ACR Meeting Abstracts

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  • Abstract Number: 0765 • ACR Convergence 2023

    RheumMadness and TheMednet: The Impact of a Collaboration Between Independent Educational Initiatives

    Guy Katz1, Melissa Briones2, Nina Couette3, Meridith Balbach4, Sabahat Usmani5, Lauren He6, Michael Macklin6, Iman Qaiser7, John Kellogg8, Courtney Bair8, Benjamin Lueck8, Akrithi Garren9, Matthew Sparks8, Lisa Criscione-Schreiber8 and David Leverenz8, 1Massachusetts General Hospital, Boston, MA, 2Loyola University, Maywood, IL, 3Genesis Healthcare System, Columbus, OH, 4Vanderbilt University Medical Center, Nashville, TN, 5Weiss Memorial Hospital, Chicago, IL, 6University of Chicago, Chicago, IL, 7Louisiana State University, Shreveport, LA, 8Duke University School of Medicine, Durham, NC, 9MedStar/Georgetown Washington Hospital Center, Silver Spring, MD

    Background/Purpose: RheumMadness is an online tournament of rheumatology concepts that has been shown to engage learners using the Community of Inquiry (CoI) framework. theMednet is…
  • Abstract Number: 0759 • ACR Convergence 2023

    Derivation and Validation of Four Patient Clusters in Still’s Disease, Results from GIRRCS AOSD-study Group and AIDA Network Still Disease Registry

    Piero Ruscitti1, Antonio Vitale2, Ilenia Di Cola1, Roberto giacomelli3 and Luca Cantarini4, 1University of L'Aquila, L'Aquila, Italy, 2University of Siena, Siena, Italy, 3University of Rome Campus Biomedico, Rome, Italy, 4Department of Medical Sciences, Surgery and Neurosciences, Rheumatology Unit, University of Siena and Azienda Ospedaliero-Universitaria Senese [European Reference Network (ERN) for Rare Immunodeficiency, Autoinflammatory and Autoimmune Diseases (RITA) Center], Siena, Italy

    Background/Purpose: Still's disease is a rare inflammatory disorder, these patients have a highly heterogeneous disease according to age of onset, clinical presentation, presence of life-threatening…
  • Abstract Number: 0758 • ACR Convergence 2023

    Clinical and Biological Characteristics of Children and Adults Affected with Still’s Disease: A Systematic Review and Meta-analysis Informing the 2023 EULAR/PReS Recommendations for the Diagnosis and Management of Systemic Juvenile Idiopathic Arthritis and Adult-onset Still’s Disease

    STEPHANE MITROVIC1, Arianna De Matteis2, Sara Bindoli3, Fabrizio De Benedetti4, Bruno Fautrel5, Loreto Carmona6 and On Behalf Of The Eular/PreS QoC011 Task Force Member7, 1Pitie Salpetriere Hospital, Sorbonne University, APHP, Paris, France, 2IRCCS Ospedale Pediatrico Bambino Gesu', Rome, Italy, 3Rheumatology Unit, Dept of Medicine, University of Padova, Padova, Italy, 4Bambino Gesu Children's Hospital, Division of Rheumatology, Rome, Italy, 5Sorbonne Université APHP, Paris, France, 6Instituto de Salud Musculoesquelética (InMusc), Madrid, Spain, 7EULAR/PReS QoC011 Task Force members are: Jordi Anton, Alexandre Belot, Claudia Bracaglia, Tamas Constantin, Lorenzo Dagna, Alessandro De Bartolo, Eugen Feist, Dirk Foell, Marco Gattorno, Sophie Georgin-Lavialle, Roberto Giacomelli, Alexei Grom, Yvan Jamilloux, Katarina Laskari, Calin Lazar, Francesca Minoia, Peter Nigrovic, Filipa Oliveira Ramos, Seza Ozen, Pierre Quartier-dit-Maire, Piero Ruscitti, Erdal Sag, Sinisa Savic, Marie-Elise Truchetet, Bas Vastert, Tanita Wilhelmer, Carine Wouters., Paris, France

    Background/Purpose: Systemic juvenile idiopathic arthritis (sJIA) and adult-onset Still’s disease (AOSD) are part of the non-familial (sporadic) systemic inflammatory disorders and are frequently mentioned as…
  • Abstract Number: 0732 • ACR Convergence 2023

    Should Complete B-cell Depletion Be Maintained in Patients Treated Long-term with Rituximab for Rheumatoid Arthritis?

