ACR Meeting Abstracts

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  • Abstract Number: 0004 • ACR Convergence 2021

    Unappreciated Systemic Metabolic Functions of the Canonical B Cell Cytokines, BAFF and APRIL: Regulation of Lipolysis and Non-shivering Thermogenesis and Protection from Obesogenic Diet Induced Weight Gain

    Isaac Harley1, Calvin Chan2, Paul Pfluger3, Trompette Aurelien4, Traci Stankiewicz5, Jessica Allen5, Maria Moreno-Fernandez5, Michelle Damen5, Jarren Oates5, Pablo Alarcon5, Jessica Doll6, Matthew Flick7, Leah Flick8, Juan Sanchez-Gurmaches9, Rajib Mukherjee9, Rebekah Karns10, Michael Helmrath11, Thomas Inge12, Stuart Weisberg13, Sunje Pamp14, David Relman15, Randy Seeley16, Matthias Tschoep17, Chris Karp18 and Senad Divanovic8, 1University of Colorado Anschutz Medical Campus, Aurora, CO, 2University of Cincinnati, Cincinnati, OH, 3Technical University of Munich, Munich, Germany, 4Le Centre hospitalier universitaire vaudois, Lausanne, Switzerland, 5Cincinnati Children's Hospital Medical Center, Division of Immunobiology, Cincinnati, OH, 6Cincinnati Children's Hospital Medical Center, Division of Immunobiology, Cincinn, OH, 7Division of Experimental Hematology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, 8Division of Immunobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 9Division of Endocrinology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, 10Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, 11Pediatric General and Thoracic Surgery, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, 12Department of Surgery, Children’s Hospital Colorado, Aurora, CO, 13Columbia University Medical Center, New York, NY, USA, New York, NY, 14Danmarks Tekniske Universitet, Lyngby, Denmark, 15Department: Medicine - Med/Infectious Diseases - Stanford University, Stanford, 16Department of Surgery, Internal Medicine and Nutritional Sciences, University of Michigan, Ann Arbor, MI, 17Division of Metabolic Diseases, Technische Universität München, Munich, Germany, 18Division of Molecular Immunology, Cincinnati Children’s Hospital Medical Center, Cincinnati

    Background/Purpose: The impact of immune mediators on weight homeostasis and systemic metabolism remains underdefined. Interrogation of resistance to diet-induced obesity in mice lacking a negative…
  • Abstract Number: 0009 • ACR Convergence 2021

    Humoral Immune Responses to SARS-CoV2 Infections and upon Vaccination Against SARS-CoV2

    STEPHANIE FINZEL1, Nicole Peter2, Chiara Brand2, Beate Fischer2, Bärbel Keller2, Sebastian Weigang3, Georg Kochs3, Martin Schwemmle3, Siegbert Rieg4, Philipp Mathé4, Winfried Kern4, Lia van der Hoek5, Kathrin de la Rosa6, Hans-Martin Jäck7, Klaus Warnatz2, Reinhard Voll8 and Hermann Eibel2, 1University Clinic of Freiburg, Department of Rheumatology and Clinical Immunology, Freiburg, Germany, 2Department of Rheumatology and Clinical Immunology, Medical Faculty, University of Freiburg and Center for Chronic Immunodeficiency, Medical Center, University of Freiburg, Freiburg, Germany, 3Institute of Virology, University of Freiburg, Freiburg, Germany, 4Department of Infectiology, Medical Faculty, University of Freiburg, Freiburg, Germany, 5Laboratory of Experimental Virology, Department of Medical Microbiology, Center for Infection and Immunity Amsterdam (CINIMA), Academic Medical Center of the University of Amsterdam, Amsterdam, Netherlands, 6Max-Delbrück-Centrum für Molekulare Medizin (MDC), Berlin, Germany, 7Department of Medicine 3. Division of Immunology, Friedrich-Alexander-University Erlangen, Erlangen, Germany, 8Department of Rheumatology and Clinical Immunology, University Medical Center, Faculty of Medicine, Albert-Ludwigs-University of Freiburg, Freiburg, Germany

