Abstracts Archive - Page 2261 of 2605 - ACR Meeting Abstracts

Abstract Number: 2554 • 2013 ACR/ARHP Annual Meeting
In Vitro Fertilization In Systemic Lupus Erythematosus and Antiphospholipid Syndrome: A Series Of 82 Cycles
Pauline Orquevaux¹, Agathe Masseau², Véronique le Guern³, Vanessa Gayet⁴, Danièle Vauthier-Brouzes⁵, Du Boutin⁶, Bertrand Wechsler⁷, Nathalie Morel⁸, Jean Loup Pennaforte¹, Jean-Charles Piette⁹ and Nathalie Costedoat-Chalumeau¹⁰, ¹Hu Robert Debre, CHU Reims, Reims, France, ²Internal Medicine Department, Nantes University Hospital, Nantes, France, ³Department of Internal Medicine, Hôpital Cochin, Paris, France, ⁴Cochin Hospital, Paris, France, ⁵gynecology obstetrical, Pitié Salpétrière Hospital, Paris, France, ⁶Internal Medicine, Assistance Publique-Hôpitaux de Paris, Hopital Pitié-Salpétrière, Paris, France, ⁷Internal Medicine, DHU 2iB Internal Medicine Referal Center for Autoimmune diseases Pitie Hospital, Paris, France, ⁸Internal Medicine, COCHIN, Paris, France, ⁹Department of Internal Medicine 1., CHU Pitié-Salpêtrière, Paris, France, ¹⁰Internal Medicine, Department of Internal Medicine, Referral Center for Rare Autoimmune and Systemic Diseases, Hôpital Cochin, AP–HP, Université Paris Descartes, Paris, France
Background/Purpose: Patients with systemic lupus erythematosus (SLE) and antiphospholipid syndrome (APS) undergoing in vitro fertilization (IVF) are at increased risk of both hormone-associated flare and…
Abstract Number: 2555 • 2013 ACR/ARHP Annual Meeting
Development and Validation Of a Questionnaire To Screen For The Presence Of Autoimmune Disease
Alan Boroway¹, Aileen M. Davis², Carolina Landolt-Marticorena¹ and Joan E. Wither³, ¹Rheumatology, Toronto Western Hospital, University of Toronto, Toronto, ON, Canada, ²Toronto Western Research Institute, Toronto Western Hospital, University of Toronto, Toronto, ON, Canada, ³1E420/Div of Rheumatology, Toronto Western Research Institute, Toronto Western Hospital, University of Toronto, Toronto, ON, Canada
Background/Purpose: Healthy family members of patients with systemic autoimmune rheumatic diseases (SARDs) are at higher risk of developing autoimmune disease than the general population. …
Abstract Number: 2556 • 2013 ACR/ARHP Annual Meeting
Concordance Of Indirect Immunofluorescence and Multiplex Immunoassay For Measurement Of Antinuclear Antibodies
Caroline D'Souza¹, Donald L. Kimpel², Walter Oliveira³ and Janet E. Lewis¹, ¹Rheumatology, University of Virginia School of Medicine, Charlottesville, VA, ²Rheumatology and Immunology, University of Virginia School of Medicine, Charlottesville, VA, ³Department of Pathology, Medical Laboratories, University of Virginia, Department of Pathology, Medical Laboratories, Charlottesville, VA
Background/Purpose: The indirect immunofluorescence assay (IIF) is the gold standard for ANA testing. However, many laboratories now use multiplex assay as an ANA screening test.…
Abstract Number: 2557 • 2013 ACR/ARHP Annual Meeting
Fluctuations In sVCAM-1 and Adiponectin Mirror Fluctuations In Disease Activity In Lupus, But Cannot Be Use To Accurately Predict Impending Changes In Disease State
Carolina landolt-Marticorena¹, Stephenie Prokopec², Stacey Morrison³, Heather Reich⁴, James Scholey⁴, Dafna D. Gladman⁵, Murray B. Urowitz⁵, Paul Boutros², Paul R. Fortin⁶ and Joan E. Wither⁷, ¹Rheumatology, Toronto Western Hospital, University of Toronto, Toronto, ON, Canada, ²Ontario Institute for Cancer Research, Toronto, ON, Canada, ³Div Rheumatology Rm MP-10-304, The Toronto Western Hospital, Toronto, ON, Canada, ⁴Department of Medicine, The Toronto Western Hospital, Toronto, ON, Canada, ⁵Division of Rheumatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ⁶University of Laval, Quebec, QC, Canada, ⁷1E420/Div of Rheumatology, Toronto Western Research Institute, Toronto Western Hospital, University of Toronto, Toronto, ON, Canada
Background/Purpose: Previous reports have identified a number of pro-inflammatory cyto/chemokines as candidate activity-specific SLE biomarkers. In our preliminary studies we found that out of a…
Abstract Number: 2558 • 2013 ACR/ARHP Annual Meeting
Bone Morphogenic Protein Receptor 2 (BMPR2) Gene Mutations Are Associated To The Development Of Isolated Pulmonary Arterial Hypertension (PAH) In Systemic Sclerosis (SSc) Patients
