Abstracts Archive - Page 2256 of 2605 - ACR Meeting Abstracts

Abstract Number: 2647 • 2013 ACR/ARHP Annual Meeting
Recombinant Monoclonal Antibodies Derived From Single CD19+ Synovial B Cells Of RA Patients With Tertiary Lymphoid Structures Display a Strong Immunoreactivity Towards Citrullinated Histones
Elisa Corsiero¹, Michele Bombardieri², Emanuela Carlotti¹, Hedda Wardemann³, William H. Robinson⁴ and Costantino Pitzalis¹, ¹Centre for Experimental Medicine and Rheumatology, William Harvey Research Institute, QMUL, London, United Kingdom, ²Centre for Experimental Medicine and Rheumatology, William Harvey Research Institute, Queen Mary University of London, London, United Kingdom, ³Max Planck Research Group Molecular Immunology, Max Planck Institute for Infection Biology, Berlin, Germany, ⁴Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA
Background/Purpose: Rheumatoid arthritis (RA) is characterised by breach of self-tolerance towards citrullinated proteins. Around 40% of patients display synovial tertiary lymphoid structures (TLS) with functional…
Abstract Number: 2648 • 2013 ACR/ARHP Annual Meeting
Characterization Of Histidyl-tRNA Synthetase Specific Th Cell Response In Blood and Broncheoalveolar Lavage (BAL) Of Myositis Patients
Inka Albrecht¹, Eddie James², Maryam Fathi³, Maryam Dastmalchi⁴, Jessica Herrath¹, Vivianne Malmström⁵ and Ingrid E. Lundberg⁶, ¹Department of Medicine, Solna, Unit of Rheumatology, Karolinska University Hospital, Department of Medicine, Solna, Unit of Rheumatology, Stockholm, Sweden, ²Benaroya Research Institute, Seattle, WA, ³Karolinska Institutet, Department of Medicine , Respiratory Medicine Unit, Stockholm, Sweden, ⁴Department of Medicine, Karolinska University Hospital, Department of Medicine, Solna, Unit of Rheumatology, Stockholm, Sweden, ⁵Rheumatology Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden, ⁶Rheumatology Unit, Karolinska University Hospital, Solna, Karolinska Institutet, Stockholm, Sweden
Background/Purpose: Idiopathic inflammatory myopathy is a rare chronic inflammatory disease that is associated with the presence of autoantibodies pointing to a contribution of adaptive immune…
Abstract Number: 2649 • 2013 ACR/ARHP Annual Meeting
Rituximab For The Treatment Of IgG4-Related Disease: A Prospective Clinical Trial
Mollie Carruthers¹, Mark Topazian², Arezou Khosroshahi³, Thomas Witzig⁴, Judith Oakley⁵, Philip Hart⁶, Lauren Kelly⁵, Lori Bergstrom⁶, Suresh Chari⁶ and John Stone⁷, ¹Rheumatology, Massachusetts General Hospital, Boston, MA, ²Gastroenterology, Mayo Clinic, Rochester, MA, ³Rheumatology, Emory University School of Medicine, Atlanta, GA, ⁴Hematology & Oncology, Mayo Clinic, Rochester, MN, ⁵Clinical Research Program, Massachusetts General Hospital, Boston, MA, ⁶Gastroenterology, Mayo Clinic, Rochester, MN, ⁷Rheumatology, Massachusetts General Hospital, Harvard Medical School, Boston, MA
Background/Purpose: IgG4-related disease (IgG4-RD) is a multi-organ, fibro-inflammatory disorder. An open label pilot trial of rituximab (RTX) in IgG4-RD conducted at twocentershas enrolled 29 of…
Abstract Number: 2650 • 2013 ACR/ARHP Annual Meeting
Silent Ischemic Heart Disease In Patients With Primary Antiphospholipid Syndrome
