Session Type: Abstract Submissions (ACR)
Epidemiological relationships between rheumatoid arthritis (RA) and periodontitis (PD) have been revealed recently. However, the pathologic link between RA and periodontitis has remained unclear. Resistin is adipokine which has been involved in insulin resistance in rodents but its pro-inflammatory properties are known to be superior to insulin resistance-inducing effects in human. Previous studies suggested that resistin may play a role in RA and periodontitis.
Serum resistin levels were determined by enzyme-linked immunosorbent assay (ELISA). Ninety RA patients and 45 healthy subjects (2:1 age and gender matched). Serum samples were analysed for C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), anti-cyclic citrullinated peptide (anti-CCP), IgM rheumatoid factor. The disease activity was determined using the Disease Activity Score in 28 joints (DAS28). We divided the subjects into high (DAS28 ≥ 3.2) and low (DAS28 < 3.2) disease activity groups. Clinical measurement for PD such as plaque index (PI), gingival index (GI), probing pocket depth (PPD) and clinical attachment levels (CAL) were performed in total subjects.
Serum resistin levels were significantly increased in active RA patients (DAS28 ≥ 3.2; n = 49, median 11.5 ng/mL) compared to inactive RA patients (DAS28 < 3.2; n = 41, 7.3 ng/mL) or healthy control group (p < 0.01 and p < 0.05 respectively). In total RA patients, serum resistin levels were positively correlated with ESR (r = 0.25, p < 0.05), CRP (r = 0.48, p < 0.01) and DAS28 (r = 0.26, p < 0.05) as well as the severity of PD such as PI (r = 0.36, p < 0.001) and CAL (r = 0.29, p < 0.01). Active RA subgroup had more patients with clinically significant PD (n = 40/49, 81.6%) than inactive RA subgroup (n = 22/41, 53.7%; p < 0.01) and healthy controls (n = 14/45, 31.1%; p < 0.001). Serum resistin levels were also elevated in RA patients with anti-CCP antibody compared to those without (11.28 vs. 8.00 ng/mL, p < 0.05).
Serum resistin levels were elevated in active RA patients compared to inactive RA patients or healthy controls, and associated with the severity of PD and the presence of anti-CCP. The present study suggests that resistin may play a role of pathologic cross-link between RA and PD.
B. Y. Choi,
J. H. Kim,
K. H. Kim,
K. R. Kim,
S. H. Joo,
M. J. Yoon,
H. J. Oh,
H. W. Kim,
S. H. Chang,
E. Y. Lee,
E. B. Lee,
Y. M. Lee,
Y. W. Song,
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ACR Meeting Abstracts - https://acrabstracts.org/abstract/elevated-serum-resistin-levels-in-rheumatoid-arthritis-with-periodontitis/