Abstracts Archive - Page 2002 of 2425 - ACR Meeting Abstracts

Abstract Number: 752 • 2014 ACR/ARHP Annual Meeting
Potential Roles of Toll-like Receptor 4 in the Murine Models of Systemic Sclerosis
Takehiro Takahashi, Yoshihide Asano, Yohei Ichimura, Tetsuo Toyama, Takashi Taniguchi, Shinji Noda, Kaname Akamata and Shinichi Sato, Dermatology, University of Tokyo Graduate School of Medicine, Tokyo, Japan
Background/Purpose: Bleomycin (BLM)-induced fibrosis model and tight skin mice (TSK/+) model are well-established experimental murine models of human systemic sclerosis (SSc). Growing evidence has demonstrated…
Abstract Number: 750 • 2014 ACR/ARHP Annual Meeting
Molecular Characterization of Systemic Sclerosis Esophageal Pathology Identifies Inflammatory and Proliferative Signatures with Few Fibrotic Markers
Jaclyn Taroni¹, Viktor Martyanov², Chiang-Ching Huang³, J. Matthew Mahoney⁴, Ikuo Hirano⁵, Tammara A. Wood², Brandon Shetuni⁶, Guang-Yu Yang⁶, Darren Brenner⁵, Barbara Jung⁷, Swati Bhattacharyya⁸, Orit Almagor⁹, Jungwha Lee¹⁰, Arlene Sirajuddin¹¹, Rowland W. Chang¹², John Varga¹³, Michael Whitfield¹⁴ and Monique Hinchcliff¹⁵, ¹Genetics, Giesel School of Medicine at Dartmouth, Hanover, NH, ²Department of Genetics, Geisel School of Medicine at Dartmouth, Hanover, NH, ³Zilber School of Public Health, University of Wisconsin, Milwaukee, Milwaukee, WI, ⁴Department of Neurological Sciences, College of Medicine, University of Vermont, Burlington, VT, ⁵Department of Medicine, Division of Gastroenterology, Northwestern University Feinberg School of Medicine, Chicago, IL, ⁶Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL, ⁷Department of Medicine, Division of Gastroenterology, University of Illinois at Chicago, Chicago, IL, ⁸Medicine/Rheumatology, Northwestern University, Feinberg School of Medicine, Chicago, IL, ⁹Northwestern University, Chicago, IL, ¹⁰Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, ¹¹Department of Radiology, Northwestern University Feinberg School of Medicine, Chicago, IL, ¹²Institute for Public Health and Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, ¹³Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, ¹⁴Geisel School of Medicine at Dartmouth, Hanover, NH, ¹⁵Division of Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL
Background/Purpose: Esophageal involvement in patients with systemic sclerosis (SSc) is common, but tissue-specific pathological mechanisms are poorly understood. Esophageal muscle atrophy without concomitant fibrosis is…
Abstract Number: 749 • 2014 ACR/ARHP Annual Meeting
Progranulin Overproduction Due to Fli1 Deficiency Contributes to the Resistance of Dermal Fibroblasts to Tumor Necrosis Factor a in Systemic Sclerosis
Yohei Ichimura, Yoshihide Asano, Kaname Akamata, Shinji Noda, Takashi Taniguchi, Takehiro Takahashi, Tetsuo Toyama, Yayoi Tada, Makoto Sugaya, Shinichi Sato and Takafumi Kadono, Dermatology, University of Tokyo Graduate School of Medicine, Tokyo, Japan
Background/Purpose: Systemic sclerosis (SSc) is a multisystem fibrotic connective tissue disease characterized by a dysregulated activation of fibroblasts following inflammation, autoimmune attacks, and vascular injuries.…
Abstract Number: 748 • 2014 ACR/ARHP Annual Meeting
Increased Expression of Chemerin in Endothelial Cells Due to Fli1 Deficiency May Contribute to the Development of Digital Ulcers in Systemic Sclerosis
Kaname Akamata, Yoshihide Asano, Takashi Taniguchi, Hayakazu Sumida, Naohiko Aozasa, Shinji Noda, Tetsuo Toyama, Takehiro Takahashi, Yohei Ichimura, Ayumi Yoshizaki and Shinichi Sato, Dermatology, University of Tokyo Graduate School of Medicine, Tokyo, Japan
Background/Purpose: Systemic sclerosis (SSc) is a multisystem autoimmune disorder characterized by vascular injuries and fibrosis development. In SSc lesional skin, transcription factor Friend leukemia virus…
