Abstracts Archive - Page 1787 of 2607 - ACR Meeting Abstracts

Abstract Number: 2824 • 2016 ACR/ARHP Annual Meeting
Lack of Partial Renal Response By 12 Weeks after Induction Therapy Is an Indicator to Switch the Treatment in Lupus Nephritis Class III or IV for Reducing Future Damage Accrual
Hironari Hanaoka¹, Hidehiro Yamada², Tomofumi Kiyokawa³, Harunobu Iida¹, Takeshi Suzuki¹, Yoshioki Yamasaki⁴, Seido Ooka⁵, Hiroko Nagafuchi³, Takahiro Okazaki³, Daisuke Ichikawa⁶, Sayuri Shirai⁶, Yugo Shibagaki⁷, Junki Koike⁸ and Shoichi Ozaki³, ¹Division of Rheumatology and Allergology, Department of Internal Medicine, St. Marianna University School of Medicine, Kawasaki, Japan, ²Rheumatology, Seirei Yokohama Hospital, Yokohama, Japan, ³Internal Medicine, St. Marianna University School of Medicine, Kawasaki, Japan, ⁴Internal Medicie, St. Marianna University School of Medicine, Kawasaki, Japan, ⁵Division of Rheumatology and Allergy, Department of Internal Medicine, St. Marianna University School of Medicine, Kawasaki, Japan, ⁶Division of Nephrology and Hypertension, Department of Internal Medicine, St. Marianna University School of Medicine, Kawasaki, Japan, ⁷Division of Nephrology and Hypertension, Department of Internal Medicine, St. Marianna University School of Medicine, K, Japan, ⁸Department of Pathology, St. Marianna University School of Medicine, Kawasaki, Japan
Background/Purpose: Lupus nephritis (LN) class III or IV is associated with a poor prognosis for both patient and renal survival. The guideline or recommendation for…
Abstract Number: 2825 • 2016 ACR/ARHP Annual Meeting
Urinary BAFF and APRIL Levels: Potential Biomarkers of Active Lupus Nephritis
Sanat Phatak, Smriti Chaurasia, Shravan Mishra, Ranjan Gupta, Amita Aggarwal and Ramnath Misra, Clinical Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
Background/Purpose: B cell Activating Factor of the TNF Family (BAFF) and A Proliferation Inducing Ligand (APRIL) help B cell activation, maintenance and plasma cell survival.…
Abstract Number: 2826 • 2016 ACR/ARHP Annual Meeting
Clinical Utility of Circulating Anti-N-Methyl-D-Aspartate Receptor Subunits NR2A/B Antibody for the Diagnosis of Neuropsychiatric Syndromes in Systemic Lupus Erythematosus and Sjogren’s Syndrome: An Updated Meta-Analysis
Sen Hee Tay¹, Anna-Marie Fairhurst² and Anselm Mak¹, ¹Division of Rheumatology, Department of Medicine, National University Hospital, National University Health System, Singapore, Singapore, Singapore, ²Singapore Immunology Network, Agency for Science, Technology and Research, Singapore, Singapore
Background/Purpose: Neuropsychiatric (NP) events are found in patients with rheumatic diseases, commonly in systemic lupus erythematosus (SLE) and Sjögren's syndrome (SS). The standard nomenclature and…
Abstract Number: 2827 • 2016 ACR/ARHP Annual Meeting
Prognostic Significance of Repeat Biopsy in Lupus Nephritis: Histopathologic Worsening Is an Independent Risk Factor for End Stage Renal Disease and Death
Cristina Arriens¹, Sixia Chen², David Karp³, Ramesh Saxena⁴, Kamalanathan Sambandam⁴, Eliza Chakravarty¹, Judith A. James⁵ and Joan T. Merrill⁶, ¹Arthritis & Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ²Biostatistics and Epidemiology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ³Internal Medicine/Division of Rheumatic Diseases, University of Texas Southwestern Medical Center, Dallas, TX, ⁴Internal Medicine/Division of Nephrology, University of Texas Southwestern Medical Center, Dallas, TX, ⁵Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁶Clinical Pharmacology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK
