Abstracts Archive - Page 2451 of 2607 - ACR Meeting Abstracts

Abstract Number: 2286 • 2012 ACR/ARHP Annual Meeting
Dysregulated Discoidin Domain Receptor 2-Microrna 196a-Mediated Negative Feedback Against Excess Type I Collagen Expression in Scleroderma Dermal Fibroblasts
Katsunari Makino¹, Masatoshi Jinnin¹, Jun Aoi¹, Ikko Kajihara¹, Takamitsu Makino², Keisuke Sakai¹, Satoshi Fukushima¹, Yuji Inoue¹ and Hironobu Ihn², ¹Department of Dermatology and Plastic Surgery, Kumamoto University, Kumamoto, Japan, ²Dermatology and Plastic Surgery, Kumamoto University, Kumamoto, Japan
Background/Purpose: Systemic sclerosis (SSc) is characterized by the excess deposition of collagen in the skin, due to intrinsic transforming growth factor (TGF)-β activation. The discoidin…
Abstract Number: 2287 • 2012 ACR/ARHP Annual Meeting
Altered Regulation of Metabolic Pathways in Systemic Sclerosis Evidenced by Metabolomics
Emmanuel Chatelus¹, Jacques-Eric Gottenberg¹, François-Marie Moussallieh¹, Christelle Sordet¹, Arnaud Theulin¹, Alain Meyer¹, Jean-Francois Kleimann¹, Jean Sibilia¹ and Izzie Jacques Namer², ¹Rheumatology, Strasbourg University Hospital, Strasbourg, France, ²Nuclear Medicine, Strasbourg University Hospital, Strasbourg, France
Background/Purpose: High throughput study of metabolic pathways might help identify new biomarkers and therapeutic targets in autoimmune diseases. Systemic sclerosis (SSc) currently lacks prognostic biomarkers…
Abstract Number: 2288 • 2012 ACR/ARHP Annual Meeting
The Role of TCR Vä1⁺ NKT Cells in Systemic Sclerosis Patients with Interstitial Pneumonitis
Seiji Segawa¹, Daisuke Goto², Masanobu Horikoshi², Shinya Hagiwara², Naoto Umeda², Hiroshi Ogishima², Yuya Kondo¹, Hiroto Tsuboi¹, Makoto Sugihara¹, Taichi Hayashi¹, Yusuke Chino¹, Isao Matsumoto¹ and Takayuki Sumida¹, ¹Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba City, Japan, ²Department of Internal Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba City, Japan
Background/Purpose: Interstitial pneumonia (IP) is one of the critical complications in patients with several autoimmune diseases. However, the exact mechanism of IP remains elusive. Recently,…
Abstract Number: 2289 • 2012 ACR/ARHP Annual Meeting
Adiponectin Has Potent Anti-Fibrotic Effects Mediated Via AMP Kinase: Novel Target for Fibrosis Therap
Feng Fang¹, Lei Liu², Yang Yang², Jun Wei¹, Swati Bhattacharyya³, Ross Summer⁴, Boping Ye² and John Varga³, ¹Rheumatology Division, Northwestern University, Chicago, IL, ²School of Life Science and Technology, China Pharmaceutical University, Nanjing, China, ³Division of Rheumatology, Northwestern University, Chicago, IL, ⁴Pulmonary Center, Boston University, Boston, MA
Background/Purpose: Fibrosis in scleroderma is associated with transforming growth factor-β (TGF-β) signaling activation, collagen deposition and myofibroblast accumulation. Peroxisome proliferator activated receptor gamma (PPAR-γ) inhibits…
Abstract Number: 2290 • 2012 ACR/ARHP Annual Meeting
Type I Interferon Associated Gene IRF7 in the Pathogenesis of Fibrosis in Systemic Sclerosis (SSc)
Minghua Wu¹, Michael R. Blackburn², Shervin Assassi¹, Xiaochun Liu¹, John D. Reveille¹, Filemon K. Tan¹, Sandeep K. Agarwal³ and Maureen D. Mayes¹, ¹Rheumatology, University of Texas Health Science Center at Houston, Houston, TX, ²Biochemistry and Molecular Biology, The University of Texas Medical School at Houston, Houston, TX, ³Medicine, Section of Immunology, Allergy and Rheumatology, Baylor College of Medicine, Houston, TX
Background/Purpose: Fibrosis in Systemic Sclerosis is characterized by excessive collagen production and accumulation in the skin and lungs. It has been increasingly appreciated that a…
Abstract Number: 2291 • 2012 ACR/ARHP Annual Meeting
Enhanced Release of S100A9 and Hepatocyte Growth Factor by the Epidermis in Systemic Sclerosis
Joanna Nikitorowicz Buniak¹, Christopher P. Denton¹, David J. Abraham² and Richard J. Stratton¹, ¹Centre for Rheumatology and Connective Tissue Diseases, UCL Medical School, London, United Kingdom, ²UCL Medical School, London, United Kingdom
Background/Purpose: Systemic sclerosis (SSc) is a severe disease of unknown aetiology characterised by cellular injury and activation in early stage, followed by autoimmunity and fibrosis.…
