Abstracts Archive - Page 2600 of 2607 - ACR Meeting Abstracts

Abstract Number: 64 • 2012 ACR/ARHP Annual Meeting
Use of Moist Snuff and the Risk of Developing Rheumatoid Arthritis; Results From the Swedish Epidemiological Investigation of Rheumatoid Arthritis Study
Lars Alfredsson¹, Lars Klareskog² and Camilla Bengtsson¹, ¹Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden, ²Department of Medicine, Rheumatology Unit, Karolinska Institute, Stockholm, Sweden
Background/Purpose: Smoking is the major known environmental risk factor for RA, and notably this risk factor is exclusively seen in ACPA-positive RA. Whether this increased…
Abstract Number: 65 • 2012 ACR/ARHP Annual Meeting
Serum Inflammatory Biomarkers Correlated Stronger with a Panel of Serum Steroid and Pituitary Hormones in a Cohort of Pre-Rheumatoid Arthritis (pre-RA) Than in Non-RA Control (CN) Subjects
Alfonse T. Masi¹, Kevin B. Elmore¹, Azeem A. Rehman¹, Jean C. Aldag¹ and Robert T. Chatterton², ¹Medicine, University of Illinois College of Medicine at Peoria, Peoria, IL, ²Obstetrics and Gynecology and Physiology, Northwestern University, Chicago, IL
Background/Purpose: Inflammatory cytokines influence steroid hormone production in tissue culture and affect serum levels and synovial fluid of active RA patients. Inflammatory biomarker and hormonal…
Abstract Number: 26 • 2012 ACR/ARHP Annual Meeting
Quantitative Analysis of Bone Damage Morphological Changes in the Citrullinated Collagen Induced Arthritis Mouse Model Using Micro CT
Anand Dusad¹, Michael J. Duryee², Dong Wang³, James R. O'Dell⁴, Ted R. Mikuls⁵, Geoffrey M. Thiele⁶ and Lynell W. Klassen⁴, ¹Rheumatology, University of Nebraska Medical Center, Omaha, NE, ²Internal Medicine Division of Rheumatology, University of Nebraska Medical Center, Omaha, NE, ³Pharmaceutical Sciences, Univ of Nebraska Medical Ctr, Omaha, NE, ⁴Dept of Internal Medicine, Univ of Nebraska Med Ctr, Omaha, NE, ⁵Omaha VA Medical Center and University of Nebraska Medical Center, Omaha, NE, ⁶Int Med/Sec of Rheum/Immun, Univ of Nebraska Med Ctr, Omaha, NE
Background/Purpose: Patients with rheumatic diseases given immunosuppressive therapy are susceptible to various types of infections, especially pulmonary infections that affect their vital prognosis. The aim…
Abstract Number: 27 • 2012 ACR/ARHP Annual Meeting
Anti-Citrullinated Protein Antibodies As an Indicator of Bone Damage in the Citrullinated Collagen Induced Arthritis Model
Anand Dusad¹, Michael J. Duryee², Dong Wang³, Carlos D. Hunter², Bartlett C. Hamilton III⁴, James R. O'Dell⁵, Ted R. Mikuls⁶, Lynell W. Klassen⁵ and Geoffrey M. Thiele⁷, ¹Rheumatology, University of Nebraska Medical Center, Omaha, NE, ²Internal Medicine Division of Rheumatology, University of Nebraska Medical Center, Omaha, NE, ³Pharmaceutical Sciences, Univ of Nebraska Medical Ctr, Omaha, NE, ⁴University of Nebraska Medical Center and Omaha VA Medical Center, Omaha, NE, ⁵Dept of Internal Medicine, Univ of Nebraska Med Ctr, Omaha, NE, ⁶Omaha VA Medical Center and University of Nebraska Medical Center, Omaha, NE, ⁷Int Med/Sec of Rheum/Immun, Univ of Nebraska Med Ctr, Omaha, NE
Background/Purpose: Although the pathogenesis and cause of rheumatoid arthritis (RA) remains uncertain, various disease-driving auto-antigens and auto-antibodies with different specificities have been used as diagnostic…
Abstract Number: 28 • 2012 ACR/ARHP Annual Meeting
Role of Microrna 455 Networks in Mesenchymal Cell Differentiation and Osteoarthritis
Fumiaki Ayabe¹, Shigeru Miyaki², Diana Brinson¹, Satoshi Yamashita³, Hiroyuki Nakahara¹, Koji Otabe¹, Stuart Duffy¹, Shawn Grogan⁴, Shuji Takada³, Martin K. Lotz¹ and Hiroshi Asahara⁵, ¹Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA, ²Department of Orthopaedic Surgery, Hiroshima University, Hiroshima, Japan, ³Department of Systems BioMedicine, National Research Institute for Child Health and Development, Tokyo, Japan, ⁴The Scripps Research Institute, La Jolla, CA, ⁵Molecular & Experimental Med, The Scripps Research Institute, La Jolla, CA