Background/Purpose: Approximately half of SLE patients develop lupus nephritis (LN), a major cause of morbidity and early mortality. It is known that prolonged renal inflammation…
Abstract Number: 2828 • 2016 ACR/ARHP Annual Meeting
Difference of d-Dimer Between Two Time Points Predicts Prognosis of Admitted Patients with SLE Flare up
Sejin Byun¹, Seung Min Jung¹, Sang-Won Lee², Yong-Beom Park² and Jason Jungsik Song², ¹Division of Rheumatology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea, The Republic of, ²Division of Rheumatology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea
Background/Purpose: Even though the survival rate among SLE patients has improved over the past few decades, the mortality rate caused by the acute flare of…
Abstract Number: 2829 • 2016 ACR/ARHP Annual Meeting
Adherence to Treatment and Renal Transplantation Graft Failure in Lupus Nephritis
Eleana Ntatsaki¹, Alba Velo Garcia², Alan D. Salama³ and David A. Isenberg⁴, ¹Centre for Rheumatology, University College London, London, United Kingdom, ²Internal Medicine Department, University Hospital Complex of Pontevedra, Pontevedra, Spain, ³Centre for Nephrology, University College London, London, United Kingdom, ⁴Centre for Rheumatology, Division of Medicine, University College London, London, United Kingdom
Background/Purpose: Patient non-adherence has been reported as a potential adverse outcome predictor in renal transplantation (rTp) for patients with lupus nephritis (LN). We investigated potential…
Abstract Number: 2830 • 2016 ACR/ARHP Annual Meeting
Non-Calcified Coronary Artery Plaque Associates with Adverse Lipoprotein Profiles in Systemic Lupus Erythematosus
Laura Durcan¹, Armin Zadeh², Margery Connelly³, James Otvos³, Laurence S Magder⁴ and Michelle Petri⁵, ¹University of Washington, Seattle, WA, ²Johns Hopkins University School of Medicine, Baltimore, MD, ³LabCorp, Raleigh, NC, ⁴Epidemiology and Public Health, Division of Rheumatology, School of Medicine, Johns Hopkins University, Baltimore, MD, ⁵Rheumatology Division, Johns Hopkins University School of Medicine, Baltimore, MD
Background/Purpose: Systemic lupus erythematosus (SLE) associates with atherosclerotic cardiovascular (CV) disease and related mortality. This is contributed to, but cannot be fully explained, by traditional…
Abstract Number: 2831 • 2016 ACR/ARHP Annual Meeting
Associations of BAFF and Anti-BAFF Autoantibodies with Disease Activity in Oriental Systemic Lupus Erythematosus
Hwee-Siew Howe¹, Bernard Thong², Kok Ooi Kong³, Hiok-Hee Chng², Tsui Yee Lian², Faith Chia², Karine Tay², Tang Ching Lau⁴, Weng Giap Law², Ee Tzun Koh⁵ and Bernard Pui Lam Leung^6,7, ¹Rheumatology, Allergy and Immunology, Tan Tock Seng Hospital, Singapore, SINGAPORE, Singapore, ²Rheumatology, Allergy and Immunology, Tan Tock Seng Hospital, ., Singapore, ³Rheumatology, Allergy and Immunology, Tan Tock Seng Hospital, Singapore, Singapore, ⁴Yong Loo Lin School of Medicine,, National University of Singapore, ., Singapore, ⁵Department of Rheumatology, Allergy and Immunology, Tan Tock Seng Hospital, ., Singapore, ⁶Physiology, National University of Singapore, ., Singapore, ⁷Rheumatology, Allergy & Immunology, Tan Tock Seng Hospital, ., Singapore
