ACR Meeting Abstracts

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  • Abstract Number: 1950 • 2015 ACR/ARHP Annual Meeting

    Methylation-Dependent Interference of Two Promoters for the Treg-Specific Protein, Garp, Contributes to Altered Treg Function in Rheumatoid Arthritis

    Viktoria Soentgerath1, Sonja Haupt2, Jan Leipe3, Hendrik Schulze-Koops1 and Alla Skapenko1, 1Division of Rheumatology and Clinical Immunology, University of Munich, Munich, Germany, 2Division of Rheumatology and Clinical Immunology, Med.Klinik und Poliklinik IV, University of Munich, Munich, Germany, 3Division of Rheumatology, University of Munich, Munich, Germany

    Background/Purpose: Recently, genome-wide studies identified several Treg-specific genes containing hypomethylated regions that are critical for their expression, so called Treg-specific demethylated regions (TSDR). For example,…
  • Abstract Number: 1951 • 2015 ACR/ARHP Annual Meeting

    The Incidence Rate of Giant Cell Arteritis in Slovenia

    Natasa Potocnik1, Alojzija Hocevar1, Ziga Rotar1, Joze Pizem2, Marko Hawlina3, Ana Fakin3 and Matija Tomšič1, 1Department of Rheumatology, University Medical Centre Ljubljana, Ljubljana, Slovenia, 2Institute of Pathology, University of Ljubljana, Faculty of Medicine, Ljubljana, Slovenia, 3Department of Ophthalmology, University Medical Centre Ljubljana, Ljubljana, Slovenia

    Background/Purpose: Giant cell arteritis (GCA) is the most common systemic vasculitis in adults aged 50 years or above. Annual incidence rates vary widely from 6.9–76.6…
  • Abstract Number: 1952 • 2015 ACR/ARHP Annual Meeting

    Lack of Association of a 6.7 Kbp Deletion of LILRA3 with Giant Cell Arteritis

    Ana Márquez1, Tamara Fernández-Aranguren2, Maria C. Cid3, José Hernández-Rodríguez3, Roser Solans4, Marc Ramentol4, Santos Castañeda5, Jose A. Miranda-Filloy6, Inmaculada C. Morado7, Javier Narváez8, Eugenio De Miguel9, Bernardo Sopeña10, Jordi Monfort11, Maria Jesus Garcia-Villanueva12, Norberto Ortego-Centeno13, Torsten Witte14, Miguel Angel Gonzalez-Gay15, Javier Martín2 and Spanish GCA Group, 1Instituto de Parasitología y Biomedicina López-Neyra, IPBLN-CSIC, PTS-Granada and Systemic Autoimmune Diseases Unit, Hospital Clínico San Cecilio, Granada, Spain, 2Instituto de Parasitología y Biomedicina López- Neyra, IPBLN-CSIC, PTS-Granada, Granada, Spain, 3Vasculitis Research Unit, Department of Autoimmune Diseases, Hospital Clínic University of Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain, 4Autoimmune Systemic Diseases Unit, Department of Internal Medicine, Hospital Vall d’Hebron, Autonomous University of Barcelona, Barcelona, Spain, 5Hospital Universitario de La Princesa. IIS La Princesa, Madrid, Spain, 6Department of Rheumatology, Hospital Xeral-Calde, Lugo, Spain, 7Department of Rheumatology, Hospital Clínico San Carlos, Madrid, Spain, 8Rheumatology Department, Hospital Universitari de Bellvitge, L'Hospitalet de Llobregat, Spain, 9Department of Rheumatology, Hospital Universitario La Paz, Madrid, Spain, 10Department of Internal Medicine, Complejo Hospitalario Universitario de Vigo, Vigo, Spain, 11Department of Rheumatology, Grup de recerca cel•lular en inflamació i cartílag. IMIM (Institut de Recerca Hospital del Mar), Barcelona, Spain, 12Department of Rheumatology, Hospital Ramón y Cajal, Madrid, Spain, 13Systemic Autoimmune Diseases Unit, Hospital Clínico San Cecilio, Granada, Spain, 14Hannover Medical School, Hanover, Germany, 15Department of Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL, Santander, Spain

    Background/Purpose: Leukocyte immunoglobulin-like receptor A3 (LILRA3A) encodes a member of a family of immunoreceptors which is predominantly expressed on antigen presenting cells, acting as a…
  • Abstract Number: 1953 • 2015 ACR/ARHP Annual Meeting

