Abstracts Archive - Page 2070 of 2425 - ACR Meeting Abstracts

Abstract Number: 2719 • 2013 ACR/ARHP Annual Meeting
Urinary Angiostatin As Alternative To Biopsy In lupus Nephritis Patients Among Egyptian
Shereen Algergawy¹, Osama Alshaar² and Rania Zakaria³, ¹rheumatology and rehabilitation, associate prof at benha university faculty of medicine rheumatology and rehabilitation department Egypt, cairo, Egypt, ²clinical pathology, benha university faculty of medicine, benha, Egypt, ³pathology, benha university faculty of medicine, benha, Egypt
Background/Purpose: Lupus nephritis (LN) is one of the most frequent manifestations of SLE and can be present in 60% of SLE patients. Kidney biopsy remains…
Abstract Number: 2720 • 2013 ACR/ARHP Annual Meeting
Providing Comprehensive, Comparative Post-TJR Outcome Feedback To Surgeons For Quality Monitoring and Value Decisions
Patricia D. Franklin¹, Bruce Barton², Leslie R. Harrold³, Wenjun Li¹, Regis O'Keefe⁴, Jeroan Allison² and David Ayers¹, ¹Orthopedics and Physical Rehabilitation, University of Massachusetts Medical School, Worcester, MA, ²Quantitative Health Sciences, University of Massachusetts Medical School, Worcester, MA, ³University of Massachusetts Medical School, Worcester, MA, ⁴University of Rochester Medical Center, Rochester, NY
Background/Purpose: With the CMS decision to publicly report hospital-specific post-operative total joint replacement (TJR) events and readmissions, surgeons and hospitals need comprehensive post-hospital data by…
Abstract Number: 2721 • 2013 ACR/ARHP Annual Meeting
Exercise Therapy and Ultrasound Guided Glucocorticoid Injection In Patients With Painful Shoulder: A Randomised Controlled Trial
Karen Ellegaard¹, Robin Christensen², Sara Rosager Mortensen¹, Cecilie Bartholby³, Søren Torp-Pedersen⁴, Thomas Bandholm⁵, Bente Danneskiold-Samsøe⁴, Henning Bliddal⁶ and Marius Henriksen⁷, ¹Department of rheumatology, Frederiksberg Hospital, The Parker Institute, Copenhagen, Denmark, ²Musculoskeletal Statistics Unit, The Parker Institute, Department of Rheumatology, Copenhagen University Hospital, Bispebjerg and Frederiksberg, Denmark, ³Department of rheumatology, Frederiksberg Hospital, The Parker Institute, Copenhangen, Denmark, ⁴Rheumatology, Copenhagen University Hospital, Bispebjerg and Frederiksberg, The Parker Institute, Department of Rheumatology, Copenhagen University Hospital, Bispebjerg and Frederiksberg, Denmark, Frederiksberg, Denmark, ⁵Hvidovre Hospital, Copenhagen, Denmark, ⁶The Parker Institute, Copenhagen, Denmark, ⁷Department of Rheumatology, The Parker Institute, Copenhagen University Hospital at Frederiksberg, Copenhagen F, Denmark
Background/Purpose: SubAcromial Impingement (SAI) accounts for approximately 50% of all shoulder pain. The most commonly used treatments for SAI are glucocorticoid injection, exercise therapy or…
Abstract Number: 2722 • 2013 ACR/ARHP Annual Meeting
In Vivo Administration Of MiR-146a Protects C57BL/6 Mice From Pristane-Induced Pulmonary Hemorrhage Via Suppressing Type I Interferon Response
Dong Liang¹, Shiyu Zhou², Zheng Liu³, Zhengyuan Shan¹, Philip Brohawn³, Yihong Yao³, John B. Harley^4,5 and Nan Shen^1,2,6, ¹Division of Rheumatology & the Center for Autoimmune Genomics and Etiology (CAGE), Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, ²Shanghai Institutes for Biological Sciences Chinese Academy of Sciences & Shanghai Jiao Tong University School of Medicine, Shanghai, China, ³Translational Sciences, MedImmune, LLC, Gaithersburg, MD, ⁴Division of Rheumatology and The Center for Autoimmune Genomics & Etiology, University of Cincinnati, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, ⁵US Department of Veterans Affairs Medical Center, Cincinnati, OH, ⁶Shanghai Institute of Rheumatology, Shanghai Institute of Rheumatology, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
Background/Purpose: miR-146a as an endogenous regulator plays a critical role in resolving acute inflammation. The risk-associated genetic variant in miR-146a promoter was linked to reduced…
Abstract Number: 2723 • 2013 ACR/ARHP Annual Meeting
Role Of Interferon-Inducible RNA-Dependent Protein Kinase In The Pathogenesis Of Systemic Lupus Erythematosus
Aurélie De Groof¹, Benoît Van den Eynde², Frédéric A. Houssiau³ and Bernard Lauwerys¹, ¹Pôle de Maladies Rhumatismales, Institut de Recherche Expérimentale et Clinique, Université catholique de Louvain, Brussels, Belgium, ²Institut de Duve, Université catholique de Louvain, Brussels, Belgium, ³Institut de Recherche Expérimentale et Clinique, Pôle de Maladies Rhumatismales, Université catholique de Louvain, Brussels, Belgium
