Abstracts Archive - Page 788 of 2607 - ACR Meeting Abstracts

Abstract Number: 1243 • ACR Convergence 2021
Real World Validation of a Rule to Predict Response to Sarilumab in Patients with Rheumatoid Arthritis: Analysis from the RISE Registry
Huifeng Yun¹, Jeffrey Curtis², Lang Chen³, cassie Clinton³, Hubert van Hoogstraten⁴, Stefano Fiore⁴, Markus Rehberg⁵ and Ernest Choy⁶, ¹University of Alabama Birmingham, Birmingham, AL, ²Division of Clinical Immunology and Rheumatology, Department of Medicine, Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL, ³University of Alabama at Birmingham, Birmingham, AL, ⁴Sanofi, Bridgewater, NJ, ⁵Sanofi, Franfurt, Germany, ⁶CREATE Centre, Cardiff University, Cardiff, Wales, United Kingdom
Background/Purpose: Accurately identifying patients who may respond better to a specific drug or mechanism of action could improve rational selection of medications to optimize clinical…
Abstract Number: 1244 • ACR Convergence 2021
Mindfulness-Based Stress Reduction (MBSR) to Improve Patient-Related Outcomes (PROs) in Patients with Rheumatoid Arthritis in Clinical Remission but Elevated Negative PROs: A Pragmatic Pilot Study
Marie-Claude Beaulieu¹, Isabelle Gaboury², Patricia L Dobkin³, Nathalie Carrier⁴, France Gervais⁵, Françoise Gendron⁶, Pasquale Roberge⁷, PIERRE DAGENAIS⁷, Sophie Roux⁷ and Gilles Boire¹, ¹Universite de Sherbrooke, Sherbrooke, QC, Canada, ²University of Sherbrooke, Sherbrooke, QC, Canada, ³McGill University, Montréal, QC, Canada, ⁴CIUSSS de l'Estrie - CHUS, Sherbrooke, QC, Canada, ⁵NA, Rimouski, QC, Canada, ⁶NA, Sherbrooke, QC, Canada, ⁷Université de Sherbrooke, Sherbrooke, QC, Canada
Background/Purpose: Many patients with controlled rheumatoid arthritis (RA) continue to report high levels of disease activity (PGA), as well as other disturbing patient-related outcomes (PROs),…
Abstract Number: 1245 • ACR Convergence 2021
Characteristics of RA Patients Treated with JAK Inhibitors Before versus After VTE Warnings: Results of a Real-World Multicentric Study
Cecile PHILIPPOTEAUX¹, Valentine DEPREZ², Jean-Guillaume LETAROUILLY¹, Emeline CAILLIAU³, Eric HOUVENAGEL⁴, Xavier DEPREZ⁵, Aurore NOTTEZ⁶, Peggy PHILIPPE¹, Tristan PASCART⁷, Vincent GOEB² and Rene-Marc FLIPO⁸, ¹Rheumatology Department, University Hospital of Lille, Lille, France, ²Rheumatology Department, University Hospital of Amiens, Amiens, France, ³Assessment of Health Technologies and Medical Practices Department, University Hospital of Lille, Lille, France, ⁴Rheumatology Department, Lille Catholic Hospitals, Lomme, France, ⁵Rheumatology Department, Hospital Center of Valenciennes, Valenciennes, France, ⁶Rheumatology Department, University Hospital of Dunkerque, Dunkerque, France, ⁷Department of Rheumatology, Lille Catholic Hospitals, Lomme, France, ⁸Rheumatology Department, Lille University Hospital, Lille, France
Background/Purpose: In recent decades, the therapeutic arsenal in RA has dramatically expanded. Baricitinib (BARI) and Tofacitinib (TOFA) were the first JAK inhibitors (JAKi) to be…
Abstract Number: 1246 • ACR Convergence 2021
The Effect of Tocilizumab on miR-146a-5p and EMMPRIN/CD147 in Rheumatoid Arthritis Patients
Devy Zisman¹, Mirna Safieh¹, Elina Simanovich¹, Joy Feld², Amalia Kinarty¹, Liron Zisman¹, Tal Gazitt³, Amir Haddad⁴, Muna Elias¹, Itzhak Rosner⁵, Lisa Kaly⁶ and Michal A Rahat⁷, ¹Carmel Medical Center, Haifa, Israel, ²Carmel and Zvulun Medical Centre, Haifa, Israel, ³Carmel Hospital, Haifa, Israel, ⁴Carmel Medical Centre, Haifa, Israel, ⁵Rheumatology Unit, Bnai Zion Medical Center, Haifa, Israel, ⁶Bnei Zion Medical Center, Haifa, Israel, ⁷Carmel Medical Center/Ruth and Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel
