Abstracts Archive - Page 2271 of 2425 - ACR Meeting Abstracts

Abstract Number: 2272 • 2012 ACR/ARHP Annual Meeting
Gene Expression Signatures in Monocytes From Primary Antiphospholipd Syndrome, Systemic Lupus Erythematosus and Lupus with Antiphospholipid Syndrome Identify Specific Pathways Involved in the Pathogenesis of Atherosclerosis and Cardiovascular Disease
Chary Lopez-Pedrera¹, Sebastiano Messineo², Carlos Perez-Sanchez¹, Patricia Ruiz-Limon¹, Mª Angeles Aguirre³, Rosario M. Carretero-Prieto⁴, Antonio Rodriguez-Ariza¹, Nuria Barbarroja⁴, Francisco Velasco¹, Munther A. Khamashta⁵, Eduardo Collantes-Estevez¹ and Mª Jose Cuadrado⁶, ¹IMIBIC-Reina Sofia Hospital, Cordoba, Spain, ²Dipartimento di Scienze della Salute, Universitá Magna Graecia di Catanzaro, Dipartimento di Scienze della Salute, Universitá Magna Graecia di Catanzaro, Italy., Catanzaro, Italy, ³Rheumatology, IMIBIC-Reina Sofia Hospital, Cordoba, Spain, ⁴Rheumatology Unit, IMIBIC-Reina Sofia University Hospital, Cordoba, Spain, ⁵Lupus Research Unit, The Rayne Institute, St Thomas Hospital, Kings College London School of Medicine, London, United Kingdom, ⁶Lupus Research Unit, The Rayne Institute, Kings College London School of Medicine, London, United Kingdom
Background/Purpose: Systemic lupus erythematosus (SLE) is characterized by immune-mediated inflammation in multiple organ systems. SLE, primary Antiphospholipid syndrome (APS) and secondary APS (SAPS) share several…
Abstract Number: 2273 • 2012 ACR/ARHP Annual Meeting
Functional Genetic Polymorphisms in Immunoglobulin-Like Transcript 3 Are Associated with Decreased Surface Expression On Dendritic Cells and Increased Serum Cytokines in Lupus Patients
Mark A. Jensen, Karen C. Patterson, Akaash A. Kumar, Marissa Kumabe, Beverly S. Franek and Timothy B. Niewold, Section of Rheumatology and Gwen Knapp Center for Lupus and Immunology Research, University of Chicago, Chicago, IL
Background/Purpose: Hyperactivity of the type I interferon (IFN) pathway is involved in the pathogenesis of systemic lupus erythematosus (SLE). Immunoglobulin like transcript (ILT3) is an…
Abstract Number: 2274 • 2012 ACR/ARHP Annual Meeting
Genes Associated with Systemic Lupus Erythematosus Show Evidence of Selection in the Gullah African American Population
Paula S. Ramos¹, Satria Sajuthi², Yiqi Huang³, Diane L. Kamen⁴, Jasmin Divers², Kenneth M. Kaufman⁵, John B. Harley⁶, Robert P. Kimberly⁷, Carl D. Langefeld², Michèle M. Sale³, W. Timothy Garvey⁸ and Gary S. Gilkeson⁹, ¹Department of Medicine, Medical University of South Carolina, Charleston, SC, ²Department of Biostatistical Sciences, Wake Forest School of Medicine, Winston-Salem, NC, ³Department of Medicine and Center for Public Health Genomics, University of Virginia, Charlottesville, VA, ⁴Department of Medicine, Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, Charleston, SC, ⁵1Center for Autoimmune Genomics and Etiology and Rheumatology Division, Cincinnati Children’s Hospital Medical Center and the University of Cincinnati, Cincinnati, OH, ⁶Division of Rheumatology and The Center for Autoimmune Genomics & Etiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ⁷Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, ⁸Department of Nutrition Sciences and Birmingham VA Medical Center, University of Alabama at Birmingham, Birmingham, AL, ⁹Department of Medicine, Division of Rheumatology, Medical University of South Carolina, Charleston, SC
Background/Purpose: In spite of its higher prevalence and severity, little is known about the genetic etiology of systemic lupus erythematosus (SLE) in African Americans (AA).…
Abstract Number: 2275 • 2012 ACR/ARHP Annual Meeting
NR1H3 (LXR alpha) Gene Polymorphisms Are Associated with Systemic Lupus Erythematosus in Koreans
