ACR Meeting Abstracts

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  • Abstract Number: 032 • 2026 Pediatric Rheumatology Symposium

    Methotrexate Response in Systemic JIA: Real-World Evidence from a Tertiary-Care Cohort

    Malavika Mittal1, Neha Rajpal2, manjari Agarwal3 and sujata Sawhney4, 1Sir Ganga Ram Hospital, DELHI, Delhi, India, 2Sir Ganga Ram Hospital, India, 3Sir Ganga Ram Hospital, NEW DELHI, Delhi, India, 4Sir Ganga Ram Hospital, Sector 37 noida, Uttar Pradesh, India

    Background/Purpose: Systemic juvenile idiopathic arthritis (SJIA) shows heterogeneous disease trajectories, and the subset of patients who achieve remission with methotrexate (MTX) monotherapy is not well…
  • Abstract Number: 003 • 2026 Pediatric Rheumatology Symposium

    Dysregulated Macrophage–Fibroblast Crosstalk Identified by Single-Cell RNA-seq in Juvenile Systemic Scleroderma Skin

    Aneri Shethji1, Theresa Hutchins1, Anwesha Sanyal1 and Kathryn Torok2, 1UPMC Childrens Hospital of Pittsburgh, 2University of Pittsburgh, Pittsburgh, PA

    Background/Purpose: Juvenile systemic scleroderma (jSSc) is a rare autoimmune disease characterized by progressive fibrosis and vascular dysfunction. Although jSSc shares important clinical features with adult…
  • Abstract Number: 026 • 2026 Pediatric Rheumatology Symposium

    Treatment strategies for articular flares in JIA patients receiving biologic therapy

    Jonatan zalcman, Yoel Levinsky, Liora Harel, Ruth Livny and gil amarilyo, Schneider Children's medical center of Israel

    Background/Purpose: Biologic agents form the cornerstone of therapy for Juvenile Idiopathic Arthritis (JIA); however, the optimal management of flares that occur during ongoing treatment remains…
  • Abstract Number: 055 • 2026 Pediatric Rheumatology Symposium

    Referrals Leading to Rheumatologic Diagnosis in a Pediatric Rheumatology Center: Influence of Referring Provider Practice and Training

    Amira Elfergani1, Ritika Patel2, Elizabeth Hussar1, Freddy Murgida1, Alexandra Sutherland3 and Barbara Ostrov4, 1Albany Medical Center, 2Albany Medical College, Albany, NY, 3Albany Medical College, 4Albany Medical College, Slingerlands, NY

    Background/Purpose: Recently, there has been a dramatic increase in referrals made to pediatric rheumatologists (PR) for non-specific symptoms and test results rather than overt signs…
  • Abstract Number: 015 • 2026 Pediatric Rheumatology Symposium

    Obinutuzumab Induces Histologic Remission And Deep Kidney Parenchymal B-Cell Depletion In Patients With Lupus Nephritis: Exploratory Analyses From The REGENCY Trial