Background/Purpose: PRKR (interferon-inducible RNA-dependent protein kinase) is an intracytoplasmic molecule that induces the production of interferon(IFN)-induced genes upon binding of double-stranded RNA viruses. PRKR is…
Abstract Number: 2724 • 2013 ACR/ARHP Annual Meeting
cAMP Responsive Element Modulator (CREM)α Governs CD8 Expression and Contributes to the Generation of CD3⁺CD4^–CD8^– T Cells in Lupus
Christian M. Hedrich¹, José C. Crispín¹, Thomas Rauen¹, Christina Ioannidis¹, Tomohiro Koga², Noe Rodriguez Rodriguez², Sokratis A. Apostolidis³, Vasileios C. Kyttaris² and George C. Tsokos¹, ¹Medicine/Rheumatology, BIDMC, Harvard Medical School, Boston, MA, ²Medicine/Rheumatology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, ³Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA
Background/Purpose: CD3+CD4-CD8- "double negative" T cells are expanded in the peripheral blood of patients with systemic lupus erythematosus (SLE) and lupus-prone mice. Double negative T…
Abstract Number: 2725 • 2013 ACR/ARHP Annual Meeting
Regulation Of Aberrant CD4 T Cell Activation By Suppressor Of Cytokine Signaling-1 (SOCS1) Mimetic Peptide, Has Relevance To Human Systemic Lupus Erythematosus
Tenisha Wilson¹, Cristina Armbruster², Simone Bedoya², Howard M. Johnson², Westley H. Reeves³, Yi Li⁴, Ying Yi Zheng⁵, Laurence Morel⁶ and Joseph Larkin III², ¹Division of Rheumatology & Clinical Immunology, University of Florida, Gainesville, FL, ²Microbiology and Cell Science, University of Florida, Gainesville, FL, ³Rheumatology & Clinical Imm, University of Florida, Gainesville, FL, ⁴Medicine, University of Florida, Gainesville, FL, ⁵Pathology, University of Florida, Gainesville, FL, ⁶Pathology/Immunology/Lab Medical, University of Florida, Gainesville, FL
Background/Purpose: Systemic lupus erythematosus (SLE) is an autoimmune disease, mediated by aberrantly activated CD4 T cells. Notably, suppressor of cytokine signaling-1 (SOCS1) regulates CD4 T…
Abstract Number: 2727 • 2013 ACR/ARHP Annual Meeting
Immunologic and Inflammatory Markers Of Impending Disease Flare In Systemic Lupus Erythematosus Patients Not Taking Immunosuppressive Medications In The Biomarkers Of Lupus Disease (BOLD) Study
Joel M. Guthridge¹, Mikhail G. Dozmorov², Melissa E. Munroe³, Krista M. Bean¹, Sudhakar T. Sridharan⁴, Joan T. Merrill⁵ and Judith A. James⁶, ¹Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ²Arthritis and Clincial Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ³Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁴BioTherapeutics R&D, Pfizer Inc, Collegeville, PA, ⁵Department of Clinical Pharmacology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁶Clinical Arthritis and Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK
Background/Purpose: Systemic lupus erythematosus (SLE) is a clinically heterogeneous disorder characterized by a waxing and waning clinical course. Predictors of clinical disease flare have been…
Abstract Number: 2728 • 2013 ACR/ARHP Annual Meeting
The Small Ubiquitin Related Modifier-1 (SUMO-1) Regulates Osteoclast Differentiation In Vitro and In Vivo.
Svetlana Frank¹, Daniel Umlauf², Olli A. Jänne³ and Thomas Pap⁴, ¹Institute of Experimental Musculoskeletal Medicine, University Hospital Münster, Muenster, Germany, ²Institute of Experimental Musculoskeletal Medicine, University Hospital Muenster, Muenster, Germany, ³Univ Helsinki, Inst Biomed Physiol, Biomedicum, Helsinki, Finland, ⁴Institute of Experimental Muskuloskeletal Medicine, University Hospital Münster, Münster, Germany
Background/Purpose: Posttranslational modification of proteins by SUMO has been shown for a number of target molecules including transcription factors and is involved in a variety…
Abstract Number: 2729 • 2013 ACR/ARHP Annual Meeting
Identification Of Osteoarthritis Patients With Chronic Inflammation Driven Disease Progression
Anne Sofie Siebuhr¹, Kristian Kjaer Petersen², Lars Arendt-Nielsen³, Line Egsgaard², Thomas Navndrup Eskehave⁴, Ole Simonsen⁵, Claus Christiansen^4,6, Hans Christian Hoeck⁴, Morten Asser Karsdal⁷ and Anne C. Bay-Jensen⁸, ¹Cartilage Biomarkers and Research, Nordic Bioscience, Herlev, Denmark, ²Department of Health Science and Technology, Faculty of Medicine, Aalborg University, Denmark, Center for Sensory-Motor Interaction, Aalborg, Denmark, ³Department of Health Science and Technology, Faculty of Medicine, Aalborg University, Center for Sensory-Motor Interaction, Aalborg, Denmark, ⁴Center for Clinical and Basic Research and C4Pain, Aalborg, Denmark, ⁵Frederikshavn Hospital, Frederikshavn, Denmark, ⁶Nordic Bioscience, Herlev, Denmark, ⁷Nordic Bioscience, Biomarkers and Research, Herlev, Denmark, ⁸Rheumatology, Nordic Bioscience, Biomarkers and Research, Herlev, Denmark
