Abstracts Archive - Page 1794 of 2607 - ACR Meeting Abstracts

Abstract Number: 2929 • 2016 ACR/ARHP Annual Meeting
The Baseline Th17 Lymphocytes Level Is a Predictive Marker of Good Response to Biologics in Rheumatoid Arthritis
Sarah Salomon¹, Caroline Guignant², Pierre Morel³, Brigitte Gubler⁴, Patrice Fardellone⁵, Jean-Pierre Marolleau⁶ and Vincent Goeb⁷, ¹Rheumatology, University Hospital of Amiens, Amiens, France, ²Immunology Laboratory, University Hospital of Amiens, Amiens, France, ³Hematology, University Hospital of Amiens, Amiens, France, ⁴Immunology, University Hospital of Amiens, Amiens, France, ⁵Department of Rheumatology, Amiens University hospital, Amiens, France, ⁶hematology, University Hospital of Amiens, Amiens, France, ⁷Rheumatology, Amiens University Hospital, Amiens, France
Background/Purpose: In clinical daily practice, the response to biologic drugs is unpredictable in patients with rheumatoid arthritis (RA). Thus, there is a crucial need for…
Abstract Number: 2930 • 2016 ACR/ARHP Annual Meeting
Specific Metabolic and Functional Changes in Peripheral CD8+ T Cells Specifically Distinguish RA from PSA and SPA
Rui Carvalho¹, Christine Tucher², Lars Tykocinski², Susanne Neu², Karel Klika³, H.-M. Lorenz² and Margarida Souto-Carneiro², ¹Life Sciences Department, FCTUC, Center for Functional Ecology, University of Coimbra, Coimbra, Portugal, ²Rheumatology, Department of Rheumatology, University of Heidelberg, Heidelberg, Germany, ³German Cancer Research Center, Heidelberg, Germany
Background/Purpose: Studies by our team and others have shown that CD8 T cells (CD8s) in RA have a pro-inflammatory, cytotoxic effector phenotype and may, therefore,…
Abstract Number: 2931 • 2016 ACR/ARHP Annual Meeting
Endogenous Nur77 Is a Specific Indicator of Antigen Receptor Signaling in Human T and B Cells
Judith Ashouri and Arthur Weiss, Department of Medicine, Division of Rheumatology, 1Howard Hughes Medical Institute, Rosalind Russell and Ephraim P. Engleman Rheumatology Research Center, University of California, San Francisco, San Francisco, CA
D Intracellular Nur77 protein amounts were assessed by immunofluorescence and flow cytometry in T and B cells isolated from human PBMCs stimulated through their Ag…
Abstract Number: 2932 • 2016 ACR/ARHP Annual Meeting
HLA-DR3 Restricted Response to Lupus-Related Auto-Antigen Smd: Autoreactive T Cells Are Inherent in Normal Immune Repertoires
Zhenhuan Zhao¹, Jiling Ren¹, Chao Dai², Carol Kannapell¹, Qian Wang³, Felicia Gaskin⁴ and Shu Man Fu⁵, ¹Medicine/CIIR/Rheumatology, University of Virginia, Charlottesville, VA, ²Center for Immunity, Inflammation, and Regenerative Medicine, University of Virginia, Charlottesville, VA, ³University of Virginia, Charlottesville, VA, ⁴Psychiatry and Neurobehavioral Sciences, University of Virginia, Charlottesville, VA, ⁵Department of Medicine, University of Virginia, Charlottesville, VA
Background/Purpose: HLA class II is the major susceptibility region for systemic lupus erythematosus (SLE) and other autoimmune disorders such as rheumatoid arthritis, multiple sclerosis and…
Abstract Number: 2933 • 2016 ACR/ARHP Annual Meeting
HLA-DR3 Restricted T Cell Response to Smd and Ro60 Reveals Multiple Cross-Reactive Intra- and Inter-Molecular T Cell Epitopes: Unique Antigenic Structures of Lupus-Related Auto-Antigens and the Basis for B Cell Epitope Spreading