    Brad H. Rovin1, Elsa Martins2, Cary D. Austin3, Harini Raghu3, Caleb Chan3, Patrick S. Chang3, Jay P. Garg3, Valeria Alberton4, Mittermayer B. Santiago5, Gustavo Aroca-Martínez6, Fedra I. Palazuelos7, Teresa Baczkowska8, Jose Alfaro9, Jorge Ravelo-Hernandez10, Richard A. Furie11, Luis F. Pinto12, Eduardo H. Albeiro13, Christopher Larsen14, Bongin Yoo3, Jennifer Pulley15, Andrew Thorley3, Thomas Schindler16, Theodore A. Omachi3, William F. Pendergraft3, Betty Loflin3 and Ana Malvar17, 1The Ohio State University, Columbus, OH, 2F. Hoffmann-La Roche Ltd, Basel-Landschaft, Switzerland, 3Genentech, Inc., CA, 4Pathology Unit, Fernández Hospital, Buenos Aires, Argentina, 5Bahiana School of Medicine and Public Health and UFBA, Federal University of Bahia, and Clínica SER da Bahia, Bahia, Brazil, 6Universidad Simón Bolívar y Clínica de la Costa, Barranquilla, Colombia, 7Centro de Investigación y Tratamiento Reumatológico S.C, Distrito Federal, Mexico, 8Department of Transplantation Medicine, Nephrology and Inernal Medicine, Medical University of Warsaw, Poland, 9Instituto Peruano del Hueso y la Articulación, Lima, Peru, 10Clínica San Juan Bautista, Unidad de Investigación en Reumatología e Inmunología, Lima, Peru, 11Division of Rheumatology, Northwell Health, NY, 12Internal Medicine and Rheumatology, Hospital Pablo Tobón Uribe, Colombia, 13Sanatorio Allende, Cordoba, Argentina, 14Arkana Laboratories, Little Rock, AR, 15Roche Products Ltd, Welwyn Garden City, England, United Kingdom, 16F. Hoffmann-La Roche Ltd, Basel, Basel-Landschaft, Switzerland, 17Organización Médica de Investigación, Buenos Aires, Argentina

    Background/Purpose: The REGENCY trial (NCT04221477) demonstrated superiority of obinutuzumab (OBI) plus standard therapy (+ST) vs placebo (PBO) +ST in achieving complete renal response (CRR) at…
  • Abstract Number: 016 • 2026 Pediatric Rheumatology Symposium

    Still’s Disease Associated Lung Disease: Experience from a Tertiary Italian Centre

    Claudia Bracaglia1, Manuela Pardeo2, Matteo Trevisan2, Arianna De Matteis2, Ivan Caiello3, Giusi Prencipe3 and Fabrizio De Benedetti4, 1Division of Rheumatology Ospedale Pediatrico Bambino Gesu' IRCCS, Roma, Italy, Rome, Rome, Italy, 2Division of Rheumatology, Ospedale Pediatrico Bambino Gesù IRCCS, Roma, Italy, Rome, Lazio, Italy, 3Laboratory of Immuno-Rheumatology, Ospedale Pediatrico Bambino Gesù IRCCS, Roma, Italy, Rome, Lazio, Italy, 4Bambino Gesu Children's Hospital, Rome, Rome, Italy

    Background/Purpose: Still’s Disease (SD)-associated lung disease (SD-LD) is a severe potentially life-threatening condition characterized by peculiar features. For the rarity of this condition, the experience…
  • Abstract Number: 005 • 2026 Pediatric Rheumatology Symposium

    Magnetic Resonance Enterography Detected Sacroiliitis in Pediatric Crohn’s Disease: A Retrospective Cohort Study

    Aaisham Ali1, Vishal Kalia2, Ian Ross2, Luke Daichendt3, Julia Sawicka4, Michael R Miller5, Sarah Wells6, Eileen Crowley6 and Roberta A Berard7, 1Schulich School of Medicine & Dentistry, Pediatrics, London Health Sciences Centre, London, ON, Canada, 2Department of Medical Imaging, Western University, 3Schulich School of Medicine & Dentistry, Western University, 4Western University, 5Department of Pediatrics, Children's Hospital, London Health Sciences Centre, 6London Children's Hospital, ON, Canada, 7London Health Sciences Centre, London, ON, Canada

    Background/Purpose: Musculoskeletal (MSK) manifestations are amongst the most common extraintestinal manifestations (EIMs) in pediatric Crohn’s disease (CD). MSK EIMs contribute to reduced quality of life…
  • Abstract Number: 067 • 2026 Pediatric Rheumatology Symposium

    Standardizing Effective Education and Intervention for Chronic Non-Inflammatory Pain in Children with Juvenile Idiopathic Arthritis: A Quality Improvement Initiative

