Abstract Number: 1909 • 2015 ACR/ARHP Annual Meeting
Nailfold Capillaroscopic Assessment and Vascular Biomarkers in Systemic Sclerosis: Low CD40L Levels in Patients with Late Scleroderma Patterns
Background/Purpose: To determine the relationship between vascular biomarkers reflecting the vascular injury and neoangiogenesis with nailfold capillaroscopic changes in systemic sclerosis (SSc). Methods: Seventy-two SSc…Abstract Number: 1910 • 2015 ACR/ARHP Annual Meeting
Increased Circulating CD204/CD206 Double Positive Monocyte/Macrophages in Systemic Sclerosis Patients with “Early” Capillaroscopic Pattern of Microvascular Damage
Background/Purpose: Immune-inflammatory cells participate together with endothelial cells and myofibroblasts in the tissue damage that characterizes fibrotic diseases, including systemic sclerosis (SSc) (1). Among immune…Abstract Number: 1911 • 2015 ACR/ARHP Annual Meeting
Monocyte Chemoattractant Protein-1 (MCP-1, CCL2) Is a Potential Local Marker of Renal Involvement in Scleroderma
Background/Purpose: Renal disease in scleroderma (SSc), including scleroderma renal crisis (SRC), remains a major clinical challenge. Previous studies showed up to 50% of SSc patients…Abstract Number: 1912 • 2015 ACR/ARHP Annual Meeting
Glycyrrhizin Ameliorates Fibrosis, Vasculopathy, and Immune Abnormalities in Animal Models of Systemic Sclerosis
Background/Purpose: Systemic sclerosis (SSc) is a multisystem autoimmune disease characterized by vasculopathy and fibrosis of the skin and various internal organs. Glycyrrhizin, a triterpenoid saponin…Abstract Number: 1913 • 2015 ACR/ARHP Annual Meeting
Lysyl Oxidase Induces Fibrosis Via Upregulation of IL-6 and Serves As a Biomarker to Monitor Response to Therapy
Background/Purpose: Lysyl oxidase (LOX) is a copper-dependent amine oxidase whose primary function is the covalent crosslinking of collagens in the extracellular matrix (ECM). Fibrosis is…Abstract Number: 1914 • 2015 ACR/ARHP Annual Meeting
Oncostatin M As a Potential Molecular Target in Systemic Sclerosis
Background/Purpose: Oncostatin M (OSM) is a pleiotropic member of the gp130/ IL-6 cytokine family, produced by a variety of immune cells, including macrophages, neutrophils…Abstract Number: 1915 • 2015 ACR/ARHP Annual Meeting
Pathogenetic Overlap Between Localised and Systemic Scleroderma: A Study of Nodular and Keloidal Morphea Occurring in Systemic Sclerosis
Background/Purpose: Localised scleroderma can occur in overlap with systemic sclerosis (SSc); nodular and keloidal morphea are rare subtypes but can be disfiguring and challenging to…Abstract Number: 1916 • 2015 ACR/ARHP Annual Meeting
Validation of Novel Biomarker Candidates for Systemic Sclerosis
Background/Purpose: Systemic sclerosis (SSc) is a systemic autoimmune disease that manifests as progressive fibrosis of the skin and internal organs. SSc is associated with the…Abstract Number: 1917 • 2015 ACR/ARHP Annual Meeting
Developing and Validating a Serum Biomarker for the Extent of Skin Disease in Patients with Diffuse Cutaneous Systemic Sclerosis
Background/Purpose: In this study we aimed to both agonistically investigate alterations in the serum proteome of patients with diffuse cutaneous systemic sclerosis (dcSSc), as well…Abstract Number: 1918 • 2015 ACR/ARHP Annual Meeting
Pharmacologic Targeting of Mitochondrial Dysfunction in Systemic Sclerosis: Enhanced SIRT3 Signaling
Background/Purpose: Recent evidences suggest that cytosolic and mitochondrial reactive oxygen species (ROS), play pivotal roles in modulating TGF-β-induced profibrotic responses and are implicated in pathogenesis…Abstract Number: 1919 • 2015 ACR/ARHP Annual Meeting
Genetic Deletion of Toll-like Receptor 4 (Tlr4) Abrogates TGF-β1-Induced Endothelial-to-Mesenchymal Transition (EndoMT) in Murine Pulmonary Endothelial Cells
Background/Purpose: Systemic sclerosis (SSc) is a systemic autoimmune disease of unknown etiology whose pathogenesis involves the regulation of a diverse range of molecular pathways. The…Abstract Number: 1920 • 2015 ACR/ARHP Annual Meeting
Differential Production of Th17-Related Cytokines By Toll like Receptor (TLR)-Ligands-Stimulated Monocyte-Derived Dendritic Cells (Mo-DCs) from Systemic Sclerosis (SSc) Patients; Relevance of IL-22 and IL-33 According to Disease Subtype and Stage
Background/Purpose: Systemic sclerosis (SSc) patients exhibit alterations in innate and acquired cellular responses including an enhanced inflammatory response to toll like receptor (TLR) agonists that…Abstract Number: 1921 • 2015 ACR/ARHP Annual Meeting
Role of TLRs in the Abnormal Secretion of CXCL-4 By Plasmacytoid Dendritic Cells of Patients with Systemic Sclerosis
Background/Purpose: Systemic Sclerosis (SSc) is an autoimmune disorder of the connective tissue due to excessive extracellular matrix deposition, leading to fibrosis of the skin and…Abstract Number: 1922 • 2015 ACR/ARHP Annual Meeting
Peripheral B Lymphocytes Secrete Both Interleukin 6 and Transforming Growth Factor-Beta and Potentiate Fibroblast Activation in Systemic Sclerosis
Background/Purpose: Systemic sclerosis (SSc) is a rare connective tissue disease characterized by fibroblasts activation, increased extra-cellular matrix synthesis associated with autoimmunity. However, the potential role…Abstract Number: 1923 • 2015 ACR/ARHP Annual Meeting
The Role of Inflammatory Myeloid Cell Compartment in Myocardial Fibrogenesis and Remodelling in Systemic Sclerosis
Background/Purpose: During the last years, there was a shift in systemic sclerosis (SSc)-related causes of death, indicating cardiac involvement and inflammatory dilated cardiomyopathy (iDCM) as…
ACR Meeting Abstracts