Abstracts Archive - Page 2271 of 2607 - ACR Meeting Abstracts

Abstract Number: 2444 • 2013 ACR/ARHP Annual Meeting
The Contribution Of Disease Activity On Function and Quality Of Life In Patients With Ankylosing Spondylitis; Investigating Causality By Using Structural Equation Model
Servet Akar¹, Sabri Erdem², Kivanc Akat³, Dilek Solmaz¹ and Ismail Sari¹, ¹Rheumatology, Dokuz Eylul University School of Medicine, Izmir, Turkey, ²Business Administration, Dokuz Eylul University Faculty of Business, Izmir, Turkey, ³Internal Medicine, Dokuz Eylul University School of Medicine, Izmir, Turkey
Background/Purpose: It has been demonstrated that patient reported questionnaires including disease activity, functional impairment, anxiety and depression were correlated each other. However the causal relationships…
Abstract Number: 2445 • 2013 ACR/ARHP Annual Meeting
Acute Phase Reactant As a Marker Of Anti-Drug Antibody Formation In Ankylosing Spondylitis
Seokchan Hong¹, Eun-Ju Lee², You Jae Kim², Bon San Koo², Wook Jang Seo³, Kyung joo Ahn⁴, Yong-Gil Kim², Chang-Keun Lee² and Bin Yoo², ¹Department of rheumatology, Department of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea, ²Division of Rheumatology, Department of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea, ³Seoul Veterans Hospital, Seoul, South Korea, ⁴KEPCO medical center, Seoul, South Korea
Acute Phase Reactant as a Marker of Anti-drug Antibody Formation in Ankylosing SpondylitisBackground/Purpose: The development of antibodies to biologics is one of the main mechanisms…
Abstract Number: 2446 • 2013 ACR/ARHP Annual Meeting
Opiate Use In Patients With Ankylosing Spondylitis
John D. Reveille¹, Michael M. Ward², MinJae Lee³, Mohammad Rahbar⁴, Manouchehr Ardjomand-Hessabi⁵, Laura A. Diekman⁵, Matthew A. Brown⁶, Lianne S. Gensler⁷ and Michael H. Weisman⁸, ¹Rheumatology, University of Texas Health Science Center at Houston, Houston, TX, ²Bldg 10 CRC Rm 4-1339, NIAMS/NIH, Bethesda, MD, ³Medicine, University of Texas Health Science Center at Houston, Houston, TX, ⁴The University of Texas Health Science Center at Houston, Houston, TX, ⁵Rheumatology, The University of Texas Health Science Center at Houston, Houston, TX, ⁶Translational Research Institute, University of Queensland Diamantina Institute, Brisbane, Australia, ⁷Medicine/Rheumatology, University of California, San Francisco, San Francisco, CA, ⁸Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA
Background/Purpose: Prescription opiates are commonly prescribed in patients with chronic pain, yet there is no evidence that these drugs ameliorate disease progression, and are associated with numerous…
Abstract Number: 2447 • 2013 ACR/ARHP Annual Meeting
Disease Activity Is Associated With Development Of Inflammatory Bowel Disease In Ankylosing Spondylitis: 12-Year Results From OASIS
Ivette Essers^1,2, Sofia Ramiro^3,4, Carmen Stolwijk^1,2, Robert Landewé^5,6, Désirée van der Heijde⁷, Filip van Den Bosch⁸, Maxime Dougados⁹ and Astrid Van Tubergen^1,2, ¹School for Public Health and Primary Care (CAPHRI), Maastricht University, Maastricht, Netherlands, ²Rheumatology, Maastricht University Medical Center, Maastricht, Netherlands, ³Clinical Immunology & Rheumatology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands, ⁴Rheumatology, Hospital Garcia de Orta, Almada, Portugal, ⁵Clinical Immunology and Rheumatology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands, ⁶Rheumatology, Atrium Medical Center, Heerlen, Netherlands, ⁷Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ⁸Rheumatology, Department of Rheumatology Ghent University Hospital, Ghent, Belgium, ⁹Rheumatology B Department, Paris-Descartes University, Cochin Hospital, Paris, France
Background/Purpose: Ankylosing spondylitis (AS) is associated with extra-articular manifestations (EAMs) such as acute anterior uveitis (AAU), inflammatory bowel disease (IBD), and psoriasis. Little is known…
Abstract Number: 2448 • 2013 ACR/ARHP Annual Meeting
Cardiovascular Disease Is Associated With Worse Functional Outcomes In Ankylosing Spondylitis
Lianne S. Gensler¹, Michael M. Ward², MinJae Lee³, Mohammad Rahbar⁴, Matthew A. Brown⁵, John D. Reveille⁶ and Michael H. Weisman⁷, ¹Medicine/Rheumatology, University of California, San Francisco, San Francisco, CA, ²Bldg 10 CRC Rm 4-1339, NIAMS/NIH, Bethesda, MD, ³Medicine, University of Texas Health Science Center at Houston, Houston, TX, ⁴The University of Texas Health Science Center at Houston, Houston, TX, ⁵Translational Research Institute, University of Queensland Diamantina Institute, Brisbane, Australia, ⁶Rheumatology, University of Texas Health Science Center at Houston, Houston, TX, ⁷Rheumatology, Cedars-Sinai Med Ctr, Los Angeles, CA