Abstract Number: 2292 • 2012 ACR/ARHP Annual Meeting
Increased Synthesis of Leukotrienes by Peripheral Blood Mononuclear Cells Is Associated with More Severe Disease and Worse Prognosis in Patients with Systemic Sclerosis
Otylia M. Kowal-Bielecka¹, Anna Lapinska², Marek Bielecki³, Oliver Distler⁴, Izabela Domyslawska¹, Lech Chyczewski², Stanislaw Sierakowski⁵, Steffen Gay⁶ and Krzysztof Kowal⁷, ¹Department of Rheumatology and Internal Medicine, Medical University in Bialystok, Bialystok, Poland, ²Department of Medical Pathomorphology, Medical University in Bialystok, Bialystok, Poland, ³Department of Orthopedics and Traumatology, Medical University in Bialystok, Bialystok, Poland, ⁴Department of Rheumatology and Center of Experimental Rheumatology, University Hospital Zurich, Zurich, Switzerland, ⁵Department of Rheumatology and Internal Diseases, Medical University in Bialystok, Bialystok, Poland, ⁶Center of Experimental Rheumatology, University Hospital Zurich and Zurich Center of Integrative Human Physiology (ZIHP), Switzerland, Zurich, Switzerland, ⁷Department of Allergology and Internal Medicine, Medical University of Bialystok, Bialystok, Poland
Background/Purpose: Eicosanoids are a group of arachidonic acid-derived lipid mediators which play a key role in the regulation of inflammatory response and connective tissue remodeling.…
Abstract Number: 2293 • 2012 ACR/ARHP Annual Meeting
Interleukin-17A Positive Cells Are Increased in Systemic Sclerosis Skin and Their Number Is Inversely Correlated to Skin Thickness
Marie-Elise Truchetet¹, Nicolò Costantino Brembilla¹, Elisa Montanari¹, Paola Lonati², Pier Luigi Meroni³ and Carlo Chizzolini¹, ¹University hospital of Geneva, Geneva, Switzerland, ²Division of Rheumatology, Istituto G. Pini, University of Milan, Milan, Italy, ³Division of Rheumatology, Istituto G. Pini, University of Milan, Milano, Italy
Background/Purpose: T cell producing IL-17A are increased in the peripheral blood of individuals affected by systemic sclerosis (SSc). We asked the question whether IL-17A-producing cells…
Abstract Number: 2294 • 2012 ACR/ARHP Annual Meeting
The Histone Deacetylase SIRT1 Is Anti-Fibrotic and Mediates Resveratrol Effects
Roberta G. Marangoni¹, Archit Ghosh¹, Jun Wei² and John Varga³, ¹Medicine, Rheumatolgoy, Northwestern University, Feinberg School of Medicine, Chicago, IL, ²Rheumatology Division, Northwestern University, Chicago, IL, ³Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL
Background/Purpose: Fibrosis in scleroderma is associated with increased collagen synthesis driven by TGF-β and associated epigenetic modifications. The Class III histone deacetylase SIRT1 has anticancer…
Abstract Number: 2295 • 2012 ACR/ARHP Annual Meeting
Caveolin-1 Deficiency Induces Spontaneous Endothelial-to-Mesenchymal Transition (EndoMT) in Murine Pulmonary Endothelial Cells in Vitro
Zhaodong Li¹, Peter J. Wermuth², Bryan Benn², Michael P. Lisanti³ and Sergio A. Jimenez², ¹Jefferson Institute of Molecular Medicine, Division of Connective Tissue Diseases and Scleroderma Center,Thomas Jefferson University, Philadelphia, PA, ²Jefferson Institute of Molecular Medicine, Division of Connective Tissue Diseases and Scleroderma Center, Thomas Jefferson University, Philadelphia, PA, ³Jefferson Stem Cell Biology and Regenerative Medicine Center, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA
Background/Purpose: Recent studies demonstrated that the phenotypic transition of endothelial cells (EC) into activated mesenchymal cells, a process known an endothelial-to-mesenchymal transition (EndoMT), may be…
Abstract Number: 2296 • 2012 ACR/ARHP Annual Meeting
Platelet Release Products Mediate Endothelial Apoptosis: A Possible Role for Thrombospondin 1- CD36 Pathway in SSc-Endothelial Apoptosis
Bashar Kahaleh¹ and Yongqing Wang², ¹Medicine/Rheumatology, University of Toledo, Toledo, OH, ²Medicine, University of Toledo, Toledo, OH
Background/Purpose: Sequential pathologic observations in the early stages of SSc demonstrated evidence for platelet aggregation and binding to blood vessels that is generally followed by…
Abstract Number: 2297 • 2012 ACR/ARHP Annual Meeting