    Roba Ghossan1, Omar AL TABAA2, Alice Combier3, Alexia STEELANDT3, Marion THOMAS3, Olivier Fogel3, Corinne MICELI4, Anna Molto3 and Jérôme Avouac5, 1COCHIN HOSPITAL, Paris, France, 2APHP / Cochin Hospital, Paris, France, 3HOPITAL COCHIN AP-HP, Service de Rhumatologie, Paris, France, 4Université de Paris Cité, HOPITAL COCHIN AP-HP, Service de Rhumatologie, Paris, France, 5Service de Rhumatologie, Hôpital Cochin, AP-HP.Centre – Université Paris Cité, Paris, France

    Background/Purpose: Complete peripheral B cell depletion has been considered as a relevant indicator of short-term response to rituximab (RTX) in rheumatoid arthritis (RA). The purpose…
  • Abstract Number: 0766 • ACR Convergence 2023

    The OMERACT GCA Phantom Project: Validation of 3D Printed Ultrasound Training Models for Giant Cell Arteritis

    Valentin Sebastian Schäfer1, Tobias Schremmer2, Florian Recker3, Wolfgang Hartung4, Christina Duftner5, Sara Monti6, Alojzija Hocevar7, Rositsa Karalilova8, Annamaria Iagnocco9, PIERLUIGI MACCHIONI10, Giuseppe Antonio Germano11, Maria Esperanza Naredo Sanchez12, Eugenio De Miguel13, Luca Seitz14, Thomas Daikeler15, Markus Aschwanden16, Dennis Boumans17, Chetan Mukhtyar18, smith kate19, Richard Wakefield20, Andreas Diamantopoulos21, Stavros Chrysidis22, Berit Dalsgaard Nielsen23, Kresten Keller24, Uffe Dohn25, Lene Terslev26, Marcin Milchert27, Aaron Juche28, Wolfgang Schmidt29, George A. W. Bruyn30 and Christian Dejaco31, 1Clinic of Internal Medicine III, Department of Oncology, Hematology, Rheumatology and Clinical Immunology, University Hospital of Bonn, Bonn, Germany, 2Universitätsklinikum Bonn, Bonn, Germany, 3Department for Gynecology and Obstetrics, University Hospital Bonn, Bonn, Germany, 4Asklepios Clinic, Tegernheim, Germany, 5Department of Internal Medicine, Clinical Division of Internal Medicine II, Medical University Innsbruck, Innsbruck, Austria, 6Division of Rheumatology, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy; Department of Internal Medicine and Therapeutics, Università di Pavia, Pavia, Italy, 7Department of Rheumatology, Universitiy Medical Centre Ljubljana, Ljubljana, Slovenia, 8Clinic of Rheumatology, Medical University Plovdiv, Plovdiv, Bulgaria, 9University of Turin, Roma, Italy, 10Azienda USL -IRCCS di Reggio Emilia, Reggio Emilia, Italy, 11Rheumatology Unit- Arcispedale Santa Maria Nuova Reggio Emilia-Italy, Reggio Emilia, Italy, 12Rheumatology Department and Joint and Bone Research Unit, Hospital Universitario Fundación Jiménez Díaz, Madrid, Spain, 13Hospital Universitario La Paz, Madrid, Spain, 14Rheumatology and Immunology, Inselspital University Hospital Bern, Bern, Switzerland, 15Clinic for Rheumatology, University Hospital Basel, Basel, Switzerland, 16Department of Angiology, University Hospital Basel, Basel, Switzerland, 17Rheumatology and Clinical Immunology, Hospital Group Twente, Almelo, Netherlands, 18Vasculitis service, Rheumatology department, Norfolk and Norwich University Hospital, Norwich, United Kingdom, 19NIHR Leeds Biomedical Research Centre, Leeds, United Kingdom, 20s Leeds Insitute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, 21Akershus University Hospital, Lørenskog, Norway, 22Department of Rheumatology, Southwest Jutland Hospital Esbjerg, Esbjerg, Denmark, 23Department of Rheumatology, Aarhus University Hospital, Aarhus, Denmark; Department of Medicine, The Regional Hospital in Horsens, Horsens, Denmark, 24Department of Rheumatology, Aarhus University Hospital; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark, 25Copenhagen University Hospital at Hvidovre, Hvidovre, Denmark, 26Center for Rheumatology and Spine Diseases, Rigshospitalet, Glostrup, Denmark, 27Department of Internal Medicine, Rheumatology, Diabetology, Geriatrics and Clinical Immunology, Pomeranian Medical University in Szczecin, Szczecin, Poland, 28Immanuel Krankenhaus Berlin, Medical Centre for Rheumatology Berlin-Buch, Berlin, Germany, 29Rheumatology, Immanuel Krankenhaus Berlin, Medical Centre for Rheumatology Berlin-Buch, Berlin, Germany, 30Reumakliniek Lelystad, Loenga, Netherlands, 31Azienda Sanitaria Alto Adige, Brunico, Italy

