ACR Meeting Abstracts

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  • Abstract Number: 818 • 2014 ACR/ARHP Annual Meeting

    Incident Rheumatoid Arthritis and Risk of Mortality Among Women Followed Prospectively from 1976 to 2010 in the Nurses’ Health Study

    Jeffrey A. Sparks1, Shun-Chiao Chang1,2, Katherine P. Liao1, Bing Lu1, Daniel H. Solomon1, Karen H. Costenbader1 and Elizabeth W. Karlson1, 1Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 2Channing Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA

    Background/Purpose RA has been associated with increased mortality compared to general population estimates. Previous studies were limited due to the inability to directly compare RA…
  • Abstract Number: 817 • 2014 ACR/ARHP Annual Meeting

    Mortality in a Large Cohort of Patients with Early Rheumatoid Arthritis That Were Treated-to-Target for 10 Years

    I.M. Markusse1, L. Dirven2, J.H. van Groenendael3, K.H. Han4, H.K Ronday5, P.J.S.M. Kerstens6, W.F. Lems7,8, T.W.J. Huizinga2 and C.F. Allaart2, 1Leiden University Medical Center, Leiden, Netherlands, 2Rheumatology, Leiden University Medical Center, Leiden, Netherlands, 3Rheumatology, Fransiscus Hospital, Roosendaal, Netherlands, 4Rheumatology, MCRZ hospital, Rotterdam, Netherlands, 5Rheumatology, Haga Hospital, The Hague, Netherlands, 6Rheumatology, Jan van Breemen Research Institute | Reade, Amsterdam, Netherlands, 7Rheumatology, VU Medical Center, Amsterdam, Netherlands, 8Jan van Breemen Research Institute | Reade, Amsterdam, Netherlands

    Background/Purpose: Recent studies showed diverging results about mortality trends in patients with rheumatoid arthritis (RA). Our aim was to determine survival after 10 years of…
  • Abstract Number: 816 • 2014 ACR/ARHP Annual Meeting

    TRNT1 Missense Mutations Define a New Periodic Fever Syndrome

    Angeliki Giannelou1, Qing Zhou2, Monique Stoffels3, Amanda Ombrello4, Deborah Stone2, Jehad H. Edwan5, Martin Pelletier6, Wanxia Tsai7, Katherine Calvo8, Sergio Rosenzweig9, Karyl Barron10, Massimo Gadina11, Ivona Aksentijevich12 and Daniel L. Kastner13, 1National Institute for Arthritis and Musculoskeletal and Skin Diseases, bethesda, MD, 2National Human Genome Research Institute, Bethesda, MD, 3National Human Genome Research Institute, bethesda, MD, 4Inflammatory Diseases Section, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, 5NIAMS NIH, Bethesda, MD, 6Niams, Immunoregulation Section, Autoimmunity Branch, Bethesda, MD, 7Translational Immunology Section, NIAMS / NIH, Bethesda, MD, 8Department of Laboratory Medicine, Hematology Section, National Institutes of Health Clinical Center, Bethesda, MD, 9National Institute of Allergy and Infectious Diseases, Bethesda, MD, 10NIH, Bethesda, MD, 11NIAMS/NIH, Bethesda, MD, 12Inflammatory Diseases Section, National Human Genome Research Institute, Bethesda, MD, 13Inflammatory Disease Section, National Human Genome Research Institute, Bethesda, MD

    Background/Purpose Two thirds of the 1700 patients seen at our NIH clinic for autoinflammatory diseases do not have a genetic diagnosis.  Whole exome sequencing permits…
  • Abstract Number: 815 • 2014 ACR/ARHP Annual Meeting

    Netosis Induced Histone Citrullination Facilitates Onset and Propagation of Rheumatoid Arthritis

    Dong Hyun Sohn1, Kazuhiro Onuma1, Chris Rhodes1, Xioayan Zhao1, Tal Gazitt2, Rani Shiao1, Justyna Fert Bober3, Danye Cheng1, Lauren J. Lahey1, Heidi Wong4, Jennifer van Eyk3, William H. Robinson1,5 and Jeremy Sokolove1, 1VA Palo Alto Healthcare System and Stanford University, Palo Alto, CA, 2Rheumatology, University of Washington, Seattle, WA, 3Johns Hopkins University and Cedars Sinai Medical Center, Los Angeles, CA, 4Stanford University School of Medicine, Stanford, CA, 5Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA

    Background/Purpose:   Anti-citrullinated protein antibodies (ACPAs) are characteristic of rheumatoid arthritis however, their presence years before onset of clinical RA is perplexing.  Although multiple putative…
  • Abstract Number: 814 • 2014 ACR/ARHP Annual Meeting