Background/Purpose: Angiogenesis is an important contributor to the development of rheumatoid arthritis (RA). Tocilizumab (TCZ), an anti-IL-6 receptor antibody used in the treatment of RA…
Abstract Number: 1247 • ACR Convergence 2021
Plasma Cell-free DNA Is a Useful Biomarker for Tocilizumab Therapy in Rheumatoid Arthritis
Teppei Hashimoto¹, Yuichi Yokoyama², Takahiro Yoshikawa³, Tetsuya Furukawa⁴, Naoto Azuma⁵, Akira Hashiramoto⁶ and Kiyoshi Matsui⁷, ¹Hyogo College of Medicine, Kobe, Hyogo, Japan, ²Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, ³Hyogo College of Medicine, Nishinomiya, Japan, ⁴Hyogo college of Medicine, Nishinomiya, Hyogo, Japan, ⁵Division of Rheumatology, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan, ⁶Kobe University, Kobe, Japan, ⁷Hyogo College of Medicine, Nishinomiya-city, Hyogo, Japan
Background/Purpose: Endogenous DNA derived from nuclei is released into the blood circulation as cell-free DNA (cfDNA) following cell damage or death. cfDNA is associated with…
Abstract Number: 1248 • ACR Convergence 2021
Adjusted Analyses of the Benefits of Autoantibody Enrichment on Efficacy Outcomes in Early RA, from a Pooled Analysis of 4 Abatacept RCTs
Janet Pope¹, Sang Hee Park², Mirko Fillbrunn³, Karissa Lozenski², Vadim Khaychuk², Kaleb Michaud⁴, James Signorovitch³, Henry Lane³, Ha Nguyen³ and Philip Conaghan⁵, ¹University of Western Ontario, London, ON, Canada, ²Bristol Myers Squibb, Princeton, NJ, ³Analysis Group, Inc., Boston, MA, ⁴University of Nebraska Medical Center, Omaha, NE, ⁵Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom
Background/Purpose: Previous studies have found differential treatment efficacy of abatacept (ABA) for the treatment of RA based on biomarker-seropositivity.1-4 An earlier study found a differential…
Abstract Number: 1249 • ACR Convergence 2021
In Rheumatoid Arthritis, Inhibition of the Lactate Monocarboxylate Transporters-1, and -4 in Pathological Fibroblast-Like Synoviocytes Led to Decreased ChemokineProduction
Morten Aagaard Nielsen¹, Maithri Aspari², Klaus Frommer³, Malene Hvid², Tue Kragstrup² and Bent Deleuran², ¹Aarhus University / Aarhus University Hopital, Aarhus, Denmark, ²Aarhus University, Aarhus, Denmark, ³Justus-Liebig-University Giessen, Bad Nauheim, Germany
Background/Purpose: Pathological subsets of fibroblast-like synoviocytes (FLS) have recently been identified as key players in the aggravation of both persistent joint inflammation and destruction in…
Abstract Number: 1250 • ACR Convergence 2021
Abatacept and Other DMARDs Have Common Transcriptomic Effects on RA Synovial Tissue
Clément TRIAILLE¹, Tatiana SOKOLOVA¹, Gaëlle TILMAN¹, Laurent MERIC de BELLEFON², Christine GALANT³, Patrick DUREZ⁴, Bernard LAUWERYS⁵ and Nisha LIMAYE⁶, ¹Pôle de pathologies rhumatismales systémiques et inflammatoires, Institut de Recherche Expérimentale et Clinique, Université catholique de Louvain, Brussels, Belgium, ²Service de Rhumatologie, Cliniques Universitaires Saint-Luc, Brussels, Belgium, ³Service d’Anatomie Pathologique, Cliniques Universitaires Saint-Luc, Brussels, Belgium, ⁴Pôle de Recherche en Rhumatologie, Institut de Recherche Expérimentale et Clinique, Brussels, Belgium, ⁵UCB Pharma, Brussels, Belgium, ⁶Genetics of Autoimmune Diseases and Cancer, de Duve Institute, Université catholique de Louvain, Brussels, Belgium
Background/Purpose: Our goal was to assess histological and transcriptomic effects of Abatacept (ABA) on RA synovium, and to compare them with previously published data obtained…
