Session Type: ACR Poster Session C
Session Time: 9:00AM-11:00AM
Background/Purpose: Behçet’s disease (BD) is a multisystem inflammatory disorder characterized by recurrent oro-genital ulcers, mucocutaneous lesions and serious organ involvement. The goal of this study was to investigate the structure of the salivary microbiome in patients with BD.
Results: Sequence analysis identified a total of 908 OTUs present across all samples. Patients had a microbial community structure that is significantly less diverse than healthy controls. The most overabundant species in BD patients compared to controls was Haemophilus parainfluenzae, while the most depleted included Alloprevotella rava and species in the genus Leptotrichia. Patients receiving periodontal treatment showed improvements in oral health indices, but no short-term differences in bacterial community structure. Neither the BD-associated genetic risk locus within the HLA-B/MICA region nor being on immunosuppressive medications explained the differences between patients and controls.
Conclusion: This is the first high-throughput sequencing-based evaluation of the salivary microbiome in BD. Salivary microbiome of BD patients has a specific signature characterized by changes at the community and species level.
To cite this abstract in AMA style:Coit P, Mumcu G, Ture Ozdemir F, Unal AU, Alpar U, Bostanci N, Ergun T, Direskeneli H, Sawalha A. Sequencing of 16S rRNA Reveals a Distinct Salivary Microbiome Signature in Behcet’s Disease [abstract]. Arthritis Rheumatol. 2016; 68 (suppl 10). https://acrabstracts.org/abstract/sequencing-of-16s-rrna-reveals-a-distinct-salivary-microbiome-signature-in-behcets-disease/. Accessed .
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ACR Meeting Abstracts - https://acrabstracts.org/abstract/sequencing-of-16s-rrna-reveals-a-distinct-salivary-microbiome-signature-in-behcets-disease/