Zhenhuan Zhao¹, Jiling Ren¹, Chao Dai², Carol Kannapell¹, Qian Wang³, Felicia Gaskin⁴ and Shu Man Fu⁵, ¹Medicine/CIIR/Rheumatology, University of Virginia, Charlottesville, VA, ²Center for Immunity, Inflammation, and Regenerative Medicine, University of Virginia, Charlottesville, VA, ³University of Virginia, Charlottesville, VA, ⁴Psychiatry and Neurobehavioral Sciences, University of Virginia, Charlottesville, VA, ⁵Department of Medicine, University of Virginia, Charlottesville, VA
Background/Purpose: Complex auto-Abs targeting nuclear proteins is a hallmark of systemic lupus erythematosus (SLE). It is documented that this complexity is the result of “B cell…
Abstract Number: 2934 • 2016 ACR/ARHP Annual Meeting
Clinical Assessment of the Monoclonal Anitbody, PRX003, a Potential Novel Treatment for Th17-Mediated Inflammatory Disease
Gene G. Kinney¹, Kenneth Flanagan¹, Michael Skov¹, Ronald Goldblum², Sue Griffith³, Robin M. Barbour¹, Wagner Zago¹, Ted Yednock¹, Martin Koller¹ and Dan Ness¹, ¹Prothena Biosciences Inc, South San Francisco, CA, ²Carlsbad Pharmaceutical Consulting, Inc., Carlsbad, CA, ³ClinPharma Services, Inc, San Diego, CA
Background/Purpose: Melanoma cell adhesion molecule (MCAM; CD146) is expressed on the surface of Th17 cells, which have the capacity to produce IL-17 and a multitude…
Abstract Number: 2935 • 2016 ACR/ARHP Annual Meeting
Activation Status of Mucosal-Associated Invariant T Cells Sensitively Reflects Disease Activity of Systemic Lupus Erythematosus
Asako Chiba¹, Goh Murayama², Mie Kitagaichi³, Naoto Tamura⁴, Ken Yamaji², Yoshinari Takasaki⁴ and Sachiko Miyake¹, ¹Immunology, Juntendo University School of Medicine, Tokyo, Japan, ²Department of Internal Medicine and Rheumatology, Juntendo University School of Medicine, Tokyo, Japan, ³Department of Rheumatology, Juntendo University School of Medicine, Tokyo, Japan, ⁴Internal Medicine and Rheumatology, Juntendo University School of Medicine, Tokyo, Japan
Background/Purpose: Mucosal-associated invariant T (MAIT) cells are innate-like lymphocytes that express a semi-invariant TCRα chain: Vα7.2-Jα33 in humans and Vα19-Jα33 in mice. MAIT cells are…
Abstract Number: 2936 • 2016 ACR/ARHP Annual Meeting
All-Trans Retinoic Acid Stabilizes Natural T Regulatory Cells Isolated from Patients with Systemic Lupus Erythematosus Under Inflammatory Conditions
Julie Wang¹, Zixuan Qiao², Feng Huang³, Ya Liu², Nancy J. Olsen⁴ and Song Guo Zheng⁵, ¹Medicine, Penn State Hershey Medical Center, Hershey, PA, ²Medicine, Xuzhou Medical University, Xuzhou, China, ³Center for Clinic Immunology, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, China, Guangzhou, China, ⁴Medicine/Rheumatology, Penn State Hershey Medical Center, Hershey, PA, ⁵Medicine/Rheumatology, Penn State University Hershey Medical Center, Hershey, PA
Background/Purpose: Recent studies have demonstrated that naturally occurring CD4+Foxp3+regulatory T cells (nTregs) are unstable and dysfunctional in the presence of pro-inflammatory cytokines. All-trans RA (atRA),…
Abstract Number: 2937 • 2016 ACR/ARHP Annual Meeting
Regulation of Follicular Helper T (TFH) Cells By ROCK2 (Rho-associated coiled-coil containing protein kinase 2)