Background/Purpose: B cell activating factor (BAFF) is implicated in the pathogenesis of systemic lupus erythematosus (SLE). A previous small scale study reported that endogenous neutralizing…
Abstract Number: 2832 • 2016 ACR/ARHP Annual Meeting
Novel Gene Variants Associated with Cardiovascular Disease in Systemic Lupus Erythematosus
Dag Leonard¹, Andrei Alexsson¹, Johanna Dahlqvist², Kimberly Taylor³, Johanna K Sandling⁴, Christine Bengtsson⁵, Elisabet Svenungsson⁶, Christopher Sjöwall⁷, Andreas Jönsen⁸, Iva Gunnarsson⁶, Anders A. Bengtsson⁸, Solbritt Rantapaa-Dahlqvist⁵, Maija-Leena Eloranta¹, Ann-Christine Syvänen⁴, Lindsey A. Criswell⁹ and Lars Rönnblom¹, ¹Uppsala University, Department of Medical Sciences, Rheumatology and Science for Life Laboratory, Uppsala, Sweden, ²Uppsala University, Department of Medical Biochemistry and Microbiology Science for Life Laboratory, Uppsala, Sweden, ³University of California, San Francisco, Rosalind Russell / Ephraim P. Engleman Rheumatology Research Center, San Francisco, CA, ⁴Uppsala University, Department of Medical Sciences, Molecular Medicine and Science for Life Laboratory, Uppsala, Sweden, ⁵Umeå University, Department of Public Health and Clinical Medicine/ Rheumatology, Umeå, Sweden, ⁶Karolinska Institutet, Department of Medicine, Unit of Rheumatology, Stockholm, Sweden, ⁷Linköping University, Department of Clinical and Experimental Medicine Rheumatology/AIR, Linköping, Sweden, ⁸Lund University, Department of Clinical Sciences, Rheumatology, Lund, Sweden, ⁹Medicine, University of California, San Francisco, Rosalind Russell / Ephraim P. Engleman Rheumatology Research Center, San Francisco, CA
Background/Purpose: Methods: An association between a locus located on chromosome 14 and stroke/TIA was shown in both the Swedish (OR 1.8, p=0.0002) and the US…
Abstract Number: 2833 • 2016 ACR/ARHP Annual Meeting
Low Plasma Concentrations of Apolipoprotein M Correlate to Disease Activity and Endothelial Dysfunction in SLE
Helena Tydén¹, Christian Lood², Andreas Jönsen³, Birgitta Gullstrand⁴, Bjorn Dahlback⁵ and Anders A. Bengtsson³, ¹Department of Clinical Sciences, Section of Rheumatology, Lund University, Lund, Sweden, ²Department of Clinical Sciences, Section of Rheumatology, Lund University and Skane University Hospital Lund Sweden, Lund University, Lund, Sweden, ³Lund University, Department of Clinical Sciences, Rheumatology, Lund, Sweden, ⁴Department of Clinical Sciences, Division of Rheumatology, Lund University, Lund, Sweden, ⁵Department of Translational Medicine, Division of Clinical Chemistry, Lund University, Skane University Hospital Malmö, Malmö, Sweden
Background/Purpose: Human apoM is a 25kDa apolipoprotein present in 5% of HDL particles in plasma. In mouse models, apoM is antiatherogenic and vasculoprotective and…
Abstract Number: 2834 • 2016 ACR/ARHP Annual Meeting
Utility of the Brain Perfusion Single Photon Emission Computed Tomography in Neuropsychiatric Manifestations of Systemic Lupus Erythematosus
Jorge Medina-Rosas¹, Murray Urowitz², Jiandong Su³, Dafna D Gladman⁴ and Zahi Touma², ¹Medicine, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ²Rheumatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ³Rheumatology, Toronto Western Hospital and University of Toronto, Toronto, ON, Canada, ⁴University of Toronto, Toronto, ON, Canada
Background/Purpose: The diagnosis of Neuropsychiatric Events (NPE) in SLE is challenging and it is mainly based on the physician judgment. Structural brain imaging has…
Abstract Number: 2835 • 2016 ACR/ARHP Annual Meeting