    Rina Ferguson1, Leonida Radford2, Erik Friedrichsen3, See Wan Tham4, Esi Morgan5 and Natalie Rosenwasser6, 1Seattle Children's Hopsital, 2University of Washington School of Medicine, 3Seattle Children's Hospital, 4Department of Anesthesiology and Pain Medicine at the University of Washington School of Medicine and Seattle Children’s Hospital; Center for Child Health Behavior and Development at Seattle Children's Hospital, 5Division of Pediatric Rheumatology, Seattle Children's Hospital; Center for Clinical and Translational Research, Seattle Children’s Research Institute; Department of Pediatrics, University of Washington School of Medicine, 6Division of Pediatric Rheumatology, Seattle Children's Hospital; Center for Clinical and Translational Research, Seattle Children’s Research Institute

    Background/Purpose: 5-10% of patients with juvenile idiopathic arthritis (JIA) can have chronic pain lasting >3 months despite well-controlled disease. This pain is from altered pain-related sensory pathways in the periphery and central…
  • Abstract Number: 035 • 2026 Pediatric Rheumatology Symposium

    Healthcare and Medication Utilization Before and After JIA diagnosis in Publicly Insured Children in the United States

    Melissa Mannion1, Yuyang Zhu2, Sanika Rege2, Julianne Varga2, Stephen Crystal3, Tobias Gerhard2, Carlos Rose4, Brian Strom5 and Daniel Horton6, 1University of Alabama at Birmingham, 2Rutgers Center for Pharmacoepidemiology and Treatment Science, 3Rutgers Center for Health Services Research, 4Thomas Jefferson University, 5Rutgers University, Newark, NJ, 6Rutgers Robert Wood Johnson Medical School, Rutgers Center for Pharmacoepidemiology and Treatment Science, New Brunswick, NJ

    Background/Purpose: We assessed patterns of healthcare and medication utilization in children newly diagnosed with JIA compared to matched children without JIA. We hypothesized that healthcare…
  • Abstract Number: 044 • 2026 Pediatric Rheumatology Symposium

    Efficacy of Rituximab Biosimilars in Pediatric ANCA-Associated Vasculitis

    Ryan Mitacek1, Rudolph Valentini2, Rossana Baracco2 and Basil Fathalla3, 1Central Michigan University, Detroit, MI, 2Central Michigan University, 3Children's Hospital of Michigan, Detroit, MI

    Background/Purpose: Antineutrophil cytoplasmic antibody-associated vasculitis (AAV) is a severe small vessel vasculitis. Rituximab is a monoclonal anti-CD20 antibody that is effective for induction and maintenance…
  • Abstract Number: 024 • 2026 Pediatric Rheumatology Symposium

    Therapeutic Plasma Exchange in Pediatric Autoimmune Encephalitis

    Ingrid Kattan1, PAOLA LARA HERERA2, ENRIQUE FAUGIER FUENTES3, Candy Leon, MD3, Andrea Sanchez3, VIanca De Leon3 and Enrique Juarez3, 1HOSPITAL INFANTIL DE MEXICO FEDERICO GOMEZ, Ciudad de Mxico, Mexico, 2HOSPITAL INFANTIL DE MEXICO FEDERICO GOMEZ, MEXICO CITY, Mexico, 3HOSPITAL INFANTIL DE MEXICO FEDERICO GOMEZ

    Background/Purpose: Autoimmune encephalitis (AE) is a severe neuroinflammatory disorder mediated by antibodies against neuronal receptors. Therapeutic plasma exchange (TPE) can remove autoantibodies, immune complexes, and…
  • Abstract Number: 037 • 2026 Pediatric Rheumatology Symposium

    Off-the-Shelf Anti-CD19 CAR T-cell Therapy with Reduced or No Conditioning Chemotherapy Demonstrates Efficacy and Tolerability in Systemic Lupus Erythematosus: Meaningful Activity Supports Planned Adolescent Enrollment

