Abstracts Archive - Page 2001 of 2425 - ACR Meeting Abstracts

Abstract Number: 778 • 2014 ACR/ARHP Annual Meeting
PTPN22 rs2476601 and Susceptibility to Biopsy Proven Giant Cell Arteritis (GCA) in an Australian Sample
Susan Lester¹, Alex Hewitt², Linda Bradbury³, Elisabeth De Smit⁴, Andrew Harrison⁵, Graeme Jones⁶, Geoffrey O. Littlejohn⁷, Tony R. Merriman⁸, Bain Shenstone⁹, Malcolm D. Smith¹⁰, Maureen Rischmueller¹¹, Matthew A. Brown¹² and Catherine L. Hill^13,14, ¹Rheumatology Unit, Queen Elizabeth Hospital, Woodville South, Australia, ²Lions Eye Institute, University of Western Australia, Perth, Australia, ³The University of Queensland, Brisbane, Australia, ⁴Centre for Eye Research, University of Melbourne, Melbourne, Australia, ⁵Medicine, University of Otago, Wellington, New Zealand, ⁶Menzies Research Institute Tasmania, University of Tasmania, HOBART, Australia, ⁷Rheumatology, Monash Medical Center, Melbourne, Australia, ⁸Department of Biochemistry, University of Otago, Dunedin, New Zealand, ⁹Concord Hospital, Sydney, Australia, ¹⁰Rheumatology Research Unit, Repatriation General Hospital, Adelaide SA, Australia, ¹¹Department of Rheumatology, The Queen Elizabeth Hospital, SA, Australia, ¹²University of Queensland Diamantina Institute, Brisbane, Australia, ¹³Discipline of Medicine, University of Adelaide, Adelaide, Australia, ¹⁴Rheumatology Unit, The Queen Elizabeth Hospital, Woodville, Australia
Background/Purpose: The aetiology and genetic background of GCA remains unclear, although genetic susceptibility is known to play a role. Recently, an association with the minor,…
Abstract Number: 779 • 2014 ACR/ARHP Annual Meeting
Toll-like Receptor 2 Agonism Induces Inflammation, Angiogenesis and Cell Migration in Giant Cell Arteritis
Lorraine O'Neill¹, Aoife Maher¹, Jennifer McCormick², Conor Murphy³, Geraldine M. McCarthy⁴, Douglas J. Veale⁵, Ursula Fearon² and Eamonn S. Molloy¹, ¹Rheumatology, St. Vincent's University Hospital, Dublin 4, Ireland, ²Dublin Academic Medical Centre, Translational Rheumatology Research Group, Dublin, Ireland, ³Department of Ophthalmology, Royal Victoria Eye and Ear Hospital, Dublin, Ireland, ⁴Medicine/Rheumatology, Mater Misericordiae University Hospital, Dublin 7, Ireland, ⁵Translational Rheumatology Research Group, St. Vincent's University Hospital, Dublin 4, Ireland
Background/Purpose Activation of dendritic cells (DCs) is one of the earliest inciting events in Giant Cell Arteritis (GCA). TLR 2 is expressed on DCs in…
Abstract Number: 777 • 2014 ACR/ARHP Annual Meeting
Influence of the IL17A Locus in Giant Cell Arteritis Susceptibility
Javier Martin¹, Ana Márquez², José Hernández-Rodríguez³, Maria C. Cid⁴, Roser Solans⁵, Santos Castañeda⁶, Inmaculada C. Morado⁷, Javier Narváez⁸, Victor M. Martinez-Taboada⁹, Norberto Ortego-Centeno¹⁰, Bernardo Sopeña¹¹, Jordi Monfort¹², Maria Jesus Garcia-Villanueva¹³, Luis Caminal-Montero¹⁴, Eugenio De Miguel¹⁵, Ricardo Blanco¹⁶, Øyvind Palm¹⁷, Øyvind Molberg¹⁸, Joerg Latus¹⁹, Niko Braun¹⁹, Frank Moosig²⁰, Torsten Witte²¹, Lorenzo Beretta²², Alessandro Santaniello²³, Giulia Pazzola²⁴, Luigi Boiardi²⁵, Carlo Salvarani²⁶ and Miguel A. Gonzalez-Gay⁹, ¹Immunology, Instituto de Parasitología y Biomedicina López-Neyra, IPBLN-CSIC, Armilla (Granada), Spain, ²Instituto de Parasitologia y Biomedicina López-Neyra (IPBLN-CSIC) and Systemic Autoimmune Diseases Unit, Hospital Clínico San Cecilio, Granada, Spain, ³Vasculitis Research Unit, Department of Autoimmune Diseases, Hospital Clínic University of Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain, ⁴Vasculitis Research Unit, Department of Autoimmune Diseases, Hospital Clínic University of Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 08036- Barcelona, Spain, ⁵Autoimmune Systemic Diseases Unit, Department of Internal Medicine, Hospital Vall d'Hebron, Autonomous University of Barcelona, Barcelona, Spain, ⁶Department of Rheumatology, Hospital de la Princesa, IIS-Princesa, Madrid, Spain, ⁷Department of Rheumatology, Hospital Clínico San Carlos, Madrid, Spain, ⁸Rheumatology, Hospital Universitario de Bellvitge. Barcelona. Spain, Barcelona, Spain, ⁹Department of Rheumatology, Hospital Universitario Marqués de Valdecilla, IFIMAV, Santander, Spain, ¹⁰Systemic Autoimmune Diseases Unit, Hospital Clínico San Cecilio, Granada, Spain, ¹¹Department of Internal Medicine, Complejo Hospitalario Universitario de Vigo, Vigo, Spain, ¹²Department of Rheumatology, Grup de recerca cel•lular en inflamació i cartílag. IMIM (Institut de Recerca Hospital del Mar), Barcelona, Spain, ¹³Department of Rheumatology, Hospital Ramón y Cajal, Madrid, Spain, ¹⁴Department of Internal Medicine, Hospital Universitario Central de Asturias, Oviedo, Spain, ¹⁵Department of Rheumatology, Hospital Universitario La Paz, Madrid, Spain, ¹⁶Hospital Marques de Valdecilla, Santander, Spain, ¹⁷Department of Rheumatology, Oslo University Hospital and University of Oslo, Oslo, Norway, ¹⁸Department of Rheumatology, Oslo University Hospital Rikshospitalet, Oslo, Norway, ¹⁹Department of Internal Medicine, Division of Nephrology, Robert-Bosch-Hospital, Stuttgart, Germany, ²⁰Department of Clinical Immunology and Rheumatology, University of Luebeck, Bad Bramstedt, Germany, ²¹Clinic for Immunology and Rheumatology, Hannover Medical School, Hannover, Germany, ²²Referral Center for Systemic Autoimmune Diseases, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico di Milano, Milan, Italy, ²³Referral Center for Systemic Autoimmune Diseases, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico di Milano, Milan, Italy, ²⁴Rheumatology Unit, Arcispedale S Maria Nuova, Reggio Emilia, Italy, ²⁵Unita` Operativa di Reumatologia, Azienda Ospedaliera ASMN, Istituto di Ricovero e Cura a Carattere Scientifico, Reggio Emilia, Italy, ²⁶Rheumatology Unit, Department of Internal Medicine, Azienda Ospedaliera ASMN, Istituto di Ricovero e Cura a Carattere Scientifico, Reggio Emilia, Italy
Background/Purpose: A recent study has showed that the number of Th17 lymphocytes is significantly increased in patients with GCA, resulting in an imbalance between Th17…
Abstract Number: 744 • 2014 ACR/ARHP Annual Meeting
Integrin Inhibitor Modulates Pulmonary Fibrosis in the Reactive Oxygen Species Murine Model of Systemic Sclerosis
Gianluca Bagnato¹, Alessandra Bitto², Natasha Irrera², Gabriele Pizzino², Neal Roberts³, Domenica Altavilla², Francesco Squadrito², Antonino Saitta⁴ and Gianfilippo Bagnato⁵, ¹Rheumatology, University of Messina, Messina, Italy, ²Pharmacology, University of Messina, Messina, Italy, ³University of Louisville, Louisville, KY, ⁴Internal Medicine, University of Messina, Messina, Italy, ⁵Via C. Colombo, 41, Universita Messina, Villafranca Tirrena, Italy
Background/Purpose: Systemic sclerosis (SSc) is an acquired connective tissue disorder in which inflammation, immune dysregulation and vascular damage lead to fibroblast activation that results in…
Abstract Number: 743 • 2014 ACR/ARHP Annual Meeting
Outcome of Patients with Systemic Sclerosis Admitted to the Intensive Care Unit