Antonio R. Cabral¹, Gregoria Gómez-Hernández², Martha Morelos-Guzmán³, Tatiana Rodriguez-Reyna⁴, Carlos Alberto Núñez-Alvarez⁵ and Jorge Vazquez-Lamadrid³, ¹Immunology and Rheumatology, Instituto Nacional de Ciencias Medicas y Nutricion, Mexico City, Mexico, ²Internal Medicine, Instituto Nacional De Ciencias Médicas y Nutrición Salvador Zubirán, Mexico, Mexico, ³Radiology, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico, ⁴Immunology and Rheumatology, National Institute of Medical Sciences and Nutrition, Mexico City, Mexico, ⁵Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico
Background/Purpose: Premature atherosclerosis in PAPS is still a matter of debate Patients and Methods: To determine the prevalence of ischemic heart disease in…
Abstract Number: 2651 • 2013 ACR/ARHP Annual Meeting
The Association Between Antiphospolipid Antibodies and Related Clinical Outcomes: A Critical Review Of The Literature
Cecilia B. Chighizola¹, Laura Andreoli², Alessandra Banzato³, Guilherme Ramires de Jesus⁴, Guillermo J. Pons-Estel⁵, Doruk Erkan⁶ and On Behalf of APS Action⁷, ¹Rheumatology, Istituto Auxologico Italiano, University of Milan, Cusano Milanino, Italy, ²Rheumatology Unit, University of Brescia, Brescia, Italy, ³Department of Cardiac Thoracic and Vascular Sciences, Department of Cardiac Thoracic and Vascular Sciences, University of Padua, Padua, Italy, ⁴Department of Obstetrics, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil, ⁵Servicio de Enfermedades Autoinmunes, Department of Autoimmune Diseases, Institut Clìnic de Medicina i Dermatologia, Hospital Clìnic, Barcelona, Spain, ⁶Rheumatology, Hospital for Special Surgery, New York, NY, ⁷APS ACTION, New York, NY
Background/Purpose: AntiPhospholipid Syndrome Alliance For Clinical Trials and InternatiOnal Networking (APS ACTION) is an international network that has been created to design and conduct APS…
Abstract Number: 2652 • 2013 ACR/ARHP Annual Meeting
Ovarian Reserve In Women With Primary Antiphospholipid Syndrome
Lucas Yamakami¹, Paulo Serafini², Daniel B. Araujo³, Eloisa Bonfá⁴, Elaine P. Leon⁵, Edmund C. Baracat⁶ and Clovis A. Silva⁷, ¹Gynecology Department, Faculdade de Medicina da Universidade de São Paulo, Sao Paulo, Brazil, ²MD; PhD, Sao Paulo, Brazil, ³Rheumatology, Faculdade de Medicina da Universidade de São Paulo (FMUSP), São Paulo, Brazil, ⁴Rheumatology Division, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil, ⁵Rheumatology, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil, ⁶Gynecology, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil, ⁷Pediatric Rheumatology Unit, University of São Paulo, São Paulo, Brazil
Background/Purpose: Aging, smoking, obesity and surgery have been found to influence the quantity and quality of primordial follicles in ovaries and, ultimately, the ovarian reserve.…
Abstract Number: 2653 • 2013 ACR/ARHP Annual Meeting
Low Vitamin D Is Associated With Increased Risk of Venous Thrombosis in Systemic Lupus Erythematosus, Regardless of Lupus Anticoagulant Status
Michelle Petri and Hong Fang, Johns Hopkins University School of Medicine, Baltimore, MD