Longitudinal Analysis of Th1 and Th2 Cytokines in Systemic Lupus Erythematosus
Mariana Postal¹, Karina O. Peliçari¹, Nailu A. Sinicato², Aline Tamires Lapa¹, Fernando A. Peres¹, André Moreno Morcillo³, Lilian TL Costallat³ and Simone Appenzeller⁴, ¹Medicine, State University of Campinas, Campinas, Brazil, ²Pediatrics, State University of Campinas, Campinas, Brazil, ³State University of Campinas, Campinas, Brazil, ⁴Division of Rheumatology, Faculty of Medical Science, State University of Campinas, São Paulo, Brazil
Background/Purpose: While autoantibodies production and immune complex deposition are cornered as hallmark features of systemic lupus erythematosus (SLE), there is growing evidence to propose the…
Abstract Number: 2836 • 2016 ACR/ARHP Annual Meeting
Microparticles of Endothelial Origin in Women with Systemic LUPUS Erythematosus UNDER Treatment
WALTER CICARINI¹, KARINE SILVESTRE FERREIRA¹, Renato Vargas Consoli², Claudia Lopes Santoro Neiva³, PAULO MADUREIRA PADUA⁴, ANA FLAVIA PADUA DIAS⁵, fernanda freire Campos Sr.⁶, LUAN CARLOS ALVES¹, Cristina Mello Gomide Loures Sr.⁶, Marcos Ferreira Silva Sr.⁶, TANIA MARA PINTO DABES GUIMARAES¹, Vicente Peixoto Toledo Sr.⁶ and MARIA DAS GRAÇAS CARVALHO¹, ¹Department of Clinical and Toxicological Analysis, Federal University of Minas Gerais, Belo Horizonte/MG, Brazil, ²Rheumatology Unit, Santa Casa Hospital, Belo Horizonte, Brazil, Belo Horizonte, Brazil, ³Rheumatology Unit, Santa Casa Hospital-Belo Horizonte- Bras, Belo Horizonte, Brazil, ⁴Rheumatology Unit, Santa Casa Hospital, Belo Horizonte, Brazil., Belo Horizonte/MG, Brazil, ⁵Rheumatology Unit, Santa Casa Hospital, Belo Horizonte, Brazil, Belo Horizonte/MG, Brazil, ⁶Department of Clinical and Toxicological Analysis, Federal University of Minas Gerais, Belo Horizonte, Brazil
Background/Purpose: Systemic Lupus Erythematosus (SLE) is an inflammatory and multisystem disease. Microparticles (MPs) are cell membrane-shedded fragments released during apoptosis and cell activation. Several diseases are…
Abstract Number: 2837 • 2016 ACR/ARHP Annual Meeting
Importance of Mixed Speckled/ Homogeneous DFS70 ANA Patterns
Bruce Goeckeritz¹, Janie Bruce¹, Sara Carter² and John Carter², ¹Lexington Medical Center, West Columbia, SC, ²Lexington Medical Laboratories, West Columbia, SC
Background/Purpose: A Mixed Speckled/Homogeneous (MS/H) pattern is the single most common ANA pattern identified in our community hospital patient population, often in very high titers, and has…
Abstract Number: 2838 • 2016 ACR/ARHP Annual Meeting
Histopatholgic Predictors of Poor Renal Outcomes in a Multi-Ethnic Cohort
Stacy Tanner¹, Dominick Santoriello², Shanthi Dhaduvai³, Thania Perez⁴, Anca D. Askanase⁵ and Laura Geraldino-Pardilla⁶, ¹Division of Rheumatology, Columbia University College of Physicians & Surgeons, New York, NY, ²Renal Pathology, Columbia University College of Physicians & Surgeons, New York, NY, ³Rheumatology, Carilion Clinic, Roanoke, VA, ⁴Columbia University College of Physicians & Surgeons, New York, NY, ⁵Department of Medicine, Rheumatology, Columbia University College of Physicians & Surgeons, New York, NY, ⁶Columbia University College of Physicians & Surgeons, new york, NY
Background/Purpose: Lupus nephritis (LN) remains an important cause of morbidity and mortality in patients with SLE. Tubular atrophy and interstitial fibrosis on initial renal biopsies…

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