Tarik Hissem¹, Alice Berezne², David Grimaldi³, Alain Cariou¹, Julien Charpentier¹, Jean-Daniel Chiche¹, Yannick Allanore⁴, Jean-Paul Mira¹, Frédéric Pène⁵ and Luc Mouthon⁶, ¹Intensive care unit - Cochin University Hospital, Paris, France, ²Paris Descartes University, Internal Medicine department, Cochin Hospital, Paris, France, ³Intensive Care Unit - Cochin University Hospital, Paris, France, ⁴Paris Descartes University, Rheumatology A Department and INSERM U1016, Cochin Hospital, Paris, France, ⁵Intensive care unit - Cochin university hospital, Paris, France, ⁶National Referral Center for Rare Systemic Autoimmune Diseases, Hôpital Cochin, AP–HP, Université Paris Descartes, Paris, Paris, France
Background/Purpose Studies on the outcome of patients with systemic sclerosis (SSc) in intensive care unit (ICU) are scarce in the literature. Objective: To assess the…
Abstract Number: 742 • 2014 ACR/ARHP Annual Meeting
Precision of Ultrasound Skin Thickness Measurements: Influence of Examiner and Ultrasound Transducer
Ingeborg A. Sacksen¹, P. Scott Pollock² and Mark H. Wener³, ¹Rheumatology, University of Washington, Seattle, WA, ²Internal Medicine, Division of Rheumatology, University of Washington, Seattle, WA, ³Rheumatology & Lab Med, University of Washington, Seattle, WA
Background/Purpose Ultrasound has been used to measure scleroderma skin thickness, but it has not been established that routine clinical ultrasound equipment is adequate. We compared skin…
Abstract Number: 741 • 2014 ACR/ARHP Annual Meeting
Abnormal Right Ventricular Longitudinal Strain Detected in Systemic Sclerosis Patients Prior to Abnormalities in Conventional Measures of Right Ventricular Size and Function
Monica Mukherjee¹, Shang-En Chung², Laura K. Hummers³, Fredrick M. Wigley³, Theodore P. Abraham¹ and Ami A. Shah³, ¹Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, MD, ²Division of Biostatistics, Johns Hopkins University, Baltimore, MD, ³Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD
Background/Purpose Cardiac involvement in systemic sclerosis (SSc) adversely affects long-term prognosis, remaining undetectable despite frequent echocardiographic monitoring. Speckle tracking derived strain of the RV free…
Abstract Number: 740 • 2014 ACR/ARHP Annual Meeting
Right Ventricular Diastolic Impairment Is Common in Systemic Sclerosis and Is a Marker of Several Organ-Target Damage of the Disease
Christophe Meune¹, Dinesh Khanna², Jamil Aboulhosn³, Jerome Avouac⁴, Andre Kahan⁵, Daniel E. Furst⁶ and Yannick Allanore⁴, ¹Paris 13 University, University Hospital of Paris-Seine-Saint-Denis, Cardiology Department, Bobigny, France, ²University of Michigan Health System, Ann Arbor, MI, ³Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, ⁴Paris Descartes University, Rheumatology A Department and INSERM U1016, Cochin Hospital, Paris, France, ⁵Paris Descartes University, Rheumatology A department, Cochin Hospital, Paris, France, ⁶University of California, Los Angeles, Department of Medicine, Los Angeles, CA
Background/Purpose Heart failure and cardiac dysfunctions both of intrinsic or secondary origin and targeting LV (left ventricule) and/or RV (right ventricule) are critical complications promoting…
Abstract Number: 758 • 2014 ACR/ARHP Annual Meeting
Assessment of mRNA Gene Expression Based on Forearm Skin Score in Systemic Sclerosis Patients
Lisa Rice¹, Giuseppina Stifano¹, Jessica Ziemek² and Robert Lafyatis³, ¹Rheumatology, Boston University Medical Center, Boston, MA, ²Rheumatology/Arthritis Center, Boston University School of Medicine, Boston, MA, ³Rheumatology, Boston University School of Medicine, Boston, MA
Background/Purpose: The extent of skin disease in patients with systemic sclerosis is typically measured through physical examination of patients at 17 sites and involvement is…
Abstract Number: 759 • 2014 ACR/ARHP Annual Meeting
The Anti-Fibrotic Effect of Endostatin-Derived Peptide Is Mediated By Urokinase