    Background/Purpose: We compared humoral immune responses against SARS-CoV-2 to responses against spike-antigen after vaccination.Methods: 800 health-care workers from University Medical Center Freiburg, Germany, were pursued…
  • Abstract Number: 0008 • ACR Convergence 2021

    Jo-1-Binding and Clonally-Expanded Memory B Cells Express Germline and Somatically-Mutated B Cell Receptors in Anti-tRNA Synthetase Syndrome Patients

    Erin Wilfong, Alberto Cisneros, Jennifer Young-Glazer, Scott Smith, Leslie Crofford and Rachel Bonami, Vanderbilt University Medical Center, Nashville, TN

    Background/Purpose: Anti-tRNA synthetase syndrome (ARS) is a severe systemic autoimmune disease associated with myositis, interstitial lung disease, rash, and arthritis. ARS is associated with autoantibodies…
  • Abstract Number: 0011 • ACR Convergence 2021

    Differential Inflammation-mediated Function of Prokineticin 2 in the Synovial Fibroblasts of Patients with Rheumatoid Arthritis Compared to Osteoarthritis

    Kentaro Noda, Bianca Dufner and Rainer Straub, Laboratory of Experimental Rheumatology and Neuroendocrine Immunology, Department of Internal Medicine I, University Hospital Regensburg, Regensburg, Germany

    Background/Purpose: Prokineticin 2 (PK2) is a secreted protein involved in several pathological and physiological processes, including the regulation of inflammation, sickness behaviors, and the circadian…
  • Abstract Number: 0014 • ACR Convergence 2021

    Low Baseline Expression of Pyruvate Kinase and Succinate Dehydrogenase Genes in the Peripheral Blood of Rheumatoid Arthritis Patients Treated with Tofacitinib Is Associated with Clinical Remission at the End of Follow-up

    Elena Tchetina1, Azamat Satybaldyev2, Galina Markova1 and Alexander Lila2, 1Nasonova Research Institute of Rheumatology, Moscow, Russia, 2V.A. Nasonova Reseach Institute of Rheumatology, Moscow, Russia

    Background/Purpose: Rheumatoid arthritis (RA) is an autoimmune disease of unknown etiology, which is characterized by erosive arthritis and systemic inflammation. Tofacitinib (TFCN) is a Janus…
  • Abstract Number: 0013 • ACR Convergence 2021

    Cyclin Dependent Kinase 4 and 6 Determine the Cytokine Responsiveness by Stabilizing JUN in Rheumatoid Arthritis Synovial Fibroblasts

    Tadashi Hosoya1, Tetsuya Saito2, Hiroyuki Baba2, Nao Tanaka2, Seiji Noda2, Yoji Komiya2, Yasuhiro tagawa2, Akio Yamamoto2 and Shinsuke Yasuda2, 1Tokyo Medical and Dental University(TMDU), Tokyo, Japan, 2Tokyo Medical and Dental University (TMDU), Tokyo, Japan

    Background/Purpose: Although current inflammation-targeted therapy improved the outcome of patients with rheumatoid arthritis (RA), the achievement of complete disease remission was still challenging. Since synovial…
  • Abstract Number: 0012 • ACR Convergence 2021

    A Novel Mechanism Linking Mucosal Bacteria with Autoantibody Responses in RA: Acetylated Bacterial Lysate as a Model Antigen

    Mikhail Volkov, Arieke Kampstra, Karin van Schie, Joanneke Kwekkeboom, Tom WJ Huizinga, René Toes and Diane van der Woude, Leiden University Medical Center, Leiden, Netherlands

    Background/Purpose: Rheumatoid arthritis (RA) is characterized by autoantibodies against post-translationally modified proteins (AMPA) such as citrullinated, carbamylated and acetylated proteins. Importantly, these antibodies are highly…
  • Abstract Number: 0007 • ACR Convergence 2021

    Divergent Reactivities of Rheumatoid Factors and Anti-Modified Protein Antibodies Converge on IgG Epitopes