    Identification of Genetic Factors Associated with Clinical Manifestations of Giant Cell Arteritis through a Stratified Large-Scale Analysis

    Ana Márquez1, Francisco David Carmona2, Maria C. Cid3, José Hernández-Rodríguez3, Roser Solans4, Marc Ramentol4, Santos Castañeda5, Jose A. Miranda-Filloy6, Inmaculada C. Morado7, Javier Narváez8, Eugenio De Miguel9, Bernardo Sopeña10, Jordi Monfort11, Maria Jesus Garcia-Villanueva12, Norberto Ortego-Centeno13, Miguel Angel Gonzalez-Gay14, Javier Martín15 and Spanish GCA Group, 1Instituto de Parasitología y Biomedicina López-Neyra, IPBLN-CSIC, PTS-Granada and Systemic Autoimmune Diseases Unit, Hospital Clínico San Cecilio, Granada, Spain, 2Instituto de Parasitología y Biomedicina López-Neyra, IPBLN-CSIC, PTS-Granada, Granada, Spain, 3Vasculitis Research Unit, Department of Autoimmune Diseases, Hospital Clínic University of Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain, 4Autoimmune Systemic Diseases Unit, Department of Internal Medicine, Hospital Vall d’Hebron, Autonomous University of Barcelona, Barcelona, Spain, 5Department of Rheumatology, Hospital de la Princesa, IIS-Princesa, Madrid, Spain, 6Department of Rheumatology, Hospital Xeral-Calde, Lugo, Spain, 7Department of Rheumatology, Hospital Clínico San Carlos, Madrid, Spain, 8Rheumatology, Hospital Universitario de Bellvitge, Barcelona, Spain, 9Department of Rheumatology, Hospital Universitario La Paz, Madrid, Spain, 10Department of Internal Medicine, Complejo Hospitalario Universitario de Vigo, Vigo, Spain, 11Department of Rheumatology, Grup de recerca cel•lular en inflamació i cartílag. IMIM (Institut de Recerca Hospital del Mar), Barcelona, Spain, 12Department of Rheumatology, Hospital Ramón y Cajal, Madrid, Spain, 13Systemic Autoimmune Diseases Unit, Hospital Clínico San Cecilio, Granada, Spain, 14Rheumatology, Hospital Universitario Marqués de Valdecilla. IDIVAL, Santander, Spain, 15Instituto de Parasitología y Biomedicina López- Neyra, IPBLN-CSIC, PTS-Granada, Granada, Spain

    Background/Purpose: Giant cell arteritis (GCA) is a large-vessel vasculitis that primarily affects the aorta and external carotid arteries and their branches, leading to ischemic manifestations…
  • Abstract Number: 1954 • 2015 ACR/ARHP Annual Meeting

    How Can We Use Ultrasound in the Diagnosis and Management of Patients with Giant Cell Arteritis?

    Cristina Ponte1,2, Sophie Vaggers1, Jan Sznajd1, Lorraine O'Neill1, Jennifer Piper3, Jessica Gunn1, Kulveer Mankia1 and Raashid Luqmani1, 1Nuffield Department of Orthopaedics Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, United Kingdom, 2Rheumatology and Metabolic Bone Diseases Department, Rheumatology Research Unit - IMM, Lisbon Academic Medical Centre, Lisbon, Portugal, 3Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, United Kingdom

    Background/Purpose: Giant cell arteritis (GCA), the most common primary vasculitis, can cause irreversible blindness in 20-30% of untreated cases, but glucocorticoid therapy leads to significant…
  • Abstract Number: 1955 • 2015 ACR/ARHP Annual Meeting

    The Performance of Colour-Doppler Sonography of Temporal Arteries in Patients Suspect of Having Giant Cell Arteritis in Daily Clinical Practice

    Alojzija Hocevar, Rok Ješe, Ziga Rotar and Matija Tomšič, Department of Rheumatology, University Medical Centre Ljubljana, Ljubljana, Slovenia

    Background/Purpose: The Colour-Doppler Sonography of temporal arteries (CDS-TA) has recently gained momentum as a potential non-invasive tool for diagnosing GCA. Our aim was to evaluate the…
  • Abstract Number: 1956 • 2015 ACR/ARHP Annual Meeting

    Risk of Cerebrovascular Accident in Patients with Polymyalgia Rheumatica: A Systematic Review and Meta-Analysis

    Patompong Ungprasert1, Narat Srivali2 and Wonngarm Kittanamongkolchai3, 1Rheumatology, Mayo Clinic, Rochester, MN, 2Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, MN, 3Nephrology and hypertension, Mayo Clinic, Rochester, MN