Woelsung Yi¹, Sanjay Gupta², Chien-Huan Weng³, Yurii Chinenov⁴, James K. Liao⁵ and Alessandra B. Pernis⁶, ¹Hospital for Special Surgery, New York, NY, ²Autoimmunity & Inflammation Research Program, Hospital for Special Surgery, New York, NY, ³Weill Cornell Medical College, New York, NY, ⁴Arthritis & Tissue Degeneration Program, Hospital for Special Surgery, New York, NY, ⁵Cardiology Section, University of Chicago Medical Center, Chicago, IL, ⁶David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery, New York, NY
Background/Purpose: Follicular helper T (TFH) cells promote humoral responses and serve as a limiting factor for the selection of high affinity germinal center B cells.…
Abstract Number: 2938 • 2016 ACR/ARHP Annual Meeting
U4ATAC Mutation Is Associated with an Immune Dysregulation Syndrome Characterized By Primary Immunodeficiency, Short Stature and Polyglandular Endocrinopathy
Maria Gutierrez¹, Zuoming Deng², Joshua McElwee³, Richard M. Siegel⁴ and Eric Hanson⁵, ¹NIAMS, NIH, Bethesda, MD, ²NIAMS/NIH, Bethesda, MD, ³Immunogenetics Genetics and Pharmacogenomics, Merck Research Laboratories, Boston, MA, ⁴National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, MD, ⁵National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD
Background/Purpose: A host of primary immunodeficiencies, such as autoimmune polyendocrinopathy, candidiasis, ectodermal dysplasia (APECED), immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX), and STAT5b insufficiency can…
Abstract Number: 2939 • 2016 ACR/ARHP Annual Meeting
Risk of Venous Thromboembolism in Patients with Systemic Vasculitides: A Systematic Review and Meta-Analysis
Patompong Ungprasert¹, Matthew J. Koster² and Kenneth J. Warrington³, ¹Rheumatology, Mayo Clinic, Rochester, MN, ²Rheumatology, University of California Los Angeles, CA, USA Mayo Clinic, Rochester, MN, ³Rheumatology, University of California Los Angeles, CA, USA Mayo, Rochester, MN
Risk of Venous Thromboembolism in Patients with Systemic Vasculitides: A Systematic Review and Meta-analysis Background/Purpose: Venous thromboembolism (VTE) is a common medical problem with a…
Abstract Number: 2940 • 2016 ACR/ARHP Annual Meeting
Bechet’s Disease and Sleep Quality in Korean Patients
Chang-Nam Son¹, Ji Min Lee¹, Hye-Jin Jeong², Ji-Min Kim¹, Sang-Hyon Kim¹, Sung Soo Kim³ and Seung-Hyeon Bae⁴, ¹Division of Rheumatology, Department of Internal Medicine, Dongsan Medical Center, Keimyung University School of Medicine, Daegu, Korea, The Republic of, ²Division of Rheumatology, Department of Internal Medicine, Dongsan Medical Center, Keimyung University School of Medicine, Daegu, South Korea, ³Division of Rheumatology, Department of Internal Medicine, Ulsan University School of Medicine, GangNeung Asan Hospital, Gangneung, South Korea, ⁴Division of Rheumatology, Department of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea
Background/Purpose: The purpose of this study was to find out the effects of sleep quality on Behcet’s disease in Korean population. We also investigated the…
Abstract Number: 2941 • 2016 ACR/ARHP Annual Meeting
Optimization of Adalimumab on Refractory Uveitis of Behcet’s Syndrome. Multicenter Study of 23 Patients
