Abstract Number: 65 • 2012 ACR/ARHP Annual Meeting
Serum Inflammatory Biomarkers Correlated Stronger with a Panel of Serum Steroid and Pituitary Hormones in a Cohort of Pre-Rheumatoid Arthritis (pre-RA) Than in Non-RA Control (CN) Subjects
Background/Purpose: Inflammatory cytokines influence steroid hormone production in tissue culture and affect serum levels and synovial fluid of active RA patients. Inflammatory biomarker and hormonal…Abstract Number: 26 • 2012 ACR/ARHP Annual Meeting
Quantitative Analysis of Bone Damage Morphological Changes in the Citrullinated Collagen Induced Arthritis Mouse Model Using Micro CT
Background/Purpose: Patients with rheumatic diseases given immunosuppressive therapy are susceptible to various types of infections, especially pulmonary infections that affect their vital prognosis. The aim…Abstract Number: 27 • 2012 ACR/ARHP Annual Meeting
Anti-Citrullinated Protein Antibodies As an Indicator of Bone Damage in the Citrullinated Collagen Induced Arthritis Model
Background/Purpose: Although the pathogenesis and cause of rheumatoid arthritis (RA) remains uncertain, various disease-driving auto-antigens and auto-antibodies with different specificities have been used as diagnostic…Abstract Number: 28 • 2012 ACR/ARHP Annual Meeting
Role of Microrna 455 Networks in Mesenchymal Cell Differentiation and Osteoarthritis
Background/Purpose: The objectives of this study were to identify cartilage specific microRNAs (miRNAs, miR-) that are regulated by SOX9 and are increased in chondrogenesis, to…Abstract Number: 29 • 2012 ACR/ARHP Annual Meeting
Level of IL-1â-Induced Epigenetic Modifications Differ in Chondrocytes From Different Histological Zones of Human Cartilage
Background/Purpose: Osteoarthritis (OA) reduces mobility and function of the affected joint and is a leading cause of disability among the elderly. Recent evidence points to…Abstract Number: 30 • 2012 ACR/ARHP Annual Meeting
A Mouse Myeloid Precursor with Osteoclastogenic Function in Vivo
Background/Purpose: Osteoporosis and peri-articular erosions in patients with inflammatory arthritis are characterized by increased osteoclast resorptive activity. Although a great deal is known about how…Abstract Number: 31 • 2012 ACR/ARHP Annual Meeting
Anti Citrullinated Protein Antibodies From Synovial Fluid of Rheumatoid Arthritis Patients Enhance Osteoclastogenesis
Background/Purpose: Presence of anti CCP2 antibodies identifies a subgroup of RA patients that are more prone to develop bone erosions. We hypothesized that anti CCP2…Abstract Number: 32 • 2012 ACR/ARHP Annual Meeting
Development of a Quantitative Model of Endotoxin-Induced Calvarial Bone Erosion Utilizing Micro-Computed Tomography and Pax-It Imaging Analysis Software
Background/Purpose: To facilitate an understanding of the biological factors involved in inflammation- mediated bone loss, in vitro systems and murine models of bone loss, such…Abstract Number: 33 • 2012 ACR/ARHP Annual Meeting
Novel Targets for Blocking Osteoclast-Mediated Resorption in Inflammatory Disorders
Background/Purpose: Osteoclasts are specialized myeloid lineage cells that mediate both pathologic and physiologic bone remodeling Fully differentiated and functional osteoclasts are found exclusively associated with…Abstract Number: 34 • 2012 ACR/ARHP Annual Meeting
Rebamipide Attenuates Pain Severity and Cartilage Degeneration in a Rat Model of Osteoarthritis by Downregulating Oxidative Damage and Catabolic Activity in Chondrocytes
Background/Purpose: The development and progression of osteoarthritis (OA) are now believed to involve inflammation, even in the early stage of disease. Proinflammatory cytokines and chemokines are…Abstract Number: 35 • 2012 ACR/ARHP Annual Meeting
Changes in Tibial Bone and Cartilage Structure in a Mouse Surgical Model of Osteoarthritis
Background/Purpose: The destabilisation of the medial meniscus (DMM) mouse osteoarthritis (OA) model is commonly used to study OA joint degeneration. In DMM-OA, the knee is…Abstract Number: 36 • 2012 ACR/ARHP Annual Meeting
Role of FK506 Binding Protein 5 in Osteoclast Differentiation
Background/Purpose: RA is a chronic, systemic inflammatory disease characterized by the destruction of bone in the joints. Moreover, it is well appreciated that systemic osteoporosis…Abstract Number: 37 • 2012 ACR/ARHP Annual Meeting
Development of a Mouse Model of Natural Osteoarthritis of Knee by Induction of obesity and Bipedal Walking
Background/Purpose: Animal models of osteoarthritis(OA) are used extensively in research of its pathogenesis and in search of disease modifying anti-OA drugs. However, whether current animal models…Abstract Number: 38 • 2012 ACR/ARHP Annual Meeting
Bone Marrow Lesions On Magnetic Resonance Imaging Are Not Associated with Regions of Hypermetabolism in an Animal Model of Osteoarthritis
Background/Purpose: The underlying histopathological basis for bone marrow lesions (BML) on magnetic resonance imaging (MRI) in osteoarthritis (OA) is unclear, but may be associated with…Abstract Number: 39 • 2012 ACR/ARHP Annual Meeting
SDF-1 Induces Osteoclastogenesis in Rheumatoid Arthritis by Upregulating of RANKL Expression in Synovial Fibroblasts and CD4+ T Cells
Background/Purpose: Stromal cell-derived factor (SDF)-1 is involved in bone destructive process in rheumatoid arthritis (RA) and bony metastasis in malignancy, through inducing angiogenesis, producing matrix-degrading…