    Risk of Cerebrovascular Accident in Patients with Polymyalgia Rheumatica: A Systematic Review and Meta-analysisBackground/Purpose: Several chronic inflammatory disorders, such as rheumatoid arthritis and systemic lupus…
  • Abstract Number: 1957 • 2015 ACR/ARHP Annual Meeting

    Colour-Doppler Ultrasonography of Epiaortic Arteries in Patients with Giant Cell Arteritis

    Alojzija Hocevar, Rok Ješe, Ziga Rotar and Matija Tomšič, Department of Rheumatology, University Medical Centre Ljubljana, Ljubljana, Slovenia

    Background/Purpose: Giant cell arteritis (GCA) is the most common systemic vasculitis in patients over 50 years of age. Large vessel disease outside temporal arteries is…
  • Abstract Number: 1958 • 2015 ACR/ARHP Annual Meeting

    Diagnostic Value of Ultrasonography-Derived Signs in Giant Cell Arteritis: Literature Review and Meta-Analysis

    Fanny BUSQUET1, Léa Rouxel2, Thomas Barnetche3 and Thierry Schaeverbeke4, 1intern of hospital, BORDEAUX, France, 2intern of hospital, Bordeaux, France, 3PHD, bordeaux, France, 4department head, Bordeaux, France

    Background/Purpose: Giant Cell Arteritis (GCA) is the most common form of systemic inflammatory vasculitis in elderly people, with prevalence still increasing, and for which there…
  • Abstract Number: 1959 • 2015 ACR/ARHP Annual Meeting

    Color Doppler Ultrasonography Appears to Perform Better Than Magnetic Resonance Angiography in the Diagnostics of Patients with Systemic Large Vessel Vasculitis

    Andreas P Diamantopoulos1,2, Julia Geiger3, Frode Lohne4, Geirmund Myklebust5 and Wolfgang A. Schmidt6, 1Rheumatology, Hospital of Southern Norway Trust, Kristiansand, Norway, 2Rheumatology, Haugesund Hospital for Rheumatic Diseases, Haugesund, Norway, 3Department of Radiology, University Children's Hospital, Zurich, Switzerland, 4Radiology, Hospital of Southern Norway Trust, Kristiansand, Norway, 5Rheumatology, Hospital of Southern Norway, Kristiansand, Norway, 6Medical Center for Rheumatology and Clinical Immunology Berlin-Buch, Immanuel Krankenhaus Berlin, Berlin, Germany

    Background/Purpose: Color Doppler ultrasound (CDUS) and Magnetic resonance angiography (MRA) has been extensively used in the diagnostics of large vessel vasculitis (LVV) [giant cell arteritis…
  • Abstract Number: 1960 • 2015 ACR/ARHP Annual Meeting

    a Structured and Extensive Training Program on Vascular Ultrasound, Results in an Excellent Agreement Between Ultrasound and Temporal Artery Biopsy in the Diagnosis of Giant Cell Arteritis

    Stavros Chrysidis1, Ulrich Fredberg2, Uffe Møller Døhn3, Tove Lorenzen4, Lene Terslev5, Knud Larsen6 and Andreas P Diamantopoulos7, 1Department of Rheumatology, Hospital of Southwest Denmark, Esbjerg, Denmark, 2Department of Internal Medicine, Diagnostic Centre Region Hospital Silkeborg Denmark, Silkeborg, Denmark, 3Center for Rheumatology and Spine Diseases, Copenhagen Center for Arthritis Research (COPECARE), Center for Rheumatology and Spine Diseases, Rigshospitalet - Glostrup, University of Copenhagen, Glostrup, Denmark, 4Diagnostic Centre, Region Hospital Silkeborg, Silkeborg, Denmark, 5Copenhagen University Hospital at Glostrup, Copenhagen, Denmark, 6otolaryngology, Southwest hospital, Esbjerg, Denmark, 7Rheumatology, Haugesund Hospital for Rheumatic Diseases, Haugesund, Norway

    Background/Purpose: There is an increased use of vascular ultrasound (US) for diagnosing giant cell arteritis (GCA).  Consequently, extensive and structured training of ultrasonographers performing vascular…
  • Abstract Number: 1961 • 2015 ACR/ARHP Annual Meeting

    Interobserver Agreement on Ultrasonographic and Magnetic Resonance Angiography Findings in Patients with Large Vessel Vasculitis

