Abstracts Archive - Page 2228 of 2605 - ACR Meeting Abstracts

Abstract Number: 40 • 2014 ACR/ARHP Annual Meeting
Prevalence of Spondyloarthritis (ASAS Criteria) in First-Degree Relatives of Patients with Ankylosing Spondylitis
Raúl Menor Almagro¹, Carmen Ordas², Carlos Montilla³, Jose Luis Alvarez-Vega⁴, Íñigo Hernández-Rodríguez⁵, Montserrat Corteguera⁶, Santiago MuÑoz Fernandez⁷, Claudia Urrego⁸, Rafael Ariza-Ariza⁹, Mireia Moreno¹⁰, Xavier Juanola¹¹, Maria Isabel Tévar¹², Eduardo Collantes- Estevez¹³, Juan Mulero- Mendoza¹⁴ and Ana Ruiz-Zorrilla¹⁵, ¹Rheumatology, Hospital de Jerez, Jerez de la Frontera, Spain, ²Hospital de Cabueñes, Gijón, Spain, ³Rheumatology, Hospital Clínico Universitario de Salamanca, Salamanca, Spain, ⁴H. de Salamanca, Salamanca, Spain, ⁵Rheumatology, University Hospital Complex of Vigo, Vigo, Spain, ⁶Hospital Nª Sª Sonsoles, Avila, Spain, ⁷Sección de Reumatología, Hospital Universitario Infanta Sofía, San Sebastián de los Reyes, Madrid, Spain, ⁸Hospital G. Segovia, Segovia, Spain, ⁹Rheumatology, University Hospital Virgen Macarena, Sevilla, Spain, ¹⁰Rheumatology, Hospital Universitari Parc Taulí, Sabadell, Spain, ¹¹Rheumatology, University Hospital Bellvitge, Barcelona, Spain, ¹²Hospital Vega Baja, Orihuela, Alicante, Spain, ¹³Hospital Reina Sofía, Córdoba, Spain, ¹⁴Hospital Puerta de Hierro, Madrid, Spain, ¹⁵Abbvie, Madrid, Spain
Background/Purpose: Spondyloarthritis (SpA), a group of inflammatory diseases which exhibit similar genetic background, clinical features and symptoms1, has an estimated prevalence of 0.5-1%2 in Spain.…
Abstract Number: 38 • 2014 ACR/ARHP Annual Meeting
Angiopoietin-like 4 Is over-Expressed in Rheumatoid Arthritis: A Potential Role in Pathological Bone Resorption
Catherine Swales¹, Nick Athanasou² and Helen Knowles³, ¹Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, The Botnar Research Centre, Oxford, United Kingdom, ²Nuffield Orthopaedic Centre, Department of Pathology, Oxford, United Kingdom, ³Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Botnar Research Centre, Oxford, United Kingdom
Background/Purpose In contrast to normal synovial tissue, rheumatoid synovium is hypoxic, and expresses the hypoxia-inducible transcription factors HIF-1α and HIF-2α which allow the transcription of…
Abstract Number: 39 • 2014 ACR/ARHP Annual Meeting
Human CD14⁺ Monocytes Stimulated with a Combination of TNFα and IL-6 Differentiate into Osteoclast-like Cells with Bone-Resorption Activity
Kazuhiro Yokota¹, Kojiro Sato², Yoshimi Aizaki², Yuji Akiyama² and Toshihide Mimura², ¹Department of Rheumatology & Applied Immunology, Faculty of Medicine, Saitama Medical University, Saitama, Japan, ²Department of Rheumatology and Applied Immunology, Faculty of Medicine, Saitama Medical University, Saitama, Japan
Background/Purpose Proinflammatory cytokines play an important role in bone destruction in rheumatoid arthritis (RA), as inferred by the efficacy of biologics. Previously, we reported that…
Abstract Number: 37 • 2014 ACR/ARHP Annual Meeting
Regulation of Osteoclast and T Cell Differentiation By DC-STAMP and TRAF3
Yahui Grace Chiu¹, Jinbo Li², Dongge Li¹, Brendan Boyce² and Christopher T. Ritchlin³, ¹Allergy, Immunology and Rheumatology, University of Rochester, Rochester, NY, ²Pathology, University of Rochester, Rochester, NY, ³Allergy Immunology & Rheumatology, University of Rochester Medical Center, Rochester, NY
Background/Purpose DC-STAMP (Dendritic Cell-Specific Transmembrane Protein) is a 7-pass transmembrane protein essential for cell-to-cell fusion during OC differentiation. We have previously shown that DC-STAMP is…
Abstract Number: 56 • 2014 ACR/ARHP Annual Meeting
High Prevalence of Cervical Malignant and Premalignant Lesions Among Women with Rheumatoid and Psoriatic Arthritis
Majed Khraishi¹, Rana Aslanov² and Sarah Khraishi³, ¹Nexus Clinical Research, St John's, NF, Canada, ²Clinical Epidemiology Department, Faculty of Medicine, Memorial University of Newfoundland, St.John's, NF, Canada, ³NL Research Technologies (NLRT), St. John's, NF, Canada