    Aisha Mergaert1, Zihao Zheng1, Michael Denny1, Maya Amjadi1, Janna Bashar1, Michael Newton1, Vivianne Malmström2, Caroline Grönwall2, Sara McCoy1 and Miriam Shelef1, 1University of Wisconsin, Madison, WI, 2Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden

    Background/Purpose: Rheumatoid arthritis (RA) patients often develop rheumatoid factors (RFs), antibodies that bind IgG Fc, and anti-modified protein antibodies (AMPAs), multi-reactive autoantibodies that commonly bind…
  • Abstract Number: 0018 • ACR Convergence 2021

    Caspase-8 Variant G Regulates Rheumatoid Arthritis Fibroblast-Like Synoviocyte Aggressive Behavior

    Cecilia Ansalone1, Gyrid Nygaard1, Richard Ainsworth1, Rizi Ai1, Deepa Hammaker1, Narayanan Perumal2, Ken Weichert2, Frances Tung2, Lalitha Kodandapani2, Michael Sauder2, Elisabeth Mertsching2, Robert Benschop3, Wei Wang1, David Boyle1 and Gary Firestein1, 1University of California San Diego, San Diego, CA, 2Eli Lilly and Company, San Diego, CA, 3Eli Lilly and Company, Indianapolis, IN

    Background/Purpose: Rheumatoid arthritis (RA) fibroblast-like synoviocytes (FLS) display an aggressive phenotype, including abnormal migration and invasion. Using data from our previous studies defining the epigenetic…
  • Abstract Number: 0017 • ACR Convergence 2021

    Lessons Learnt from Associations Between Anti-modified Protein Antibodies and Risk Factors: Human Leukocyte Antigen – Shared Epitope Alleles Solely Associate with Anti-citrullinated Protein Antibodies

    Tineke J van wesemael, Annemarie L. Dorjee, Tom WJ Huizinga, Annette H.M van der Helm-van Mil, René Toes and Diane van der Woude, Leiden University Medical Center, Leiden, Netherlands

    Background/Purpose: Rheumatoid arthritis (RA) is characterized by the presence of auto-antibodies to post translationally modified proteins (anti-modified protein antibodies (AMPA)): anti-citrullinated protein antibodies (ACPA), anti-carbamylated…
  • Abstract Number: 0015 • ACR Convergence 2021

    Rheumatoid Factor Recognizes Specific Domains of IgG Heavy Chain Complexed with HLA Class II Molecules

    Shanshan Zhang1, Hideaki Tsuji1, Hui Jin2, Koji Kitagori1, Shuji Akizuki3, Kosaku Murakami1, Ran Nakashima1, Hajime Yoshifuji1, Masao Tanaka1, Hisashi Arase2, Koichiro Ohmura4 and Akio Morinobu1, 1Kyoto University, Kyoto, Japan, 2Osaka University, Osaka, Japan, 3Kyoto Universtiy, Kyoto City, Japan, 4Kobe City Medical Center General Hospital, Kobe, Japan

    Background/Purpose: Rheumatoid factor (RF) is an autoantibody that binds to IgG Fc region (CH2 and CH3 domains) and is detectable in patients with rheumatoid arthritis…
  • Abstract Number: 0019 • ACR Convergence 2021

    Increased Circulating CD39+FoxP3+CD4+ Treg Cells in Early Rheumatoid Arthritis Facilitate the Antiinflammatory Action of Methotrexate

    Laura Nuño1, Alejandro Villalba1, Marta Novella-Navarro2, Irene Monjo1, Diana Peitado1, Sara Garcia-Carazo1, Alejandro Balsa2 and Maria-Eugenia Miranda-Carus1, 1Hospital La Paz - IdiPAZ, Madrid, Spain, 2Immuno-Rheumatology Research Group, Hospital La Paz Institute for Health Research-IdiPAZ, Rheumatology, La Paz University Hospital, Madrid, Spain

