Abstracts Archive - Page 554 of 2425 - ACR Meeting Abstracts

Abstract Number: 0024 • ACR Convergence 2021
Heterogeneity of Inflammatory HLA-DR+ Synovial Fibroblasts in Rheumatoid Arthritis Is Driven by Responses to Leukocyte-Derived Cytokines
Melanie Smith¹, Alejandro Kochen¹, Vianne Gao², Michail Schizas², Edward DiCarlo¹, Susan Goodman¹, Christina Leslie³, Laura Donlin¹ and Alexander Rudensky⁴, ¹Hospital for Special Surgery, New York, NY, ²Memorial Sloan Kettering Cancer Center, New York, NY, ³Computational and Systems Biology Program Memorial Sloan Kettering Cancer Center, New York, NY, ⁴Memorial Sloan Kettering Cancer Center / Howard Hughes Medical Institute, New York, NY
Background/Purpose: Treatment-refractory rheumatoid arthritis (RA) represents a major unmet need with substantial societal burden. Targeting RA-associated fibroblast-like synoviocytes (FLS) may provide a less-immunosuppressive therapeutic option.…
Abstract Number: 0023 • ACR Convergence 2021
Investigating Temporal Changes in Pregnancy Among Women with Rheumatoid Arthritis and Healthy Women Using Co-expression Network Analysis
Matthew Wright¹, Dana Goin², Mette Smed³, J Lee Nelson⁴, Nicholas Jewell⁵, Jorn Olsen⁶, Merete Hetland⁷, Vibeke Zoffmann³ and Damini Jawaheer⁸, ¹UCSF Benioff Children's Hospital Oakland, Oakland, CA, ²University of California San Francisco, San Francisco, CA, ³Juliane Marie Center, Rigshospitalet, Copenhagen, Denmark, ⁴Fred Hutchinson Cancer Research Center, University of Washington, Seattle, WA, ⁵University of California Berkeley, Berkeley, CA, ⁶Aarhus University Hospital, Aarhus, Denmark, ⁷DANBIO and COPECARE, Centre for Rheumatology and Spine Diseases, Rigshospitalet, Glostrup, Denmark, ⁸UCSF Benioff Children's Hospital Oakland / University of California San Francisco, Oakland, CA
Background/Purpose: Rheumatoid arthritis (RA), while still an incurable disease, can often improve naturally during pregnancy. The specific mechanism(s) underlying this pregnancy-induced improvement, however, are not…
Abstract Number: 0026 • ACR Convergence 2021
Synovial Fibroblasts Acquire a Proinflammatory and Destructive Phenotype After Exposure to αS1-Casein (CSN1S1)
Nadine Honke¹, Tim Appel¹, Matthias Schneider² and Georg Pongratz³, ¹Department of Rheumatology, Hiller Research Center Rheumatology, University Hospital Düsseldorf, Germany (* contributed equally), Düsseldorf, Germany, ²Policlinic & Hiller Research Unit Rheumatology, UKD, Heinrich-Heine University, Düsseldorf, Germany, ³Polyclinic and Functional Area for Rheumatology & Hiller Research Center Rheumatology, University Hospital Düsseldorf, Düsseldorf, Germany
Background/Purpose: The milk protein αS1-Casein (CSN1S1) was described to be overexpressed in synovial tissue of patients with rheumatoid arthritis (RA) and osteoarthritis (OA). Recently we…
Abstract Number: 0029 • ACR Convergence 2021
JAK1 Regulates Autophagy and Reinforces the Inflammatory and Autoimmune Potentials in Rheumatoid Arthritis Synovial Fibroblasts
Keita Ninagawa¹, Masaru Kato¹, Yuki Kudo², Masaru Yoshimura², Michihito Kono², Yuichiro Fujieda¹, Kenji Oku² and Tatsuya Atsumi³, ¹Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan, ²1. Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan, ³Hokkaido University, Sapporo, Japan
Background/Purpose: Rheumatoid arthritis (RA) is pathologically characterized by autoimmunity against citrullinated proteins, proliferative synovitis, and ultimately joint destruction. Synovial fibroblasts (SFs) are, when activated, capable…
Abstract Number: 0028 • ACR Convergence 2021
Evolution of Anti-modified Protein Antibody Responses Can Be Driven by Consecutive Exposure to Different Post-translational Modifications
Mikhail Volkov, Arieke Kampstra, Karin van Schie, Tom WJ Huizinga, René Toes and Diane van der Woude, Leiden University Medical Center, Leiden, Netherlands
