Abstract Number: 959 • 2013 ACR/ARHP Annual Meeting
Interleukin 10 Negatively Correlates With Glycoprotein VI-Related Platelet Activation In Rheumatoid Arthritis (RA): A Novel Potential Target Of Cardiovascular Morbidity In RA
Background/Purpose: Patients with rheumatoid arthritis (RA) die prematurely of cardiovascular disease (CVD). Platelet mediated thrombosis is a major cause of CVD. Platelets amplify inflammation in RA via the collagen receptor,…Abstract Number: 960 • 2013 ACR/ARHP Annual Meeting
Self-Perceived Efficacy of a Workshop On Musculoskeletal Clinical Anatomy
Background/Purpose: Knowledge of musculoskeletal anatomy is suboptimal at many levels of rheumatology training and practice. In a recent practical anatomy pre-test administered prior to a…Abstract Number: 961 • 2013 ACR/ARHP Annual Meeting
Assessment and Promotion of a National Immunology Curriculum for Adult Rheumatology Residents
Background/Purpose: Immunologic mechanisms play an integral role in understanding the pathogenesis and management of rheumatic conditions. Currently, there is limited access to standardized formal instruction…Abstract Number: 962 • 2013 ACR/ARHP Annual Meeting
Electronic Learning Module Enhances Rheumatology Education
Background/Purpose: Electronic-learning (e-learning) has recently increased in use. Blended learning combines e-learning with traditional training. At the University of Cincinnati Division of Rheumatology, only traditional…Abstract Number: 963 • 2013 ACR/ARHP Annual Meeting
Impact Of a Nurse-Led Program On Comorbidity Management In Rheumatoid Arthritis (RA): Results Of a Prospective, Multicenter, Randomized, Controlled Trial
Background/Purpose: Patients with rheumatoid arthritis (RA) are at an increased risk of developing numerous comorbid conditions that affect both mortality and RA outcome. Objectives: To…Abstract Number: 964 • 2013 ACR/ARHP Annual Meeting
Redesign Of a Rheumatology Curriculum For Internal Medicine Residents: Results Of Needs Assessment Survey
Background/Purpose: We plan to improve internal medicine (IM) resident competence in caring for patients with rheumatologic disease and increase resident interest in rheumatology as a…Abstract Number: 965 • 2013 ACR/ARHP Annual Meeting
The “Mini-Residency” In Musculoskeletal Care: An Efficient and Effective Mixed Method Model For Continuing Professional Education
Background/Purpose: The societal burden of musculoskeletal (MSK) disease is amplified by the limited number of subspecialists. Developing knowledge and skills of primary providers is projected…Abstract Number: 966 • 2013 ACR/ARHP Annual Meeting
Less Is More? A Targeted Intervention Results In Substantial Improvement In rheumatologists’ Ordering Of Anti Nuclear Antibodies (ANA) In Patients With Rheumatic Complaints
Background/Purpose: Anti-Nuclear Antibodies (ANA) are found both in patients with (non-)rheumatic diseases and in healthy controls1. ANA testing is useful in the diagnostic process of…Abstract Number: 967 • 2013 ACR/ARHP Annual Meeting
‘Bending’ Ethical Norms To Serve Patients’ Interests: Tensions In Medical Professionalism
Background/Purpose: The rheumatic diseases are a common cause of short and long-term disability. Affecting all sectors of the population, they diminish wellbeing, affect quality of…Abstract Number: 930 • 2013 ACR/ARHP Annual Meeting
The Endocannabinoid Anandamide Modulates Adhesion, Proliferation and The Production Of Inflammatory Mediators In Rheumatoid Arthritis Synovial Fibroblasts By Activating CB1, TRPV1, TRPA1 and Non-Cannabinoid Receptor Targets
Background/Purpose: In rheumatoid arthritis (RA), synovial fibroblasts (SF) secrete large amounts of IL-6, IL-8 and matrix metalloproteinases (MMPs) which are crucial for cartilage destruction. RASFs…Abstract Number: 939 • 2013 ACR/ARHP Annual Meeting
Reduction Of Circulating Blood Neutrophils In Mice By Anti-IL-6R Alpha Monoclonal Antibody is Not Due To Apoptosis Or Blockade Of Neutrophil Differentiation
Background/Purpose: Blockade of IL-6/IL-6Rα signaling is associated with a reduction of circulating neutrophils in the blood of patients treated with anti-IL-6Rα mAb but the mechanism…Abstract Number: 928 • 2013 ACR/ARHP Annual Meeting
The Bioenergetic Role of HIF-1 and HIF-2 During Angiogenesis of Human Microvascular Endothelial Cells
Background/Purpose: Hypoxia is a feature of inflamed tissues. The transcription factors Hypoxia inducible factor (HIF)-1 and (HIF)-2 regulate the cellular and metabolic responses to reduced…Abstract Number: 929 • 2013 ACR/ARHP Annual Meeting
Blockade Of TNFα Produced By TSLP-Primed CD1c Myeloid Dendritic Cells Skews T Cell Response To Th2 Activity In Rheumatoid Arthritis Patients
Background/Purpose: Thymic stromal lymphopoietin (TSLP) is well known for its potent activation of myeloid dendritic cells (mDCs) to induce Th2-mediated immune responses. Additionally, TSLP and…Abstract Number: 931 • 2013 ACR/ARHP Annual Meeting
Effect Of Neutralizing IL-17A and IL-17F Antibodies On Host Resistance To Acute Mycobacterium Tuberculosis Infection In Mice In Comparison With Neutralizing TNF-α Treatment
Background/Purpose: Antibodies targeting IL-17A or IL-17RA are in clinical trials for the treatment of several autoimmune diseases. However, these therapies, by blocking critical mediators of…Abstract Number: 932 • 2013 ACR/ARHP Annual Meeting
Hypoxia and Signal Transducer and Activator Of Transcription 3 Signalling Interactions Regulate Pro-Inflammatory Pathways In Rheumatoid Arthritis
Background/Purpose: Signal Transducer and Activator of Transcription 3 (STAT3), a critical transcription activator in angiogenesis, plays a crucial role in the pathogenesis of Rheumatoid Arthritis…