    Tocilizumab in Giant Cell Arteritis: Multicenter Open-Label Study of 22 Patients

    Montserrat Santos-Gómez1, Javier Loricera1, Ricardo Blanco1, Jose L. Hernández2, Antonio Mera3, Eva Pérez-Pampin4, M. Enriqueta Peiró1, Santos Castañeda-Sanz5, Alicia Humbría6, Jaime Calvo-Alen7, Elena Aurrecoechea8, Javier Narváez9, Amalia Sánchez-Andrade10, Paloma Vela11, Elvira Díez Álvarez12, Cristina Mata13, Pablo Lluch Mesquida14, Concepcion Moll Tuduri14, Vanesa Calvo-Río1, Francisco Ortiz-Sanjuán1, Trinitario Pina Murcia15, Carmen Gonzalez-Vela16, Leyre Riancho-Zarrabeitia1 and Miguel A. González-Gay1, 1Rheumatology, Hospital Universitario Marqués de Valdecilla. IDIVAL. Santander. Spain, Santander, Spain, 2Internal Medicine, Hospital Universitario Marqués de Valdecilla. IDIVAL. Santander. Spain, Santander, Spain, 3Hospital Clínico Universitario de Santiago de Compostela. Spain, Santiago de Compostela, Spain, 4Rheumatology, Hospital Clínico Universitario de Santiago de Compostela. Spain, Santiago de Compostela, Spain, 5Rheumatology, Hospital Universitario de La Princesa. Madrid. Spain, Madrid, Spain, 6Rheumatology, Hospital Universitario de La Princesa. IIS-Princesa, Madrid, Madrid, Spain, 7Rheumatology, Hospital de Sierrallana. Torrelavega. Spain, Torrelavega, Spain, 8Hospital de Sierrallana. Torrelavega. Spain, Torrelavega, Spain, 9Rheumatology, Hospital Universitario de Bellvitge. Barcelona. Spain, Barcelona, Spain, 10Rheumatology, Hospital Universitario Lucus Augusti. Lugo. Spain, Lugo, Spain, 11Rheumatology, Hospital General de Alicante. Spain, Alicante, Spain, 12Rheumatology, Hospital de León. Spain, León, Spain, 13Rheumatology, Hospital Comarcal de Laredo. Spain, Laredo, Spain, 14Hospital Mateu Orfila. Menorca. Spain, Mahón (Menorca), Spain, 15Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Rheumatology Division, IDIVAL, Santander, Spain, 16Pathology, Hospital Universitario Marqués de Valdecilla. IDIVAL. Santander. Spain, Santander, Spain

    Background/Purpose  Giant cell arteritis (GCA) is a primary vasculitis that involves the aorta and its major branches. It usually affects people aged more than 50…
  • Abstract Number: 813 • 2014 ACR/ARHP Annual Meeting

    Long-Term Outcomes of Takayasu’s Arteritis Patients with Renal Artery Involvement

    Corisande Baldwin1, Aladdin Mohammad2 and David Jayne3, 1Rheumatology, University of British Columbia, Vancouver, BC, Canada, 2Dept. of Rheumatology, Lund University Hospital, Lund University, Lund, Lund, Sweden, 3Vasculitis and Lupus Clinic, Addenbrookes Hospital University of Cambridge, Cambridge, United Kingdom

    Background/Purpose: Takayasu's Arteritis (TAK) is a chronic inflammatory large vessel vasculitis characterized by granulomatous inflammation of the aorta and its branches. TAK incidence is 2.6/million…
  • Abstract Number: 800 • 2014 ACR/ARHP Annual Meeting

    Hospitalization Rates and Utilization Among Patients with Giant Cell Arteritis: A Population-Based Study from 1987 to 2012

    C. John Michet III1, Sara J. Achenbach2, Cynthia S. Crowson3 and Eric L. Matteson4, 1Division of Rheumatology, Mayo Clinic College of Medicine, Rochester, MN, 2Department of Health Sciences Research, Mayo Clinic, Rochester, MN, 3Health Sciences Research, Mayo Clinic, Rochester, MN, 4Rheumatology, Mayo Clinic, Rochester, MN

    Background/Purpose Patients with giant cell arteritis (GCA) may experience serious vascular and visual complications. It is unknown, however, to what extent the difficulties of the…
  • Abstract Number: 812 • 2014 ACR/ARHP Annual Meeting

    Prognosis of Clinically Inactive Takayasu’s Arteritis

    Seung-Hyeon Bae, Seokchan Hong, Soo Min Ahn, Doo-Ho Lim, Yong-Gil Kim, Chang-Keun Lee and Bin Yoo, Division of Rheumatology, Department of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea

