Session Type: ACR Poster Session C
Session Time: 9:00AM-11:00AM
Background/Purpose: Primary angiitis of the CNS (PACNS) is a rare form of vasculitis confined to the brain and spinal cord, which often presents with severe cognitive and functional deficits.
Methods: This is a cross-sectional study from a tertiary referral center. Eligible patient records were identified via retrospective chart review using the ICD-9 code for cerebral angiitis. Patients were included if they met 2 of the 3 following criteria: inflammatory CSF, angiogram typical of vasculitis, or vasculitis present on pathology of the brain. In addition, the diagnosis of PACNS was further agreed upon by 2 rheumatologists in the department who have particular expertise in this disease. Self-reported questionnaires were prospectively collected from eligible subjects. Measure of disability was assessed by the Barthel Index (BI), quality of life was assessed by EuroQOL (EQ-5D-5L), and depression was assessed with Patient Health Questionnaire (PHQ-9). Treatment history was collected from patient report and chart review.
Results: 1855 patient records were identified using the ICD-9 code for cerebral angiitis. 78 patients met inclusion criteria, of which 27 responded to the questionnaires (34.6%).
Conclusion: This is the longest reported follow-up of patients with PACNS described in the literature to-date. Most patients have mild long-term disability and minimal to no depression, which may be reflective of the advances of treatment. The data shows a slight tendency towards better scores being associated with longer treatments. However, larger studies are needed to verify the extent and strength of these relationships.
To cite this abstract in AMA style:Ray E, Saygin D, Morales-Mena A, Messner W, Calabrese LH, Hajj-Ali RA. Patient Outcomes in Primary Angiitis of the Central Nervous System [abstract]. Arthritis Rheumatol. 2016; 68 (suppl 10). https://acrabstracts.org/abstract/patient-outcomes-in-primary-angiitis-of-the-central-nervous-system/. Accessed July 4, 2020.
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ACR Meeting Abstracts - https://acrabstracts.org/abstract/patient-outcomes-in-primary-angiitis-of-the-central-nervous-system/