Abstract Number: 747 • 2014 ACR/ARHP Annual Meeting
Systemic Sclerosis Patients with Antitopoisomerase Antibodies Showed Significant Association with CCR6 Polymorphisms
Javier Martin¹, Eguzkine Ochoa², Jose Ezequiel Martin¹, Shervin Assassi³, Lorenzo Beretta⁴, Patricia Carreira⁵, Carmen Pilar Simeon⁶, Eugénie Koumakis⁷, Philippe Dieude⁸, Yannick Allanore⁹, Francisco J. García-Hernández¹⁰, Gerard Espinosa¹¹, Ivan Castellvi Barranco¹², Luis Trapiella¹³, Luis Rodriguez Rodriguez¹⁴, Miguel A González-Gay¹⁵, María-Victoria Egurbide¹⁶, Luis Saez¹⁷, José Luis Callejas¹⁸, JA Vargas-Hitos¹⁹, Nicolas Hunzelmann²⁰, Gabriela Riemekasten²¹, Torsten Witte²², Jörg HW Distler²³, Alexander Kreuter²⁴, Claudio Lunardi²⁵, Alessandro Santaniello²⁶, Filemon K. Tan³, Frank C. Arnett³, Paul Shiels²⁷, Ariane L. Herrick²⁸, Jane Worthington²⁹, Madelon C. Vonk³⁰, Bobby P.C. Koeleman³¹, T.R.D.J. Radstake³² and Maureen Mayes³³, ¹Immunology, Instituto de Parasitología y Biomedicina López-Neyra, IPBLN-CSIC, Armilla (Granada), Spain, ²Immunology, Instituto de Parasitología y Biomedicina Lopez Neyra (IPBLN-CSIC), Granada, Spain, ³Rheumatology, University of Texas Health Science Center at Houston, Houston, TX, ⁴Via Francesco Sforza 28, Ospedale Maggiore Policlinico, Milano, Italy, ⁵Hospital Universitario 12 de Octubre, Department of Rheumatology, Madrid, Spain, ⁶Servicio de Medicina Interna, Hospital Valle de Hebron, Barcelona, Spain, ⁷Rheumatology A department, Cochin Hospital, Paris Descartes University, Rheumatology A department, Cochin Hospital, Paris, France, ⁸Rhumatologie, Hopital Bichat Claude Bernard, Paris, France, ⁹Department of Rheumatology, University Paris Descartes and Cochin Hospital, Paris, France, ¹⁰Internal Medicine, Hospital Virgen del Rocío, Sevilla, Spain, ¹¹Department of Autoimmune Diseases, Hospital Clínic, Barcelona, Barcelona, Spain, ¹²Hosp. De Sta. Creu i S. Pau, Vilafranca del Pened, Spain, ¹³Department of Internal Medicine,, Hospital Universitario Central de Asturias, Asturias, Spain, ¹⁴Department of Rheumatology, Hospital Clínico San Carlos, Madrid, Spain, ¹⁵Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Rheumatology Division, IDIVAL, Santander, Spain, ¹⁶Autoimmune Disease Research Unit, Service of Internal Medicine,, Hospital de Cruces, UPV/EHU, Barakaldo, Spain, Barakaldo, Spain, ¹⁷Unidad de Enfermedades Autoinmunes, Servicio de Medicina Interna, Hospital Miguel Servet, Zaragoza, Spain, ¹⁸Internal Medicine, Hospital Clínico San Cecilio, Granada, Spain, ¹⁹Internal Medicine, Hospital Universitario Virgen de las Nieves, Granada, Spain, ²⁰Department of Dermatology, University of Cologne, Cologne, Germany, ²¹Charité University Hospital and German Rheumatism Research Centre, a Leibniz Institute, Berlin, Germany, ²²Clinic for Immunology and Rheumatology, Hannover Medical School, Hannover, Germany, ²³Department of Internal Medicine, Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, ²⁴Department of Dermatology, Venereology, and Allergologie, HELIOS St. Elisabeth Hospital, Oberhausen, Germany, ²⁵Department of Medicine, Università degli Studi di Verona, Verona, Italy, ²⁶Referral Center for Systemic Autoimmune Diseases, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico di Milano, Milan, Italy, ²⁷University of Glasgow, Glasgow, United Kingdom, ²⁸Musculoskeletal Research Group, School of Translational Medicine, Manchester Academic Health Science Centre, Salford Royal Hospital, University of Manchester., Salford, United Kingdom, ²⁹Arthritis Research UK Centre for Genetics and Genomics, The University of Manchester, Manchester, United Kingdom, ³⁰Department of Rheumatology, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, ³¹Department of Medical Genetics, University Medical Center Utrecht, Utrecht, Netherlands, ³²Department of Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands, ³³Internal Medicine/Rheumatology, University of TX Health Science Center -Houston, Houston, TX