Background/Purpose: The objectives of this study were to identify cartilage specific microRNAs (miRNAs, miR-) that are regulated by SOX9 and are increased in chondrogenesis, to…
Abstract Number: 29 • 2012 ACR/ARHP Annual Meeting
Level of IL-1â-Induced Epigenetic Modifications Differ in Chondrocytes From Different Histological Zones of Human Cartilage
Nahid Akhtar¹ and Tariq M. Haqqi², ¹Medicine/Rheumatology, Case Western Reserve University/Metrohealth Medical Center, Cleveland, OH, ²Medicine/Rheumatology/Haman 586, Metro Health Medical Center, Cleveland, OH
Background/Purpose: Osteoarthritis (OA) reduces mobility and function of the affected joint and is a leading cause of disability among the elderly. Recent evidence points to…
Abstract Number: 30 • 2012 ACR/ARHP Annual Meeting
A Mouse Myeloid Precursor with Osteoclastogenic Function in Vivo
Julia F. Charles¹, Erene Niemi², Mary C. Nakamura³ and Antonios O. Aliprantis⁴, ¹Rheumatology, Allergy and Immunology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, ²Medicine, University of California, San Francisco; VA Medical Center, San Francisco, ³Arthritis/Rheumatology 111-R, SFVAMC/UCSF, San Francisco, CA, ⁴Rheumatology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA
Background/Purpose: Osteoporosis and peri-articular erosions in patients with inflammatory arthritis are characterized by increased osteoclast resorptive activity. Although a great deal is known about how…
Abstract Number: 31 • 2012 ACR/ARHP Annual Meeting
Anti Citrullinated Protein Antibodies From Synovial Fluid of Rheumatoid Arthritis Patients Enhance Osteoclastogenesis
Akilan Krishnamurthy¹, Nancy Vivar Pomiano², Catia Cerqueira³, Elena Ossipova³, Karin Lundberg⁴, Ulrike Harre⁵, Vivianne Malmström⁶, Per Johan Jakobsson⁷, Lars Klareskog⁸, Georg Schett⁹ and Anca Catrina³, ¹Medicine, Rheumatology Unit, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden, ²Rheumatology unit, Karolinska University Hospital, Karolinska Institute, Stockholm, Sweden, ³Department of Medicine, Rheumatology unit, Karolinska University Hospital, Karolinska Institute, Stockholm, Sweden, ⁴Rheumatology unit, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden, ⁵Institute for Clinical Immunology, Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, ⁶Rheumatology Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden, ⁷Rheumatology unit, Department of Medicine, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden, ⁸Department of Medicine, Rheumatology Unit, Karolinska Institute, Stockholm, Sweden, ⁹Dept of Medicine 3, Rheumatology and Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany
Background/Purpose: Presence of anti CCP2 antibodies identifies a subgroup of RA patients that are more prone to develop bone erosions. We hypothesized that anti CCP2…
Abstract Number: 32 • 2012 ACR/ARHP Annual Meeting
Development of a Quantitative Model of Endotoxin-Induced Calvarial Bone Erosion Utilizing Micro-Computed Tomography and Pax-It Imaging Analysis Software
Diane Thome, Donald Souza, Aruna Behera, Jie Zheng, Jennifer Swantek and Gerald H. Nabozny, Immunology and Inflammation, Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, CT
Background/Purpose: To facilitate an understanding of the biological factors involved in inflammation- mediated bone loss, in vitro systems and murine models of bone loss, such…
Abstract Number: 33 • 2012 ACR/ARHP Annual Meeting
Novel Targets for Blocking Osteoclast-Mediated Resorption in Inflammatory Disorders
Kevin P. McHugh¹, Tania N. Crotti¹, Jun Li², Jon Hill³, Gerald H. Nabozny², Steven R. Goldring⁴ and P. Edward Purdue⁵, ¹Orthopedic Surgery, Center for Advanced Orthopedic Studies, Beth Israel Deaconess Medical Center, Boston, MA, ²Immunology and Inflammation, Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, CT, ³Scientific Knowledge Discovery, Boehringer Ingelheim Pharmaceuticals Inc, Ridgefield, CT, ⁴Hospital for Special Surgery, New York, NY, ⁵Hospital for Special Surgery, Weill Cornell Medical Center, New York, NY