Background/Purpose Rheumatic diseases have been associated with an increased prevalence of malignancy. We aimed to examine the prevalence of precancerous lesions and malignancy in the entire…
Abstract Number: 55 • 2014 ACR/ARHP Annual Meeting
Validation of the Diagnosis of Avascular Necrosis of Bone in Administrative Data
Medha Barbhaiya¹, Yan Dong², Jeffrey A. Sparks¹, Elena Losina², Karen H. Costenbader¹ and Jeffrey N. Katz³, ¹Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, ²Orthopaedic and Arthritis Center for Outcomes Research, Brigham and Women's Hospital, Boston, MA, ³Rheumatology and Orthopedics, Brigham and Women's Hospital, Boston, MA
Background/Purpose: Avascular necrosis (AVN) of bone is a painful, disabling condition. Studies aimed at improving the diagnosis or treatment of AVN require accurate case-finding methods.…
Abstract Number: 54 • 2014 ACR/ARHP Annual Meeting
Concordance with the National Osteoporosis Foundation Treatment Guidelines After DXA Result Notification
Nicole Wright¹, Xin Lu², Stephanie Edmonds², Fredric Wolinsky², Douglas Roblin³, Peter Cram^4,5 and Kenneth G. Saag⁶, ¹Epidemiology, University of Alabama at Birmingham, Birmingham, AL, ²Public Health, University of Iowa, Iowa City, IA, ³Kaiser Permanente Georgia, Atlanta, GA, ⁴University of Iowa, Iowa City, IA, ⁵University of Toronto, Toronto, ON, Canada, ⁶Immunology & Rheumatology, The University of Alabama at Birmingham, Birmingham, AL
Background/Purpose: The National Osteoporosis Foundation (NOF) published treatment guidelines to help guide clinicians on which patients should be considered for osteoporosis (OP) therapy. We examined…
Abstract Number: 53 • 2014 ACR/ARHP Annual Meeting
Spine-Hip Diagnostic Discordance in the United Arab Emirates
Nicholas Wilson, Lidia Sanchez Riera, Iman Hobeldin, Salman Waheeduddin, Nehad Ibrahim, Suneetha Gonuguntla, Tahir Khan, Ritu Aneja, Samer Nuhaily and Mustafa Al Maini, Mafraq Hospital, Abu Dhabi, United Arab Emirates
Background/Purpose Diagnostic discordance for osteoporosis is the presence of different T-scores in two skeletal sites in the same subject leading to different WHO diagnostic categories. Discordance is defined…
Abstract Number: 51 • 2014 ACR/ARHP Annual Meeting
High Incidence of Non-Vertebral Osteoporotic Fracture and Hip Fracture in Brazilian Low-Income Community-Dwelling Elderly: A Population-Based Prospective Cohort Analysis from the São Paulo Ageing & Health (SPAH) Study
Diogo S. Domiciano¹, Luana G. Machado², Jaqueline B. Lopes², Camille P. Figueiredo², Valéria Caparbo², Liliam Takayama², Ricardo Oliveira³, Paulo R Menezes⁴ and Rosa M. R. Pereira⁵, ¹Rheumatology, Faculdade de Medicina, University of São Paulo, São Paulo, Brazil, ²Rheumatology Division, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil, ³RDO Diagnósticos Médicos, São Paulo, Brazil, ⁴Preventive Medicine, Faculdade de Medicina, University of São Paulo, São Paulo, Brazil, ⁵Reumatologia, Faculdade de Medicina, University of São Paulo, São Paulo, Brazil
Background/Purpose: There is considerable variability in the incidence of hip fracture among countries, even among different geographical areas within the same country. In Brazil, population…
Abstract Number: 52 • 2014 ACR/ARHP Annual Meeting
Visceral Fat Measured By Dual-Energy X-Ray Absorptiometry Is Associated with Increased Risk of Non-Spine Fractures in Nonobese Elderly Women: a Population-Based Prospective Cohort Analysis from the São Paulo Ageing & Health (SPAH) Study
Luana G. Machado¹, Diogo S Domiciano¹, Camille P. Figueiredo¹, Jaqueline B. Lopes¹, Valéria Caparbo¹, Liliam Takayama¹, Ricardo M. Oliveira² and Rosa M R Pereira¹, ¹Rheumatology Division, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil, ²RDO Diagnosticos Medicos, São Paulo, Brazil
Background/Purpose The protective role of obesity on bone health has currently been questioned, since it has been demonstrated that visceral fat have a deleterious effect…
Abstract Number: 50 • 2014 ACR/ARHP Annual Meeting