Background/Purpose: Systemic sclerosis (SSc), also known as scleroderma, is an inflammatory autoimmune disease characterized by fibrosis of the skin and internal organs, vascular damage and…
Abstract Number: 746 • 2014 ACR/ARHP Annual Meeting
Elevated Pentraxin 3 in Patients with Systemic Sclerosis: Associations with Vascular Manifestations and Defective Vasculogenesis
Yuichiro Shirai¹, Yuka Okazaki¹, Yumiko Inoue¹, Yuichi Tamura², Hidekata Yasuoka³, Tsutomu Takeuchi¹ and Masataka Kuwana¹, ¹Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan, ²Department of Cardiology, Keio University School of Medicine, Tokyo, Japan, ³Division of Rheumatology, Department of Internal Medicine, Keio Univ School of Medicine, Tokyo, Japan
Background/Purpose: Pentraxin 3 (PTX3) is a multi-functional pattern recognition protein involved in inflammation, extracellular matrix deposition, and suppression of neovascularization mediated by fibroblast growth factor-2…
Abstract Number: 745 • 2014 ACR/ARHP Annual Meeting
Genetic Susceptibility Loci of Idiopathic Interstitial Pneumonitis Do Not Represent Risk for Systemic Sclerosis
Minghua Wu¹, Shervin Assassi¹, Gloria Salazar¹, Olga Y Gorlova², Wei V Chen³, Julio Charles⁴, Fredrick M. Wigley⁵, Laura K. Hummers⁵, Ami A. Shah⁵, Monique Hinchcliff⁶, Dinesh Khanna⁷, Elena Schiopu⁸, Kristine Phillips⁷, Daniel E. Furst⁹, Virginia D. Steen¹⁰, Murray Baron¹¹, Marie Hudson¹¹, Xiaodong Zhou¹, Janet E. Pope¹², Niall Jones¹³, Peter Docherty¹⁴, Nader A. Khalidi¹⁵, David B. Robinson¹⁶, Robert W. Simms¹⁷, Richard Silver¹⁸, Tracy Frech¹⁹, Barri J. Fessler²⁰, Marvin J. Fritzler²¹, Jerry A. Molitor²², Barbara M. Segal²², Javier Martín²³, John Varga²⁴ and Maureen D Mayes¹, ¹Rheumatology, University of Texas Health Science Center at Houston, Houston, TX, ²Department of Community and Family Medicine, Geisel School of Medicine at Dartmouth, Hanover, NH, ³Geisel School of Medicine at Dartmouth, Hanover, NH, ⁴Internal Medicine/Rheumatology, University of Texas Health Science Center at Houston, Houston, TX, ⁵Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, ⁶Division of Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, ⁷Division of Rheumatology, University of Michigan, Ann Arbor, MI, ⁸Rheumatology, University of Michigan, Ann Arbor, MI, ⁹University of California, Los Angeles, Department of Medicine, Los Angeles, CA, ¹⁰Department of Rheumatology, Georgetown University Medical Center, Washington, DC, ¹¹Division of Rheumatology, McGill University, Montreal, QC, Canada, ¹²Medicine/Rheumatology, St. Joseph's Health Care, University of Western Ontario, London, ON, Canada, ¹³Division of Rheumatology, University of Alberta, Edmonton, AB, Canada, ¹⁴Internal Medicine, The Moncton Hospital, Moncton, NB, Canada, ¹⁵Division of Rheumatology, St. Joseph’s Hospital, McMaster University, Hamilton, ON, Canada, ¹⁶Arthritis Centre, University of Manitoba, Winnipeg, MB, Canada, ¹⁷Rheumatology, Boston University School of Medicine, Boston, MA, ¹⁸Division of Rheumatology & Immunology, Medical University of South Carolina, Charleston, SC, ¹⁹Div of Rheumatology, University of Utah, Salt Lake City, UT, ²⁰Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, ²¹Mitogen Advanced Diagnostics Laboratory, Faculty of Medicine, University of Calgary, Calgary, AB, Canada, ²²Rheumatology, University of Minnesota, Minneapolis, MN, ²³Instituto de Parasitología y Biomedicina López-Neyra, Consejo Superior de Investigaciones Científicas, Granada, Spain, ²⁴Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL
Background/Purpose: Systemic sclerosis (SSc) related interstitial lung disease (ILD) has phenotypic similarities to idiopathic interstitial pneumonia (IIP). The objective of this study was to assess…
Abstract Number: 751 • 2014 ACR/ARHP Annual Meeting