    Natalie Shiff1, Jennifer Medlin2, Parastoo Fazeli3, Shirley Pang4, Sheetal Desai5, Andrew BitMansour6, Claudette Bethune1, Debra Zack7, Rebecca Elstrom8, Trever Greene1, Lilly Wong1, Carol Wong1, Beatrice Ferguson1 and Vaneet Sandhu1, 1Fate Therapeutics, Inc., San Diego, CA, 2University of Nebraska Medical Center, Omaha, NE, 3University of Minnesota, ST PAUL, MN, 4Providence Medical Foundation, Fullerton, CA, 5University of California Irvine, Orange, CA, 6Fate Therapeutics, Inc., San Carlos, CA, 7Fate Therapeutics, Inc., Solana Beach, CA, 8Fate Therapeutics, Inc.

    Background/Purpose: Childhood-onset systemic lupus erythematosus (SLE) is typically more severe than adult-onset disease, with higher morbidity, organ damage, and mortality. Despite this, pediatric drug trials…
  • Abstract Number: 040 • 2026 Pediatric Rheumatology Symposium

    Antiphospholipid Antibody-Mediated Disease: Clinical Characteristics and Outcomes of Catastrophic Antiphospholipid Syndrome and Lupus Anticoagulant Hypoprothrombinemia in a Single Center Pediatric Cohort

    Rasha Elrefai1, Olivia Kwan2, Jamie Lai3, Maria Pereira1, Katie Stewart4 and Marietta DeGuzman1, 1Baylor College of Medicine, Houston, TX, 2Baylor College of Medicine; Texas Children's Hospital, 3Baylor College of Medicine, The Woodlands, TX, 4Baylor College of Medicine

    Background/Purpose: Catastrophic antiphospholipid syndrome (CAPS) and lupus anticoagulant hypoprothrombinemia syndrome (LAHPS) represent distinct yet closely related antiphospholipid antibody-driven disease entities, caused by immune-mediated dysregulation of…
  • Abstract Number: 052 • 2026 Pediatric Rheumatology Symposium

    Case Series: Treatment of Refractory Lung Disease in Systemic Juvenile Idiopathic Arthritis with Cyclophosphamide and Rituximab Combination Therapy

    William Freeman1, Randy Cron2 and Eileen Rife3, 1Zucker School of Medicine at Hofstra University, Bellerose, NY, 2University of Alabama at Birmingham, Birmingham, AL, 3University of Alabama Birmingham, Vestavia Hills, AL

    Background/Purpose: Systemic juvenile idiopathic arthritis-associated lung disease (sJIA-LD) is a rare, potentially fatal complication of sJIA, often accompanied by pulmonary hypertension (PH) and macrophage activation…
  • Abstract Number: 018 • 2026 Pediatric Rheumatology Symposium

    Abnormal Cortical Grey Matter, White Matter and Subcortical Grey Matter Morphometry is Associated with Disease Features and Quality of Life in Patients with Craniofacial Localized Scleroderma

    Diana Valdes Cabrera1, Subramanian Subramanian2, Daniel Glaser3, Elena deRosas4, Haley Havrilla5, Kathryn Torok4 and Andrea Knight6, 1The Hospital for Sick Children, Toronto, ON, Canada, 2UPMC Children’s Hospital of Pittsburgh, 3Yale University School of Medicine, New Haven, CT, 4University of Pittsburgh, Pittsburgh, PA, 5Division of Rheumatology, Department of Pediatrics, UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA, USA, Pittsburgh, PA, 6Hospital for Sick Children, Toronto, ON, Canada

    Background/Purpose: Craniofacial localized scleroderma (Cf-LS) is a rare autoimmune disorder that affects face and scalp tissues and is often diagnosed during childhood. Children with Cf-LS…
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All abstracts accepted to PRYSM are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 6:00 PM CT on March 18. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

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