Background/Purpose: In osteoarthritis (OA) it is evident that a subset of patients experiences chronic tissue inflammation and may benefit from anti-inflammatory treatment. The systemic inflammation…
Abstract Number: 2730 • 2013 ACR/ARHP Annual Meeting
Netrin1 Is a Critical Autocrine Factor For Osteoclast Differentiation
Aranzazu Mediero¹, Bhama Ramkhelawon², Kathryn Moore², P. Edward Purdue³, Steven R. Goldring⁴ and Bruce N. Cronstein⁵, ¹Medicine, Division of Translational Medicine, NYU School of Medicine, New York, NY, ²Leon H. Charney Division of Cardiology, Department of Medicine,, NYU School of Medicine, New York, NY, ³Research, Hospital for Special Surgery, New York, NY, ⁴Hospital for Special Surgery, New York, NY, ⁵Internal Medicine, NYU School of Medicine, Division of Rheumatology, New York, NY
Background/Purpose: Netrins have been extensively studied for their role in axonal guidance during neural development. In addition, netrins are chemopulsants for a variety of non-neuronal…
Abstract Number: 2731 • 2013 ACR/ARHP Annual Meeting
An Acetyl-Histone Mimetic Blocks Proinflammatory Activation Of Rheumatoid Arthritis Fibroblast-Like Synoviocytes
P. A. Kabala¹, A.M. Grabiec¹, C. Angiolilli¹, Nicholas Smithers², Jason Witherington³, Paul Peter Tak⁴, Rabinder Prinjha³ and Kris A. Reedquist⁵, ¹Department of Experimental Immunology, Department of Clinical Immunology and Rheumatology Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands, ²Immuno Inflammation, GlaxoSmithKline, Stevenage, United Kingdom, ³GlaxoSmithKline, Stevenage, United Kingdom, ⁴Academic Medical Center / University of Amsterdam, Department of Clinical Immunology and Rheumatology & GlaxoSmithKline, Amsterdam, Netherlands, ⁵Department of Experimental Immunology and Division of Clinical Immunology and Rheumatology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands
Background/Purpose: Genetic backgrounds and environmental factors do not completely explain the etiology of disease and predisposition to rheumatoid arthritis (RA), and increasing attention has turned…
Abstract Number: 2732 • 2013 ACR/ARHP Annual Meeting
Inhibition Of Autophagy Prevents Ovariectomy Induced Bone Loss
Neng-Yu Lin¹, Joerg H. W. Distler¹, Alfiya Distler¹, Christian Beyer¹, Georg Schett² and Oliver Distler³, ¹Department of Internal Medicine III and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, ²Dept of Medicine 3, Rheumatology and Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, ³Division of Rheumatology, University Hospital Zurich, Zurich, Switzerland
Background/Purpose: Autophagy is an essential, homeostatic process by which cells digest unnecessary or damaged organelles. Atg7 is essentially required for formation of the autophagosome. The…
Abstract Number: 2733 • 2013 ACR/ARHP Annual Meeting
Spontaneous Osteoarthritis In Mice By Genetic Deletion Of Nfatc1 and Nfatc2
Susan Y. Ritter¹, Matthew B. Greenblatt², Kelly Tsang¹, Dorothy Z. Hu³, John Wright⁴ and Antonios O. Aliprantis¹, ¹Rheumatology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, ²Pathology, Brigham and Women's Hospital, Boston, MA, ³Endocrine Unit, Massachusetts General Hospital, Boston, MA, ⁴Orthopedic Surgery, Brigham and Women's Hospital, Boston, MA
Background/Purpose: Osteoarthritis (OA) was once viewed as a mechanical disease of “wear and tear”, but recent advances suggest that OA results from active dysregulation of…
Abstract Number: 2734 • 2013 ACR/ARHP Annual Meeting
Epigenetic Control Of a Gene Regulatory Network Associated With Experimental Autoimmune Arthritis and Rheumatoid Arthritis
Andras Vida¹, Janos Gal², Gyorgyi Soos², Attila Balog³, Laszlo G. Puskas⁴, Katalin Mikecz¹, Tibor T. Glant¹ and Tibor A. Rauch¹, ¹Orthopedic Surgery, Rush University Medical Center, Chicago, IL, ²Rheumatology, Bacs-Kiskun County Hospital, Kecskemet, Hungary, ³Rheumatology, Albert Szent-Gyorgyi University, Szeged, Hungary, ⁴Laboratory of Functional Genomics, Biological Research Center, Szeged, Hungary
Background/Purpose: Rheumatoid arthritis (RA) is an autoimmune inflammatory disorder that mainly affects the synovial joints, leading to destruction of articular cartilage and bone. There is…

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