Session Information
Session Title: Systemic Lupus Erythematosus - Clinical Aspects and Treatment: Treatment and Management Studies
Session Type: Abstract Submissions (ACR)
Background/Purpose
Physical activity (PA) plays a decisive role in primary and secondary prevention in various domains of medicine. Our examination aimed to determine association PA and on outcomes in systemic lupus erythematodes (SLE).
Methods
The LuLa-Study is a prospective long-term study since 2001, which systematically collects patients’ reported outcomes among members of the German SLE Self-Help Organization. In 2006 and 2009 we analysed data of 750 patients (94.4% female, age 52.3±12.9 years (mean±SD), duration of disease 15.9 years in 2009) with regard to their PA applying the „Freiburger Questionnaire on physical activity“. We calculated the Metabolic Equivalent of Task (MET) for every patient. In the univariate analysis we compared 422 patients with low/intermediate PA (<30 MET, n=259) to those with high/very high activity (>30 MET, n=163) in both years. Furthermore, we examined the association of PA to disease activity, HRQoL (SF-12) and clinical symptoms in a multivariate regression analysis with age, sex, BMI and number of comorbidities.
Results
The medium MET of the group with low/intermediate PA was 13.4±7.6 respectively, 73.9±31.5 with high/very high PA. A high PA in 2006 and 2009 was associated with less cephalgia (p<0.006) and muscle weakness (p<0.009) and with lower disease activity in 2009 (determined with SLE Activity Questionnaire (SLAQ) and VAS; p<0.001). No statistically significant relation between PA and myalgia or arthralgia could be found. Patients with high MET in 2006 and 2009 showed a better HRQoL (Physical Component Summary (p<0.001) and Mental Component Summary (p<0.014) determined with SF 12) in 2009. Both groups of activity improved their emotional HRQoL between 2006 and 2009, whereas the physical HRQoL stagnated in both groups. A higher PA in 2006 and 2009 was connected to a lower damage (determined by System Lupus International Collaborating Clinics/ACR Damage Index for SLE (SLICC-) Score; p<0.012) as well as to an improved fatigue (Vanderbilt Fatigue Score (VFS); p<0.001) and a different cognition of pain (FSS-Score; p<0.001) in 2009. The multivariate analysis included all 750 patients (medium MET in 2006 28.5±26.1, in 2009 34.5±37.7) and affirmed the influence of higher MET to the above outlined scores. It could be shown, that a higher PA of 10 MET is related to a decreasing SLAQ (-0.43 points) three years later (p<0.001). This effect remained after adjusting for the covariates. The same activity of 10 MET in 2009 is only associated with a decreasing SLAQ (-0.30 points) (p<0.001). A similar observation could be depicted for emotional and physical HRQoL.
Conclusion
PA of SLE patients does have an impact on clinical manifestations and is related to a higher HRQoL. As increased PA has an impact on HRQoL and SLAQ three years later, a recommendation of more PA seems reasonable.
Disclosure:
I. Kloubert,
GlaxoSmithKline ,
9,
UCB,
9;
G. Chehab,
GlaxoSmithKline,
9,
UCB,
9;
J. Richter,
GlaxoSmithKline,
9,
UCB,
9;
R. Fischer-Betz,
GlaxoSmithKline,
9,
UCB,
9;
R. Brinks,
GlaxoSmithKline,
9,
UCB,
9;
M. Schneider,
GlaxoSmithKline,
9,
UCB,
9.
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ACR Meeting Abstracts - https://acrabstracts.org/abstract/how-important-is-physical-activity-for-patients-with-systemic-lupus-erythematodes-results-of-lula-study/