    Prognosis of Clinically Inactive Takayasu's Arteritis Background/Purpose: Takayasu's arteritis (TA) is a chronic inflammatory vasculitis, and immunosuppressants including glucocorticoids are generally required for treatment. Although,…
  • Abstract Number: 798 • 2014 ACR/ARHP Annual Meeting

    Frequency and Predictive Variables of Relapses in Patients with Biopsy-Proven Giant Cell Arteritis

    Luigi Boiardi1, Giovanna Restuccia2, Francesco Muratore1, Alberto Cavazza3, Luca Cimino4, Raffaella Aldigeri5, Pierluigi Macchioni1, Maria Grazia Catanoso6, Nicolò Pipitone1 and Carlo Salvarani1, 1Rheumatology Unit, Arcispedale S Maria Nuova, Reggio Emilia, Italy, 2Rheumatology Unit, Arcispedale S Maria Nuova, Reggio Emilia, Italy, 3Pathology Unit, Arcispedale S Maria Nuova, Reggio Emilia, Italy, 4Ophthalmology Unit, Arcispedale S Maria Nuova, Reggio Emilia, Italy, 5Clinical and experimental Medicine, Università di parma, Parma, Italy, 6Rheumatology Service, Arcispedale S Maria Nuova, Reggio Emilia, Italy

    Background/Purpose: Giant cell arteritis (GCA) is a vasculitis that involves large and medium sized arteries in patients older than 50 years. Relapses and recurrences of…
  • Abstract Number: 797 • 2014 ACR/ARHP Annual Meeting

    PET/CT for the Diagnosis of Giant Cell Arteritis: A Prospective Study

    Alison Clifford1, Elana Murphy1, Steven Burrell2, Matthew Bligh3, Godfrey Heathcote3, Mathieu Castonguay3, Kara Thompson4 and John G. Hanly5, 1Rheumatology, Dalhousie University and Capital Health, Halifax, NS, Canada, 2Diagnostic imaging, Dalhousie University and Capital Health, Halifax, NS, Canada, 3Dalhousie University and Capital Health, Halifax, NS, Canada, 4Department of Medicine, Queen Elizabeth II Health Sciences Centre and Dalhousie University, Halifax, NS, Canada, 5Division of Rheumatology, Dalhousie University and Capital Health, Halifax, NS, Canada

    Background/Purpose: Temporal artery (TA) biopsies are negative in up to 50% of patients with giant cell arteritis (GCA). In such cases, increased uptake in large…
  • Abstract Number: 796 • 2014 ACR/ARHP Annual Meeting

    Early Halo Sign Features on Ultrasound Examination of Treated Patients with Giant Cell Arteritis

    Ana Sofia Serafim1, Surjeet Singh1, Jennifer Piper1, Andrew Hutchings2, Mike Bradburn3, Cristina Ponte4, Bhaskar Dasgupta5, Wolfgang A. Schmidt6, Andreas P. Diamantopoulos7, Eugene McNally8 and Raashid Luqmani9, 1Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, United Kingdom, 2Department of Health Services Research and Policy, London School of Hygiene and Tropical Medicine, London, United Kingdom, 3Clinical Trials Research Unit (CTRU), Sheffield University, Sheffield, United Kingdom, 4Rheumatology and Metabolic Bone Diseases Department, Rheumatology Research Unit - IMM, Lisbon Academic Medical Centre, Lisbon, Portugal, 5Department of Rheumatology, Southend University Hospital, Essex, United Kingdom, 6Rheumatology, Immanuel Krankenhaus, Berlin, Germany, 7Rheumatology, Hospital of Southern Norway Trust, Kristiansand, Norway, 8Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Oxford University, Oxford, United Kingdom, 9Nuffield Department of Orthopaedics Rheumatology and Musculoskeletal Sciences, Botnar Research Centre, University of Oxford, Oxford, United Kingdom

    Background/Purpose The TABUL study (Temporal Artery Biopsy Vs Ultrasound in diagnosis of Giant Cell Arteritis) is assessing the relative performance of ultrasound and temporal artery…
  • Abstract Number: 795 • 2014 ACR/ARHP Annual Meeting

    High Interobserver Agreement on Ultrasonographic Findings in Patients with Large Vessel Vasculitis

    Andreas P. Diamantopoulos1, Julia Geiger2, Frode Lohne3, Geirmund Myklebust1 and Wolfgang A. Schmidt4, 1Rheumatology, Hospital of Southern Norway Trust, Kristiansand, Norway, 2Department of Radiology, University Children's Hospital, Zurich, Switzerland, 3Unilabs Røntgen Kristiansand, Kristiansand, Norway, 4Rheumatology, Immanuel Krankenhaus, Berlin, Germany