Ja-Young Jeon¹, Hyoun-Ah Kim¹ and Chang-Hee Suh², ¹Department of Rheumatology, Ajou University School of Medicine, Suwon, South Korea, ²Department of Rheumatology, Ajou University Hospital, Suwon, South Korea
Background/Purpose: Liver X receptorsare established sensors of lipid and cholesterol homeostasis. The recent studies have reported that LXRs are involved in regulation of inflammation and…
Abstract Number: 2276 • 2012 ACR/ARHP Annual Meeting
Signature of Circulating Micro-RNA in Systemic Lupus Erythematosus
Anting L. Carlsen¹, Aaron J. Schetter², Christoffer T. Nielsen³, Christian Lood⁴, Steen Knudsen⁵, Anne Voss⁶, Curtis C. Harris⁷, Thomas Hellmark⁸, Mårten Segelmark⁹, Søren Jacobsen¹⁰, Anders A. Bengtsson⁴ and Niels H. H. Heegaard¹¹, ¹Clinical Biochemistry, Immunology & Genetics, Statens Serum Institut, Copenhagen, Denmark, ²National Cancer Institute, National Institutes of Health, Bethesda, MD, ³Department of Clinical Biochemistry, Immunology & Genetics, Statens Serum Institut, Copenhagen S, Denmark, ⁴Department of Clinical Sciences, Section of Rheumatology, Lund University, Lund, Sweden, ⁵Medical Prognosis Institute, Horsholm, Denmark, ⁶Dept of Rheumatology, Odense University Hospital, Odense C, Denmark, ⁷Laboratory of Human Carcinogenesis, National Cancer Institute NIH, Bethesda, MD, ⁸Nephrology, Department of Clinical Sciences, Lund University, Lund, Sweden, ⁹Nephrology, Linkobing University, Linkoping University, Linkoping, Sweden, ¹⁰Department of Rheumatology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark, ¹¹Department of Clinical Biochemistry, Immunology & Genetics, Statens Serum Institut, Copenhagen, Denmark
Background/Purpose: Systemic lupus erythematosus (SLE) is a systemic autoimmune disease characterized by chronic inflammation sustained by a type I interferon response. The diagnostic value of…
Abstract Number: 2277 • 2012 ACR/ARHP Annual Meeting
Familial Aggregation and Heritability of Systemic Lupus Erythematosus in Taiwan: A Nationwide Population Study
Chang-Fu Kuo¹, Matthew J. Grainge², Lai-Chu See³, Kuang-Hui Yu⁴, Shue-Fen Luo⁴, Ana M. Valdes⁵, Hsiao-Chun Chang⁴, I-Jun Chou⁶, Weiya Zhang¹ and Michael Doherty⁷, ¹Academic Rheumatology, School of Clinical Sciences, University of Nottingham, Nottingham, United Kingdom, ²Division of Epidemiology and Public Health, School of Community Health Sciences, University of Nottingham, Nottingham, United Kingdom, ³Department of Public Health, College of Medicine, Chang Gung University, Taoyuan, Taiwan, ⁴Division of Rheumatology, Immunology and Allergy, Chang Gung Memorial Hospital, Taoyuan, Taiwan, ⁵Dept of Twin Research and Genetic Epidemiology, St. Thomas' Hospital, King's College London, London, United Kingdom, ⁶Department of Pediatrics, Chang Gung Memorial Hospital, Taoyuan, Taiwan, ⁷Academic Rheumatology, University of Nottingham, Nottingham, United Kingdom
Background/Purpose: The aims of the present study were to estimate relative risk (RR) of systemic lupus erythematosus (SLE) in individuals with affected relatives in comparison…
Abstract Number: 2278 • 2012 ACR/ARHP Annual Meeting
Single Nucleotide Polymorphisms (SNPs) of Integrin-á-M (ITGAM) Are Associated with Susceptibility to Systemic Lupus Erythematosus (SLE) in an Asian Lupus Cohort
Weng-Giap Law¹, Kok Ooi Kong², Bernard Pui Lam Leung¹, Chack-Yung Yu³, Yeong W. Song⁴, Yun Deng⁵, Hiok-Hee Chng², Betty P. Tsao⁶ and Hwee-Siew Howe⁷, ¹Rheumatology, Allergy & Immunology, Tan Tock Seng Hospital, Singapore, Singapore, ²Department of Rheumatology, Allergy and Immunology, Tan Tock Seng Hospital, Singapore, Singapore, ³Department of Pediatrics, 7Center for Molecular and Human Genetics, The Research Institute at Nationwide Children's Hospital and The Ohio State University, Columbus, OH, ⁴Seoul National University, Seoul, South Korea, ⁵Division of Rheumatology, Department of Medicine, David Geffen School of Medicine University of California Los Angeles, Los Angeles, CA, ⁶Medicine/Rheumatology, UCLA School of Medicine, Los Angeles, CA, ⁷Rheumatology, Allergy and Immunology, Tan Tock Seng Hospital, Singapore, Singapore