Background/Purpose: Cardiovascular disease is an important comorbidity in inflammatory arthritis. There is evidence that AS patients have a significant burden of cardiovascular comorbidity. This appears…
Abstract Number: 2449 • 2013 ACR/ARHP Annual Meeting
Patient-Reported Disease Activity and Outcome In Male Versus Female Patients Of The Groningen Leeuwarden Axial Spondyloarthritis (GLAS) Cohort
Suzanne Arends^1,2, Fiona Maas¹, Eveline van der Veer³, Reinhard Bos², Monique Efde², Martha K. Leijsma¹, Hendrika Bootsma¹, Elisabeth Brouwer¹ and Anneke Spoorenberg¹, ¹Rheumatology and Clinical Immunology, University Medical Center Groningen, Groningen, Netherlands, ²Rheumatology, Medical Center Leeuwarden, Leeuwarden, Netherlands, ³Laboratory Medicine, University Medical Center Groningen, Groningen, Netherlands
Background/Purpose: Ankylosing Spondylitis (AS) occurs more often in males than in females. Most women tend to have milder disease and may therefore be underdiagnosed. Male…
Abstract Number: 2450 • 2013 ACR/ARHP Annual Meeting
Differences and Similarities Of Spondyloarthritis Classification Subgroups Defined By The Assessment Of Spondyloarthritis International Society (ASAS)
Jacqueline E. Paramarta¹, Maud Van de Schoot², Maureen C. Turina¹, Carmen A. Ambarus³, Johannes W.J. Bijlsma⁴, Leen de Rycke^1,4 and Dominique L. Baeten⁵, ¹Department of Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands, ²University Medical Center Utrecht, Utrecht, Netherlands, ³Department Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands, ⁴Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands, ⁵Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands
Background/Purpose: Since the Assessment of SpondyloArthritis international Society (ASAS) developed new classification criteria, spondyloarthritis (SpA) is no longer divided into different phenotypic subtypes such as…
Abstract Number: 2411 • 2013 ACR/ARHP Annual Meeting
The Peripheral Blood T Cell Repertoire Before The Clinical Onset Of Rheumatoid Arthritis – a Study Of Incident Cases and Controls
Carl Turesson¹, Ulf Bergström², Edgars Grins³, Olle Melander⁴, Lennart Truedsson⁵, Lennart Jacobsson² and Stefan Jovinge³, ¹Section of Rheumatology, Department of Clinical Sciences, Malmö, Lund University, Malmö, Sweden, ²Rheumatology, Department of Clinical Sciences, Malmö, Lund University, Malmö, Sweden, ³Strategic Research Center for Stem Cell Biology and Cell Therapy, Lund University, Lund, Sweden, ⁴Unit of Hypertension and Cardiovascular Disease, Department of Clinical Sciences, Malmö, Lund University, Malmö, Sweden, ⁵Department of Laboratory Medicine, Section of Microbiology, Immunology and Glycobiology, Lund University, Lund, Sweden
Background/Purpose: Previous studies indicate that circulating antibodies may be detected in individuals who later develop rheumatoid arthritis (RA) years before onset, and T cells have…
Abstract Number: 2413 • 2013 ACR/ARHP Annual Meeting
Expression and Function Of a YAP, a Novel Pathway In Fibroblast-Like Synoviocyte In Rheumatoid Arthritis
Beatrix Bartok, Rheumatology, UCSD School of Medicine, La Jolla, CA
Background/Purpose: Modulating molecular pathways that regulate pathogenic behavior fibroblast-like synoviocytes (FLS) could lead to new therapies for rheumatoid arthritis (RA). Targeting transcription factors are especially…
Abstract Number: 2412 • 2013 ACR/ARHP Annual Meeting
Anti-CCP Antibodies and Increased Cartilage Turnover In Patients Developing Rheumatoid Arthritis
Carl Turesson¹, Christina Book², Ulf Bergström², Lennart Truedsson³, Lennart Jacobsson² and Tore Saxne⁴, ¹Section of Rheumatology, Department of Clinical Sciences, Malmö, Lund University, Malmö, Sweden, ²Rheumatology, Department of Clinical Sciences, Malmö, Lund University, Malmö, Sweden, ³Department of Laboratory Medicine, Section of Microbiology, Immunology and Glycobiology, Lund University, Lund, Sweden, ⁴Section of Rheumatology, Deparment of Clinical Sciences, Lund, Lund University, Lund, Sweden
Background/Purpose: Autoantibodies may be detected years before the onset of rheumatoid arthritis (RA). We have previously shown that levels of Cartilage oligomeric matrix protein (COMP),…