    Background/Purpose Ultrasound has a high sensitivity and specificity regarding the diagnosis of giant cell arteritis (GCA). Ultrasound can also depict extracranial large vessel vasculitis (LVV)…
  • Abstract Number: 794 • 2014 ACR/ARHP Annual Meeting

    Color Doppler Ultrasonography Findings in Giant Cell Arteritis and Their Relationship with Clinical Manifestations

    Cristina Ponte1,2, Ruth Geraldes3, Anthea Craven1, Andrew Judge4, Peter C. Grayson5, Ravi Suppiah6, Joanna Robson1, Richard A. Watts7, Peter A. Merkel8 and Raashid Luqmani1, 1Nuffield Department of Orthopaedics Rheumatology and Musculoskeletal Sciences, Botnar Research Centre, University of Oxford, Oxford, United Kingdom, 2Rheumatology and Metabolic Bone Diseases Department, Rheumatology Research Unit - IMM, Lisbon Academic Medical Centre, Lisbon, Portugal, 3Neurology Department, Lisbon Academic Medical Centre, Lisbon, Portugal, 4Musculoskeletal Biomedical Research Unit, University of Oxford, Oxford, United Kingdom, 5NIAMS Systemic Autoimmunity Branch, National Institutes of Health, Bethesda, MD, 6Department of Rheumatology, Auckland District Health Board, Auckland, New Zealand, 7Rheumatology Department Ipswich Hospital and University of East Anglia, Ipswich, United Kingdom, 8University of Pennsylvania, Philadelphia, PA

    Background/Purpose Colour Doppler ultrasonography (CDU) of the temporal (TA), axillary (AA) and common carotid arteries (CA) has excellent sensitivity and specificity for the diagnosis of…
  • Abstract Number: 793 • 2014 ACR/ARHP Annual Meeting

    Preliminary Analysis of Histological Findings in Diagnosis of Giant Cell Arteritis Biopsy Positive Patients

    Surjeet Singh1, Andrew Hutchings2, Wulf Forrester-Barker3, Bhaskar Dasgupta4, Andreas P. Diamantopoulos5, Peter Lanyon6, Malgorzata Magliano7, Brendan McDonald8, Konrad Wolfe9 and Raashid Luqmani10, 1Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, United Kingdom, 2Department of Health Services Research and Policy, London School of Hygiene and Tropical Medicine, London, United Kingdom, 3University of Oxford, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Oxford, United Kingdom, 4Department of Rheumatology, Southend University Hospital, Essex, United Kingdom, 5Rheumatology, Hospital of Southern Norway Trust, Kristiansand, Norway, 6Nottingham University Hospitals NHS Trust, Nottingham, United Kingdom, 7Department of Rheumatology,, Stoke Mandeville Hospital, Aylesbury, United Kingdom, 8Department of Pathology, John Radcliffe Hospital, Oxford, United Kingdom, 9Department of Pathology, Southend University Hospital, Essex, United Kingdom, 10Nuffield Department of Orthopaedics Rheumatology and Musculoskeletal Sciences, Botnar Research Centre, University of Oxford, Oxford, United Kingdom

    Background/Purpose A positive temporal artery biopsy (TAB) with giant cells, active inflammation and intimal hyperplasia is the gold standard test for diagnosing temporal arteritis. However,…
  • Abstract Number: 792 • 2014 ACR/ARHP Annual Meeting

    Is Temporal Artery Biopsy the Gold Standard for the Diagnosis of Giant Cell Arteritis?

    Marina Scolnik1, Aldo Fabian Ojeda2, Valeria Scaglioni3 and Enrique R. Soriano4, 1Rheumatology Unit, Internal Medical Services, Hospital Italiano de Buenos Aires, Instituto Universitario Hospital Italiano de Buenos Aires, and Fundacion PM Catoggio, Buenos Aires, Argentina, 2Departamento de Reumatología, Hospital de Clínicas, FCM-UNA, Asuncion, Paraguay, 3Rheumatology Unit, Internal Medical Service, Hospital Italiano de Buenos Aires, Instituto Universitario Hospital Italiano de Buenos Aires, and Fundacion PM Catoggio, Buenos Aires, Argentina, 4Rheumatology Unit, Internal Medicine Service, Hospital Italiano de Buenos Aires, Instituto Universitario Hospital Italiano de Buenos Aires, and Fundacion PM Catoggio, Buenos Aires, Argentina

    Background/Purpose: The only test that confirms diagnosis of Giant Cell Arteritis (GCA) is a temporal artery biopsy showing vasculitis with mononuclear cell inflammatory infiltrates, often with…
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