Background/Purpose: SLE is a systemic autoimmune disease where lupus nephritis (LN) is a major cause of morbidity and mortality. Integrin-a-M (ITGAM) is critical for the…
Abstract Number: 2279 • 2012 ACR/ARHP Annual Meeting
Genetic Markers for Circulating Vitamin D and the Associations with Risk of Systemic Lupus Erythematosus
Linda T. Hiraki¹, Adrienne H. Williams², Arun-Prasad Manoharan³, Peter Kraft⁴, Carl D. Langefeld⁵, Robert R. Graham⁶ and Elizabeth W. Karlson⁷, ¹Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Harvard School of Public Health, Boston, MA, ²Department of Biostatistical Sciences, Wake Forest School of Medicine, Winston-Salem, NC, ³Genentech, Inc., ⁴Program in Molecular and Genetic Epidemiology, Harvard School of Public Health, Boston, MA, ⁵Center for Public Health Genomics and Department of Biostatistical Sciences, Wake Forest School of Medicine, Winston-Salem, NC, ⁶ITGR Human Genetics, Genentech, Inc., South San Francisco, CA, ⁷Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA
Background/Purpose: Systemic lupus erythematosus (SLE) is a complex, life threatening autoimmune disease and a presumed consequence of susceptibility genes interacting with environmental exposures. Vitamin D…
Abstract Number: 2280 • 2012 ACR/ARHP Annual Meeting
Serum Metabolomics As a Novel Diagnostic Approach for Systemic Lupus Erythematosus
Jun Saegusa¹, Yasuhiro Irino², Masaru Yoshida², Shino Tanaka¹, Yoshinori Kogata¹, Goichi Kageyama¹, Seiji Kawano¹, Goh Tsuji³, Shunichi Kumagai³ and Akio Morinobu¹, ¹Rheumatology and Clinical Immunology, Kobe University Graduate School of Medicine, Kobe, Japan, ²The Integrated Center for Mass Spectrometry, Kobe University Graduate School of Medicine, Kobe University Graduate School of Medicine, Kobe, Japan, ³The Center for Rheumatic Diseases, Shinko Hospital, Kobe, Japan
Background/Purpose: Metabolomics, or metabolome analysis, is the comprehensive study of low-molecular-weight metabolites. The metabolome represents the metabolite profiles of all the cellular processes in a…
Abstract Number: 2281 • 2012 ACR/ARHP Annual Meeting
Tartrate-Resistant Acid Phosphatase Deficiency in the Predisposition to Systemic Lupus Erythematosus
Jie An¹, Tracy A. Briggs², Nalini Agrawal³, Alice Wiedeman⁴, Laurence Chaperot⁵, Joel Plumas⁵, Yanick J. Crow² and Keith B. Elkon⁶, ¹Division of Rheumatology, Department of Medicine & Immunology, University of Washington, Seattle, WA, ²Manchester Academic Health Science Centre, University of Manchester, Manchester, United Kingdom, ³Rheumatology, University of Washington, Seattle, WA, ⁴Department of Immunology, University of Washington, Seattle, WA, ⁵Inserm U823/Ujf/EFS, Immunobiology & Immunotherapy of Cancers, La Tronche, France, ⁶Rheumatology Box 356428, University of Washington, Seattle, WA
Background/Purpose: The enzyme tartrate-resistant acid phosphatase (TRAP) is highly expressed in osteoclasts. One of the main substrates for TRAP in bone matrix is osteopontin (OPN). …
Abstract Number: 2282 • 2012 ACR/ARHP Annual Meeting
Low Gene Copy Number for C4, C4A and C4B Is a Strong Risk Factor for Developing Systemic Lupus Erythematosus in Childhood