Abstract Number: 2414 • 2013 ACR/ARHP Annual Meeting
Elevated Serum Resistin Levels In Rheumatoid Arthritis With Periodontitis
Byoong Yong Choi¹, Jin-Hee Kim², Kyung Hwa Kim², Kyong Rok Kim³, Sang Hyun Joo⁴, Myeong Jae Yoon³, Hye Jin Oh⁵, Hye Won Kim³, Sung Hae Chang⁶, Eun Young Lee³, Eun Bong Lee⁷, Yong-Moo Lee² and Yeong Wook Song³, ¹Division of Rheumatology, Department of Internal Medicine, Seoul Medical Center, Seoul, South Korea, Seoul, South Korea, ²Department of Periodontology, School of Dentistry, Seoul National University, Seoul, South Korea, ³Division of Rheumatology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea, ⁴Division of Rheumatology, Department of Internal Medicine, Seoul National University, Seoul, South Korea, ⁵Seoul National University, Seoul, South Korea, ⁶Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea, ⁷Division of Rheumatology, Department of Internal Medicine,, Seoul National University College of Medicine, Seoul, South Korea
Background/Purpose: Epidemiological relationships between rheumatoid arthritis (RA) and periodontitis (PD) have been revealed recently. However, the pathologic link between RA and periodontitis has remained unclear.…
Abstract Number: 2415 • 2013 ACR/ARHP Annual Meeting
Phosphorylated Venous Endothelial Nitric Oxide Synthase Is Elevated In Rheumatoid Arthritis Subjects With High Disease Activity
Elizabeth Blair Solow¹, Wanpen Vongpatanasin² and David R. Karp³, ¹Rheumatology, UT Southwestern Medical Center, Dallas, TX, ²Cardiology, UT Southwestern Medical Center, Dallas, TX, ³Rheumatic Diseases Division, UT Southwestern Medical Center, Dallas, TX
Background/Purpose: Endothelial dysfunction is present in arthritis animal models and rheumatoid arthritis (RA), a population known to develop premature cardiovascular disease. Previous studies indicate inflammation…
Abstract Number: 2416 • 2013 ACR/ARHP Annual Meeting
Discovery Of Novel Biomarkers In Rheumatoid Urine : Significance Of Urinary CD14
Yune-Jung Park¹, Hyun-Sook Kim², Seung-Ah Yoo³, Susanna Choi³, Dong-Ho Kim⁴, Chul-Soo Cho⁵ and Wan-Uk Kim⁶, ¹Internal Medicine, St. Vincent's Hospital, The Catholic University of Korea, Suwon, South Korea, ²Division of Rheumatology, Department of Internal Medicine, Soonchunhyang University of Korea, Seoul, South Korea, ³Research Institute of Immunobiology, The Catholic University of Korea, Seoul, South Korea, ⁴Research Institute of Immunobiology, Catholic Research Institute of Medical Science, Seoul, Korea., Seoul, South Korea, ⁵Internal Medicine, Yeouido St. Mary's Hospital, The Catholic University of Korea, Seoul, South Korea, ⁶Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, South Korea
Background/Purpose: Current serum measures for assessing rheumatoid arthritis (RA) are invasive and are not highly sensitive to changes in disease activity. Thus, there is a…
Abstract Number: 2417 • 2013 ACR/ARHP Annual Meeting
Antibodies To Porphyromonas Gingivalis Peptidylarginine Deiminase In Rheumatoid Arthritis Are Not Directed Against The Autocitrullinated Enzyme
Maximilian F. Konig¹, Alizay Paracha², Malini Moni¹, Clifton O. Bingham III¹ and Felipe Andrade¹, ¹Division of Rheumatology, Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, ²The University of Oklahoma, Norman, OK
Background/Purpose: Porphyromonas gingivalis (Pg) has received considerable attention by investigators trying to explain the striking association of periodontal disease (PD) and rheumatoid arthritis (RA). Bacterial…
Abstract Number: 2418 • 2013 ACR/ARHP Annual Meeting
The Transmembrane Protein Tyrosine Phosphatase Kappa Promotes Aggressiveness Of Rheumatoid Arthritis Fibroblast-Like Synoviocytes
Stephanie M. Stanford¹, William B. Kiosses², Amanda M. Campbell³, Michael F. Maestre³, David L. Boyle⁴, Gary S. Firestein⁴ and Nunzio Bottini³, ¹Cellular Biology, La Jolla Institute for Allergy and Immunology, La Jolla, CA, ²The Scripps Research Institute, La Jolla, CA, ³La Jolla Institute for Allergy and Immunology, La Jolla, CA, ⁴Division of Rheumatology, Allergy and Immunology, University of California at San Diego School of Medicine, La Jolla, CA
Background/Purpose: Fibroblast-like synoviocytes (FLS) in the synovial intimal lining are key mediators of inflammation and joint destruction in rheumatoid arthritis (RA). In RA these cells…

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