Dissecting the Heterogeneity of Skin Gene Expression Patterns in Systemic Sclerosis
Shervin Assassi¹, William Swindell², Minghua Wu¹, Filemon K. Tan¹, Dinesh Khanna³, Daniel E. Furst⁴, Donald Tashkin⁵, Richard Jahan-Tigh⁶, Maureen D Mayes¹, Johann Gudjonsson² and Jeffrey T. Chang⁶, ¹Rheumatology, University of Texas Health Science Center at Houston, Houston, TX, ²Dermatology, University of Michigan, Ann Arbor, MI, ³University of Michigan, Ann Arbor, MI, ⁴University of California at Los Angeles, Los Angeles, CA, ⁵Medicine, University of California at Los Angeles, Los Angeles, CA, ⁶University of Texas Health Science Center at Houston, Houston, TX
Background/Purpose: To examine the heterogeneity of global transcriptome patterns in systemic sclerosis (SSc) skin from a large cohort of patients and controls. Methods: Skin biopsies…
Abstract Number: 721 • 2014 ACR/ARHP Annual Meeting
Muscle Disease in Systemic Sclerosis Is Associated with an Increased Risk for Cardiac Involvement
Jison Hong¹, Antonia Valenzuela², David Fiorentino³ and Lorinda Chung⁴, ¹Medicine- Immunology & Rheumatology, Stanford University School of Medicine, Palo Alto, CA, ²Division of Immunology and Rheumatology, Stanford University School of Medicine, Palo Alto, CA, ³Dermatology, Stanford University, Redwood City, CA, ⁴Immunology and Rheumatology, Stanford University School of Medicine, Palo Alto, CA
Background/Purpose Patients with systemic sclerosis (SSc) and muscle involvement (myopathy/myositis) have more severe disease and worse outcomes. We sought to determine the prevalence of muscle…
Abstract Number: 720 • 2014 ACR/ARHP Annual Meeting
Measures of Disease Status in Systemic Sclerosis: Systematic Review
Tien Tay¹, Nava Ferdowsi¹, Wendy Stevens¹, Marie Hudson², Murray Baron³, Candice Rabusa¹, David Prior⁴, Susanna Proudman⁵ and Mandana Nikpour⁶, ¹Rheumatology, The University of Melbourne at St Vincent’s Hospital, Melbourne, Australia, ²Rheumatology, Lady David Institute for Medical Research and Jewish General Hospital, Montreal, QC, Canada, ³Pavillion A, Rm 216, Lady David Institute for Medical Research and Jewish General Hospital, Montreal, QC, Canada, ⁴Cardiology, The University of Melbourne at St Vincent’s Hospital, Melbourne, Australia, ⁵Royal Adelaide Hospital, Rheumatology Unit and University of Adelaide, Discipline of Medicine, Adelaide, Australia, ⁶Medicine, The University of Melbourne at St Vincent’s Hospital, Melbourne, Australia
Background/Purpose : To identify the measures of disease status in systemic sclerosis (SSc) using a systematic review. Methods: A systematic review of Medline (1966-2014), EMBASE…
Abstract Number: 739 • 2014 ACR/ARHP Annual Meeting
Lack of Association Between Esophageal Symptoms and Abnormal Findings in High-Resolution Manometry in a Mexican Mestizo Cohort with Systemic Sclerosis (SSc)
Ana Arana-Guajardo¹, Miguel Villarreal-Alarcón², Gustavo Torres-Barrera³, David Vega-Morales⁴, Hector Maldonado-Garza³ and Mario Garza-Elizondo², ¹Departamento de Medicina Interna del Hospital Universitario, Servicio de Reumatología, Departamento de Medicina Interna del Hospital Universitario “Dr. José Eleuterio González”, Universidad Autónoma de Nuevo León, Monterrey, Mexico, ²Departamento de Medicina Interna del Hospital Universitario “Dr. José Eleuterio González”, Universidad Autónoma de Nuevo León, Servicio de Reumatología, Departamento de Medicina Interna del Hospital Universitario “Dr. José Eleuterio González”, Universidad Autónoma de Nuevo León, Monterrey, Mexico, ³Departamento de Medicina Interna del Hospital Universitario, Servicio de Gastroenterología, Departamento de Medicina Interna del Hospital Universitario “Dr. José Eleuterio González”, Universidad Autónoma de Nuevo León, Monterrey, Mexico, ⁴Rheumatology, Hospital Universitario UANL, Monterrey, Mexico