Background/Purpose: Osteoclasts are specialized myeloid lineage cells that mediate both pathologic and physiologic bone remodeling Fully differentiated and functional osteoclasts are found exclusively associated with…
Abstract Number: 34 • 2012 ACR/ARHP Annual Meeting
Rebamipide Attenuates Pain Severity and Cartilage Degeneration in a Rat Model of Osteoarthritis by Downregulating Oxidative Damage and Catabolic Activity in Chondrocytes
Su-Jin Moon¹, Mi-La Cho², Yeon-Sik Hong³, Sung-Hwan Park⁴ and Jun-Ki Min¹, ¹Division of Rheumatology, Department of Internal Medicine, School of Medicine, The Catholic University of Korea, Seoul, South Korea, ²Rheumatism Research Center, Catholic Research Institute of Medical Science, Catholic University of Korea, Seoul, South Korea, ³Our Lady of Mercy Hospital, Inchon, South Africa, ⁴Catholic University of Korea, Seoul, South Korea
Background/Purpose: The development and progression of osteoarthritis (OA) are now believed to involve inflammation, even in the early stage of disease. Proinflammatory cytokines and chemokines are…
Abstract Number: 35 • 2012 ACR/ARHP Annual Meeting
Changes in Tibial Bone and Cartilage Structure in a Mouse Surgical Model of Osteoarthritis
Brett A. Tonkin¹, Evange Romas², Natalie A. Sims¹ and Nicole C. Walsh¹, ¹St Vincent's Institute of Medical Research, Melbourne, Australia, ²Dept. of Rheumatology, St Vincent's Hospital, Melbourne, Australia
Background/Purpose: The destabilisation of the medial meniscus (DMM) mouse osteoarthritis (OA) model is commonly used to study OA joint degeneration. In DMM-OA, the knee is…
Abstract Number: 36 • 2012 ACR/ARHP Annual Meeting
Role of FK506 Binding Protein 5 in Osteoclast Differentiation
Miho Kimura¹, Tatsuo Nagai², Reiko Matsushita², Atsushi Hashimoto³, Toshiyuki Miyashita⁴ and Shunsei Hirohata⁵, ¹Rheumatology and Infectious diseases, Kitasato University School of Medicine, Sagamihara, Japan, ²Rheumatology and Infectious Diseases, Kitasato University School of Medicine, Sagamihara, Japan, ³Department of Rheumatology, National Hospital Organization Sagamihara Hospital, Kanagawa, Japan, ⁴Molecular Genetics, Kitasato University School of Medicine, Sagamihara, ⁵Int Med/Rheumatol & Infec Dis, Kitasato University School of Medicine, Sagamihara, Japan
Background/Purpose: RA is a chronic, systemic inflammatory disease characterized by the destruction of bone in the joints. Moreover, it is well appreciated that systemic osteoporosis…
Abstract Number: 37 • 2012 ACR/ARHP Annual Meeting
Development of a Mouse Model of Natural Osteoarthritis of Knee by Induction of obesity and Bipedal Walking
Hyun Ah Kim¹, Su Jin Park², Eun-Jeong Cheon³, Hyun A. Jung⁴ and Kyeong Min Son⁵, ¹Division of Rheumatology, Department of Internal Medicine, Hallym university, Kyunggi, South Korea, ²Department of Internal Medicine, Hallym University Sacred Heart Hospital, Kyunggi, South Korea, ³Department of internal medicine, Hallym University Sacred Heart Hospital, Kyunggi, South Korea, ⁴Division of Rheumatology, Department of Internal Medicine, Hallym university sacred heart hospital, Kyunggi, South Korea, ⁵Division of Rheumatology, Department of Internal Medicine, Hallym university Chunchun sacred heart hospital, Chunchun, South Korea
Background/Purpose: Animal models of osteoarthritis(OA) are used extensively in research of its pathogenesis and in search of disease modifying anti-OA drugs. However, whether current animal models…
Abstract Number: 38 • 2012 ACR/ARHP Annual Meeting
Bone Marrow Lesions On Magnetic Resonance Imaging Are Not Associated with Regions of Hypermetabolism in an Animal Model of Osteoarthritis
Arash Panahifar¹, Jacob Jaremko², Robert GW Lambert², Walter P. Maksymowych³ and Michael R. Doschak¹, ¹Faculty of Pharmacy & Pharmaceutical Sciences, University of Alberta, Edmonton, AB, Canada, ²Radiology, University of Alberta, Edmonton, AB, Canada, ³Department of Medicine, University of Alberta, Edmonton, AB, Canada
Background/Purpose: The underlying histopathological basis for bone marrow lesions (BML) on magnetic resonance imaging (MRI) in osteoarthritis (OA) is unclear, but may be associated with…

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