Abstracts Archive - Page 738 of 2425 - ACR Meeting Abstracts

Abstract Number: 1250 • ACR Convergence 2020
Early Sjögren Antibodies: Potential Biomarker for Abnormal Minor Labial Salivary Gland Biopsy in Juvenile Sjögren’s Syndrome
Akaluck Thatayatikom¹, Sthorn Thatayatikom¹, Indraneel Bhattacharyya², Melissa Elder¹, Renee Modica¹ and Seunghee Cha², ¹Department of Pediatrics, University of Florida, Gainesville, FL, ²College of Dentistry, University of Florida, Gainesville, FL
Background/Purpose: Juvenile Sjögren’s Syndrome (jSS) is a perplexing systemic autoimmune disease in children presenting with positive autoantibodies, glandular, and/ or extraglandular symptoms. In pediatric practice,…
Abstract Number: 1251 • ACR Convergence 2020
Assessing the Construct Validity of the Novel OMERACT Ultrasound Scoring System for Salivary Glands Target Lesions by Comparison with MRI in Patients with Sjögren’s Syndrome – An OMERACT Ultrasound Working Group Exercise
Nevsun Inanc¹, Sandrine Jousse-Joulin², Kerem Abacar³, Çagatay Cimşit⁴, Canan Cimşit⁴, Maria D’Agostino⁵, Esperanza Naredo⁶, Alojzija Hocevar⁷, Stephanie Finzel⁸, Lene Terslev⁹, Annamaria Iagnocco¹⁰, Petra Hanova¹¹, Wolfgang Schmidt¹², Gonca Mumcu¹³ and George A. Bruyn¹⁴, ¹Marmara University, School of Medicine, Division of Rheumatology, istanbul, Turkey, ²Rheumatology Department, Cavale Blanche Hospital and Brest Occidentale University, Brest, France, ³Marmara University, School of Medicine, Division of Rheumatology, Istanbul, Turkey, ⁴Marmara University School of Medicine, Radiology, Istanbul, Istanbul, Turkey, ⁵Université Versailles Saint Quentin, Ambroise Paré Hospital, Paris, France, ⁶Department of Rheumatology, Joint and Bone Research Unit. Hospital Universitario Fundación Jiménez Díaz, IIS Fundación Jiménez Díaz and Universidad Autónoma de Madrid, Madrid, Spain, ⁷University Medical Center, Rheumatology, Ljubljana, LJUBLJANA, Slovenia, ⁸Universitätsklinikum Freiburg, Klinik für Rheumatologie und Klinische Immunologie, Freiburg, Germany, ⁹Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, Glostrup., Copenhagen, Denmark, ¹⁰Università degli Studi di Torino, Academic Rheumatology Centre, Turin, Italy, ¹¹Institute of Rheumatology, Prague, Czech Republic, Prague, Czech Republic, ¹²Immanuel Krankenhaus Berlin, Medical Center for Rheumatology Berlin-Buch, Berlin, Germany, ¹³Marmara University School of Health Sciences, Health Management, Istanbul, Istanbul, Turkey, ¹⁴Rheumatology, Reumakliniek Lelystad, Lelystad, Netherlands
Background/Purpose: Imaging techniques such as salivary gland ultrasound and magnetic resonance imaging (MRI) are able to diagnose primary Sjögren syndrome (pSS) patients with high sensitivity…
Abstract Number: 1252 • ACR Convergence 2020
Ultrasound-guided Parotid Gland Biopsy in Cadavers Performed by Rheumatologists – an OMERACT Ultrasound Working Group Study
Nevsun Inanc¹, Sandrine Jousse-Joulin², Kerem Abacar³, Leyla Cinel⁴, Maria D’Agostino⁵, Esperanza Naredo⁶, Alojzija Hocevar⁷, Stephanie Finzel⁸, Lene Terslev⁹, Annamaria Iagnocco¹⁰, Petra Hanova¹¹, Wolfgang Schmidt¹², Gonca Mumcu¹³, Ümit S. Şehirli¹⁴ and George A. Bruyn¹⁵, ¹Marmara University, School of Medicine, Division of Rheumatology, istanbul, Turkey, ²Rheumatology Department, Cavale Blanche Hospital and Brest Occidentale University, Brest, France, ³Marmara University, School of Medicine, Division of Rheumatology, Istanbul, Turkey, ⁴Marmara University, School of Medicine, Division of Pathology, Istanbul, Turkey, ⁵Université Versailles Saint Quentin, Ambroise Paré Hospital, Paris, France, ⁶Department of Rheumatology, Joint and Bone Research Unit. Hospital Universitario Fundación Jiménez Díaz, IIS Fundación Jiménez Díaz and Universidad Autónoma de Madrid, Madrid, Spain, ⁷University Medical Center, Rheumatology, Ljubljana, LJUBLJANA, Slovenia, ⁸Universitätsklinikum Freiburg, Klinik für Rheumatologie und Klinische Immunologie, Freiburg, Germany, ⁹Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, Glostrup., Copenhagen, Denmark, ¹⁰Università degli Studi di Torino, Academic Rheumatology Centre, Turin, Italy, ¹¹Institute of Rheumatology, Prague, Czech Republic, Prague, Czech Republic, ¹²Immanuel Krankenhaus Berlin, Medical Center for Rheumatology Berlin-Buch, Berlin, Germany, ¹³Marmara University School of Health Sciences, Health Management, Istanbul, Istanbul, Turkey, ¹⁴Marmara University, School of Medicine, Anatomy, Istanbul, Turkey, ¹⁵Rheumatology, Reumakliniek Lelystad, Lelystad, Netherlands