Background/Purpose . Esophageal involvement is present in 50-70% of SSc patients and it is the most common visceral organ complication. The impact of the esophageal…
Abstract Number: 738 • 2014 ACR/ARHP Annual Meeting
Troponin T as a Diagnostic and Prognostic Biomarker of Primary Cardiac Involvement in Systemic Sclerosis
Silvia Laura Bosello, Giacomo De Luca, Federico Parisi, Giorgia Berardi, Manuela Rucco, Giovanni Canestrari and Gianfranco Ferraccioli, Division of Rheumatology, Institute of Rheumatology and Affine Sciences, Catholic University of the Sacred Heart, Rome, Italy
Background/Purpose .Heart involvement is common in Systemic Sclerosis (SSc), even if often clinically silent, and represents one of the leading cause of death in these…
Abstract Number: 737 • 2014 ACR/ARHP Annual Meeting
Reliability of Nailfold Capillary Density Measurement As a Possible Outcome Measure for Systemic Sclerosis-Related Microangiopathy
Graham Dinsdale¹, Tonia Moore², Joanne Manning², Andrea Murray¹, Michael Berks³, Philip Tresadern³, Chris Taylor³, Neil O'Leary⁴, Chris Roberts⁴, John Allen⁵, Marina Anderson⁶, Maurizio Cutolo⁷, Roger Hesselstrand⁸, Kevin Howell⁹, Paula Pyrkotsch⁶, Francesca Ravera⁷, Vanessa Smith¹⁰, Alberto Sulli⁷, Marie Wildt⁸ and Ariane Herrick¹, ¹Centre for Musculoskeletal Research, University of Manchester, Manchester Academic Health Science Centre, Manchester, United Kingdom, ²Salford Royal Hospital NHS Foundation Trust, Salford, United Kingdom, ³Centre for Imaging Sciences, University of Manchester, Institute of Population Health, Manchester, United Kingdom, ⁴Centre for Biostatistics, Institute of Population Health, University of Manchester, Manchester, United Kingdom, ⁵Regional Medical Physics Department, Freeman Hospital, Newcastle upon Tyne, United Kingdom, ⁶Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool, United Kingdom, ⁷Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genova, Genoa, Italy, ⁸Rheumatology, Lund University, Lund, Sweden, ⁹Institute of Immunity and Transplantation, University College London, Royal Free Campus, London, United Kingdom, ¹⁰Department of Rheumatology, Ghent University Hospital, Ghent, Belgium
Background/Purpose Nailfold videocapillaroscopy allows non-invasive assessment of the microcirculation. Image annotation software allows tracking of changes over time; a potential outcome measure for systemic sclerosis…
Abstract Number: 736 • 2014 ACR/ARHP Annual Meeting
Serum Galectin-3 Levels in Early Diffuse Systemic Sclerosis and the Relationship to Skin Score and Skin Score Change
Siamak Moghadam-Kia¹, Thomas A. Medsger Jr.² and Robyn T. Domsic³, ¹Medicine, University of Pittsburgh, Pittsburgh, PA, ²Medicine/Rheumatology, University of Pittsburgh, Pittsburgh, PA, ³Medicine - Rheumatology, University of Pittsburgh, Pittsburgh, PA
Background/Purpose Galectin-3 is a β-galactoside-binding animal lectin which is associated with inflammation, angiogenesis and fibrosis. Galectin-3 is upregulated in hepatic fibrosis, idiopathic pulmonary fibrosis and…
Abstract Number: 735 • 2014 ACR/ARHP Annual Meeting
Sarcopenia in Systemic Sclerosis: Prevalence and Association with Functional Parameters and Quality of Life
Elise Siegert¹, Kristina Norman², Emilie Preis³, Alexander Makowka³, Gerd Burmester⁴ and Gabriela Riemekasten¹, ¹Rheumatology and Clinical Immunology, Charité – University Hospital, Berlin, Germany, ²Geriatrics Research Group, Charité – University Medicine Berlin, Berlin, Germany, ³Rheumatology and Clinical Immunology, Charité – University Medicine Berlin, Berlin, Germany, ⁴Charité – University Medicine Berlin, Berlin, Germany
Background/Purpose: Systemic Sclerosis (SSc) is an autoimmune disease that characterized by endothelial dysfunction, inflammation and fibrosis. It is associated with high mortality and physical impairment.…

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