Tatiana Sofia Rodriguez-Reyna¹, Jose Luis Hernandez-Oropeza², Tomas Rene Pulido-Zamudio³, Felipe Massó⁴, Jessica Gutierrez-Manjarrez¹, Alexandra Rueda de Leon-Aguirre¹, Julio Sandoval-Zarate³ and Carlos Rodriguez-Osorio⁵, ¹Immunology and Rheumatology, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico, ²Pulmonary Circulation Clinic, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico, ³Pulmonary Circulation Clinic, Instituto Nacional de Cardiologia Ignacio Chavez, Mexico City, Mexico, ⁴Immunology, Instituto Nacional de Cardiologia Ignacio Chavez, Mexico City, Mexico, ⁵Intensive Care Unit, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico
Background/Purpose: Isolated pulmonary arterial hypertension (PAH) secondary to Systemic Sclerosis (SSc) is a severe life-threatening complication. Several pathogenic pathways have been implicated in its development.…
Abstract Number: 2560 • 2013 ACR/ARHP Annual Meeting
Analysis Of Global Gene Expression Of Pulmonary Endothelial Cells From Caveolin-1 Knock-Out Mice
Sonsoles Piera-Velazquez¹, Zhaodong Li¹, Sankar Addya², Peter J. Wermuth¹ and Sergio A. Jimenez¹, ¹Jefferson Institute of Molecular Medicine, Division of Connective Tissue Diseases and Scleroderma Center,Thomas Jefferson University, Philadelphia, PA, ²Department of Cancer Biology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA
Background/Purpose: Caveolin-1 (Cav-1) deficiency has recently been shown to participate in the pathogenesis of tissue fibrosis in Systemic Sclerosis (SSc). Although the mechanisms involved have…
Abstract Number: 2561 • 2013 ACR/ARHP Annual Meeting
Multiplex Cytokine Analysis Of Dermal Interstitial Blister Fluid In Systemic Sclerosis Defines Potential Pathogenic Pathways and Differentiates Clinical Subsets
Kristina E.N. Clark¹, Henry Lopez², Joanna Nikotorowicz-Buniak¹, Xu Shiwen^1,3, Korsa Khan⁴, George Martin⁵, David J. Abraham¹, Christopher P. Denton¹ and Richard J. Stratton¹, ¹Centre for Rheumatology and Connective Tissue Diseases, UCL Medical School, London, United Kingdom, ²Murigenics, Vallejo, CA, ³Rheumatology, Royal Free Hospital, London, United Kingdom, ⁴Centre for Rheumatology and Connective Tissue Diseases, UCL Medical School Royal Free Campus, London, United Kingdom, ⁵Aero Dap, Vallejo, CA
Background/Purpose: Clinical diversity in systemic sclerosis (SSc) is likely to reflect multifaceted pathogenesis and the effect of key growth factors or cytokines operating within a…
Abstract Number: 2563 • 2013 ACR/ARHP Annual Meeting
Modulating Myofibroblast Transition Of Human Scleroderma Fibroblasts Through Inhibition Of Rho Guanine Nucleotidase-Regulated Gene Transcription
Andrew Haak¹, Pei-Suen Tsou², Dinesh Khanna³, David A. Fox², Scott D. Larsen⁴ and Richard R. Neubig⁵, ¹Department of Pharmacology, University of Michigan Medical Center, Ann Arbor, MI, ²Internal Medicine, Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI, ³University of Michigan Health System, Ann Arbor, MI, ⁴Vahlteich Medicinal Chemistry Core, College of Pharmacy, University of Michigan, Ann Arbor, MI, ⁵Department of Pharmacology & Toxicology, Michigan State University, East Lansing, MI
Background/Purpose: Systemic sclerosis (SSc) or scleroderma, like many fibrotic disorders, has no effective therapy. Deposition of collagen and excess extracellular matrix depends on the transition…
Abstract Number: 2566 • 2013 ACR/ARHP Annual Meeting
Nilotinib Treatment Effect In The Skin As Measured By DNA Microarray In Patients With Diffuse Systemic Sclerosis
Jessica K. Gordon¹, Tammara A. Wood², Robert F. Spiera¹ and Michael L. Whitfield², ¹Rheumatology, Hospital for Special Surgery, New York, NY, ²Department of Genetics, Geisel School of Medicine at Dartmouth, Hanover, NH
Background/Purpose: Gene expression profiling by DNA microarray is used to identify potential biomarkers in Systemic Sclerosis (SSc). Discrete gene expression signatures have been observed to…
Abstract Number: 2568 • 2013 ACR/ARHP Annual Meeting
Involvement Of Collagen-Binding Heat Shock Protein 47 In The Scleroderma-Associated Fibrosis
Haiyan Chu¹, Ting Wu¹, Wenyu Wu², Wenzhen Tu³, Yanyun Ma¹, Qingmei Liu¹, Hejian Zou⁴, Li Jin¹ and Jiu-Cun Wang¹, ¹Ministry of Education Key Laboratory of Contemporary Anthropology, School of Life Sciences, Fudan University, Shanghai, China, ²Division of Dermatology, Division of Dermatology, Huashan Hospital, Fudan University, Shanghai, Shanghai, China, ³Medicine, Shanghai Traditional Chinese Medicine-Integrated Hospital, Shang hai, China, ⁴Rheumatology, Huashan Hospital, Shanghai, China