Background/Purpose: Vitamin D deficiency is common in SLE. Vitamin D deficiency is also associated with activation of Tissue Factor. In cross-sectional studies, vitamin D deficiency…
Abstract Number: 2654 • 2013 ACR/ARHP Annual Meeting
IgG Antibodies Directed Against Domain I Of ß₂-Glycoprotein I Are Significant Predictors Of Thromboembolic Events In Patients With Antiphospholipid Antibodies. A Prospective Cohort Study
Stephane Zuily¹, Bas de Laat², Francis Guillemin³, Pierre Kaminsky⁴, Hilde Kelchtermans⁵, Roger Albesa⁶, Gary L. Norman⁶, Anne-Christine Rat⁷, Philip de Groot⁸, Thomas Lecompte⁹, Veronique Regnault¹⁰ and Denis Wahl¹, ¹CHU de Nancy, Vascular Medicine Division and Regional Competence Center For Rare Vascular And Systemic Autoimmune Diseases, Nancy, F-54000, France; Inserm, UMR_S 1116, Nancy, F-54000, France; Université de Lorraine, Nancy, F-54000, France, Nancy, France, ²Biochemistry, CARIM, Maastricht University, The Netherlands; Clinical Chemistry and Hematology, UMC Utrecht, The Netherlands; Synapse BV, Maastricht, The Netherlands; Sanquin Research, Amsterdam, The Netherlands, Maastricht, Netherlands, ³CHU Nancy, Clinical Epidemiology and Evaluation, Université de Lorraine, Paris Descartes University, APEMAC, EA 4360, Nancy, France, ⁴Université de Lorraine, Nancy, F-54000, France; CHU de Nancy, Orphan disease unit, Nancy, F-54000, France;, Nancy, France, ⁵Biochemistry, CARIM, Maastricht University, The Netherlands; Synapse BV, Maastricht, The Netherlands, Maastricht, Netherlands, ⁶Research, INOVA Diagnostics, San Diego, CA, ⁷Université de Lorraine, Nancy, F-54000, France; Inserm, CIC-EC CIE6, Nancy, F-54000, France; CHU de Nancy, Clinical Epidemiology and Evaluation Department, Nancy, F-54000, France; CHU de Nancy, Rheumatology department, Nancy, France, ⁸Clinical Chemistry and Hematology, UMC Utrecht, The Netherlands, Utrecht, Netherlands, ⁹Inserm, UMR_S 1116, Nancy, F-54000, France; Université de Lorraine, Nancy, F-54000, France; CHU de Nancy, Haematology Laboratory, Nancy, F-54000, France; Division of Haematology, HUG, Geneva, Switzerland (current address), Geneva, Switzerland, ¹⁰Inserm, UMR_S 1116, Nancy, F-54000, France; Université de Lorraine, Nancy, F-54000, France; CHU de Nancy, Contrat d’interface, Nancy, F-54000, France, Nancy, France
AbstractBackground/Purpose : Our objective was to prospectively determine the prognostic significance of laboratory variables regarding thrombotic events during follow-up, including novel assays IgG antibodies directed…
Abstract Number: 2615 • 2013 ACR/ARHP Annual Meeting
Serum Beta 2 Microglobulin and Its Association With Disease Activity in Patients With Behcet’s Disease
Meltem Alkan Melikoglu¹ and Mehmet Melikoglu², ¹Rheumatology, Ataturk University Faculty of Medicine, Erzurum, Turkey, ²Dermatology, Health Ministry Erzurum Regional Training and Research Hospital, Dermatology, Erzurum, Turkey
Background/Purpose: β2-microglobulin (β2M) is a low-molecular weight protein, that is a constant component of human leukocyte antigen (HLA), which is secreted from all nucleated cells.…
Abstract Number: 2616 • 2013 ACR/ARHP Annual Meeting
Ischemia-Modified Albumin : A Novel Marker of Vascular Involvement in Behcet’s Disease ?
