Medicine, Suita, Japan, ³Department of Infection Metagenomics, Research Institute for Microbial Diseases, Osaka University, Suita, Japan, ⁴Rheumatology and Allergology, NHO Osaka Minami Medical Center, Kawachinagano, Japan, ⁵Rheumatology and Allergology, NHO Osaka Minami Medical Center, Suita, Japan, ⁶Department of Otorhinolaryngology - Head and Neck Surgery, Osaka University Graduate School of Medicine, Suita, Japan, ⁷Laboratory of Immune Regulation, Department of Microbiology and Immunology, Osaka University Graduate School of Medicine, Suita, Japan
Background/Purpose: Alteration of the gut microbiome has been linked to the pathogenesis of systemic lupus erythematosus (SLE). However, a comprehensive view of the gut microbiome…
Abstract Number: 1497 • ACR Convergence 2021
Kidney Disease in Lupus Patients Is Linked to Monocytes’ Aberrant Spliceosome and Altered Expression of IFN-Response Related Genes
Chary Lopez-Pedrera¹, Alejandra Patiño-Trives², Alejandro Ibañez-Costa³, Maria Luque-Tevar², Iván Arias de la Rosa⁴, Desiree Ruiz⁵, Pedro Seguí-Azpilicueta⁵, Mario Espinosa⁵, Rosa Ortega⁵, Nuria Barbarroja⁴, Justo P Cataño³, Raul Luque³, Maria Angeles Aguirre¹ and Carlos Pérez-Sánchez⁶, ¹IMIBIC/Reina Sofia Hospital/University of Córdoba, Córdoba, Spain, ²Rheumatology Department, Reina Sofia University Hospital/ Maimonides Institute for Research in Biomedicine of Cordoba (IMIBIC)/ University of Cordoba, Cordoba, Spain, ³IMIBIC, Department of Cell Biology, Physiology and Immunology, University of Cordoba, Córdoba, Spain, ⁴University of Cordoba/IMIBIC/Reina Sofia Hospital, Cordoba, Spain, ⁵IMIBIC, Reina Sofia Hospital/University of Córdoba, Córdoba, Spain, ⁶IMIBIC, Córdoba, Spain
Background/Purpose: The present study aimed at: 1- Identifying altered SLE monocytes transcriptomic signatures linked to the immune response and its association with clinical features. 2-…

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