Abstract Number: 1797 • 2015 ACR/ARHP Annual Meeting
Insulin Resistance Is Not Associated with Increased Risk of Subclinical Atheromatosis in Patients with Systemic Lupus Erythematosus from Northern Spain
Background/Purpose: Metabolic syndrome is a recently defined clustering of cardiovascular risk (CV) factors associated with insulin resistance (IR) and an increased risk of CV disease.…Abstract Number: 1798 • 2015 ACR/ARHP Annual Meeting
Progression of Noncalcified and Calcified Coronary Plaque (by CT Angiography) in SLE
Background/Purpose: Accelerated atherosclerosis leading to premature coronary artery disease remains the major cause of late death in SLE. Coronary artery calcium (CAC) is a late…Abstract Number: 1799 • 2015 ACR/ARHP Annual Meeting
IgG Levels Correlate Inversely with Proteinuria Among Participants in the Abatacept and Cyclophosphamide Combination Therapy for Lupus Nephritis Trial, but Hypogammaglobulinemia Was Not Associated with an Increased Risk of Serious Infection
Background/Purpose: Hypogammaglobulinemia has been associated with serious infectious adverse events (SIAE) and may occur during immunosuppressive therapy for lupus nephritis (LN). It is possible that…Abstract Number: 1800 • 2015 ACR/ARHP Annual Meeting
A Novel Anti-CD28 Domain Antibody Antagonist Shows a Favorable Pharmacokinetic, Pharmacodynamic and Safety Profile
Background/Purpose: Antagonism of the CD28 costimulation receptor is thought to block T-cell activation, making this a promising target for the treatment of many autoimmune diseases,…Abstract Number: 1801 • 2015 ACR/ARHP Annual Meeting
Hydroxychloroquine Retinopathy: Application of the 2011 Screening Guidelines in an Academic Practice
Background/Purpose: The risk of end-stage retinopathy (bull’s eye maculopathy) from hydroxychloroquine (HCQ) is low (0.65%, Wolfe and Marmor, 2010). With recent advances in retinal structure…Abstract Number: 1802 • 2015 ACR/ARHP Annual Meeting
Hydroxychloroquine Level Variants and Predictors in a Connective Tissue Disease Population
Background/Purpose: Hydroxychloroquine (HCQ) dose adjustment in patients with impaired renal function has been suggested to prevent toxicity. However, evidence to support this practice is scant. …Abstract Number: 1803 • 2015 ACR/ARHP Annual Meeting
Serum Adipocyte Fatty Acid-Binding Protein Level Is Elevated in Patients with Systemic Lupus Erythematosus (SLE) but Not Associated with Biophysical Markers of Cardiovascular Disease
Background/Purpose: Adipocyte fatty acid-binding protein (aFABP) is an intracellular lipid-binding protein expressed in adipocytes and macrophages, particularly in inflammatory conditions. Recently, high circulating serum aFABP…Abstract Number: 1804 • 2015 ACR/ARHP Annual Meeting
Association of the Metabolic Syndrome (MetS) with Vascular Complications, End Stage Renal Failure (ESRF) and Mortality in Patients with Systemic Lupus Erythematosus (SLE): A Cohort Analysis
Background/Purpose: To study the association between the metabolic syndrome (MetS) and vascular events, end stage renal failure (ESRF) and mortality in patients with SLEMethods: Patients…Abstract Number: 1805 • 2015 ACR/ARHP Annual Meeting
Functional and Mechanistic Characterization of Anifrolumab, a Fully Human, Anti-IFNAR1 Monoclonal Antibody for the Treatment of Systemic Lupus Erythematosus
Background/Purpose: Increased type I interferon (IFN) activities are associated with the pathogenesis of systemic lupus erythematosus (SLE). Anifrolumab, a fully human, IgG1 κ monoclonal antibody…Abstract Number: 1806 • 2015 ACR/ARHP Annual Meeting
Hydroxychloroquine Serum Levels and Flares of Systemic Lupus Erythematosus: A Longitudinal Cohort Analysis
Background/Purpose: To study the relationship between the serum hydroxychloroquine (HCQ) concentration and flares of systemic lupus erythematosus (SLE) in a longitudinal cohort of Chinese patients.Methods:…Abstract Number: 1807 • 2015 ACR/ARHP Annual Meeting
Estimated Sodium and Potassium Intake Are Associated with Blood Pressure in Patients with Systemic Lupus Erythematosus
Background/Purpose: The prevalence of hypertension is increased in patients with systemic lupus erythematosus (SLE). Sodium (Na+) and potassium (K+) intake are modifiable determinants of blood…Abstract Number: 1808 • 2015 ACR/ARHP Annual Meeting
Exercise Is Associated with Improved Cardiometabolic Risk Factors in Patients with SLE
Background/Purpose: Patients with systemic lupus erythematosus (SLE) have an increased prevalence of insulin resistance and the metabolic syndrome. Exercise has been shown to improve insulin…Abstract Number: 1809 • 2015 ACR/ARHP Annual Meeting
Real Life Implementation of Lupus Nephritis Randomized Controlled Trials
Background/Purpose: Randomized controlled trials (RCTs) are the gold standard for assessing treatment efficacy. However, due to their often strict design, generalization of research results to…Abstract Number: 1810 • 2015 ACR/ARHP Annual Meeting
A Five-Year Follow-up of Microvascular Dysfunction and Coronary Artery Disease in SLE: Results from a Community-Based Lupus Cohort
Background/Purpose: To investigate serial changes in the prevalence of coronary microvascular dysfunction and coronary artery disease (CAD) by cardiac imaging in a cohort of SLE…Abstract Number: 1811 • 2015 ACR/ARHP Annual Meeting
Depression and Progression of Subclinical Cardiovascular Disease in Systemic Lupus Erythematosus
Background/Purpose: Women with SLE have an increased incidence of premature cardiovascular disease (CVD). Depression is also common among SLE patients. A relationship between depression and…
ACR Meeting Abstracts