Abstract Number: 1251 • ACR Convergence 2021
Serum B Cell Activating Factor Reflects Good EULAR Response to TNF Inhibition in Patients with Rheumatoid Arthritis
Borja Hernandez-Breijo¹, Ioannis Parodis², Chamaida Plasencia-Rodríguez³, Mariana Díaz-Almirón⁴, Ana Martínez-Feito⁵, Marta Novella-Navarro³, Dora Pascual-Salcedo¹ and Alejandro Balsa³, ¹Immuno-Rheumatology Research Group, Hospital La Paz Institute for Health Research-IdiPAZ, Madrid, Spain, ²Division of Rheumatology, Department of Medicine Solna, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden and Department of Rheumatology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden, ³Immuno-Rheumatology Research Group, Hospital La Paz Institute for Health Research-IdiPAZ, Rheumatology, La Paz University Hospital, Madrid, Spain, ⁴Biostatistics Unit, Hospital La Paz Institute for Health Research-IdiPAZ, Madrid, Spain, ⁵Immuno-Rheumatology Research Group, Hospital La Paz Institute for Health Research-IdiPAZ, Immunology Unit, La Paz University Hospital, Madrid, Spain
Background/Purpose: The latest breakthroughs in the pathophysiology of rheumatoid arthritis (RA) highlighted the activation of B cells as a trigger of the joint flare initiation…
Abstract Number: 1252 • ACR Convergence 2021
Discontinuation of TNFi Treatment Among Rheumatoid Arthritis Patients with a Molecular Signature of Non-response to Tumor Necrosis Factor-ɑ Inhibitor Therapies
Jeffrey Curtis¹, Joel Kremer², Dimitrios Pappas³, Lixia Zhang⁴, Erin Connolly-Strong⁵, Johanna Withers⁴, Viatcheslav Akmae⁴ and Alif Saleh⁴, ¹Division of Clinical Immunology and Rheumatology, Department of Medicine, Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL, ²Albany Medical College, Latham, NY, ³CorEvitas, LLC, Waltham, MA, ⁴Scipher Medicine, Waltham, MA, ⁵Scipher Medicine, Austin, TX
Background/Purpose: A 23-feature blood-based molecular signature response classifier1 (MSRC) identifies rheumatoid arthritis (RA) patients who are unlikely to respond to tumor necrosis factor-ɑ inhibitor (TNFi)…
Abstract Number: 1253 • ACR Convergence 2021
Acupuncture in Rheumatoid Arthritis Activity
Diana Seixas¹, Fátima Farinha², Marcos Pacheco da Fonte³, Manuel Laranjeira¹ and Marília Rua⁴, ¹ICBAS, Porto, Portugal, ²CHUP-HSA, Porto, Portugal, ³CHEDV, Santa Maria da Feira, Portugal, ⁴University Aveiro, Aveiro, Portugal
Background/Purpose: High activity rates of Rheumatoid Arthritis (RA) lead to an increased risk of mortality. RA patients have a high incidence of comorbidities, associated with…
Abstract Number: 1254 • ACR Convergence 2021
The Role of Regulatory T Cells (CD4+CD25+FOXP3) in Methotrexate Unresponsiveness in a Cohort of Naive Rheumatoid Arthritis Patients
Anna Abou-Raya, Darwish ELHallous, Mohamed Ossama, Nahla Farahat, Mohamed Khaled and Suzan Abou-Raya, Faculty of Medicine, Alexandria University, Alexandria, Egypt
Background/Purpose: Rheumatoid Arthritis (RA) is a chronic immune-mediated heterogenous disease characterized by a defect in the compartment of regulatory CD4+Foxp3+ T cells (Treg) which are…
Abstract Number: 1255 • ACR Convergence 2021
A Molecular Signature Response Classifier Predicts the Likelihood of Non-response to TNF Inhibitor Therapies in RA at 3 Months
Stanley Cohen¹, Theodore Mellors², Lixia Zhang³, Alex Jones³, Erin Connolly-Strong⁴, Dimitrios Pappas⁵, Joel Kremer⁶, Johanna Withers³ and Viatcheslav Akmae³, ¹Metroplex Clinical Research Center, Dallas, TX, ²Scipher Medicine, Waltham, TX, ³Scipher Medicine, Waltham, MA, ⁴Scipher Medicine, Austin, TX, ⁵CorEvitas, LLC, Waltham, MA, ⁶Albany Medical College, Latham, NY