    Background/Purpose: Ultrasonography has been validated as a diagnostic tool for giant cell arteritis (GCA). There is a need to develop training resources, because the glucocorticoid…
  • Abstract Number: 0673 • ACR Convergence 2023

    Reporting of Race, Ethnicity, Sex, Gender, Socioeconomic Status and Representativeness of Race and Ethnicity in ANCA-associated Vasculitis Randomized Trials

    Michele Iudici1, Juan C. Rueda2 and Xavier Puéchal3, 1Division of Rheumatology, Department of Internal Medicine Specialties, Geneva University Hospitals, Geneva, Switzerland, 2Universidad de La Sabana, Chía, Colombia, Chia, Colombia, 3National Referral Center for Rare Systemic Autoimmune Diseases, Paris, France

    Background/Purpose: To assess how and to what extent race, ethnicity, sex, gender and socioeconomic status of participants are reported in ANCA-associated vasculitis (AAV) randomized controlled…
  • Abstract Number: 0772 • ACR Convergence 2023

    MUC5B Promoter Variant and Survival in Rheumatoid Arthritis-Associated Interstitial Lung Disease

    Jacob Klein1, Austin Wheeler1, Joshua Baker2, Yangyuna Yang1, Punyasha Roul1, K Wysham3, Gail Kerr4, Andreas Reimold5, Dana Ascherman6, Gary Kunkel7, Grant Cannon8, Paul Monach9, Jill Poole1, Geoffrey Thiele1, Ted R Mikuls10 and Bryant England1, 1University of Nebraska Medical Center, Omaha, NE, 2University of Pennsylvania, Philadelphia, PA, 3VA Puget Sound/University of Washington, Seattle, WA, 4Washington DC VAMC/Georgetown and Howard Universities, Washington, DC, 5University of Texas Southwestern Medical Center, Dallas, TX, 6University of Pittsburgh, Pittsburgh, PA, 7University of Utah, Salt Lake City, UT, 8University of Utah and Salt Lake City VA, Salt Lake City, UT, 9VA Boston Healthcare System, Boston, MA, 10Division of Rheumatology and Immunology, University of Nebraska Medical Center, Omaha, NE

    Background/Purpose: The gain of function MUC5B rs35705950 promoter variant is the strongest genetic risk factor for the development of RA-ILD (specific to a usual interstitial…
  • Abstract Number: 0785 • ACR Convergence 2023

    Therapeutic Range of Hydroxychloroquine Blood Levels May Reduce Odds of High Lupus Disease Activity

    Shivani Garg1, Betty Chewning2, Brad Astor3 and Christie M. Bartels3, 1Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, 2University of Wisconsin, School of Pharmacy, Madison, WI, 3University of Wisconsin, School of Medicine and Public Health, Madison, WI

    Background/Purpose: Hydroxychloroquine (HCQ) is the cornerstone of lupus (or SLE) treatment. Yet the optimal dosing of HCQ in SLE is unknown. Reducing HCQ dose to…
  • Abstract Number: 0754 • ACR Convergence 2023

    Towards a Guide for Evidence-based Remote Monitoring: Sensitivity of Patient Reported Outcomes to Change in Disease Activity Status in Early and Established Rheumatoid Arthritis

    Agnes Loiojen1, Elise van Mulligen2, Annette van der Helm-van Mil3 and Pascal de Jong2, 1Erasmus Medical Center, department of rheumatology, Rotterdam, Netherlands, 2Erasmus Medical Center, Rotterdam, Netherlands, 3Leiden University Medical Center, Leiden, Netherlands

