Abstracts Archive - Page 802 of 2425 - ACR Meeting Abstracts

Abstract Number: 146 • 2020 Pediatric Rheumatology Symposium
Immersive Virtual Reality for Management of Amplified Musculoskeletal Pain Syndrome in Adolescents: A Pilot Randomized Controlled Trial
Saumya Joshi¹, Yujuan Zhang ¹, Lori Lyn Price ², Trevor Davis ³ and Raveendhara Bannuru ¹, ¹Tufts Medical Center, Boston, Massachusetts, ²Boston, Massachusetts, ³Norwell, Massachusetts
Background/Purpose: Amplified Musculoskeletal Pain Syndrome (AMPS), a chronic pain syndrome with excessive musculoskeletal pain without a primary organic etiology, has a high prevalence in adolescents.…
Abstract Number: 147 • 2020 Pediatric Rheumatology Symposium
Familial Clustering of Immune-mediated Diseases in Children with Abrupt-onset OCD
Avis Chan ¹, Tiffany Phu ¹, Bahare Farhadian ², Theresa Willett ³, Melissa Silverman ¹, Paula Tran ¹, Margo Thienemann ³ and Jennifer Frankovich⁴, ¹Stanford University School of Medicine, Palo Alto, ²Stanford Immune Behavioral Health Clinic and PANS Research Program at Lucile Packard Children's Hospital, Palo Alto, ³Stanford University School of Medicine, Palo Alto, California, ⁴Stanford
Background/Purpose: Recent epidemiologic studies have reported increased rates of immune-mediated comorbidities among first-degree relatives of patients with OCD and tic disorders.(Mataix-Cols et al., Mol Psychiatry…
Abstract Number: 148 • 2020 Pediatric Rheumatology Symposium
Chronic Fatigue Symptoms in Children with Abrupt Early-onset OCD And/or PANS
Avis Chan ¹, Angeline Truong ², Bahare Farhadian ³, Theresa Willett ², Melissa Silverman ¹, Paula Tran ¹, Margo Thienemann ² and Jennifer Frankovich⁴, ¹Stanford University School of Medicine, Palo Alto, ²Stanford University School of Medicine, Palo Alto, California, ³Stanford Immune Behavioral Health Clinic and PANS Research Program at Lucile Packard Children's Hospital, Palo Alto, ⁴Stanford
Background/Purpose: Chronic Fatigue Syndrome (CFS)/Myalgic encephalomyelitis (ME) affects roughly 2.5 million people in the United States, and is challenging both in diagnosis and treatment. Many…
Abstract Number: 149 • 2020 Pediatric Rheumatology Symposium
Low C4 Copy Number of Total C4 Gene, C4B Gene and C4BL Gene in Children with Pediatric Acute-onset Neuropsychiatric Syndrome (PANS)
Agnieszka Kalinowski ¹, Justin Lee ², Haley Hedlin ², Reenal Pattini ², Hanna Ollila ², Emmanuel Mignot ¹, Douglas Levinson ², Susan Swedo ³, Tanya Murphy ⁴, Avis Chan ⁵, Margo Thienemann ¹, Alexander Urban ² and Jennifer Frankovich⁶, ¹Stanford University School of Medicine, Palo Alto, California, ²Stanford University, Palo Alto, California, ³National Institute of Mental Health, Bethesda, Maryland, ⁴University of South Florida, Tampa, Florida, ⁵Stanford University School of Medicine, Palo Alto, ⁶Stanford
Background/Purpose: Pediatric Acute-Onset Neuropsychiatric Syndrome (PANS) is characterized by sudden-onset OCD and additional neuropsychiatric symptoms. Imaging studies point to inflammation in the basal ganglia as…
Abstract Number: 150 • 2020 Pediatric Rheumatology Symposium
The Killer Immunoglobulin-like Receptor KIR3DL1 in Combination with HLA-Bw4 Is Associated with Pediatric Acute-onset Neuropsychiatric Syndrome (PANS)