Background/Purpose: Besides anti-citrullinated protein antibodies (ACPA), rheumatoid arthritis patients (RA) often display autoantibody reactivities against other post-translationally modified (PTM) proteins, more specifically carbamylated and acetylated…
Abstract Number: 0027 • ACR Convergence 2021
Metabolomic Study of Rheumatoid Arthritis Using 1H Nuclear Magnetic Resonance (1H NMR)
Konstantina Tsezou, Dimitra Benaki, Katerina iliou, Emmanuel Mikros and Panayiotis Vlachoyiannopoulos, National and Kapodistrian University of Athens, Athens, Greece
Background/Purpose: Rheumatoid arthritis (RA) remains a disease with high morbidity. Biologic agents revolutionized the therapy of RA, but they are withdrawn in 50% of patients…
Abstract Number: 0022 • ACR Convergence 2021
The Effects of MAA-Modified and/or Citrullinated Proteins on Calcium Influx and Peptidyl Arginine Deiminase (PAD) Expression in Macrophage
Andrew Gerber, Michael Duryee, Nozima Aripova, Bryant England, James O'Dell, Ted Mikuls and Geoffrey Thiele, University of Nebraska Medical Center, Omaha, NE
Background/Purpose: Expressed in synovial fluid mononuclear and other inflammatory cells, peptidyl arginine deiminase (PAD) catalyzes post-translational citrullination of synovial proteins in a calcium (Ca2+)-dependent manner.…
Abstract Number: 0033 • ACR Convergence 2021
Impaired Adipose Tissue Function in Rheumatoid Arthritis: Association with Autoimmunity, Disease Activity and Therapeutic Response
Iván Arias de la Rosa¹, alejandro Escudero², Cristobal Román-Rodriguez², Rocio Guzmán-Ruiz², Maria del Mar Malagón², Carlos Pérez-Sánchez³, Chamaida Plasencia-Rodríguez⁴, Ana Martinez-Feito⁵, Maria del Carmen Ábalos-Aguilera², Alejandra Patiño-Trives⁶, Jerusalem Calvo², Rafaela Ortega², Eduardo Collantes-Estevez², Chary Lopez-Pedrera² and Nuria Barbarroja¹, ¹University of Cordoba/IMIBIC/Reina Sofia Hospital, Cordoba, Spain, ²IMIBIC/Reina Sofia Hospital/University of Córdoba, Córdoba, Spain, ³IMIBIC, Córdoba, Spain, ⁴Immuno-Rheumatology Research Group, Hospital La Paz Institute for Health Research-IdiPAZ, Rheumatology, La Paz University Hospital, Madrid, Spain, ⁵ImmunoRheumatology Department, IDIPAZ, Madrid, Spain, ⁶Rheumatology Department, Reina Sofia University Hospital/ Maimonides Institute for Research in Biomedicine of Cordoba (IMIBIC)/ University of Cordoba, Cordoba, Spain
Background/Purpose: 1) to evaluate the relationship among adipose tissue dysfunction, autoimmunity and disease activity in rheumatoid arthritis (RA) patients; 2) to analyze the direct effect…
Abstract Number: 0032 • ACR Convergence 2021
IL-40: A New B-cell Associated Cytokine Up-regulated in Rheumatoid Arthritis Decreases Following the Rituximab Therapy and Correlates with Disease Activity, Autoantibodies and NETosis
Adela Navratilova¹, Lucie Andrés Cerezo¹, Hana Hulejová², Viktor Bečvář², Michal Tomcik³, Dana Tegzova², Martina Olejárová¹, David Veigl⁴, Karel Pavelka³, Jiri Vencovsky² and Ladislav Senolt³, ¹Institute of Rheumatology and Department of Rheumatology, First Faculty of Medicine, Charles University, Prague, Czech Republic, ²Institute of Rheumatology, Prague, Czech Republic, ³Institute of Rheumatology, Department of Rheumatology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic, ⁴First Orthopaedic Clinic, 1st Faculty of Medicine, Charles University, Prague, Czech Republic, Prague, Czech Republic
Background/Purpose: Interleukin 40 (IL-40) is recently identified B cell - associated cytokine implicated in humoral immune responses and in B cell development and homeostasis. As…
Abstract Number: 0030 • ACR Convergence 2021
Interleukin-9 Enhances the Osteoclastogenesis in Rheumatoid Arthritis
Santanu Kar¹, Dipendra Mitra², Vijay Kumar D¹ and Sushmita Chakraborty¹, ¹AIIMS, New Delhi, India, ²ALL INDIAN INSTITUTE OF MEDICAL SCIENCES, New Delhi, India
Background/Purpose: Rheumatoid Arthritis (RA) is a chronic inflammatory disease characterized by synovial inflammation leading to bone destruction. Bone erosion in RA results from excessive resorption…