Background/Purpose: Scleroderma or systemic sclerosis (SSc) is characterized by the fibrosis of skin and visceral organs, especially the uncontrolled fibrosis of multiple organs. Collagen is…
Abstract Number: 2569 • 2013 ACR/ARHP Annual Meeting
Serum S100A4 Levels Correlate With Skin Fibrosis and Lung Involvement In Systemic Sclerosis
Michal Tomcik¹, Lucie Andres Cerezo¹, Simona Skacelova², Martin Komarc³, Radim Becvar¹, Mariam Grigorian⁴, Joerg HW Distler⁵ and Ladislav Senolt¹, ¹Institute of Rheumatology, Department of Rheumatology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic, ²Institute of Rheumatology, Department of Rheumatology, 1st Faculty of Medicine, Charles University, Prague, Prague, Czech Republic, ³Institute of Biophysics and Informatics of the First Faculty of Medicine, Charles University, Prague, Czech Republic, ⁴Institute of Cancer Biology, Danish Cancer Society, Copenhagen, Denmark, ⁵Department of Internal Medicine III and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany
Background/Purpose: Our previous study demonstrated that S100A4 is overexpressed in scleroderma (SSc) skin, fibroblasts and preclinical models of SSc in a TGF-β dependent manner. Furthermore,…
Abstract Number: 2570 • 2013 ACR/ARHP Annual Meeting
Tenofovir But Not Adefovir Prevents Liver and Skin Fibrosis In Two Models Of Adenosine-Mediated Injury
Jessica L. Feig¹, Doreen Tivon², Miguel perez Aso³, Timothy Cardozo² and Bruce N. Cronstein⁴, ¹Medicine. Department of Translational Medicine, New York University School of Medicine, New York, NY, ²Department of Translational Medicine, New York University School of Medicine, New York, NY, ³NYU Univ Medical Center, New York, NY, ⁴Internal Medicine, NYU School of Medicine, Division of Rheumatology, New York, NY
Background/Purpose: Acyclic nucleoside phosphonates are a key class of antivirals commonly used in the treatment of both DNA and retroviral infections. Adefovir and tenofovir are…
Abstract Number: 2571 • 2013 ACR/ARHP Annual Meeting
Pigment Epithelium Derived Factor Secreted By Activated Fibroblasts Can Contribute To Impaired Angio and Vasculogenesis In Scleroderma
Vasiliki Liakouli^1,2, Georgia Mavria³, Justin Gillespie⁴, Margherita Scarcia³, Paola Cipriani², Roberto Giacomelli², Paul Emery⁵ and Francesco Del Galdo⁵, ¹Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, UK., Leeds, United Kingdom, ²Rheumatology Unit, University of Aquila, L'Aquila, IT, L'Aquila, Italy, ³Signal Transduction and Angiogenesis group, Leeds Institute of Cancer and Pathology, University of Leeds, Leeds, UK, Leeds, United Kingdom, ⁴Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, ⁵Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds and NIHR Leeds Musculoskeletal Biomedical Research Unit, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom
Background/Purpose: Systemic Sclerosis (SSc) is an autoimmune disorder characterized by tissue fibrosis and vasculopathy. This latter comprises both neointima proliferation and defective angio and vasculogenesis.…
Abstract Number: 2541 • 2013 ACR/ARHP Annual Meeting
Disease Activity Does Not Improve Significantly In One System and Worsen In Another System
Zahi Touma¹, Dafna D. Gladman² and Murray B. Urowitz², ¹Rheumatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ²Division of Rheumatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada
Background/Purpose: Systemic Lupus Erythematous Disease Activity Index-2000 (SLEDAI-2K) is a global index that describes disease activity overall in 9 systems. The use of multiple measures…
Abstract Number: 2532 • 2013 ACR/ARHP Annual Meeting
Changes In Quality Of Life In The First 5 Years Of Disease In The Systemic Lupus Erythematosus International Collaborating Clinics (SLICC) Cohort
Murray B. Urowitz¹, Dominique Ibanez¹, Nicole Anderson¹, Dafna D. Gladman¹ and Systemic Lupus SLICC², ¹Division of Rheumatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ²(coordinating centre), Toronto Western Hospital, Toronto, ON, Canada
Background/Purpose: The Medical Outcome Survey Short Form 36 (SF-36) is one of the most widely used tools for measuring patient reported outcomes. In cross-sectional studies,…

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