Jennifer Frankovich¹, Kirstin Anderson ², Gonzalo Montero-Martin ³, Avis Chan ⁴, Margo Thienemann ⁵, Bahare Farhadian ⁶, Theresa Willett ⁵, Elizabeth Mellins ⁷, Alicia Madden ⁵, Tanya Murphy ⁸, Susan Swedo ⁹, Marcelo Fernandez-Vina ³ and Jill Hollenbach ², ¹Stanford, ²University of California San Francisco, San Francisco, California, ³Stanford University, Palo Alto, California, ⁴Stanford University School of Medicine, Palo Alto, ⁵Stanford University School of Medicine, Palo Alto, California, ⁶Stanford Immune Behavioral Health Clinic and PANS Research Program at Lucile Packard Children's Hospital, Palo Alto, ⁷Stanford University, Stanford, ⁸University of South Florida, Tampa, Florida, ⁹National Institute of Mental Health, Bethesda, Maryland
Background/Purpose: Pediatric Acute-onset Neuropsychiatric Syndrome (PANS) is characterized by abrupt onset of obsessive-compulsive disorder (OCD) and/or food restriction with other specified neuropsychiatric symptoms. Patients with…
Abstract Number: 151 • 2020 Pediatric Rheumatology Symposium
Differences in Chromatin Architecture Between Treatment-Naïve Pediatric and Adult Lupus Patients
Joyce Hui-Yuen¹, Frank Jenkins ², Kaiyu Jiang ³, Betty Diamond ² and James Jarvis ⁴, ¹Cohen Children's Medical Center, New Hyde Park, ²Northwell Health, Manhasset, ³University at Buffalo, Buffalo, ⁴University at Buffalo Jacobs School of Medicine, Buffalo
Background/Purpose: Systemic lupus erythematosus (SLE) is possibly triggered by gene-environment interactions. We showed most of the SLE haplotypes contain epigenetic marks associated with enhancer function…
Abstract Number: 152 • 2020 Pediatric Rheumatology Symposium
Hemophagocytic Lymphohistiocytosis (HLH) Genetic Variants in Childhood-onset SLE (cSLE) with Macrophage Activation Syndrome (MAS)
Piya Lahiry¹, Sergey Naumenko ², Fangming Liao ³, Daniela Dominguez ⁴, Andrea Knight ⁵, Deborah Levy ³, Lawrence Ng ⁴, Earl D. Silverman ⁶ and Linda Hiraki ⁷, ¹Hospital for Sick Children, Toronto, Canada, ²The Centre for Computational Medicine, Toronto, Canada, ³Division of Rheumatology, The Hospital for Sick Children, Department of Pediatrics, University of Toronto, Toronto, Canada, ⁴Division of Rheumatology, The Hospital for Sick Children, Toronto, Canada, ⁵SickKids Research Institute, Toronto, Canada, ⁶Division of Rheumatology, The Hospital for Sick Children, Department of Paediatrics, University of Toronto, Translational Medicine, Research Institute, The Hospital for Sick Children, Toronto, Canada, ⁷Division of Rheumatology, The Hospital for Sick Children, Department of Paediatrics, University of Toronto, Child Health Evaluative Sciences, Research Institute, The Hospital for Sick Children, Toronto, Canada
Background/Purpose: Hemophagocytic lymphohistocytosis (HLH) is a life-threatening hyper-inflammatory syndrome characterized by excessive activation and proliferation of T-lymphocytes and macrophages. Familial HLH (fHLH), is an autosomal…
Abstract Number: 153 • 2020 Pediatric Rheumatology Symposium
Double Negative T Cells in Juvenile Dermatomyositis
Amer Khojah¹, Gabrielle Morgan ², Wilfredo Marin ³, Najah Ahsan ⁴ and Lauren Pachman ⁵, ¹Lurie Children's Hospital, Chicago, ²Ann & Robert H. Lurie Children's Hospital of Chicago and Northwestern University Feinberg School of Medicine, Chicago, Illinois, ³Ann & Robert H. Lurie Children's Hospital, Chicago, ⁴Ann and Robert H. Lurie Children's Hospital, Chicago, ⁵Northwestern's Feinberg School of Medicine. Ann and Robert H. Lurie Children's Hospital of Chicago; Stanley Manne Children's Research Institute of Chicago, 303 E Superior, Chicago