Background/Purpose: Most people with rheumatoid arthritis (RA) are prescribed a TNF inhibitor (TNFi) as their first targeted therapy. A blood-based molecular signature response classifier (MSRC)…
Abstract Number: 1256 • ACR Convergence 2021
Factors Associated with the Use of Biologic Disease-modifying Antirheumatic Drugs in Patients with Rheumatoid Arthritis
Roya Hosseini¹, Souhiela fawaz² and Enrique Seoane-Vazquez², ¹Chapman University School of Pharmacy, Aliso Viejo, CA, ²Chapman University School of Pharmacy, Irvine, CA
Background/Purpose: Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory disease characterized by polyarthritis of small and large joints. RA is the second most common type…
Abstract Number: 1257 • ACR Convergence 2021
Improvements in Abnormal Laboratory Tests Are Associated with Clinical Outcomes in Patients with Active Systemic Lupus Erythematosus
Kathryn Connelly¹, Rangi Kandane-Rathnayake¹, Alberta Hoi², Worawit Louthrenoo³, Laniyati Hamijoyo⁴, Jiacai Cho⁵, Aisha Lateef⁶, Shue-Fen Luo⁷, Yeong-Jian Wu⁸, Zhanguo Li⁹, Yuan An⁹, Sandra Navarra¹⁰, Leonid Zamora¹⁰, Sargunan Sockalingam¹¹, Yanjie Hao¹², Zhuoli Zhang¹², Yasuhiro Katsumata¹³, Masayoshi Harigai¹³, Shereen Oon¹⁴, Madelynn Chan¹⁵, YI-HSING CHEN¹⁶, Sang-Cheol Bae¹⁷, Sean O’Neill¹⁸, Kathryn Gibson¹⁸, Fiona Goldblatt¹⁹, Jun Kikuchi²⁰, Tsutomu Takeuchi²¹, Kristine (Pek Ling) Ng²², Nicola Tugnet²³, B.M.D.B. Basnayake²⁴, Yoshiya Tanaka²⁵, C.S. Lau²⁶, Mandana Nikpour²⁷, Vera Golder¹ and Eric Morand²⁸, ¹Monash University, Clayton, Australia, ²Department of Rheumatology, Monash Health & Department of Medicine, School of Clinical Sciences, Monash University, Melbourne, Australia, ³Maharaj Nakorn Chiangmai, Chiang Mai, Thailand, ⁴University of Padjadjaran, Bandung, Indonesia, ⁵National University Health System (NUHS), Singapore, Singapore, ⁶National University Hospital, Singapore, Singapore, ⁷Chang Gung Memorial Hospital, Taipei, Taiwan, ⁸Chang Gung Memorial Hospital, Taoyuan County, Taiwan, ⁹People's Hospital, Peking University Health Science Center, Beijing, China (People's Republic), ¹⁰University of Santo Tomas Hospital, Manila, Philippines, ¹¹University of Malaya, Kuala Lumpur, Malaysia, ¹²Peking University First Hospital, Beijing, China (People's Republic), ¹³Tokyo Women's Medical University School of Medicine, Tokyo, Japan, ¹⁴Melbourne Health, Parkville, Australia, ¹⁵Tan Tock Seng Hospital, Singapore, Singapore, ¹⁶Taichung Veterans General Hospital, Taichung, Taiwan (Republic of China), ¹⁷Hanyang University Medical Center, Seoul, Republic of Korea, ¹⁸Liverpool Hospital, Sydney, Australia, ¹⁹Flinders Medical Centre, Adelaide, Australia, ²⁰Keio University School of Medicine, Tokyo, Japan, ²¹Div. Rheumatology, Keio University, Tokyo, Japan, ²²North Shore Hospital, Auckland, New Zealand, ²³Auckland District Health Board, Auckland, New Zealand, ²⁴Teaching (General) Hospital, Kandy, Sri Lanka, ²⁵University of Occupational and Environmental Health, Kitakyushu, Japan, ²⁶University of Hong Kong, Hong Kong, Hong Kong, ²⁷University of Melbourne at St Vincent's Hospital, Melbourne, Australia, ²⁸School of Clinical Sciences at Monash Health, Monash University Faculty of Medicine, Nursing and Health Sciences, Monash Medical Centre Clayton, Melbourne, Australia
Background/Purpose: Laboratory tests are routine in the management of SLE. In clinical trial endpoints, data from laboratory tests contribute to responder status, but this is…

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