    Background/Purpose: In the treatment and follow-up of rheumatoid arthritis (RA) patients, it has become more desirable to detect changes in disease activity through remote monitoring.…
  • Abstract Number: 0781 • ACR Convergence 2023

    Low vs. High Initial Oral Glucocorticoid Dose for Lupus Nephritis Induction Treatment: A Pooled Analysis of Randomized Controlled Clinical Trials

    Amit Saxena1, Peter Izmirly2, Jammie Law3, Cristina Sorrento3, H Michael Belmont4 and Jill Buyon5, 1New York University Grossman School of Medicine, Rheumatology, New York, NY, 2New York University School of Medicine, New York, NY, 3New York University, New York, NY, 4NYU School of Medicine, New York, NY, 5NYU Grossman School of Medicine, New York, NY

    Background/Purpose: Traditional induction treatment regimens for proliferative or membranous lupus nephritis (LN) have utilized oral glucocorticoids (GC) in initial doses up to 1.0 mg/kg/day prednisone…
  • Abstract Number: 0761 • ACR Convergence 2023

    EULAR / PreS Recommendations for the Diagnosis and Management of Systemic Juvenile Idiopathic Arthritis (sJIA) and Adult Onset Still’s Disease (AOSD)

    Bruno Fautrel1, STEPHANE MITROVIC2, Arianna De Matteis3, Sara Bindoli4, Jordi Anton5, Alexandre Belot6, Claudia Bracaglia3, Tamas Constantin7, Lorenzo Dagna8, Alessandro de Bartolo9, Eugen Feist10, Dirk Foell11, Marco Gattorno12, Sophie Georgin-Lavialle13, Roberto Giacomelli14, Alexei Grom15, Yvan Jamilloux16, Katerina Laskari17, Calin Lazar18, Francesca Minoia19, Peter Nigrovic20, Filipa Oliveira Ramos21, Seza Ozen22, Pierre Quartier Dit Maire23, Piero Ruscitti24, Erdal Sag25, Sinisa Savic26, Marie-Elise Truchetet27, Sebastiaan Vastert28, Tanita Wilhelmer29, Carine Wouters30, Loreto Carmona31 and Fabrizio De Benedetti32, 1Sorbonne Université APHP, Paris, France, 2Pitie Salpetriere Hospital, Sorbonne University, APHP, Paris, France, 3IRCCS Ospedale Pediatrico Bambino Gesu', Rome, Italy, 4Rheumatology Unit, department of Medicine,University of Padova, Padova, Italy, 5Hospital Sant Joan de Déu, Pediatric Rheumatology Department, Universitat de Barcelona, Barcelona, Spain, 6Hospices Civils de Lyon, Collonges au mont d'or, France, 7Semmelweis University, Budapest, Hungary, 8Ospedale San Raffaele, Milano, Italy, 9PReS Patient Research Partner, Milan, Italy, 10Helios Department of Rheumatology and Clinical Immunology, Vogelsang-Gommern, Germany, 11University Hospital Münster, Münster, Germany, 12UOC Reumatologia e Malattie Autoinfiammatorie, Genoa, Italy, 13AP-HP, Tenon hospital, Paris, France, 14Policlinico Universitario Campus Bio-Medico, Roma, Italy, 15Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 16Hospices Civils de Lyon, Lyon, France, 17Athens University Medical School, Athens, Greece, 18University of Medicine and Pharmacy, Cluj-Napoca, Romania, 19Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milano, Italy, 20Boston Children's Hospital, Boston, MA, 21Centro Hospitalar Universitário Lisboa Norte, Lisbon, Portugal, 22Hacettepe University Medical Faculty, Ankara, Turkey, 23Necker Hospital, Paris Cedex 15, France, 24University of L'Aquila, L'Aquila, Italy, 25Department of Pediatric Rheumatology, Hacettepe University, Ankara, Turkey, 26Leeds University, Leeds, United Kingdom, 27Bordeaux University Hospital, Bordeaux, France, 28University Medical Center Utrecht, Utrecht, Netherlands, 29EULAR Patient Research Partner, Bludenz, Austria, 30Leuven University, Leuven, Belgium, 31Instituto de Salud Musculoesquelética (InMusc), Madrid, Spain, 32Bambino Gesu Children's Hospital, Division of Rheumatology, Rome, Italy