Background/Purpose: Double Negative (DN) T cells was initially described in the context of autoimmune lymphoproliferative disease, which is caused by defective T cells apoptosis due…
Abstract Number: 154 • 2020 Pediatric Rheumatology Symposium
T Helper Cell Differentiation in Polyarticular Juvenile Idiopathic Arthritis
Anna Patrick¹, Tashawna Esmond ², David Flaherty ², Thomas Brent Graham ², Susan Thompson ³ and Thomas Aune ¹, ¹Vanderbilt University Medical Center, Nashville, Tennessee, ²Vanderbilt University Medical Center, Nashville, ³Cincinnati Children's Hospital Medical Center/Univ of Cincinnati College of Medicine, Cincinnati
Background/Purpose: Juvenile idiopathic arthritis (JIA) is the most common autoimmune arthritis in children. Polyarticular JIA and extended oligoarticular JIA both have genetic associations near genes…
Abstract Number: 155 • 2020 Pediatric Rheumatology Symposium
Pediatric Acute-onset Neuropsychiatric Syndrome (PANS) Is Characterized by a Novel Subset of Monocytes with Markers Associated with Crossing the Blood Brain Barrier (BBB)
Shamma Rahman¹, Fabian Gaertner ¹, Jessica Houghton ¹, Claudia Macaubas ¹, Avis Chan ², Laurie Columbo ¹, Jennifer Frankovich ³ and Elizabeth Mellins ¹, ¹Stanford University, Stanford, ²Stanford University School of Medicine, Palo Alto, ³Stanford
Background/Purpose: Pediatric Acute-onset Neuropsychiatric Syndrome (PANS) is characterized by abrupt onset of obsessive-compulsive disorder (OCD) and/or food restriction with other specified neuropsychiatric symptoms. 65% of…
Abstract Number: 156 • 2020 Pediatric Rheumatology Symposium
Metabolic Profiling in Juvenile Dermatomyositis
Jeffrey Dvergsten¹, Olga Ilkayeva ², Lawrence Landerman ², Michael Muehlbauer ³, David Pisetsky ⁴, Ann Reed ³ and Kim Huffman ⁵, ¹Duke University Hospital, Hillsborough, ²Duke University, Durham, NC, ³Duke University, Durham, ⁴Duke University Medical Center, Durham, ⁵Durham
Background/Purpose: Investigators have made significant progress piecing together pathogenic mechanisms of juvenile dermatomyositis (DM). However, this remains an incomplete puzzle, and optimal approaches to diagnosing,…
Abstract Number: 157 • 2020 Pediatric Rheumatology Symposium
Chondrocytes Influence Fibroblast-like Synoviocytes from Patients with Juvenile Idiopathic Arthritis, Through the Abrogation of BMP Signaling, to Delay Cell Differentiation and Maturation
Megan Simonds ¹, Amanda Schlefman ², Kathleen Sullivan ³, Carlos Rose ⁴ and AnneMarie Brescia⁵, ¹Nemours Biomedical Research, Wilmington, ²Johns Hopkins Rheumatology, ST PETERSBURG, Florida, ³The Children's Hospital of Philadelphia, Philadelphia, ⁴Thomas Jefferson University/duPont Hospital for Children, Wilmington, ⁵Nemours/ Alfred I duPont Hospital for Children, Wilmington
Background/Purpose: Juvenile Idiopathic Arthritis (JIA) progression leads to growth disturbances in affected joints. Fibroblast-like synoviocytes (FLS) play a key role in JIA pathogenesis; however, the…
Abstract Number: 158 • 2020 Pediatric Rheumatology Symposium