    Background/Purpose: Inhibition of AICAR transformylase by MTX results in augmented release of adenine nucleotides to the extracellular space; these are rapidly hydrolysed by ectonucleotidases CD39…
  • Abstract Number: 0021 • ACR Convergence 2021

    Unique Alterations in Circulating T Peripheral Helper Cells Are Found in Different Ethnic Groups of ACPA+ Individuals Both At-risk for and with Classified RA

    Hideto Takada1, Yuko Okamoto2, Yasuhiro Katsumata3, Jennifer Seifert4, Kristen Demoruelle5, Jill Norris6, Kevin Deane7, Masayoshi Harigai3 and V. Michael Holers8, 1Tokyo Women's Medical University School of Medicine, Shinjuku-ku, Japan, 2Tokyo Women's Medical University Division of Rheumatology, 10-22 Kawada-cho, Shinjyuku-ku, Tokyo, Japan, 3Tokyo Women's Medical University School of Medicine, Tokyo, Japan, 4University of Colorado School of Medicine, Littleton, CO, 5University of Colorado Anschutz Medical Campus, Aurora, CO, 6Colorado School of Public Health, Aurora, CO, 7University of Colorado Denver, Denver, CO, 8University of Colorado, Denver, CO

    Background/Purpose: Production of autoantibodies following pathogenic T and B cell interactions precede the development of RA. T follicular helper (Tfh) cells and T peripheral helper…
  • Abstract Number: 0020 • ACR Convergence 2021

    Citrullination Drives the Expression of Pro-fibrotic Genes in Rheumatoid Arthritis Fibroblast-like Cells

    Peter Maloley, Evan Ryan, Nozima Aripova, Michael Duryee, Bryant England, Ted Mikuls and Geoffrey Thiele, University of Nebraska Medical Center, Omaha, NE

    Background/Purpose: The pathophysiology of rheumatoid arthritis (RA) is hallmarked by joint inflammation, thickening of the pannus, and resultant joint destruction. Within the synovial tissue, citrullinated…
  • Abstract Number: 0016 • ACR Convergence 2021

    Structural and Functional Neurobiological Alterations of Salience and Sensorimotor Networks in Juvenile Idiopathic Arthritis

    Hanne van der Heijden1, Jordan Lemme2, Mariesa Cay2, Diana Sibai2, Benjamin Goodlett3, Jeffrey Lo4, Peter Nigrovic5, Margaret Chang4, Esra Meidan4, Olha Halyabar4, Melissa Hazen6, Maria Taylor4, Kacie Hoyt4, Camilo Jaimes7, Lauren Henderson3, Kirsten Ecklund7, Rudy Schreiber8, Robert Sundel4 and Jaymin Upadhyay9, 1Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children’s Hospital, Harvard Medical School, Boston, MA USA/ Faculty of Psychology and Neuroscience, Section Neuropsychology & Psychopharmacology Maastricht University, Maastricht, The Netherlands/ Faculty of Science, Biomedical Sciences Neurobiology, University of Amsterdam, Amsterdam, The Netherlands, Sittard, Netherlands, 2Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children’s Hospital, Harvard Medical School, Boston, MA USA, Boston, MA, 3Division of Genetics and Genomics, Boston Children’s Hospital, Harvard Medical School, Boston, MA, 4Division of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, MA, 5Boston Children's Hospital, Brookline, MA, 6Boston Children's Hospital, Boston, MA, 7Department of Radiology, Boston Children’s Hospital, Harvard Medical School, Boston, 8Faculty of Psychology and Neuroscience, Section Neuropsychology & Psychopharmacology Maastricht University, Maastricht, The Netherlands., Maastricht, Netherlands, 9Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children’s Hospital, Harvard Medical School, Boston, MA USA/ Department of Psychiatry, McLean Hospital, Harvard Medical School, Belmont, MA USA, Boston, MA

    Background/Purpose: Juvenile Idiopathic Arthritis (JIA) is a common childhood illness, characterized by inflammation of the joint, chronic pain and decreased physical functioning. To date, the…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

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