    Andreas P Diamantopoulos1,2, Julia Geiger3, Frode Lohne4, Geirmund Myklebust5 and Wolfgang A. Schmidt6, 1Rheumatology, Haugesund Hospital for Rheumatic Diseases, Haugesund, Norway, 2Rheumatology, Hospital of Southern Norway Trust, Kristiansand, Norway, 3Department of Radiology, University Children's Hospital, Zurich, Switzerland, 4Radiology, Hospital of Southern Norway Trust, Kristiansand, Norway, 5Rheumatology, Hospital of Southern Norway, Kristiansand, Norway, 6Medical Center for Rheumatology and Clinical Immunology Berlin-Buch, Immanuel Krankenhaus Berlin, Berlin, Germany

    Background/Purpose: Ultrasound and Magnetic resonance angiography (MRA) yields a high sensitivity and specificity regarding the diagnosis of cranial giant cell arteritis (GCA). Ultrasound and MRA…
  • Abstract Number: 1962 • 2015 ACR/ARHP Annual Meeting

    Inter-Rater Analysis of Ultrasound and Histological Findings in Patients with Suspected Giant Cell Arteritis

    Raashid Luqmani1, Ellen Lee2, Surjeet Singh3, Michael Gillett2, Wolfgang A. Schmidt4, Mike Bradburn2, Bhaskar Dasgupta5, Andreas P Diamantopoulos6, Wulf Forrester-Barker7, William Hamilton8, Shauna Masters9, Brendan McDonald10, Eugene McNally7, Colin T. Pease11, Jennifer Piper7, John Salmon12, Allan Wailoo2, Konrad Wolfe13, Andrew Hutchings14 and TABUL Sonographers Group and TABUL Pathologists Group, 1Nuffield Department of Orthopaedics Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, United Kingdom, 2School of Health and Related Research, University of Sheffield, Sheffield, United Kingdom, 31Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, United Kingdom, 4Medical Center for Rheumatology and Clinical Immunology Berlin-Buch, Immanuel Krankenhaus Berlin, Berlin, Germany, 5Rheumatology, Southend University Hospital, Essex, United Kingdom, 6Department of Rheumatology, Hospital of Southern Norway Trust, Kristiansand, Norway, 7Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, United Kingdom, 8Primary Care, University of Exeter, Exeter, United Kingdom, 9Nuffield Department of Orthopaedics Rheumatology and Musculoskeletal Science, University of Oxford, Oxford, United Kingdom, 10Department of Neuropathology and Ocular Pathology, Oxford University Hospitals NHS Trust, Oxford, United Kingdom, 11Rheumatology, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom, 12Ophthalmology, Oxford University Hospitals NHS Trust, Oxford, United Kingdom, 13Department of Pathology, Southend University Hospital, Essex, United Kingdom, 14Health Services Research Unit, London School of Hygiene and Tropical Medicine, London, United Kingdom

    Background/Purpose: Ultrasound is emerging as an alternative test to performing a temporal artery biopsy in the diagnosis of giant cell arteritis (GCA). Little is known…
  • Abstract Number: 1963 • 2015 ACR/ARHP Annual Meeting

    Specialty of Provider Referring for Temporal Artery Biopsy Affects the Likelihood of Giant Cell Arteritis (GCA) Diagnosis

    Lindsay Lally1 and Robert F. Spiera2, 1Rheumatology, Hospital for Special Surgery, New York, NY, 2Rheumatology, HSS, New York, NY

    Background/Purpose: Presenting signs/symptoms of GCA can be nonspecific and patients can initially present to a spectrum of clinical specialties.  While temporal artery biopsy (TAB) is…
  • Abstract Number: 1964 • 2015 ACR/ARHP Annual Meeting

    Biomarkers in Temporal Artery Biopsies and Sera of Patients with Giant Cell Arteritis

    Katja Lakota1, Tadeja Kuret2, Polona Žigon1, Ziga Rotar1, Matija Tomsic1, Saša Čučnik1,2, Snezna Sodin Semrl1,3 and Alojzija Hocevar1, 1Department of Rheumatology, University Medical Centre Ljubljana, Ljubljana, Slovenia, 2Faculty of Pharmacy, University of Ljubljana, Ljubljana, Slovenia, 3Faculty of Mathematics, Natural Science and Information Technology, University of Primorska, Koper, Slovenia

    Background/Purpose: Giant cell arteritis (GCA) is a large- and medium- vessel arteritis characterized by a range of histological patterns of vascular wall injury. The temporal…
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