Tetsuya Nishimoto¹, Takahisa Takihara², Yunyun Su³, Roger Chambers⁴, Logan Mlakar⁴ and Carol Feghali-Bostwick⁴, ¹Department of Medicine, Medical University of South Carolina, Charleston, SC, ²Tokai University School of Medicine, Kanagawa, Japan, ³Medicine, Medical University of South Carolina, Charleston, SC, ⁴Medical University of South Carolina, Charleston, SC
Background/Purpose: Fibroproliferative disorders such as systemic sclerosis (SSc) have no effective therapies and result in significant morbidity and mortality as a result of organ fibrosis.…
Abstract Number: 757 • 2014 ACR/ARHP Annual Meeting
Distinctive Patterns of Telomere Shortening and Apoptosis in Limited and Diffuse cutaneous Systemic Sclerosis
Jasper Broen¹, Liane McGlynn², Dagmara McGuinness², Rina Wichers³, Jacqueline Thomson², Rajan Madhok⁴, Robert Lafyatis⁵, Carol A. Feghali-Bostwick⁶, Paul Shiels² and T.R.D.J. Radstake¹, ¹Department of Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands, ²University of Glasgow, Glasgow, United Kingdom, ³UMC Utrecht, Utrecht, Netherlands, ⁴Glasgow Royal Infirmary, Glasgow, United Kingdom, ⁵Arthritis Center, Boston University, Boston, MA, ⁶Medicine, Medical University of South Carolina, Charleston, SC
Background/Purpose: Aberrant telomere shortening and DNA damage-responses have been previously described in SSc, here we aim to validate these observations and incorporate them in a…
Abstract Number: 756 • 2014 ACR/ARHP Annual Meeting
Nucleosome, a Basic Repeating Unit of Chromatin, in Patients with Systemic Sclerosis: Possible Association with Immunological Abnormalities Via Abnormal Activation of T and B Cells
Ayumi Yoshizaki¹, Yoshihide Asano², Takashi Taniguchi¹, Ryosuke Saigusa¹, Kouki Nakamura¹, Takashi Yamashita¹, Takehiro Takahashi¹, Tetsuo Toyama¹, Yohei Ichimura¹, Zenshiro Tamaki¹, Miki Miyazaki¹ and Shinichi Sato¹, ¹Dermatology, University of Tokyo Graduate School of Medicine, Tokyo, Japan, ²University of Tokyo Graduate School of Medicine, Tokyo, Japan
Background/Purpose Nucleosome is the basic repeating units of chromatin. Each nucleosome is composed of an inner core of histones H3 and H4 and an outer…
Abstract Number: 755 • 2014 ACR/ARHP Annual Meeting
Increased Degradation of BMPR2 in a TGFβ Dependent Transgenic Mouse Model of Scleroderma with Susceptibility to Pulmonary Arterial Hypertension
Adrian J Gilbane¹, Emma C. Derrett-Smith², Andrew Pearce³, Christopher P Denton⁴ and Alan M. Holmes⁵, ¹Centre for Rheumatology and Connective Tissue Diseases, UCL Medical School, London, United Kingdom, ²Centre for Rheumatology and Connective Tissue Diseases,, UCL Medical School Royal Free Campus, London, United Kingdom, ³Respiratory Disease Area, Novartis, London, United Kingdom, ⁴Centre for Rheumatology and Connective Tissue Disease, UCL Medical School Royal Free Campus, London, United Kingdom, ⁵Centre for Rheumatology and Connective Tissue Diseases, UCL, London, United Kingdom
Background/Purpose Scleroderma patients are susceptible to development of pulmonary arterial hypertension (PAH) that has similarities to some forms of heritable PAH. The basis for this…
Abstract Number: 754 • 2014 ACR/ARHP Annual Meeting
The Global miRNA Whole Blood Profile in Systemic Sclerosis and Its Correlation with Serum Cytokine Levels
Gloria Salazar¹, Maureen Mayes², John Hagan³, Minghua Wu¹, John D. Reveille^4,5 and Shervin Assassi¹, ¹Rheumatology, University of Texas Health Science Center at Houston, Houston, TX, ²Internal Medicine/Rheumatology, University of TX Health Science Center -Houston, Houston, TX, ³Neurosurgery, University of Texas at Houston, Houston, TX, ⁴Internal Medicine/Rheumatology, University of Texas Health Science Center at Houston, Houston, TX, ⁵Internal Medicine/Rheumatology, Univ of Texas Health Science Center at Houston, Houston, TX