    Background/Purpose: Systemic juvenile idiopathic arthritis (sJIA) and adult-onset Still's disease (AOSD) are supposed to be age counterparts of the same disease, but no consensus has…
  • Abstract Number: 0677 • ACR Convergence 2023

    Analysis of Clinical Outcomes in Eosinophilic Granulomatosis with Polyangiitis (EGPA) Treated with Mepolizumab over 2 Years for Remission Induction or Maintenance: A Single Center Experience in Japan

    SOKO KAWASHIMA1, Yoshinori Komagata1, Mitsumasa Kishimoto2 and Shinya Kaname1, 1Kyorin University School of Medicine, Tokyo, Japan, 2Kyorin University School of Medicine, Yokohoma, Japan

    Background/Purpose: Contrary to Western countries, MPO-ANCA-associated vasculitis (MPO-AAV) is dominant in Japan or Asian countries. It is possible that therapeutic responses to EGPA with mepolizumab…
  • Abstract Number: 0790 • ACR Convergence 2023

    Transcriptomic Analyses of Lung Tissues Reveals Potential Key Genes Associated with Progression of Systemic Sclerosis-Interstitial Lung Disease (SSc-ILD)

    Yehya Al-Adwi1, Johanna Westra1, Harry van Goor1, Leon.C.L.T van Kempen2, Wim Timens1, C.Tji Gan1 and Douwe J Mulder1, 1University Medical Center Groningen, Groningen, Netherlands, 2UMCG and University of Antwerp, Groningen, Netherlands

    Background/Purpose: SSc-ILD is the leading cause of death in SSc affecting around 50% of the patients. Lung tissue of patients with early-stage SSc-ILD is characterized…
  • Abstract Number: 0769 • ACR Convergence 2023

    Development and Validation of a Combined Clinical and Genetic Risk Score for Interstitial Lung Disease in a Large, Multicenter, Prospective Rheumatoid Arthritis Cohort

    Austin Wheeler1, Joshua Baker2, Yangyuna Yang1, Punyasha Roul1, K Wysham3, Grant Cannon4, Gary Kunkel5, Gail Kerr6, Dana Ascherman7, Paul Monach8, Andreas Reimold9, Jill Poole1, Tony Merriman10, Ted R Mikuls11 and Bryant England1, 1University of Nebraska Medical Center, Omaha, NE, 2University of Pennsylvania, Philadelphia, PA, 3VA Puget Sound/University of Washington, Seattle, WA, 4University of Utah and Salt Lake City VA, Salt Lake City, UT, 5University of Utah, Salt Lake City, UT, 6Washington DC VAMC/Georgetown and Howard Universities, Washington, DC, 7University of Pittsburgh, Pittsburgh, PA, 8VA Boston Healthcare System, Boston, MA, 9University of Texas Southwestern Medical Center, Dallas, TX, 10University of Alabama at Birmingham, Birmingham, AL, 11Division of Rheumatology and Immunology, University of Nebraska Medical Center, Omaha, NE

    Background/Purpose: Rheumatoid arthritis-associated interstitial lung disease (RA-ILD) is an extra-articular manifestation of RA that causes substantial morbidity and mortality. Although some clinical and genetic risk…
  • Abstract Number: 0701 • ACR Convergence 2023

    Incidence of Neurobehçet Disease in Northern Spain 1999-2019. a Population-based Study

    Fabricio Benavides1, Alba Herrero-Morant2, Jose Luis Martin-Varillas3, Carmen Alvarez Reguera1, Lara Sanchez-Bilbao4, David Martinez-Lopez5, Raul Fernandez1, Ivan Ferraz Amaro6, Jose Luis Hernandez1 and Ricardo Blanco7, 1Hospital Universitario Marqués de Valdecilla, Santander, Spain, 2Hospital Universitario Marqués de Valdecilla, Ontinyent, Spain, 3Hospital de Laredo, Laredo, Spain, 4Hospital Universitario Marques de Valdecilla, Santander, Spain, 5Hospital de Sierrallana, Santander, Spain, 6Hospital Universitario de Canarias, Santa Cruz de Tenerife, Spain, 7Hospital Universitario Marqués de Valdecilla, IDIVAL, Santander, Spain

    Background/Purpose: Behçet’s Disease (BD) incidence varies widely worldwide. Neurobehcet’s disease (NBD) is one of the most severe manifestations of BD. Data on NBD incidence is…
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