Carlos Fernández-Díaz¹, Ricardo Blanco¹, Vanesa Calvo-Río¹, Javier Loricera¹, J. Sanchez-bursón², Norberto Ortego Centeno³, Jose L. García Serrano⁴, Miguel Cordero⁵, J. Vazquez⁶, Emma Beltran⁷, Elia Valls⁸, O. Maiz Alonso⁹, Ana Blanco¹⁰, Ignacio Torre¹¹, Angel García-Aparicio¹², F.j Toyos-saénz¹³, L. Martinez-Costa¹⁴, Lucia C. Domínguez-Casas¹, Natalia Palmou¹ and Miguel Angel Gonzalez-Gay¹, ¹Rheumatology, Hospital Universitario Marqués de Valdecilla. IDIVAL, Santander, Spain, ²Rheumatology, Hospital Valme, Hospital Valme, Sevilla, Spain, ³Medicine Department, Hospital Universitario San Cecilio, Granada, Spain, ⁴Ophthalmology, Hospital Universitario San Cecilio, Granada, Spain, ⁵Ophthalmology, Hospital de León, León, Spain, ⁶Rheumatology, Hospital de Ferrol, Ferrol, Spain, ⁷Rheumatology, Hospital General Universitario de Valencia, Valencia, Spain, ⁸Rheumatology, Hospital Dr. Peset., Valencia, Spain, ⁹Rheumatology, Hospital Donostia, San Sebastian, Spain, ¹⁰Ophthalmology Department. Donostia University Hospital, Donostia, Spain, ¹¹Rheumatology, Hospital de Basurto, Bilbao, Spain, ¹²Rheumatology, Ophthalmology and rheumatology, Hospital de Ferrol, Ferrol, Ferrol, Spain, ¹³Rheumatology,, Hospital Virgen de la Macarena, Sevilla, Spain, ¹⁴Hospital Dr. Peset., Valencia, Spain
Background/Purpose: In non-infectious no anterior uveitis, adalimumab (ADA) is the only biologic drug that has shown efficacy in phase III randomized, double blind studies,…
Abstract Number: 2942 • 2016 ACR/ARHP Annual Meeting
Sequencing of 16S rRNA Reveals a Distinct Salivary Microbiome Signature in Behcet’s Disease
Patrick Coit¹, Gonca Mumcu², Filiz Ture Ozdemir³, Ali Ugur Unal⁴, Ugur Alpar⁵, Nagihan Bostanci⁶, Tulin Ergun⁷, Haner Direskeneli⁴ and Amr Sawalha¹, ¹Division of Rheumatology, University of Michigan, Ann Arbor, MI, ²Department of Health Management, Marmara University, Faculty of Health Sciences, Istanbul, Turkey, ³Marmara University, School of Medicine, Department of Immunology, Istanbul, Turkey, ⁴Department of Rheumatology, Marmara University Faculty of Medicine, Istanbul, Turkey, ⁵Faculty of Dentistry, Marmara University, Istanbul, Turkey, ⁶Division of Periodontology, Department of Dental Medicine, Karolinska Institute, Stockholm, Sweden, ⁷Department of Dermatology, Faculty of Medicine, Marmara University, Istanbul, Turkey
Background/Purpose: Results: This is the first high-throughput sequencing-based evaluation of the salivary microbiome in BD. Salivary microbiome of BD patients has a specific signature…
Abstract Number: 2943 • 2016 ACR/ARHP Annual Meeting
Relationship Between Menstruation and Symptoms of Behcet’s Syndrome
Gul Guzelant¹, Yesim Ozguler², Sinem Nihal Esatoglu³, Guzin Karatemiz², Huri Ozdogan², Sebahattin Yurdakul¹, Hasan Yazici¹ and Emire Seyahi¹, ¹Istanbul University, Cerrahpasa Medical Faculty, Department of Internal Medicine, Division of Rheumatology, Istanbul, Turkey, ²Rheumatology, Istanbul University, Cerrahpasa Medical Faculty, Division of Rheumatology, Istanbul, Turkey, ³Rheumatology, Istanbul University, Cerrahpasa Medical Faculty, Department of Internal Medicine, Division of Rheumatology, Istanbul, Turkey
Background/Purpose: It is well known that menstruation triggers several conditions such as migraine, recurrent aphtous stomatitis and acne vulgaris in otherwise healthy individuals (1). It…

All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM CT on October 25. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying colleagues, institutions, communications firms, and all other stakeholders related to the development or promotion of the abstract about this policy. If you have questions about the ACR abstract embargo policy, please contact ACR abstracts staff at [email protected].