Background/Purpose: With the diagnostic capability of the parotid gland biopsy similar to minor salivary gland biopsy in Sjögren’s syndrome, the parotid gland biopsy may also…
Abstract Number: 1253 • ACR Convergence 2020
Re-evaluation of the Extent of Lymphocytic Infiltration May Improve the Diagnostic Accuracy of Lip Biopsy in Primary Sjögren’s Syndrome (pSS)
Chiara Baldini¹, Francesco Ferro¹, Gianmaria Governato¹, Giovanni Fulvio², Elena Elefante³, Marta Mosca¹, Stefano Bombardieri¹ and Valentina Donati⁴, ¹Rheumatology Unit, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy, ²Rheumatology Unit, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, ³Rheumatology Unit, Department of Clinical and Experimental Medicine, University of Pisa; Department of Medical Biotechnology, University of Siena, Pisa, Italy, ⁴Pathology Unit, AOUP, Pisa
Background/Purpose: Focus score (FS) remains the key element for the histological diagnosis of pSS; nonetheless, additional parameters have been proposed for clinical trials including the…
Abstract Number: 1254 • ACR Convergence 2020
Lack of Efficacy of Early Treatment with Hydroxychloroquine in a Group of Hispanics with Primary Sjögren’s Syndrome
Ariana González-Meléndez¹, Patricia Jordán-González¹, Ricardo Gago-Piñero¹, Noemí Varela-Rosario¹, Naydi Pérez-Ríos¹ and Luis Vilá¹, ¹University of Puerto Rico Medical Sciences Campus, San Juan, Puerto Rico
Background/Purpose: Treatment of primary Sjögren’s syndrome (pSS) with hydroxychloroquine (HCQ) has been evaluated in the past but with conflicting results regarding its efficacy. While earlier…
Abstract Number: 1255 • ACR Convergence 2020
Sjӧgren’s Syndrome Minor Salivary Gland Mesenchymal Stromal Cells Derived Deploy Intact Immune Plasticity and Display Myofibroblast-Like Properties
Sara McCoy¹, Jayeeta Giri¹, Rahul Das¹, Pradyut Paul¹, Andrea Pennati¹, Maxwell Parker¹, Yun Liang¹ and Jacques Galipeau¹, ¹University of Wisconsin, Madison
Background/Purpose: Primary Sjӧgren’s syndrome (pSS) is the second most common systemic autoimmune disease with hallmark features of severe ocular and oral sicca, leading to reduced…
Abstract Number: 1256 • ACR Convergence 2020
Mast Cells Contribute to the Development of Sialadenitis Associated with Sjögren’s Syndrome via Inducing Tissue Fibrosis by TGFβ Production
Shinjiro Kaieda¹, Kyoko Fujimoto¹ and Hiroaki Ida¹, ¹Kurume University School of Medicine, Kurume, Japan
Background/Purpose: Mast cells have been implicated in many immune-inflammatory disorders. They mediate a variety of inflammatory and fibrotic conditions, but their role in sialadenitis in…
Abstract Number: 1257 • ACR Convergence 2020
Gestational Diabetes Mellitus in Pregnant Women with Systemic Lupus Erythematosus
Sofia Gernaat¹, Julia Simard², Elisabet Svenungsson³ and Elizabeth Arkema⁴, ¹Karolinska Institutet, Stockholm, Stockholms Lan, Sweden, ²Stanford Medicine, Stanford, CA, ³Karolinska University Hospital, Stockholm, Sweden, ⁴Karolinska Institutet, Stockholm, Sweden
Background/Purpose: Increased insulin resistance is pivotal in the development of gestational diabetes mellitus (GDM). Women with SLE may be at higher risk of GDM due…
Abstract Number: 1258 • ACR Convergence 2020
Trajectory of Damage Accrual in African-American vs. Caucasian Systemic Lupus Erythematosus
Romy Kallas¹, Jessica Li², Daniel Goldman³ and Michelle Petri³, ¹Johns Hopkins Medical Institution, Baltimore, MD, ²Johns Hopkins University, Baltimore, MD, ³Johns Hopkins University School of Medicine, Timonium, MD
Background/Purpose: African-Americans have a higher incidence/prevalence of SLE, more lupus nephritis, higher rates of end stage renal disease and higher mortality than Caucasians. The aim…
Abstract Number: 1259 • ACR Convergence 2020
The Impact of Antimalarial Agents on Traditional and Non-traditional Cardiovascular Markers in Patients with Systemic Lupus Erythematosus: A Systematic Review and Meta-analysis
Claudia Mendoza-Pinto¹, Mario Garcia-Carrasco¹, Pamela Munguía-Realpozo², Ivet Etchegaray-Morales² and Socorro Mendez-Martínez¹, ¹Instituto Mexicano del Seguro Social, Puebla, Puebla, Mexico, ²Facultad de Medicina, Benemérita Universidad Autónoma de Puebla, Puebla, Puebla, Mexico