Erhan Capkin¹, Murat Karkucak², Mehmet Kola³, Adem Karaca², süleyman Caner Karahan⁴, Aysegul Sumer⁴, Arzu Aydin Capkin⁵, Ferhat Gokmen² and Refik Ali Sari⁶, ¹rheumatolgy, trabzon, Turkey, ²rheumatology, trabzon, Turkey, ³oftalmology, trabzon, Turkey, ⁴biochemistry, trabzon, Turkey, ⁵dermatology, trabzon, Turkey, ⁶immunology and allergy, trabzon, Turkey
Background/Purpose: The etiology and pathogenesis of Behçet’s disease (BD) are not yet well understood, but immunoregulatory abnormalities have been proposed as pathogenic mechanisms. Ischemia-modified albumin…
Abstract Number: 2617 • 2013 ACR/ARHP Annual Meeting
Clinical Features Of 127 Patients With Behcet’s Disease In Japan
Keisuke Nishimura¹, Jun Saegusa², Sho Sendo³, Yoshinori Kogata¹, Goichi Kageyama¹, Seiji Kawano¹, Shunichi Kumagai⁴ and Akio Morinobu¹, ¹Rheumatology and Clinical Immunology, Kobe University Graduate School of Medicine, Kobe, Japan, ²Department of Evidence-based Laboratory Medicine, Kobe University Graduate School of Medicine, Kobe, Japan, ³Department of Rheumatology and Clinical Immunology, Kobe University Graduate School of Medicine, Kobe, Japan, ⁴Center of rheumatic diseases, Shinko hospital, Kobe, Japan
Background/Purpose: Behcet’s disease (BD) is characterized by recurrent oral aphthae and any of several systemic manifestations including genital ulcer, ocular disease, skin lesions, gastrointestinal involvement,…
Abstract Number: 2618 • 2013 ACR/ARHP Annual Meeting
Bipolar Disorders May Represent a Primary Feature Of Behçet’s Disease
Rosaria Talarico¹, Laura Palagini², Elena Elefante³, Claudia Ferrari⁴, Chiara Stagnaro³, Chiara Baldini³, Chiari Tani³, Marta Mosca⁴ and Stefano Bombardieri³, ¹Rheumatology Unit, Pisa, Italy, ²University of Pisa, Psychiatry Unit, Department of Neuroscience, Pisa, Italy, ³University of Pisa, Rheumatology Unit, Pisa, Italy, ⁴Rheumatology Unit, University of Pisa, Pisa, Italy
Background/Purpose: Frequency of psychiatric disorders in BD is a debated issue: while some experts attribute their presence to the chronicity of the illness, others think…
Abstract Number: 2619 • 2013 ACR/ARHP Annual Meeting
Suicidal Ideation Among Patients With Behcet’s Syndrome
Didem Uzunaslan¹, Caner Saygin¹, Gulen Hatemi², Koray Tascilar¹, Hasan Yazici³ and Vedat Hamuryudan⁴, ¹University of Istanbul, Cerrahpasa Medical Faculty, Rheumatology, Istanbul, Turkey, ²Rheumatology, Istanbul University, Cerrahpasa Medical Faculty, Rheumatology, Istanbul, Turkey, ³Cerrahpasa Medical Faculty University of Istanbul, Istanbul University, Cerrahpasa Medical Faculty, Rheumatology, Istanbul, Turkey, ⁴Division of Rheumatology, Istanbul University, Cerrahpasa Medical Faculty, Rheumatology, Istanbul, Turkey
Background/Purpose: An increased frequency of depression has been reported in Behcet’s syndrome (BS). While an increased suicidal ideation has been reported in other chronic rheumatologic conditions, this…
Abstract Number: 2620 • 2013 ACR/ARHP Annual Meeting
Development Of De Novo Major Involvement During The Follow-Up In Behçet’s Disease
Claudia Ferrari¹, Rosaria Talarico², Chiara Stagnaro³, Anna d'Ascanio⁴, Chiara Tani³, Chiara Baldini³, Marta Mosca¹ and Stefano Bombardieri³, ¹Rheumatology Unit, University of Pisa, Pisa, Italy, ²Rheumatology Unit, Pisa, Italy, ³University of Pisa, Rheumatology Unit, Pisa, Italy, ⁴Malattie muscolo-scheletriche e cutanee, Rheumatology Unit, Pisa, Italy
Background/Purpose: Behçet’s disease (BD) is globally characterized by a variable spectrum of disease profile: while prevalent muco-cutaneous lesions and arthritis represent the only clinical features…
Abstract Number: 2621 • 2013 ACR/ARHP Annual Meeting
Venous Claudication Is A Severe and Frequent Symptom In BEHCET’S Syndrome
SerdaL Ugurlu¹, Emire Seyahi¹, Veysel Oktay², Zerrin Yigit², Serdar Kucukoglu² and Hasan Yazici¹, ¹Division of Rheumatology,Department of Medicine, Cerrahpasa Medical Faculty, University of Istanbul, Istanbul, Turkey, ²Department of Cardiology, Cardiology Institute, University of Istanbul, Istanbul, Turkey
Background/Purpose: In a previous cross-sectional questionnaire survey, we had shown that intermittent claudication was significantly more common among BS patients when compared to healthy controls,…

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