Abstract Number: 0034 • ACR Convergence 2021
Immune Complexes Contain Novel Acetylated Antigens in the Synovial Fluid of RA Patients
Khetam Ghannam¹, Holger Bang², Thomas Häupl¹, Eugen Feist³ and Gerd Burmester⁴, ¹Charite University Medicine Berlin, Berlin, Germany, ²Orgentec Diagnostika GmbH, Mainz, Germany, Mainz, Germany, ³Helios Department of Rheumatology, Vogelsang-Gommern, Germany, ⁴Charité University Medicine Berlin, Berlin, Germany
Background/Purpose: Rheumatoid arthritis (RA) is an autoimmune disease characterized by genetic predisposition and associated immunological features including the production of autoantibodies against various epitopes. Several…
Abstract Number: 0036 • ACR Convergence 2021
The NAD+ Metabolism Is Altered in Rheumatoid Arthritis and Its Modulation with NAD+ Boosters Exhibits Key Anti-Inflammatory and Anti-Oxidant Effects
Carlos Pérez-Sánchez¹, Luz Marina Sanchez-Mendoza², Nuria Barbarroja³, M.Carmen Abalos-Aguilera⁴, Maria Luque-Tevar⁵, Alejandra Patiño-Trives⁵, Iván Arias de la Rosa³, Cristobal Román-Rodriguez⁶, Juan Antonio Moreno², Maria Isabel Buron², Jose Antonio Gonzalez-Reyes², Marta Rojas-Gimenez⁴, Eduardo Collantes-Estevez⁶, alejandro Escudero⁶, Jose Manuel Villalba² and Chary lopez-pedrera⁶, ¹IMIBIC, Córdoba, Spain, ²Department of Cell Biology, Physiology and Immunology, University of Córdoba, Campus de Excelencia Internacional Agroalimentario, ceiA3, Cordoba, Spain, ³University of Cordoba/IMIBIC/Reina Sofia Hospital, Cordoba, Spain, ⁴Rheumatology service, IMIBIC/Reina Sofia Hospital/University of Córdoba, Cordoba, Spain, ⁵Rheumatology Department, Reina Sofia University Hospital/ Maimonides Institute for Research in Biomedicine of Cordoba (IMIBIC)/ University of Cordoba, Cordoba, Spain, ⁶IMIBIC/Reina Sofia Hospital/University of Córdoba, Córdoba, Spain
Background/Purpose: NAD+ is a key cofactor and second messenger for multiple cellular processes that exhibits antioxidant, anti-apoptotic, and anti-inflammatory properties. Numerous publications and clinical trials…
Abstract Number: 0035 • ACR Convergence 2021
Bromodomain Protein-regulated Stress Response in Rheumatoid Arthritis Synovial Fibroblasts
Tanja Seifritz¹, Thomas Züllig¹, Larissa Moser¹, Oliver Distler², Caroline Ospelt¹ and Kerstin Klein³, ¹Center of Experimental Rheumatology, Department of Rheumatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland, ²Center of Experimental Rheumatology, Department of Rheumatology, University Hospital Zurich/University of Zurich, Zurich, Switzerland, ³Department of Rheumatology and Immunology, University Hospital Bern, Bern, Switzerland
Background/Purpose: Hypoxia and subsequent oxidative stress are early events in the RA joint and contribute to the activation of synovial fibroblasts (SF). Small molecule inhibitors…
Abstract Number: 0031 • ACR Convergence 2021
A New Pharmacostatistical Model to Assess MTX-adherence in RA Patients
Marion Geoffroy¹, Claire Gozalo², Loic Pauvele², Elise Abboud², Zoubir Djerada³ and Jean hugues Salmon⁴, ¹CHU Reims, France, REIMS, France, ²CHU Reims, Reims, France, ³CHU Riems, Reims, France, ⁴Rheumatology, CHU Maison blanche, Reims, Reims, France
Background/Purpose: Methotrexate (MTX) is the first-line therapy for rheumatoid arthritis (RA). While therapeutic adherence is essential to the successful management of the patient, an estimated…
Abstract Number: 0025 • ACR Convergence 2021
The Modulatory Capacity of Galectin-3 on the Programmed Death-1 Signaling Axis in Rheumatoid Arthritis
Kathrine Pedersen¹, Morten Aagaard Nielsen², Malene Hvid¹, Bent Deleuran¹ and Stinne Greisen¹, ¹Aarhus University, Aarhus, Denmark, ²Aarhus University / Aarhus University Hopital, Aarhus, Denmark
Background/Purpose: Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by inflammation of the synovium. Despite a variety of treatments, 30-40% of RA patients fail…

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