The Global miRNA Whole Blood Profile in Systemic Sclerosis and its Correlation with Serum Cytokine LevelsBackground/Purpose: Several studies have implicated miRNAs in the pathogenesis of…
Abstract Number: 753 • 2014 ACR/ARHP Annual Meeting
Identification of IL12RB1 As a Novel Systemic Sclerosis Susceptibility Locus
Elena Lopez-Isac¹, Lara Bossini-Castillo^2,3, Sandra G Guerra⁴, Shervin Assassi⁵, Xiaodong Zhou⁵, Carmen P. Simeón⁶, Norberto Ortego-Centeno⁷, Ivan Castellvi⁸, Patricia Carreira⁹, Olga Gorlova¹⁰, Lorenzo Beretta¹¹, Alessandro Santaniello¹², Claudio Lunardi¹³, Roger Hesselstrand¹⁴, Annika Nordin¹⁵, Gabriela Riemekasten¹⁶, Torsten Witte¹⁷, Nicolas Hunzelmann¹⁸, Alexander Kreuter¹⁹, Jörg HW Distler²⁰, Alexandre E. Voskuyl²¹, Jeska K. De Vries-Bouwstra²², Bobby P.C. Koeleman²³, Ariane Herrick²⁴, Jane Worthington²⁵, Christopher Denton⁴, Carmen Fonseca⁴, T.R.D.J. Radstake²⁶, Maureen D. Mayes²⁷ and Javier Martin², ¹Institute of Parasitology and Biomedicine López-Neyra, IPBLN-CSIC, Granada, Spain, ²Immunology, Instituto de Parasitología y Biomedicina López-Neyra, IPBLN-CSIC, Armilla (Granada), Spain, ³Instituto de Parasitología y Biomedicina López-Neyra, IPBLN-CSIC,, Consejo Superior de Investigaciones Científicas (CSIC), Armilla (Granada), Spain, ⁴Centre for Rheumatology, Royal Free and University College Medical School, London, United Kingdom, ⁵Rheumatology, University of Texas Health Science Center at Houston, Houston, TX, ⁶Department of Internal Medicine, Hospital Valle de Hebron, Barcelona, Spain, ⁷Medicine Department, Hospital Universitario San Cecilio, Granada, Spain, ⁸Hosp. De Sta. Creu i S. Pau, Vilafranca del Pened, Spain, ⁹Rheumatology, Hospital Universitario 12 de Octubre, Madrid, Spain, ¹⁰Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX, ¹¹Referral Center for Systemic Autoimmune Diseases, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico di Milano, Milan, Italy, ¹²Referral Center for Systemic Autoimmune Diseases, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico di Milano, Milan, Italy, ¹³Department of Medicine, Università degli Studi di Verona, Verona, Italy, ¹⁴Rheumatology, Lund University, Lund, Sweden, ¹⁵Rheumatology Unit, Department of Medicine, Karolinska University Hospital, Karolinska Institute, Stockholm, Sweden, ¹⁶Charité University Hospital and German Rheumatism Research Centre, a Leibniz Institute, Berlin, Germany, ¹⁷Clinic for Immunology and Rheumatology, Hannover Medical School, Hannover, Germany, ¹⁸Department of Dermatology, University of Cologne, Cologne, Germany, ¹⁹Department of Dermatology, Venereology, and Allergologie, HELIOS St. Elisabeth Hospital, Oberhausen, Germany, ²⁰Department of Internal Medicine, Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, ²¹Department of Rheumatology, VU University Medical Center, Amsterdam, Netherlands, ²²Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ²³Department of Medical Genetics, University Medical Center Utrecht, Utrecht, Netherlands, ²⁴Centre for Musculoskeletal Research, The University of Manchester, Manchester, United Kingdom, ²⁵The University of Manchester, Manchester, United Kingdom, ²⁶Department of Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands, ²⁷University of Texas Health Science Center at Houston, Houston, TX
Background/Purpose A recent large-scale fine mapping study -Immunochip- in systemic sclerosis (SSc) identified 3 novel genome-wide significant hits as well as a wide number of…

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