Genetics of Age at Diagnosis in Childhood-Onset Systemic Lupus Erythematosus
Raffaella Carlomagno¹, Fangming Liao ¹, JingJing Cao ², Dafna Gladman ³, Marisa Klein-Gitelman ⁴, Andrea Knight ⁵, Deborah Levy ¹, Andrew Paterson ², Zahi Touma ³, Murray Urowitz ³, Declan Webber ¹, Joan Wither ³, Earl D. Silverman ⁶ and Linda Hiraki ⁷, ¹Division of Rheumatology, The Hospital for Sick Children, Department of Pediatrics, University of Toronto, Toronto, Canada, ²Genetics & Genome Biology, Research Institute, The Hospital for Sick Children, Toronto, Canada, ³Krembil Research Institute, Toronto Western Hospital, Toronto, Canada, ⁴Ann & Robert H. Lurie Children’s Hospital of Chicago, Chicago, ⁵SickKids Research Institute, Toronto, Canada, ⁶Division of Rheumatology, The Hospital for Sick Children, Department of Paediatrics, University of Toronto, Translational Medicine, Research Institute, The Hospital for Sick Children, Toronto, Canada, ⁷Division of Rheumatology, The Hospital for Sick Children, Department of Paediatrics, University of Toronto, Child Health Evaluative Sciences, Research Institute, The Hospital for Sick Children, Toronto, Canada
Background/Purpose: The genetic contribution to the development of systemic lupus erythematosus (SLE) is estimated to be 66% in twin studies. Genome wide association studies (GWAS)…
Abstract Number: 159 • 2020 Pediatric Rheumatology Symposium
Interleukin-18 as a Key Cytokine to Understand Pathology and to Decide Appropriate Therapeutic Strategy in Chronic Arthritic Systemic Juvenile Idiopathic Arthritis
Takako Miyamae¹, Yumi Tani ¹, Manabu Kawamoto ², Takayuki Kishi ³ and Masayoshi Harigai ², ¹Pediatric Rheumatology, Institute of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan, ²Institute of Rheumatology, Tokyo Women's Medical University, TOKYO, Japan, ³Department of Pediatrics, Tokyo Women's Medical University, Tokyo, Japan
Background/Purpose: Long-term outcomes of systemic JIA are highly variable. approximately half of the patients have chronic persistent arthritis requiring extended anti-inflammatory therapy, sometimes into adulthood.…
Abstract Number: 160 • 2020 Pediatric Rheumatology Symposium
CD3 Downregulation on T-cells Is Concomitant with Arginase Upregulation on Myeloid Cells in Synovial Fluid of Patients with Juvenile Idiopathic Arthritis
Vincent Giacalone ¹, Alexandre Cammarata-Mouchtouris ¹, Diego Mauricio Moncada Giraldo ¹, Sreekala Shenoy ¹, Lori Ponder ¹, Talia Gergely ², Patricia Vega-Fernandez ³, Cynthia Manos ⁴, Elaine Flanagan ¹, Rabindra Tirouvanziam ¹ and Sampath Prahalad⁵, ¹emory university, atlanta, ²Emory University School of Medicine, Atlanta, ³Cincinnati Children's Hospital Medical Center, Cincinnati, ⁴Children's Healthcare of Atlanta, Atlanta, ⁵Emory + Children's Pediatric Institute, Atlanta
Background/Purpose: Rationale: Juvenile idiopathic arthritis (JIA) is an inflammatory autoimmune disorder driven by dysfunction of the joint tissue and abnormal immune responses. As deep phenotyping…

All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying colleagues, institutions, communications firms, and all other stakeholders related to the development or promotion of the abstract about this policy. If you have questions about the ACR abstract embargo policy, please contact ACR abstracts staff at [email protected].