Decrease Activity of DNA Demethylase in SSc Fibroblast and Microvascular Endothelial Cells: A Possible Mechanism for Persistence of SSc Phenotype
Bashar Kahaleh¹ and Yongqing Wang², ¹Medicine/Rheumatology, University of Toledo, Toledo, OH, ²Medicine, University of Toledo, Toledo, OH
Background/Purpose: DNA methylation is one of the best-characterized epigenetic modifications that have been implicated in numerous biologic and pathologic processes. It is initiated by DNA…
Abstract Number: 2298 • 2012 ACR/ARHP Annual Meeting
The Arachidonate 5-Lipoxygenase Activating Protein (ALOX5AP) Polymorphism Is Associated with Risk of Scleroderma-Related Interstitial Lung Disease: A Multicenter Study From the EULAR Scleroderma Trial and Research Group
Otylia M. Kowal-Bielecka¹, Sylwia Chwiesko-Minarowska², Pawel Bernatowicz², Yannick Allanore³, Timothy RD Radstake⁴, Jasper Broen⁵, Marco Matucci-Cerinic⁶, Roger Hesselstrand⁷, Dorota Krasowska⁸, Gabriela Riemekasten⁹, Madelon C. Vonk¹⁰, Oksana Kowalczuk², Marek Bielecki¹¹, Robert Milewski¹², Lech Chyczewski¹³, Jacek Niklinski² and Krzysztof Kowal¹⁴, ¹Department of Rheumatology and Internal Medicine, Medical University in Bialystok, Bialystok, Poland, ²Department of Clinical Molecular Biology, Medical University of Bialystok, Bialystok, Poland, ³Rheumatology, Paris Descartes University, Rheumatology A department, Cochin Hospital, Paris, France, ⁴Rheumatology, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, ⁵Department of Rheumatology & Clinical Immunology, University Medical Center, Utrecht, Netherlands, ⁶Department of Biomedicine & Division of Rheumatology AOUC, University of Florence, Florence, Italy, ⁷Rheumatology, Lund University, Lund, Sweden, ⁸Department of Dermatology, Venereology and Pediatric Dermatology, Medical University of Lublin, Lublin, Poland, ⁹Charité University Hospital and German Rheumatism Research Centre, a Leibniz Institute, Berlin, Germany, ¹⁰Department of Rheumatology, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, ¹¹Department of Orthopedics and Traumatology, Medical University of Bialystok, Bialystok, Poland, ¹²Department of Statistics and Medical Informatics, Medical University of Bialystok, Bialystok, Poland, ¹³Department of Medical Pathomorphology, Medical University in Bialystok, Bialystok, Poland, ¹⁴Department of Allergology and Internal Medicine, Medical University of Bialystok, Bialystok, Poland
Background/Purpose: Systemic sclerosis (SSc, scleroderma) is an autoimmune disease characterized by chronic inflammation, vascular injury and profound fibrosis of the skin and internal organ. Leukotrienes…
Abstract Number: 2299 • 2012 ACR/ARHP Annual Meeting
Acroosteolysis Is Associated with Increased Propensity for Osteoclast Formation and Higher VEGF Levels in the Peripheral Blood of Systemic Sclerosis Patients
Jin Kyun Park¹, Andrea Fava², Antony Rosen³ and Francesco Boin⁴, ¹Division of Rheumatology, Department of Internal Medicine, Seoul National University, Seoul, South Korea, ²Internal Medicine, Johns Hopkins University, Baltimore, MD, ³Division of Rheumatology, Johns Hopkins University, Baltimore, MD, ⁴Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD
Background/Purpose: Acroosteolysis (AO) secondary to bone resorption of distal phalanges affects up to 20% of systemic sclerosis (SSc) patients leading to shortening of the digits,…
Abstract Number: 2300 • 2012 ACR/ARHP Annual Meeting
The Effects of Salvianolic Acid B in Fibrotic Models in Vivo and in Vitro
Qingmei Liu¹, Wenyu Wu², Wenzheng Tu³, Haiyan Chu¹, Yanyun Ma¹, Hejian Zou⁴, Xiaodong Zhou⁵ and Jiu-Cun Wang¹, ¹Ministry of Education Key Laboratory of Contemporary Anthropology, School of Life Sciences, Fudan University, Shanghai, China, ²Huashan Hospital, Shanghai, China, ³Shanghai Traditional Chinese Medicine-Integrated Hospital, Shanghai, China, ⁴Rheumatology, Huashan Hospital, Shanghai, China, ⁵Rheumatology, University of Texas Health Science Center at Houston, Houston, TX
Background/Purpose: , Methods: , Results: and Conclusion: Background: Scleroderma or systemic sclerosis (SSc) is characterized by the fibrosis of skin and visceral organs. Salvianolic acid…

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