Luis Eduardo C. Andrade¹, Kaline M.C. Pereira², Atila G. A. Faria³, Bernadete Liphaus⁴, Adriana A. Jesus⁵, Clovis Silva⁶ and Magda Carneiro-Sampaio⁵, ¹Rheumatology Division, Escola Paulista de Medicina - Universidade Federal de São Paulo, Sao Paulo, Brazil, ²Universidade Federal de São Paulo and Fleury Health and Medicine Laboratories, Sao Paulo, Brazil, ³Rheumatology Division, Universidade Federal de Sao Paulo, Sao Paulo, Brazil, ⁴Pediatria, Instituto da Criança, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil, ⁵Pediatrics, Instituto da Criança da Faculdade de Medicina da Universidade de São Paulo (FMUSP), Sao Paulo, Brazil, ⁶Pediatric Rheumatology, MD; PhD, São Paulo-SP, Brazil
Background/Purpose: C4 is an important component of the Complement system and plays an essential role in the activation cascade of the classical Complement pathway. Complete…
Abstract Number: 2242 • 2012 ACR/ARHP Annual Meeting
Clinical Manifestations and Predictive Factors for Response to Induction Therapy and Maintenance of Remission in ISN/RPS Class V Lupus Nephritis
Masanori Hanaoka, Takahisa Gono, Yasushi Kawaguchi, Hirotaka Kaneko, Kae Takagi, Hisae Ichida, Yasuhiro Katsumata, Yuko Okamoto, Yuko Ota, Sayuri Kataoka and Hisashi Yamanaka, Institute of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan
Background/Purpose: The pathophysiology and the content of treatment differ between International Society of Nephrology/Renal Pathology Society (ISN/RPS) class III/IV lupus nephritis (LN) and class V…
Abstract Number: 2243 • 2012 ACR/ARHP Annual Meeting
A Comparison of Systemic Lupus Erythematosus (SLE) Patients Achieving Prolonged Clinical Quiescence (PCQ) On and off Corticosteroids and/or Immunosuppressive Medications
Amanda J. Steiman¹, Dafna D. Gladman², Dominique Ibanez³, Anjali Papneja⁴ and Murray B. Urowitz³, ¹Rheumatology, Toronto Western Hospital and University of Toronto, Toronto, ON, Canada, ²Centre for Prognosis Studies in The Rheumatic Diseases, Toronto Western Research Institute, University of Toronto, University Health Network, Toronto, ON, Canada, ³Division of Rheumatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ⁴Rheumatology, University of Toronto, Toronto, ON, Canada
Background/Purpose: Some patients with SLE achieve PCQ. We previously described patients achieving corticosteroid- and immunosuppressive-free PCQ. As physicians attempt to minimize patients’ exposure to these…
Abstract Number: 2244 • 2012 ACR/ARHP Annual Meeting
Predicting Sjögren’s Syndrome At Diagnosis of Systemic Lupus Erythematosus
Gabriela Hernandez-Molina¹, Tatiana Zamora-Legoff¹, Juanita Romero-Diaz¹, Carlos Alberto Nuñez-Alvarez¹, Francisco Cárdenas-Velázquez², Carlos Hernández-Hernández³, Maria Luisa Calderillo³, Martha Marroquín³, Claudia Recillas-Gispert⁴, Carmen Ávila-Casado⁵ and Jorge Sánchez-Guerrero⁶, ¹Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico, ²Ophtalmology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico, ³Dental Service, Instituto Nacional de Ciencias Medicas y Nutricion, Mexico City, Mexico, ⁴Ophtalmology, Instituto Nacional de Ciencias Medicas y Nutricion, Mexico City, Mexico, ⁵Pathology, University Health Network, Toronto Canada., Toronto, ON, Canada, ⁶Rheumatology, Mount Sinai Hospital, Toronto Canada., Canada
Background/Purpose: Sjogren’s syndrome (SS) overlaps with systemic lupus erythematosus (SLE) in up to 20% of patients. Attempts to identify the characteristics of the SLE patients…
Abstract Number: 2245 • 2012 ACR/ARHP Annual Meeting
Vitamin D Deficiency Is Associated with, but Does Not Predict, Change in hsCRP in Systemic Lupus Erythematosus (SLE)
Adnan Kiani, Hong Fang and Michelle Petri, Johns Hopkins University School of Medicine, Baltimore, MD
Background/Purpose: In the general population the cardioprotective effects of vitamin D are thought to be due to modulation of inflammatory cytokines. However, the effects of…

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