Background/Purpose: Cardiovascular morbidity and mortality is a well-established problem in patients with systemic lupus erythematosus (SLE). Hydroxychloroquine (HCQ) has been seen as a potential atheroprotective…
Abstract Number: 1260 • ACR Convergence 2020
Longitudinal Relationships Between Depression, Anxiety and Cognition in Lupus
Kathleen Bingham¹, Juan Pablo Diaz-Martinez², Mahta Kakvan², Robin Green³, Dorcas Beaton⁴, Lesley Ruttan³, Carmela Tartaglia⁵, Marvin Fritzler⁶, May Choi⁷, Jiandong Su², Denisse Bonilla⁸, Nicole Anderson², Joan Wither², Patricia Katz⁹ and Zahi Touma¹⁰, ¹Department of Psychiatry, University of Toronto, Toronto, ON, Canada, ²University of Toronto Lupus Clinic, Centre for Prognosis Studies in Rheumatic Diseases, Toronto Western Hospital, University Health Network, Toronto, ON, Canada, ³Toronto Rehabilitation Institute, University Health Network, Toronto, ON, Canada, ⁴Institute for Work & Health, Toronto, ON, Canada, ⁵University of Toronto, Krembil Neurosciences Centre, Toronto, ON, Canada, ⁶Department of Medicine, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada, ⁷Brigham and Women's Hospital | Cumming School of Medicine, University of Calgary, Calgary, AB, Canada, ⁸University Health Network, Toronto, Canada, ⁹University of California, San Francisco, Novato, CA, ¹⁰University of Toronto, Toronto, ON, Canada
Background/Purpose: There is a consistent relationship between cognition and depression and anxiety (affective symptoms) in lupus. Together, affective and cognitive symptoms represent among lupus’ most…
Abstract Number: 1261 • ACR Convergence 2020
Antiphospholipid Patterns Predict the Risk of Thrombosis in Systemic Lupus Erythematosus
Selcan Demir¹, Jessica Li², Laurence Magder³ and Michelle Petri⁴, ¹Hacettepe University Faculty of Medicine, Ankara, Ankara, Turkey, ²Johns Hopkins University, Baltimore, MD, ³University of Maryland, Baltimore, Baltimore, MD, ⁴Johns Hopkins University School of Medicine, Timonium, MD
Background/Purpose: Antiphospholipid syndrome (APS) has been classified as the development of venous and/or arterial thromboses, and/or pregnancy morbidity, in the presence of persistently raised levels…
Abstract Number: 1262 • ACR Convergence 2020
Single LAC Positivity versus Double and Triple Positivity for Thrombosis in SLE
Selcan Demir¹, Jessica Li², Laurence Magder³ and Michelle Petri⁴, ¹Hacettepe University Faculty of Medicine, Ankara, Ankara, Turkey, ²Johns Hopkins University, Baltimore, MD, ³University of Maryland, Baltimore, Baltimore, MD, ⁴Johns Hopkins University School of Medicine, Timonium, MD
Background/Purpose:Antiphospholipid syndrome (APS) is classified as the development of venous and/or arterial thromboses, and pregnancy morbidity, in the presence of antiphospholipid antibodies (aPL); lupus anticoagulant,…
Abstract Number: 1263 • ACR Convergence 2020
Association of the Systemic Lupus International Collaborating Clinics Frailty Index (SLICC-FI) and Damage Accrual in Long Standing Systemic Lupus Erythematosus
Kaitlin Lima¹, Alexandra Legge², John Hanly², Jungwha Lee³, Jing Song³, Anh Chung³ and Rosalind Ramsey-Goldman⁴, ¹Northwestern University, Chicago, IL, ²Dalhousie University, Halifax, NS, Canada, ³Northwestern University, Chicago, ⁴Division of Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL
Background/Purpose: The Systemic Lupus International Collaborating Clinics Frailty Index (SLICC-FI) was recently shown to predict mortality and damage accrual in the SLICC inception cohort. The…
Abstract Number: 1264 • ACR Convergence 2020
Mortality in Patients with Systemic Lupus Erythematosus and Neuropsychiatric Symptoms
Rory Monahan¹, Rolf Fronczek¹, Jeroen Eikenboom¹, Huub Middelkoop¹, Liesbeth Beaart-van de Voorde¹, Gisela Terwindt¹, Nic van der Wee¹, Frits Rosendaal¹, Thomas Huizinga¹, Margreet Kloppenburg¹ and Margreet Steup-Beekman¹, ¹Leiden University Medical Center, Leiden, Netherlands
Background/Purpose: Little is known about mortality in patients with systemic lupus erythematosus (SLE) presenting with neuropsychiatric (NP) symptoms. We aimed to evaluate all-cause and cause-specific…

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