Incidence and Risk Factors for Osteoporotic Vertebral Fracture in Low-Income Community-Dwelling Elderly: A Population-Based Prospective Cohort Study in Brazil. the São Paulo Ageing & Health (SPAH) Study
Diogo S. Domiciano¹, Luana G. Machado², Jaqueline B. Lopes², Valéria Caparbo², Liliam Takayama², Ricardo M. Oliveira³ and Rosa M. R. Pereira⁴, ¹Rheumatology, Faculdade de Medicina, University of São Paulo, São Paulo, Brazil, ²Rheumatology Division, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil, ³RDO Diagnosticos Medicos, São Paulo, Brazil, ⁴Reumatologia, Faculdade de Medicina, University of São Paulo, São Paulo, Brazil
Background/Purpose: Vertebral fractures are associated with increased future fracture risk and mortality. No data on incidence of osteoporotic vertebral fracture have been reported in low-income…
Abstract Number: 49 • 2014 ACR/ARHP Annual Meeting
Long-Term Oral Bisphosphonate Use for Osteoporosis Among Older Women – US and Canadian Perspective
Nicole C. Wright¹, Wilson Smith², Amy H. Warriner³, Jeff Foster⁴, Ruth McConnell⁵, Huifeng Yun⁶, Mary H Melton⁷, Jeffrey R. Curtis⁴ and Kenneth G. Saag⁸, ¹Epidemiology, The University of Alabama at Birmingham, Birmingham, AL, ²Clinical Immunology/Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ³Endocrinology, Diabetes, and Metabolism, The University of Alabama at Birmingham, Birmingham, AL, ⁴The University of Alabama at Birmingham, Birmingham, AL, ⁵University of Alabama at Birmingham, Birmingham, AL, ⁶Epidemiology, University of Alabama at Birmingham School of Public Health, Birmingham, AL, ⁷Medicine, The University of Alabama at Birmingham, Birmingham, AL, ⁸Immunology & Rheumatology, The University of Alabama at Birmingham, Birmingham, AL
Background/Purpose: Bisphosphonates (BPs) have been widely used for the treatment and prevention of osteoporosis for two decades. Although new parenteral preparations have been introduced, oral…
Abstract Number: 48 • 2014 ACR/ARHP Annual Meeting
Osteoporotic Women at High Risk for Fractures Despite Two Years of Oral Bisphosphonate Therapy: Analysis Using the Canadian Multicentre Osteoporosis Study
Jonathan D. Adachi¹, David Goltzman², Ankita Modi³, Jackson Tang⁴, Chun-Po S. Fan⁴ and Jessica Weaver³, ¹Division of Rheumatology, McMaster University, Hamilton, ON, Canada, ²McGill University, Montreal, QC, Canada, ³Global Health Outcomes, Merck & Co., Inc., Whitehouse Station, NJ, ⁴Asclepius Analytics, New York, NY
Background/Purpose Individuals with osteoporosis (OP) have an increased susceptibility to fractures. Prevention and treatment of postmenopausal OP is critical to decreasing the risk of non-traumatic…
Abstract Number: 47 • 2014 ACR/ARHP Annual Meeting
The Risk of Aplastic Anemia and Pancytopenia with Colchicine: A Retrospective Study of Integrated Health System Database
Jasvinder A. Singh¹, Shuo Yang² and Jeff Foster³, ¹University of Alabama at Birmingham, Birmingham, AL, ²Clinical Immunology/Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ³The University of Alabama at Birmingham, Birmingham, AL
Background/Purpose Colchicine is a commonly used medication, sometime associated with bone marrow toxicity. The objective of this study was to examine the risk of severe…
Abstract Number: 46 • 2014 ACR/ARHP Annual Meeting
Xanthine Oxidase Inhibitors and Risk of Type 2 Diabetes in Patients with Gout
Seoyoung C. Kim¹, John D. Seeger², Jun Liu³ and Daniel H. Solomon⁴, ¹Div. of Pharmacoepidemiology and Pharmacoeconomics, Div. of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA, ²Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women's Hospital/Harvard Medical School, Boston, MA, ³Division of Pharmaoepidemiology, Brigham and Women's Hospital, Boston, MA, ⁴Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA
Background/Purpose: Hyperuricemia and gout are associated with an increased risk of type 2 diabetes (T2D). Xanthine oxidase inhibitors (XOI), allopurinol and febuxostat, are the main…

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